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2020

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Associations Between Sex Work And Stimulant Use By Gender Among People Who Use Methamphetamine In The Mexico-U.S. Border, Itzahi Rodela Jan 2020

Associations Between Sex Work And Stimulant Use By Gender Among People Who Use Methamphetamine In The Mexico-U.S. Border, Itzahi Rodela

Open Access Theses & Dissertations

BACKGROUND: The literature indicates that there is a strong association between sexual risk behaviors for sexually transmitted infections and drug use, specifically sex work and stimulant use, respectively. Along the Mexico-U.S. border, Cd. Juarez and Tijuana are cities with high rates of drug use and availability due to lying on major drug trafficking routes into the U.S. There is minimal literature available on sex work among men not exclusively men who have sex with men, and stimulant use in the border region. AIMS: The aim of this study is to (1) summarize the measures for sociodemographic characteristics, sexual risk behaviors, …

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Comparison Of 70% Alcohol And 2% Glutaraldehyde Effectiveness To The Amount Of Bacterial Colonies On The Dental Chair Unit In Department Of Oral And Maxillofacial Surgery Faculty Of Dentistry University Of Sumatera Utara, Hendry Rusdy, Darmayanti Siregar, Ahyar Riza, Indra B. Siregar, Novita M. Sari Jan 2020

Comparison Of 70% Alcohol And 2% Glutaraldehyde Effectiveness To The Amount Of Bacterial Colonies On The Dental Chair Unit In Department Of Oral And Maxillofacial Surgery Faculty Of Dentistry University Of Sumatera Utara, Hendry Rusdy, Darmayanti Siregar, Ahyar Riza, Indra B. Siregar, Novita M. Sari

Journal of Dentomaxillofacial Science

No abstract provided.

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The Attitudes Of Parents And Children Towards Restoration Of Deciduous Molar Teeth With Stainless Steel Crown (Ssc) In The Dental Hospital University Of Baiturrahmah, Sri P. Utami, Hanifa U. Dwi, Hamdy Lisfriza Jan 2020

The Attitudes Of Parents And Children Towards Restoration Of Deciduous Molar Teeth With Stainless Steel Crown (Ssc) In The Dental Hospital University Of Baiturrahmah, Sri P. Utami, Hanifa U. Dwi, Hamdy Lisfriza

Journal of Dentomaxillofacial Science

No abstract provided.

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A Phylogenetic Analysis Of Mycoplasma Strains Circulating In Sheep Pneumonia In Thekars Region Of Turkey, Olcay Öztürkler, Sali̇h Otlu Jan 2020

A Phylogenetic Analysis Of Mycoplasma Strains Circulating In Sheep Pneumonia In Thekars Region Of Turkey, Olcay Öztürkler, Sali̇h Otlu

Turkish Journal of Veterinary & Animal Sciences

This study aimed to investigate Mycoplasma species by cultural and molecular methods in 250 pneumonics and 30 healthy appearance sheep lungs brought from slaughterhouse and butcheries in the Kars region of Turkey. The phylogenetic positioning of the bacterial strains to be obtained in the present study was another remarkable outcome of the study. Mycoplasma isolation was achieved solely in 26 (10.4%) of 250 sheep lungs with pneumonia. Mycoplasma ovipneumoniae was found predominant species in 12 (46.15%) of samples and that was followed by Mycoplasma arginini in 4 (15.38%) of strains. Moreover, two samples were found to be co-infected with the …

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Visual Outcome Evaluation Of Complicated Perforating Corneal Injuries After Surgicalrepair In 45 Cats, Khaled M. Ali, Marwa H. Hassan Jan 2020

Visual Outcome Evaluation Of Complicated Perforating Corneal Injuries After Surgicalrepair In 45 Cats, Khaled M. Ali, Marwa H. Hassan

Turkish Journal of Veterinary & Animal Sciences

Corneal perforations and lacerations are common causes of blindness. These injuries require immediate treatment to preserve the anatomical integrity of the cornea. The purposes of our study were to demonstrate the common complications of traumatic and nontraumatic penetrating corneal injuries in cats and to assess the visual outcome after surgical repair of these cases. The present study included 45 cats with traumatic and nontraumatic perforated cornea. The cats were treated either by suturing of the corneal defect, conjunctival flap, or treating the associated complications. Regarding the surgical outcomes after a successful conjunctival flap, the corneal integrity and transparency of the …

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Typing Of Φsp-3 Lytic Salmonella Bacteriophages Obtained From Various Fecal Sources, Asli Sakmanoğlu, Hasan Hüseyi̇n Hadi̇mli̇ Jan 2020

Typing Of Φsp-3 Lytic Salmonella Bacteriophages Obtained From Various Fecal Sources, Asli Sakmanoğlu, Hasan Hüseyi̇n Hadi̇mli̇

Turkish Journal of Veterinary & Animal Sciences

Although several reports are available on both ΦSP-1 and ΦSP?3 lytic Salmonella bacteriophages obtained from poultry, further research is required to study the effectiveness of ΦSP-3 type on serovars isolated from other sources. In the present study, we aimed to isolate bacteriophages from 8 serovars previously obtained from 869 fecal samples (calf, dairy cow, buffalo, and camel), genotype the bacteriophages, and detect the cross-lytic activities of the bacteriophages on Salmonella enterica subsp. enterica serovar Kentucky, S.Anatum, and S.Muenchen. A total of 16 bacteriophages were detected as ΦSP-3 type via PCR. The Hunter-Gaston Discriminatory Index of SDS-PAGE was calculated to be …

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Investigation Of Biotype, Genotype And Virulence Associated Genes Inpasteurella Multocida Capsular Type A Strains From The Respiratory Tract Of Cattle Andtheir Relationship With Disease Cases, Özgül Gülaydin, Kemal Gürtürk Jan 2020

Investigation Of Biotype, Genotype And Virulence Associated Genes Inpasteurella Multocida Capsular Type A Strains From The Respiratory Tract Of Cattle Andtheir Relationship With Disease Cases, Özgül Gülaydin, Kemal Gürtürk

Turkish Journal of Veterinary & Animal Sciences

Pasteurella (P.) multocida, which causes respiratory disease in cattle, can also be found commensally in the upper respiratory tract. Therefore, it is epidemiologically important to determine the possible difference between pathogenic and commensal strains for the diagnosis of the disease. In this study, phenotypic and genotypic characteristics and virulence associated genes of P. multocida capsular type A strains isolated from the respiratory tract of sick and healthy cattle were investigated. Also, the relationship between the disease status of animals and the characteristics of the isolates were evaluated. Total of 51 P. multocida capsular type A strains were biotyped and genotyped …

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Application Of An Indirect Mila Elisa For The Detection Of Mycoplasma Bovis Antibodiesin Bovine Milk, Abd Al Bar Al Farha, Nadeeka Wawegama, Farhid Hemmatzadeh, Simon Firestone, Jamie Moffat, Gholam Ali Kojouri, Ania Ahaniazari, Reza Amanollahi, Andrew Hoare, Kiro Petrovski Jan 2020

Application Of An Indirect Mila Elisa For The Detection Of Mycoplasma Bovis Antibodiesin Bovine Milk, Abd Al Bar Al Farha, Nadeeka Wawegama, Farhid Hemmatzadeh, Simon Firestone, Jamie Moffat, Gholam Ali Kojouri, Ania Ahaniazari, Reza Amanollahi, Andrew Hoare, Kiro Petrovski

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to detect Mycoplasma bovis specific antibodies using a recently reported MilA ELISA with the aim to detect M. bovis antibodies in milk. An indirect ELISA, based on a recombinant fragment of the Mycoplasma immunogenic lipase A (MilA) protein, was conducted on 291 milk samples for the detection of M. bovis antibodies. Samples were also tested with conventional Mycoplasma culture and M. bovis PCR. Samples were collected from individual cows from 2 commercial dairy herds in South Australia. Of 291 samples tested, 68 (23.4%) were detected positive for M. bovis antibodies, 150 (51.5%) were positive …

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Pathogenicity Of Aerobic Bacteria Isolated From Honeybees (Apis Mellifera) In Ordu Province, Emi̇ne Şeyma Boğ, Ömer Ertürk, Mustafa Yaman Jan 2020

Pathogenicity Of Aerobic Bacteria Isolated From Honeybees (Apis Mellifera) In Ordu Province, Emi̇ne Şeyma Boğ, Ömer Ertürk, Mustafa Yaman

Turkish Journal of Veterinary & Animal Sciences

The honeybee (Apis mellifera) is an important pollinator insect. Any pathogenic infection in this beneficial insect is undesirable. In this study, bacterial diversity in beehives was investigated to determine the potential of pathogenic bacteria in honeybees. To do this, bacterial isolations were carried out from dead and diseased adult bees collected from 9 districts in Ordu Province in Turkey.Twenty species of pathogenic bacteria, 18 of which were nonsporeforming Staphylococcus lentus, Klebsiella oxytoca, Citrobacter freundii, Leucanostoc mesenteroides ssp. cremoris, Kocuria rosea, Kocuria kristinae, Sphingomonas paucimobilis slashline, Burkholderia cepacia, Leucanostoc mesenteroides ssp. dextranicum,Hafnia alvei, Escherichia coli, Aeromonas salmonicida, Citrobacter braakii, Pantoea agglomerans, …

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Extended Spectrum Beta-Lactamase (Esßl), Ampc And Carbapenemase Activities Andcolistin Resistance Of Salmonella Spp. Isolated From Food Poisoning Cases In Turkey, Si̇bel Kizil Jan 2020

Extended Spectrum Beta-Lactamase (Esßl), Ampc And Carbapenemase Activities Andcolistin Resistance Of Salmonella Spp. Isolated From Food Poisoning Cases In Turkey, Si̇bel Kizil

Turkish Journal of Veterinary & Animal Sciences

This study aims at detecting antimicrobial resistance properties including extended spectrum beta-lactamase (ESBL), AmpC, carbapenemase activities (imipenem, meropenem and ertapenem), and colistin resistance of isolated and serotyped Salmonella spp. strains from various foods (mostly chicken and chicken products) that cause food poisoning. The ISO 6579-3 (Kaufmann-White scheme) method was used for serotyping of Salmonella spp. and for detection of antimicrobial resistance with Minimum Inhibitory Concentration (MIC) as reported by EURL-AR. Inoculums were separated into EUVSEC and EUVSEC2 panels using the Sensititre AIM Automated Inoculation Delivery System. The results were monitored in a semiautomatic vision reader and evaluated according to EUCAST. …

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Biosecurity Levels Of Livestock Enterprises In Turkey And Factors Affecting These Levels, Mehmet Feri̇t Can, Nuri̇ Altuğ, Ferhan Kaygisiz Jan 2020

Biosecurity Levels Of Livestock Enterprises In Turkey And Factors Affecting These Levels, Mehmet Feri̇t Can, Nuri̇ Altuğ, Ferhan Kaygisiz

Turkish Journal of Veterinary & Animal Sciences

Biosecurity (BS) is a multidimensional preventive medicine approach that has health, technical, and financial aspects. The purpose of this study was to determine the differences of the BS scores belonging to the livestock enterprises depending on the geographical region and breeding types and to predict the socioeconomic factors having an impact over the BS level. The study was conducted with 517 breeders who live in 7 different regions of Turkey. The results have revealed that the enterprises performing "beef cattle fattening and dairy cattle breeding together" have higher BS scores than the enterprises in the other breeding category (P < 0.01). The differences between the technical and financial scores according to geographical regions were statistically significant (P < 0.01). The regions categorized as "wes" have the highest score and "south" have the lowest score. It was determined that as the "educational level of the breeder" and "enterprise scale" increased, the BS score significantly went up. The regression model was found significant as a whole (P < 0.01) and the independent variables explained the variation in the technical and financial BS scores to be 14.6% and 12.7%, respectively. Dissemination of education/training practices and increasing enterprise scales will positively affect the level of BS in the sector.

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Faculty Authors & Achievers Bibliography 2020, Luke Vilelle Jan 2020

Faculty Authors & Achievers Bibliography 2020, Luke Vilelle

WRL: Faculty Authors & Achievers Bibliographies

The office of the Vice President for Academic Affairs and the Wyndham Robertson Library congratulate all Hollins faculty who published or presented creative or scholarly works from Fall 2018 - Summer 2020. These pages include a list of those activities.

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Elucidating The Impact And Mechanism Of Hepatitis C Virus Cell-To-Cell Spread, Karina Durso-Cain Jan 2020

Elucidating The Impact And Mechanism Of Hepatitis C Virus Cell-To-Cell Spread, Karina Durso-Cain

Dissertations

Virus cell-to-cell spread has been implicated in the establishment of persistent infection and has been shown to be involved in the transmission of antiviral resistant mutants. However, relatively little is known about how virus cell-to-cell spread impacts infection or the specific mechanisms by which cell-to-cell spread occurs. as such, this dissertation focused on investigating HCV cell-to-cell spread not only to learn more about this medically important virus, but also to determine the broader impact cell-to-cell spread has on viral infection dynamics, identify the cellular factors involved, and perhaps ultimately provide insight into antiviral strategies that might enhance the barrier to …

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Developing Caspase-1 Biosensors To Monitor Inflammation In Vitro And In Vivo, Sarah Talley Jan 2020

Developing Caspase-1 Biosensors To Monitor Inflammation In Vitro And In Vivo, Sarah Talley

Dissertations

Inflammation is central to the pathogenesis of numerous human diseases. in many contexts, inflammation drives immune responses which are critical to protection against many pathogens. However, uncontrolled inflammation can drive the pathology of numerous diseases, including neurodegenerative diseases, intestinal disorders, cancer, and autoimmune diseases. a primary mediator of inflammation is the inflammasome complex, which drives the release of inflammatory mediators through caspase-1 activation. Our goal was to develop a tool that would allow us to monitor caspase-1 activation in vitro and ultimately in vivo. to this end, we employed a circularly permuted form of luciferase in which the N- and …

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Determining The Genetic And Phenotypic Profile Of Cord Blood Derived T Regulatory Cells And The Effect Of Calcitriol On Immune Suppression, Anya Nikolai-Yogerst Jan 2020

Determining The Genetic And Phenotypic Profile Of Cord Blood Derived T Regulatory Cells And The Effect Of Calcitriol On Immune Suppression, Anya Nikolai-Yogerst

Dissertations

Recent outbreaks in vertically transmitted viruses, such as Zika virus and HIV, have rejuvenated interest in fetal and neonatal immune tolerance. Babies are susceptible to vertically transmitted viruses because fetal and neonatal immune systems are considered to be immune-privileged and will tolerate antigens presented to them by their mother. Thus, understanding the mechanisms of this tolerance is important to design effective treatments for infected mothers to protect their offspring. Here, I define a novel Treg, a type of T cell that mediates tolerance, named bidirectional T cells (BiT), found in human umbilical cord blood (UCB). These cells are induced by …

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Insights Into Acinetobacter Baumannii: A Review Of Microbiological, Virulence, And Resistance Traits In A Threatening Nosocomial Pathogen, Carole Ayoub Moubareck, Dalal Hammoudi Halat Jan 2020

Insights Into Acinetobacter Baumannii: A Review Of Microbiological, Virulence, And Resistance Traits In A Threatening Nosocomial Pathogen, Carole Ayoub Moubareck, Dalal Hammoudi Halat

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Being a multidrug-resistant and an invasive pathogen, Acinetobacter baumannii is one of the major causes of nosocomial infections in the current healthcare system. It has been recognized as an agent of pneumonia, septicemia, meningitis, urinary tract and wound infections, and is associated with high mortality. Pathogenesis in A. baumannii infections is an outcome of multiple virulence factors, including porins, capsules, and cell wall lipopolysaccharide, enzymes, biofilm production, motility, and iron-acquisition systems, among others. Such virulence factors help the organism to resist stressful environmental conditions and enable development of severe infections. Parallel …

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Intrinsic Control Strategies For Herpesvirus-Based Vaccine Vectors, Hujaz Ismail Abdulrazzaq Alqirbi Jan 2020

Intrinsic Control Strategies For Herpesvirus-Based Vaccine Vectors, Hujaz Ismail Abdulrazzaq Alqirbi

Other Faculty of Health Theses

Herpesvirus-based vectors have been used in vaccine strategies to target zoonotic diseases such as Ebola and human monkeypox, through eliciting a highly immunogenic response. We are investigating strategies to attenuate the virus and control its ability to replicate and persist, while maintaining its ability to elicit protective immune responses. In this project we have investigated three distinct and innovative means to provide intrinsic control of herpesvirus-based vectors. The first strategy is based on deletion of a gene essential for viral latency to modify persistence in vivo. Studies by Thirion et al have shown that the bovine herpesvirus 4 (BoHV-4) ORF73 …

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Advanced Glycation End Products As A Biomarker For Accelerated Ocular Ageing And Glaucoma, Leanne Smewing Jan 2020

Advanced Glycation End Products As A Biomarker For Accelerated Ocular Ageing And Glaucoma, Leanne Smewing

Other Faculty of Health Theses

Advanced glycation end products (AGEs) have a large impact on the healthy ageing population and those diagnosed with pathology. Studies have linked AGEs to glaucomatous optic neuropathy, however there is little consensus on the role AGEs play in glaucoma development. Furthermore, it is known that diet is an exogenous source of AGEs, however it is not clear how dietary AGE (dAGE) influences tissue-bound levels in the body. The overarching theme of this thesis was to assess the impact of AGE level, measured both through diet and tissue-bound levels in the skin (skin autofluoresence, SAF), on retinal vessels and the cornea …

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Metagenomic Identification And Characterisation Of Emerging And Re-Emerging Viruses Causing Disease In Febrile Patients., Emma Louise Wise Jan 2020

Metagenomic Identification And Characterisation Of Emerging And Re-Emerging Viruses Causing Disease In Febrile Patients., Emma Louise Wise

Other Faculty of Health Theses

Emerging infectious diseases (EID) significantly impact public health and have the potential to cause pandemics. Outbreaks of EID have increased in recent decades, with RNA viruses responsible for a substantial proportion of them. Outbreaks are more likely to occur in areas with high biodiversity, poor sanitation and public health infrastructure, and limited resources for EID control. Furthermore, clinical symptoms of many viral infections overlap, making them challenging to diagnose correctly. Metagenomic sequencing (metagenomics) negates the need for targeted detection assays, generates virus genome information and can detect novel or genetically divergent viruses. Through combining targeted PCR-based assays with untargeted metagenomics, …

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Zika Virus Inactivates Polyamine Catabolism Via Alternative Splicing To Enhance Infection, Marion Lea Graham Jan 2020

Zika Virus Inactivates Polyamine Catabolism Via Alternative Splicing To Enhance Infection, Marion Lea Graham

Master's Theses

During viral infection, the virus and host must compete for resources inside the cell. One of these resources is polyamines. Polyamines are small, positively charged molecules that are found in all eukaryotic cells. They play a key role in several cellular functions including growth and proliferation, transcription and translation, and membrane stability. Viruses also rely polyamines for productive replication, utilizing them during DNA/RNa polymerization, nucleic acid packaging, and protein synthesis. in response to a virus infecting a host cell, the host cell will begin to regulate polyamine levels as a way to combat the infection. Polyamine levels are regulated by …

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Transforming Growth Factor Beta Suppression Of Cd8+ T Cell Proliferation, Shena Geisinger Jan 2020

Transforming Growth Factor Beta Suppression Of Cd8+ T Cell Proliferation, Shena Geisinger

Master's Theses

Transforming Growth Factor Beta (TGF-beta) is highly suppressive to both CD4+ and CD8+ T cell proliferation and function. in tumor microenvironments, TGF-beta has been described as immune suppressive, particularly to CD8+ T cells, however, the molecular mechanism behind how TGF-beta signaling controls T cell growth is not fully understood. Here, we report that TGF-beta inhibits CD8+ T cell proliferation and reduces expression of the CARMA1/BCL10/MALT1 (CBM) signalosome complex in activated CD8+ T cells. the CBM signalosome is an essential scaffold that forms after T cell receptor (TCR) stimulation, leading to the activation of NF-kB and AP-1. This observed reduction in …

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The Characterization Of Inflammatory Extracellular Vesicles, Barak Balva Jan 2020

The Characterization Of Inflammatory Extracellular Vesicles, Barak Balva

Master's Theses

One of the driving factors behind innate immunity is the early response of inflammation. While beneficial in controlling infections, when uncontrolled it can lead to a plethora of disorders. Thus, it is essential to understand the driving factors behind inflammation. a cell's ability to recycle, discard, or transfer proteins is integral for survival and intercellular communication. It has been appreciated that inflammatory components, such as caspase-1, play a huge role in driving protein secretion. Thus, inflammation also plays a role in the distribution of proteins released from cells. These proteins are released via non-conventional secretory pathways, and our lab is …

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Investigating The Role Of Hypusine In Viral Translation And Infection, Jeremy Joseph Esin Jan 2020

Investigating The Role Of Hypusine In Viral Translation And Infection, Jeremy Joseph Esin

Master's Theses

Polyamines are small, positively charged, molecules found in eukaryotic cells with roles in cellular function and viral infection. in previous work we have shown RNa viruses, including bunyaviruses, to be sensitive to polyamine depletion, but exact mechanisms are unknown. Bunyaviruses are emerging pathogens that cause encephalitis, hemorrhagic fevers, and meningitis. Rift Valley Fever Virus is a bunyavirus that infects both humans and livestock with severe mortality and morbidity. in previous work done with Rift Valley Fever Virus polyamine depleted results in noninfectious interfering particles without affecting the shape or size of the particles. Here, I investigate a specific metabolic pathway …

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Characterization Of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs, Nicholas Rohlfes Jan 2020

Characterization Of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs, Nicholas Rohlfes

Master's Theses

Inflammation is the bodies first response to defend itself against foreign pathogens and damage. Cellular sensors are constantly monitoring the body and checking for homeostatic disruption. Microbial pathogens and tissue damage are sensed by pattern recognition receptors (PRRs), which sense pathogen associated molecular patterns and damage associated molecular patterns, termed PAMPs and DAMPs respectively. Within the family of PRRs are sensors that can induce the formation of the multi-protein complex termed the inflammasome following activation. the inflammasome complex is a molecular platform for which caspase 1, a cysteine protease, is incorporated and is responsible for the maturation of pro-inflammatory cytokines …

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Enabling The Clinical Detection Of Human Papilloma Virus (Hpv) To Enhance Effective Diagnosis And Research, Jennifer Sackey Jan 2020

Enabling The Clinical Detection Of Human Papilloma Virus (Hpv) To Enhance Effective Diagnosis And Research, Jennifer Sackey

Master's Theses

Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections. There are over 150 different genotypes of HPV. Some cause benign warts, while others cause several types of cancer. Subunit vaccines comprised of the capsid protein from an increasing number of HPV genotypes have been developed; however, the vaccines are prophylactic and are documented to protect against only 9 of the HPV genotypes. Importantly, there are also significant limitations in the clinical detection of HPV. Current clinical tests can only specifically identify HPV16 and HPV18. One of the test also detects 12 of the other high-oncogenic risk …

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A Susceptibility Study Of Urinary Isolates To Methenamine Hippurate And Its Metabolites, Nancy Sloan Jan 2020

A Susceptibility Study Of Urinary Isolates To Methenamine Hippurate And Its Metabolites, Nancy Sloan

Master's Theses

Urinary Tract Infection (UTI) is one of the most common bacterial infections in adult women. Treatment is one of the most common reasons for antibiotic prescription. the rise of antibiotic-resistant infections coupled with the shortage of new antibiotics creates an urgent need for alternative non-antibiotic treatments. One alternative is methenamine hippurate (MH), which is a non-antibiotic prophylaxis. It is reported to be active against some common uropathogens including Escherichia coli and Enterococcus species, but its effects on the newly discovered bladder microbiota (urobiome) are undocumented. Given this knowledge gap, this study aimed to evaluate the drug's spectrum of susceptibility on …

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Determining Interactions Between Bacteriophage And Urinary Microbiome Lysogens, Michael Bochert Jan 2020

Determining Interactions Between Bacteriophage And Urinary Microbiome Lysogens, Michael Bochert

Master's Theses

Bacteriophages (phages) are viruses that infect bacteria. They are the most abundant life forms on earth. It is estimated that there are approximately 10³⁰ phages on the planet (Chibani-Chennoufi et al. 2004). They outnumber their bacterial hosts approximately 10 to 1. Bacteria inhabit most niches on the planet including the human body, where they play critical roles in health and disease. Since phages shape bacterial populations the same way that viruses, such as smallpox and measles, shaped human populations, it is important to understand how they interact with their bacterial hosts. The majority of the phages that we know of …

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Induction Of Zika And Dengue Virus-Specific Cd8+ T Cells By Means Of Dna Vaccine, Natalie Jachym Jan 2020

Induction Of Zika And Dengue Virus-Specific Cd8+ T Cells By Means Of Dna Vaccine, Natalie Jachym

Master's Theses

Zika virus (ZIKV) and Dengue virus (DENV) are flaviviruses that circulate in the same endemic regions and can co-infect the same individual. While primary infection by DENV leads to life-long immunity to the infecting serotype, it does not provide immunity to other serotypes. Moreover, ZIKV and DENV antibodies can be cross-reactive and potentially enhance infection of the other virus through a process known as antibody-dependent enhancement (ADE). In this mechanism, antibodies weakly bind the infecting virus and direct virions to immunoglobulin Fc receptors on macrophages. This promotes viral uptake and infection rather than neutralize the virus. Due to this mechanism, …

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Blockchain & Business Methods: How Business Method Patents May Be Redeemed By Furthering Blockchain Innovation, Kurt Prange Jan 2020

Blockchain & Business Methods: How Business Method Patents May Be Redeemed By Furthering Blockchain Innovation, Kurt Prange

Colorado Technology Law Journal

No abstract provided.

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Susceptibility Of Campylobacter Strains To Selected Natural Products And Frontline Antibiotics, Gahamanyi Noel Jan 2020

Susceptibility Of Campylobacter Strains To Selected Natural Products And Frontline Antibiotics, Gahamanyi Noel

All Rsif Scholars' Publications

Campylobacter species have developed resistance to existing antibiotics. The development of alternative therapies is, therefore, a necessity. This study evaluates the susceptibility of Campylobacter strains to selected natural products (NPs) and frontline antibiotics. Two C. jejuni strains (ATCC® 33560TM and MT947450) and two C. coli strains (ATCC® 33559TM and MT947451) were used. The antimicrobial potential of the NPs, including plant extracts, essential oils, and pure phytochemicals, was evaluated by broth microdilution. The growth was measured by spectrophotometry and iodonitrotetrazolium chloride. Antibiotic resistance genes (tet(O) and gyrA) were characterized at the molecular level. The minimum inhibitory concentrations (MICs) and the minimum …

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