Investigating The Coordinate Regulation Of Stem Cell Proliferation And Differentiation By Fbf Proteins, Xiaobo Wang

Graduate Student Theses, Dissertations, & Professional Papers

Balance of stem cell proliferation and differentiation is important for maintaining tissue homeostasis, and uncovering the mechanisms regulating the balance of proliferation and differentiation of stem cells helps us understand the causative factors for ageing, cancer and various degenerative disorders. Pumilio and FBF (PUF) family RNA-binding proteins are conserved mRNA regulators controlling stem cell development in eukaryotes. FBF-1 and FBF-2, two PUF family proteins in C. elegans, are expressed in the mitotic region of the germline and are important for maintaining germline stem cells. FBF-1 and FBF-2 are very similar in primary sequence and share most of the target mRNAs, …

A Policy Analysis Of Lead Paint Disclosure Implementation In Residential Homes In Missoula Montana, Marissa Lein Lehner

Graduate Student Theses, Dissertations, & Professional Papers

Using Weimer and Vining’s (2017) framework and interviews with key actors, this policy analysis evaluates the implementation of federal lead paint disclosure requirements in Missoula Montana. Lead based paint was commonly used in homes built prior to 1978. Disclosure requires landlords and any persons selling a home to disclose known lead-based paint hazards to buyers and renters. The policy was enacted to promote informed decisions to avoid or reduce the risk of lead paint exposure. Lead paint disclosure serves a critical purpose to inform citizens of risk of lead paint in older housing, because any lead exposure is particularly detrimental …

Exogenous Fluid Delivery Schedule And Composition On Fluid Balance, Physiologic Strain, And Substrate Use In The Heat, Alejandro M. Rosales

Graduate Student Theses, Dissertations, & Professional Papers

Introduction: Wildfire suppression is characterized by high total energy expenditures and water turnover rates. Hydration position stands outline hourly fluid intake rates. However, dose interval remains ambiguous. We aimed to determine the effects of micro- and bolus-dosing water (MW, BW) or carbohydrate-electrolyte (MCE, BCE) solutions on fluid balance, heat stress, and carbohydrate oxidation during extended thermal exercise. Methods: Males (n=12), in a repeated measures cross-over design, completed 4, 120-minute treadmill trials (1.3 m^.s^-1, 5% grade, 33°C, 30%RH) wearing a USFS uniform and 15kg pack. Fluid delivery approximated losses calculated from a pre-experiment familiarization …

Creating A Conservation Corridor In Coastal Ecuador: Constraints And Opportunities For Integrative Agroforestry, Lucille M.F. Rice

Graduate Student Theses, Dissertations, & Professional Papers

Agroforestry has the potential to address land degradation and rural livelihood concerns resulting from tropical deforestation and has therefore become a popular tool for reforestation in conservation initiatives. However, these initiatives often lack the resources to implement an integrative approach to developing site-specific agroforestry systems, leading to undesirable outcomes such as lack of community support and unmet ecological objectives. This paper presents a case study of a conservation initiative implemented by the Ceiba Foundation for Tropical Conservation (CFTC) in the Ecuadorian province of Manabí. The CFTC is working with private landowners to establish a coastal conservation corridor through reforestation and …

Dendroanthropological Applications In Adaptive Management: A Multi-Methodical Approach For Interpreting Cultural Landscape Change At Mvs-Yee-Se’-Ne, Brandy Alexandra Clark

Cal Poly Humboldt theses and projects

This thesis combined GIS analysis, archival research, and dendrochronological methods to provide a means for interpreting how the Mvs-yee-se’-ne cultural landscape has changed since the period of European contact circa 1850. By employing dendrochronological methods, a unique stand of Oregon white oak (Quercus garryana) was found to be present at Mvs-yee-se’-ne by at least 1809. Since 1850, factors such as American colonization, homesteading, mining, fire suppression, and logging have had an effect on cultural landscapes such as Mvs-yee-se’-ne regionally, but this research localized such effects in a site-specific context. Aerial imagery analysis conducted for this thesis documented extractive …

Sestrin2 Phosphorylation By Ulk1 Induces Autophagic Degradation Of Mitochondria Damaged By Copper-Induced Oxidative Stress, Heejeong Kim, Byeong Tak Jeon, Isaac M. Kim, Sydney Townsend, Carolyn M. Lorch, Martonio Viana, Jacob F. Myers, Caroline J. Trupp, Zachary T. Whipps, Mondira Kundu, Soonkyu Chung, Xinghui Sun, Oleh Khalimonchuk, Jaekwon Lee, Seung-Hyun Ro

Department of Biochemistry: Faculty Publications

Selective autolysosomal degradation of damaged mitochondria, also called mitophagy, is an indispensable process for maintaining integrity and homeostasis of mitochondria. One well-established mechanism mediating selective removal of mitochondria under relatively mild mitochondria-depolarizing stress is PINK1-Parkin-mediated or ubiquitin-dependent mitophagy. However, additional mechanisms such as LC3-mediated or ubiquitin-independent mitophagy induction by heavy environmental stress exist and remain poorly understood. The present study unravels a novel role of stress-inducible protein Sestrin2 in degradation of mitochondria damaged by transition metal stress. By utilizing proteomic methods and studies in cell culture and rodent models, we identify autophagy kinase ULK1-mediated phosphorylation sites of Sestrin2 and demonstrate …

Addressing The Covid-19 Nutrition Crisis In Vulnerable Communities: Applying A Primary Care Perspective, Madeline Mae A. Ong, Ronnah Marie Ong, Gladys Kaye Reyes, Lourdes S. Tanchanco

Ateneo School of Medicine and Public Health Publications

The coronavirus disease (COVID-19) pandemic and subsequent public health interventions have disrupted food systems all over the world. In the Philippines, where stringent lockdown rules have been implemented, households living in poverty have had to rely largely on food aid in the form of food packs distributed by local governments and private donors. An evaluation of the commonly distributed food items reveals a diet that addresses acute hunger but does not contain sufficient nutrients to promote and maintain health. Such a diet puts low-income households at a greater risk of acute and chronic disease. The negative health impact of commonly …

Catalog Of Services 2020-2021, Csusb Budget Office

University Budget Office records

No abstract provided.

Town Of Candia, New Hampshire 2019 Annual Report Town & School District For The Year Ending December 31, 2019., Candia Town Representatives

Candia, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Global Injury Morbidity And Mortality From 1990 To 2017: Results From The Global Burden Of Disease Study 2017, Spencer L. James, Chris D. Castle, Zachary V. Dingels, Jack T. Fox

Open Access archive

Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate …

The Pax-Six-Eya-Dach Network Modulates Gata-Fog Function In Fly Hematopoiesis And Human Erythropoiesis, T. Michael Creed, Rajkumar Baldeosingh, Christian L. Eberly, Caroline S. Schlee

Open Access archive

The GATA and PAX-SIX-EYA-DACH transcriptional networks (PSEDNs) are essential for proper development across taxa. Here, we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro. Using Drosophila genetics, we show that PSEDN members function with GATA to block lamellocyte differentiation and maintain the prohemocyte pool. Overexpression of human SIX1 stimulated erythroid differentiation of human erythroleukemia TF1 cells and primary hematopoietic stem-progenitor cells. Conversely, SIX1 knockout impaired erythropoiesis in both cell types. SIX1 stimulation of erythropoiesis required GATA1, as SIX1 overexpression failed to drive erythroid phenotypes and gene expression patterns in GATA1 knockout cells. SIX1 …

Early Acid/Base And Electrolyte Changes In Permanent Middle Cerebral Artery Occlusion: Aged Male And Female Rats, Sarah R. Martha, Lisa A. Collier, Stephanie M. Davis, Sarah J. Goodwin, David Powell, Doug Lukins, Justin F. Fraser, Keith R. Pennypacker

Neurosurgery Faculty Publications

BACKGROUND: Early changes in acid/base and electrolyte concentrations could provide insights into the development of neuropathology at the onset of stroke. We evaluated associations between acid/base and electrolyte concentrations, and outcomes in permanent middle cerebral artery occlusion (pMCAO) model.

METHODS: 18-month-old male and female Sprague-Dawley rats underwent pMCAO. Pre-, post- (7 min after occlusion), and at 72 hr of pMCAO venous blood samples provided pH, carbon dioxide, oxygen, glucose, hematocrit, hemoglobin, and electrolyte values of ionized calcium, potassium, and sodium. Multiple linear regression determined predictors of infarct and edema volumes from these values, Kaplan-Meier curve analyzed morality between males and …

North Fork: Whitesburg Tributaries Watershed Plan, Letcher County, Ky, Kentucky Water Resources Research Institute

KWRRI Research Reports

Crafts Colly, Sandlick, and Dry Fork are tributaries to the North Fork of the Kentucky River. The three tributaries are located immediately north of the North Fork of the Kentucky and flow southward into the river within or near the City of Whitesburg in Letcher County, Kentucky. Letcher County is found in the Appalachian coalfields of southeastern Kentucky.

To improve water quality in the Kentucky River, water quality impairments in the upper reaches of the watershed must be addressed. In focusing efforts in Crafts Colly, Sandlick, and Dry Fork, three headwater tributaries of the North Fork Kentucky River, pollution loading …

From Petri Dish To Main Dish: The Legal Pathway For Cell-Based Meat, Brian P. Sylvester, Nathan A. Beaver, Kara Schoonover, Jonathan I. Tietz

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

Meat grown outside an animal is no longer simply science fiction, and the market is poised for introduction of a variety of so-called cell-based meat products. Commercializing these products will require a clear regulatory path forward. In this Article, we explore that legal pathway. We introduce the concepts of cellular agriculture and cell-based meat, including the science, the state and history of the industry, and the general regulatory background, in which the USDA and FDA are the major players. Further, we explore in particular regulatory aspects of food safety and labeling in the context of cell-based meat. Overall, we contend …

Proposal: Protecting U.S. Agricultural Workers Utilizing Existing Legal Structures And Augments To The U.S. Farm Bill, Alexia M. Kulwiec

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Annual Report Of The Municipal Officers Of The Town Of Chatham, New Hampshire Fiscal Year Ending December 31, 2019., Chatham Town Representatives

Chatham, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Unity, New Hampshire Annual Report Year Ending December 31, 2019., Unity Town Representatives

Unity, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Report Of The Select Board And Other Town Officers Goshen, Nh For The Year Ending December, 2019., Goshen Town Representatives

Goshen, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Report Of The Town Officers Of The Town Of Columbia, New Hampshire, Including The Report Of The School Directors For The Year Ending December 31, 2019., Columbia Town Representatives

Columbia, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Did Akhenaten's Founding Of Akhetaten Cause A Malaria Epidemic, Lisa Sabbahy Dr.

Faculty Journal Articles

This paper presents and discusses evidence for changes in the environment that would have taken place at the site of Amarna, ancient Akhetaten, during the rapid building and populating of the city in the reign of King Akhenaten. The evidence suggests that the effect of the founding of this city, with all the consequences of a changed environment on both sides of the river, could have been responsible for a malaria epidemic. This scenario is backed up by the high prevalence of signs of malaria in the skeletal material from Amarna, as well as in the short-lived history of the …

Integrating Lecture And Laboratory In Anatomy And Physiology: Student Perceptions And Performance, Jessica L. Peacock, Kathleen Fitzpatrick, Kevin E. Finn

Health Sciences Faculty Publications

The authors determined whether positive perceptions of integrating lecture and lab in Anatomy and Physiology courses persisted from 2015-2018. Students (843) and instructors (56) completed the Student Assessment of Their Learning Gains survey; perceptions were positive and consistent between both groups. Participant narratives identified the ability to immediately apply theoretical knowledge in lab as an important positive attribute in improving student learning. The authors also determined whether student performance rates, including unsatisfactory grades (C-, D, F, W), improved during integrated years. Results showed that unsatisfactory grades fell in the integrated years, while results for quiz and exam grades, compared between …

Improving Natural Product Research Translation: From Source To Clinical Trial, Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss, Naomi K. Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N. Brown, Frederic D. Bushman, Steven J. Casper, Floyd H. Chilton, Christopher S. Coffey, Mario G. Ferruzzi, D. Craig Hopp, Mairead Kiely, Daniel Lakens, John B. Macmillan, David O. Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K. Quinney, Barbara Rehermann, Kenneth D.R. Setchell, Nisha S. Sipes, Jacqueline M. Stephens, D. Lansing Taylor, Hervé Tiriac, Michael A. Walters, Dan Xi, Giovanna Zappalá, Guido F. Pauli

Faculty Publications

© 2019 Federation of American Societies for Experimental Biology While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally considered the gold standard for assessing safety and efficacy, CTs, especially phase III CTs, are costly and require rigorous planning to optimize the value of the information obtained. More effective bridging from NP research to CT was the goal of a September, 2018 transdisciplinary workshop. Participants emphasized that replicability and likelihood of successful translation depend on rigor in experimental design, …

Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: The possible mechanisms of production of four novel resistant starch type 4 (RS4) products for total cecal fermentation in an in vivo rodent model are evaluated. Methods and results: Forty weanling rats are randomly assigned to five groups (n = 8) for a 3-week study. Starches are the RS type 4 products, as 10% of weight of RS diets (RSA–RSD), and AMIOCA starch (100% amylopectin) comprises 53.6% weight of control (CON) and 43.6% weight of RS diets. The RS products vary by percent purity and origin (potato, corn, tapioca). At …

Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: The possible mechanisms of production of four novel resistant starch type 4 (RS4) products for total cecal fermentation in an in vivo rodent model are evaluated. Methods and results: Forty weanling rats are randomly assigned to five groups (n = 8) for a 3-week study. Starches are the RS type 4 products, as 10% of weight of RS diets (RSA–RSD), and AMIOCA starch (100% amylopectin) comprises 53.6% weight of control (CON) and 43.6% weight of RS diets. The RS products vary by percent purity and origin (potato, corn, tapioca). At …

Tropism, Pathology, And Transmission Of Equine Parvovirus-Hepatitis, Joy Ellen Tomlinson, Mason Jager, Alyssa Struzyna, Melissa Laverack, Lisa Ann Fortier, Edward Dubovi, Lane D. Foil, Peter D. Burbelo, Thomas J. Divers, Gerlinde R. Van De Walle

Faculty Publications

© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause of Theiler's disease, we first demonstrated hepatotropism by PCR on tissues from acutely infected horses. We then experimentally inoculated horses with EqPV-H and 8 of 10 horses developed hepatitis. One horse showed clinical signs of liver failure. The onset of hepatitis was temporally associated with seroconversion and …

Response Of Liver Metabolic Pathways To Ketogenic Diet And Exercise Are Not Additive, Tai Yu Huang, Felicia R. Goldsmith, Scott E. Fuller, Jacob Simon, Heidi M. Batdorf, Matthew C. Scott, Nabil M. Essajee, John M. Brown, David H. Burk, Christopher D. Morrison, Susan J. Burke, J. Jason Collier, Robert C. Noland

Faculty Publications

© Lippincott Williams & Wilkins. Purpose Studies suggest ketogenic diets (KD) produce favorable outcomes (health and exercise performance); however, most rodent studies have used a low-protein KD, which does not reflect the normal- to high-protein KD used by humans. Liver has an important role in ketoadaptation due to its involvement in gluconeogenesis and ketogenesis. This study was designed to test the hypothesis that exercise training (ExTr) while consuming a normal-protein KD (NPKD) would induce additive/synergistic responses in liver metabolic pathways. Methods Lean, healthy male C57BL/6J mice were fed a low-fat control diet (15.9% kcal protein, 11.9% kcal fat, 72.2% kcal …

Practical Functional Assessment And Treatment Of Pediatric Food Selectivity, Holly C. Gover

Doctoral Dissertations - College of Arts and Sciences

"Food selectivity affects up to 45% and 80% of individuals with and without disabilities, respectively. Behavior analytic interventions have consisted primarily of differential reinforcement and escape extinction. Escape extinction, while efficacious, may also result in increased aggression, gagging, or vomiting, and therefore may not be feasible or desirable under some conditions. We describe a model for assessing and treating food selectivity and refusal without escape extinction for young children with and without developmental disabilities."

Massachusetts Chapter 70 Education Equity Funding In Policy And Practice, Julia E. Kostro

Honors Theses

School funding policies aim to equalize school quality between districts of varying income levels, however, vast inequalities persist in our education system. This thesis examines how and why education funding policy, despite its high potential to create meaningful reform, continues to be a weak lever to promote equitable change in the education system in Massachusetts. After considering the rationales from previous scholars used to explain this phenomenon, interviews were conducted with three key stakeholder groups (policymakers, state advocates, and local leaders such as principals and superintendents), in order to produce a cross-sectional analysis of why education funding policy tends to …

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

Vigor Difference During Storage And Germination In Indian Mustard Explained By Reactiveoxygen Species And Antioxidant Enzymes, Nipa Biswas, Sangita Yadav, Shiv Yadav, Ravish Choudhary, Navinder Saini, Anil Dahuja, Sujata Vasudev, Devendra Kumar Yadav

Turkish Journal of Agriculture and Forestry

Canola-type genotypes in Indian mustard (Brassica juncea) are a new kind of quality resource developed for their low levels of erucic acid (