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High-Efficient And New Technology For Producing 5-Nitro-2-Acetylaminobenzimidazole, Saidov Sarvar, Abdurazakov Askar, Karimov Rikhsibay, Khvan Alla

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of this work is to create new veterinary products for agriculture based on local raw materials, to develop a highly efficient technology for their production. Waste from the production of medamine produced in the pilot production of the Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan. The process of synthesis of 5-nitro-2-acetylaminobenzimidazole was studied by one-factor experiments. The structure of the obtained product was investigated by IR, Mass, 1H, 13C NMR spectroscopy. The main factors influencing the process of obtaining 5-nitro-2-acetylaminobenzimidazole were revealed. On the basis of the obtained research results, a …

A Multidisciplinary Approach To Investigate Deep-Pelagic Ecosystem Dynamics In The Gulf Of Mexico Following Deepwater Horizon, April Cook, Andrea Bernard, Kevin M. Boswell, Heather Bracken-Grissom Dr., Marta D'Elia, Sergio Derada, Cole Easson, David English, Ron Eytan, Tamara Frank, Chuanmin Hu, Matt Johnston, Heather Judkins, Chad Lembke, Jose Lopez, Rosanna Milligan, Jon A. Moore, Brad Penta, Nina Pruzinsky, John A. Quinlan, Travis M. Richards, Isabel C. Romero, Mahmood S. Shivji, Michael Vecchione, Max D. Weber, R.J. David Wells, Tracey Sutton

Marine & Environmental Sciences Faculty Articles

The pelagic Gulf of Mexico (GoM) is a complex system of dynamic physical oceanography (western boundary current, mesoscale eddies), high biological diversity, and community integration via diel vertical migration and lateral advection. Humans also heavily utilize this system, including its deep-sea components, for resource extraction, shipping, tourism, and other commercial activity. This utilization has had impacts, some with disastrous consequences. The Deepwater Horizon oil spill (DWHOS) occurred at a depth of ∼1500 m (Macondo wellhead), creating a persistent and toxic mixture of hydrocarbons and dispersant in the deep-pelagic (water column below 200 m depth) habitat. In order to assess the …

Carbon Nanotube–Liposome Complexes In Hydrogels For Controlled Drug Delivery Via Near-Infrared Laser Stimulation, S. Zahra M. Madani, Mohammad Moein Safaee, Mitchell Gravely, Carolynn Silva, Stephen Kennedy, Geoffrey D. Bothun, Daniel E. Roxbury

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Externally controllable drug delivery systems are crucial for a variety of biological applications where the dosage and timing of drug delivery need to be adjusted based on disease diagnosis and progression. Here, we have developed an externally controllable drug delivery system by combining three extensively used platforms: hydrogels, liposomes, and single-walled carbon nanotubes (SWCNTs). We have developed carbon nanotube–liposome complexes (CLCs) and incorporated these structures into a 3D alginate hydrogel for use as an optically controlled drug delivery system. The CLC structures were characterized by using a variety of imaging and spectroscopic techniques, and an optimal SWCNT/lipid ratio was selected. …

An Assessment Of Knowledge, Attitude, And Practice Of The Kuantan Community On The Effects Of Monosaccharides On Cancer, Muhammad Alif Mazlan, Muhammad Kamil Che Hasan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Cancer knowledge, attitude, and practice (KAP) levels of communities are essential to be assessed to enhance cancer educational programs. This study aimed to determine the KAP level of the Kuantan community on the effects of monosaccharides on cancer. The association between the sociodemographic data and KAP level of the community has also been evaluated.

Methods: A cross-sectional survey was performed among residents living in the Kuantan community. Only 303 of 380 responses were included in the data analysis using the chi-square test.

Results: The knowledge and practice levels were moderate, whereas the attitude was at a …

Red Panda: A Novel Method For Detecting Variants In Single-Cell Rna Sequencing, Adam Cornish, Shrabasti Roychoudhury, Krishna Sarma, Suravi Pramanik, Kishor Bhakat, A T. Dudley, Nitish K. Mishra, Chittibabu Guda

Journal Articles: Genetics, Cell Biology & Anatomy

BACKGROUND: Single-cell sequencing enables us to better understand genetic diseases, such as cancer or autoimmune disorders, which are often affected by changes in rare cells. Currently, no existing software is aimed at identifying single nucleotide variations or micro (1-50 bp) insertions and deletions in single-cell RNA sequencing (scRNA-seq) data. Generating high-quality variant data is vital to the study of the aforementioned diseases, among others.

RESULTS: In this study, we report the design and implementation of Red Panda, a novel method to accurately identify variants in scRNA-seq data. Variants were called on scRNA-seq data from human articular chondrocytes, mouse embryonic fibroblasts …

Emerging From The Deep: Complexity, Emergent Pedagogy And Deep Learning, Sue L. T. Mcgregor

Northeast Journal of Complex Systems (NEJCS)

As indicated in the title – emerging from the deep – this paper proposes that an ability to face and deal with complexity can emerge from deep learning that is facilitated by pedagogies designed to ensure this outcome, especially an emergent pedagogy that instills deep education. Educators would view the classroom as a complex adaptive system (CAS) capable of self-organizing and operating at the edge of chaos where order emerges, just not predictably. Self-directed students would experience a learning environment that is appreciative of nonequilibrium, unpredictability, shifting and emerging patterns and co-evolution. Teachers would be coaches, activators and facilitators. Students …

Mandating Covid-19 Vaccines, Lawrence O. Gostin, Daniel A. Salmon, Heidi J. Larson

Georgetown Law Faculty Publications and Other Works

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines hold promise to control the pandemic, and help restore normal social and economic life. The Food and Drug Administration (FDA) has granted emergency use authorization (EUA) for 2 mRNA vaccines and will likely issue full biologics licenses in the coming months. Anticipating vaccine scarcity, the Advisory Committee on Immunization Practice (ACIP) published guidance on vaccine priorities.

Data show 95% efficacy for vaccines granted an EUA, but even highly effective vaccines cannot curb the pandemic without high population coverage and maintenance of other mitigation strategies. Recent data from 1,676 adults surveyed November 30-December …

Noninvasive Vagus Nerve Stimulation And Morphine Transiently Inhibit Trigeminal Pain Signaling In A Chronic Headache Model, Lauren E. Cornelison, Jordan L. Hawkins, Sara E. Woodman, Paul L. Durham

College of Natural and Applied Sciences

Introduction: Chronic headache conditions are characterized by persistent sensitization of the trigeminal system, which involves dysfunction of descending pain modulation. We previously reported that noninvasive vagus nerve stimulation (nVNS) inhibits trigeminal nociception in models of episodic migraine through a mechanism involving enhanced serotonergic and GABAergic descending pain signaling. Objectives: The analgesic effectiveness of nVNS and morphine were investigated in an animal model of chronic headache mediated by the combination of the 3 migraine risk factors of neck muscle tension, paradoxical sleep deprivation, and pungent odors. Methods: Sprague-Dawley rats were injected with complete Freund's adjuvant in the trapezius and sleep deprived …

"Three Countries, Two Lakes, One Future:" The Prespa Lakes And The Signing Of The Prespa Agreement, Loring M. Danforth

All Faculty Scholarship

In this essay, I examine the history of the meaning of Prespa in order to understand its significance as the site for the signing of the agreement that bears its name. At certain times, Prespa has occupied positions of great political importance; at others, it has seemed to lie forgotten at the margins of the Balkans. I consider Prespa as the capital of the Bulgarian Empire, the site of the construction of the borders of new Balkan states, the capital of “Free Greece” during the Greek Civil War, the site of the Transboundary Prespa Park, and finally the place where …

Exploring The Relationship Between Anger, Aggression, And Perpetrator Substance Use In The Commission Of Sexual Offenses, Dominique Rivera

Student Theses

This study examined the potential association between perpetrator substance use, anger, and aggressive behavior in the commission of sexual crimes. The sample included 246 adult males convicted of rape (n = 54) or child molestation (n = 192). Descriptive statistics revealed that 64.6% of the individuals in this sample (n = 159) were intoxicated at the time of the offense. Results showed that perpetrators who used substances at the time of the offense were more likely to exhibit aggressive behavior toward the victim (e.g., weapon use, verbal abuse) than those who did not. Offenders with higher pervasive anger scores were …

Modulation Of Aub-Tdrd Interactions Elucidates Pirna Amplification And Germplasm Formation., Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Paraskevi Sgourdou, Fadia Ibrahim, Daniel Palmieri, Yohei Kirino, Phd, Zissimos Mourelatos

Computational Medicine Center Faculty Papers

Aub guided by piRNAs ensures genome integrity by cleaving retrotransposons, and genome propagation by trapping mRNAs to form the germplasm that instructs germ cell formation. Arginines at the N-terminus of Aub (Aub-NTRs) interact with Tudor and other Tudor domain-containing proteins (TDRDs). Aub-TDRD interactions suppress active retrotransposons via piRNA amplification and form germplasm via generation of Aub-Tudor ribonucleoproteins. Here, we show that Aub-NTRs are dispensable for primary piRNA biogenesis but essential for piRNA amplification and that their symmetric dimethylation is required for germplasm formation and germ cell specification but largely redundant for piRNA amplification.

Psychosocial Impacts Of Fixed Orthodontic Treatment In Lahore, Pakistan, Hazik Bin Shahzad, Dalia Iftikhar, Noor Ul Huda, Nayha Enver, Faiza Awais, Shabbir Hussain

Makara Journal of Health Research

Background: The aim of this study is to assess psychosocial impacts on oral health-related quality of life between individuals currently undergoing orthodontic treatment and those who have completed treatment.

Methods: A total of 135 individuals were selected from the Orthodontic Department at Rashid Latif Dental Hospital, Lahore, Pakistan. Current and previous orthodontic treatments were recorded. A questionnaire on oral impacts on daily performance was used to assess functional, psychological, and social limitations.

Results: The most prevalent psychosocial impact was difficulty in smiling/laughing (26.6%). Logistic regression analysis showed that individuals currently undergoing orthodontic treatment are 2.9 times more …

Evaluation Of Turkey Arthritis Syndrome By Traditional And Advanced Diagnostic Techniques, Rehab Mowafy, Azza Eldeen

Mansoura Veterinary Medical Journal

Objective: The study was done to detect possible causes of arthritis in turkey flock with emphasis on molecular detection of bacterial pathogens direct from samples and estimation of their pathology pattern. Procedure: A total of 100 arthritic legs from 125 French turkey birds were collected from different farms in Sharkia Governorate. Specimens from joint capsule, tendon, and synovial fluid of leg joints were subjected to bacteriological and direct PCR examinations. Moreover, skin, cartilage of articular surface and epiphysis were undergone pathological examination. Blood samples were collected before scarification for both hematological and biochemical examinations. Postmortem examinations revealed joints swelling, hyperkeratosis, …

Max Weber's Living Legacy, Hermann Kurthen

Peer Reviewed Articles

June 14, 2020 was the hundred-year anniversary of Max Weber's death. He died in Munich at age 56 after most likely contracting the Spanish flu. He is often considered one of the founding fathers of sociology next to Marx and Durkheim, despite Weber resisting this label. Given Weber's worldwide reception, his enduring relevance for sociology and beyond is unbroken, even though he left a huge unfinished work not intended as a conventional sociological grand theory but as a historical-comparative attempt to understand how humans interact within their social environment and how they construct a social reality of their own making. …

The Change Of Soil Temperature To Stocking Rate On The Stipa Breviflora Desert Steppe, Jian'an Wang, Guodong Han, Yajuan Jia

IGC Proceedings (1977-2023)

No abstract provided.

Rotational And Continuous Grazing Of Sheep In The Inner Mongolian Steppe Of China, C. J. Wang, B. M. Tas, T. Glindemann, K. Mueller, Anna Schiborra, P. Schoenbach, M. Gierus, Friedhelm Taube, A. Susenbeth

IGC Proceedings (1977-2023)

No abstract provided.

Rotational Grazing Effects Of Dairy Cows On Yield And Consumption In Dwarf Napiergrass At A Paddock Scale For 3 Years From The Establishment In Southern Kyushu, Japan, A. Wadi, Yasuyuki Ishii, H. Hasyim, R. F. Utamy, Sachiko Idota, Kiichi Fukuyama

IGC Proceedings (1977-2023)

No abstract provided.

Prediction Of Diet Quality In Mongolian Livestock With Portable Near Infrared Spectroscopy Offeces, G. Tolleson, G. Udval, S. Prince, K. Banik

IGC Proceedings (1977-2023)

No abstract provided.

Car Wash Complex – Object Of Harmful Impact On Water Resources, M. Radkevich, K. Shipilova, M. Abdukodirova, O. Pochugevski

Irrigation and Melioration

Deals with the problem of the impact of car wash complexes in the city of Tashkent on water resources. The analysis of the technological process of washing and a sociological survey of car owners and employees of car washes revealed the average amount of water used per car wash per year, as well as the amount of harmful substances entering the sewer network of the city of Tashkent. Calculations have shown that the annual water consumption only for passenger cars in Tashkent is about 4.34 million m³, and the wastewater is not properly treated. From one car wash …

Smokejumper Obituary: Martinez, Joe M. "Pipas" (Missoula 1946), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Mouse Mutant Phenotyping At Scale Reveals Novel Genes Controlling Bone Mineral Density., Anna L Swan, Christine Schütt, Jan Rozman, Maria Del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R Seavitt, Derek D Cissell, Terrence F Meehan, Elif F Acar, Christopher J Lelliott, Ann M Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E Braun, Heather Cater, Mary E Dickinson, Paul Flicek, Juan Gallegos, Elena J Ghirardello, Jason D Heaney, Sylvie Jacquot, Connor Lally, John G Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin Mckerlie, Stephen A Murray, Lauryl M J Nutter, Kristian F Odfalk, Helen Parkinson, Jan Prochazka, Corey L Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L. Svenson, Taylor S Vales, Sara E Wells, Jacqueline K White, Radislav Sedlacek, Wolfgang Wurst, Kent K C Lloyd, Peter I Croucher, Helmut Fuchs, Graham R Williams, Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D M Brown, Philipp Mayer-Kuckuk, Martin Hrabe De Angelis, Impc Consortium

Faculty Research 2020

The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone pathologies, including osteoporosis. A total of 200 genes were found to significantly affect BMD. This pool of BMD genes comprised 141 genes with previously unknown functions in bone biology and was complementary to pools derived from recent human studies. Nineteen of the 141 genes also caused skeletal abnormalities. Examination of the BMD genes in osteoclasts and osteoblasts underscored …

Voluntary Simplicity: An Exploration Through Text Analysis, Apollo Demierel

Barowsky School of Business | Faculty Scholarship

Overconsumption poses severe ethical problems and causes harm to the environment. Today many individuals change their consumption practices and actively limit their overall consumption due to ethical and environmental concerns. This article focuses on voluntary simplicity, a sustainable lifestyle phenomenon that comprises environment-friendly consumption practices as an innate characteristic. This paper offers a fresh and nuanced understanding of voluntary simplicity through the lens of social cognitive theory (SCT) and by examining textual content generated by voluntary simplifiers on Facebook. Five thousand three hundred thirty-six Facebook posts and comments were scrapped and examined using sentiment analysis, associative networks and cluster analysis. …

Effect Of Reaction Conditions On Cu⁃Catalyzed Co2 Electroreduction, Chang Zhu, Wei Chen, Yan-Fang Song, Xiao Dong, Gui-Hua Li, Wei Wei, Yu-Han Sun

Journal of Electrochemistry

Electrochemical conversion of carbon dioxide (CO₂) driven by renewable electricity that can meet both carbon emission reduction and renewable energy utilization has been rapidly developed in recent years. Copper (Cu) catalyst has long been a promising candidate for CO₂ electroreduction applications because of its natural abundance and specific capability of producing a substantial amount of C2 products. However, various metallic Cu electrodes reported have been significantly influenced by the adsorption of certain cation/anion ions, resulting in wide-span catalytic activities and selectivity for various products. In addition, a recent report demonstrated that by virtue of gas-diffusion flow cell …

A Trial For Mitigation Of Waterlogging Problem In New Reclaimed Areas In The Desert Fringes Of Beni Suef And El-Minya Governorates, Egypt., Mohamed Gad

Mansoura Engineering Journal

Expanding the reclamation of new lands within the unlimited desert area of Egypt has started to face the continuous growth of population and the urgent need for food security. The reclamation of the Nile valley's desert fringes affects its traditional cultivated areas as a result of the difference in the topographic level, inadequate drainage system and the existence of shallow depth clay lenses beneath these sites which creates a perched condition that helps greatly in fasting the rising rate of water table. The present paper threw light on a trial to mitigate the waterlogging problem due to the reclamation activities …

Molecular Signatures Of Sexual Communication In The Phlebotomine Sand Flies, Paul V. Hickner, Nataliya Timoshevskaya, Ronald J. Nowling, Frédéric Labbé, Andrew D. Nguyen, Mary Ann Mcdowell, Carolina N. Spiegel, Zainulabeuddin Syed

Biology Faculty Publications

Phlebotomine sand flies employ an elaborate system of pheromone communication wherein males produce pheromones that attract other males to leks (thus acting as an aggregation pheromone) and females to the lekking males (sex pheromone). In addition, the type of pheromone produced varies among populations. Despite the numerous studies on sand fly chemical communication, little is known of their chemosensory genome. Chemoreceptors interact with chemicals in an organism’s environment to elicit essential behaviors such as the identification of suitable mates and food sources. Thus, they play important roles during adaptation and speciation. Major chemoreceptor gene families, odorant receptors (ORs), gustatory receptors …

Re-Conceptualizing The International Human Right To Health: An Analysis Of The Trends In Developing And Developed Countries’ Responses To Substance Use Disorders, Leonard Mukosi

San Diego International Law Journal

This Article juxtaposes addiction paradigms seen in the United States of America and Zimbabwe, two countries with diametrically dissimilar political, economic, and social systems. Thus, an insight is provided by this Article into how developing and developed countries are transitioning from punitive to curative approaches in addressing the problem of drug addiction. Positing that addiction is a health condition, this Article recognizes the optimum realization of the addict’s right to health is best met if the required international standards of health are implemented nationally to insure, treat, and evaluate addiction like other chronic illnesses.

Drug addiction is a brain disease …

Optimal Adjustment Of The Human Circadian Clock In The Real World, Samuel Christensen, Yitong Huang, Olivia J. Walch, Daniel B. Forger

Mathematics Sciences: Faculty Publications

Which suggestions for behavioral modifications, based on mathematical models, are most likely to be followed in the real world? We address this question in the context of human circadian rhythms. Jet lag is a consequence of the misalignment of the body’s internal circadian (~24-hour) clock during an adjustment to a new schedule. Light is the clock’s primary synchronizer. Previous research has used mathematical models to compute light schedules that shift the circadian clock to a new time zone as quickly as possible. How users adjust their behavior when provided with these optimal schedules remains an open question. Here, we report …

Pyrrolidinyl Synthetic Cathinones Α-Php And 4f-Α-Pvp Metabolite Profiling Using Human Hepatocyte Incubations., Jeremy Carlier, Xingxing Diao, Raffaele Giorgetti, Francesco P Busardò, Marilyn A. Huestis

Institute of Emerging Health Professions Faculty Papers

For more than ten years, new synthetic cathinones (SCs) mimicking the effects of controlled cocaine-like stimulants have flooded the illegal drug market, causing numerous intoxications and fatalities. There are often no data on the pharmacokinetics of these substances when they first emerge onto the market. However, the detection of SC metabolites is often critical in order to prove consumption in clinical and forensic settings. In this research, the metabolite profile of two pyrrolidinyl SCs, α-pyrrolidinohexaphenone (α-PHP) and 4''-fluoro-α-pyrrolidinovalerophenone (4F-α-PVP), were characterized to identify optimal intake markers. Experiments were conducted using pooled human hepatocyte incubations followed by liquid chromatography-high-resolution tandem mass …

Investigation Of The Moisture Binding Forms In Plant Raw Materials And Thermal Characteristics Determination, Tojiniso Raxmanova, Shaxnoza Sultanova, Jasur Safarov, Esra Capanoglu

Technical science and innovation

In this article, the forms of moisture connection and the thermal characteristics of plant materials are studied. Rosehip and hawthorn fruits were chosen as the object of research. In the heat analyzer, a decrease in the mass of the product and an increase in temperature were found when the temperature was controlled in a certain gas environment. The curves of the dependence of the dog rose and hawthorn samples on the mass and temperature are given. DTA-1/10 galvanometer sensitivity; sensitivity of the DTG-1/5 galvanometer; the maximum heating temperature is 300° С and the rate of change of the furnace heating …

Diverse And Complex Muscle Spindle Afferent Firing Properties Emerge From Multiscale Muscle Mechanics, Kyle P. Blum, Kenneth S. Campbell, Brian C. Horslen, Paul Nardelli, Stephen N. Housley, Timothy C. Cope, Lena H. Ting

Physiology Faculty Publications

Despite decades of research, we lack a mechanistic framework capable of predicting how movement-related signals are transformed into the diversity of muscle spindle afferent firing patterns observed experimentally, particularly in naturalistic behaviors. Here, a biophysical model demonstrates that well-known firing characteristics of mammalian muscle spindle Ia afferents – including movement history dependence, and nonlinear scaling with muscle stretch velocity – emerge from first principles of muscle contractile mechanics. Further, mechanical interactions of the muscle spindle with muscle-tendon dynamics reveal how motor commands to the muscle (alpha drive) versus muscle spindle (gamma drive) can cause highly variable and complex activity during …