Digital Commons Network^™

Radford V. Van Orden Appellant's Reply Brief Dckt. 47364

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Mutations In Mylpf Cause A Novel Segmental Amyoplasia That Manifests As Distal Arthrogryposis, Jessica X. Chong, Jared C. Talbot, Emily M. Teets, Samantha Previs

Open Access archive

We identified ten persons in six consanguineous families with distal arthrogryposis (DA) who had congenital contractures, scoliosis, and short stature. Exome sequencing revealed that each affected person was homozygous for one of two different rare variants (c.470G>T [p.Cys157Phe] or c.469T>C [p.Cys157Arg]) affecting the same residue of myosin light chain, phosphorylatable, fast skeletal muscle (MYLPF). In a seventh family, a c.487G>A (p.Gly163Ser) variant in MYLPF arose de novo in a father, who transmitted it to his son. In an eighth family comprised of seven individuals with dominantly inherited DA, a c.98C>T (p.Ala33Val) variant segregated in all four …

Developing A Yeast Two-Hybrid System To Study Molluscum Contagiosum Virus Protein-Protein Interactions With Human Proteins, Eric Bryan

Seton Hall University Dissertations and Theses (ETDs)

The human immune system acts as our primary defense against invading pathogens including bacteria, parasites, and viruses. Molluscum Contagiosum Virus (MCV) is a poxvirus that causes persistent skin lesions in humans that can last for many months at a time. Persistence of MCV infections is attributed in part to the ability of the virus to suppress human immune signaling. Many MCV genes, including MC159, MC160, and MC163, code for products that inhibit several important innate immune signaling pathways and consequently reduce inflammation, leukocyte infiltration, and chemokine production. However, due to lack of a tissue culture system in which to propagate …

Knowlesi Malaria, Yee Ling Lau

Archival Material (2020s)

Originally a simian malaria, Plasmodium knowlesi is now known as the fifth human malaria species. Since the report of a large focus of human knowlesi cases in Sarawak in 2004, many more human cases have been reported in all of the countries in Southeast Asia and in travellers returning from these countries. The zoonotic nature of this infection hinders malaria elimination efforts. In order to grasp the current perspective of knowlesi malaria, this inaugural lecture explores the different aspects of the disease including risk factors, diagnosis, treatment, molecular and functional studies. Current studies do not provide sufficient data for an …

The Weekly Challenger, August 6, 2020, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The August 6, 2020, issue of The Weekly Challenger.

The Effect Of Bacterial Endotoxin Lps On Serotonergic Modulation Of Glutamatergic Synaptic Transmission, Jate Bernard, Abigail Greenhalgh, Oscar Istas, Nicole T. Marguerite, Robin L. Cooper

Biology Faculty Publications

The release of the endotoxin lipopolysaccharides (LPS) from gram-negative bacteria is key in the induction of the downstream cytokine release from cells targeting cells throughout the body. However, LPS itself has direct effects on cellular activity and can alter synaptic transmission. Animals experiencing septicemia are generally in a critical state and are often treated with various pharmacological agents. Since antidepressants related to the serotonergic system have been shown to have a positive outcome for septicemic conditions impacting the central nervous system, the actions of serotonin (5-HT) on neurons also exposed to LPS were investigated. At the model glutamatergic synapse of …

The Nativity Collection In The Marian Library, Sarah Burke Cahalan

Marian Library Faculty Publications

The Marian Library was founded in 1943 by the Society of Mary, the Catholic religious order which also founded the University of Dayton in 1850. Those two dates are significant because the library was established to mark the centennial of the university’s founding. With exemplary forethought, the Society of Mary allowed seven years to build a library collection so that it would be ready for the official centennial. This deliberate mindset and commitment to education is still apparent today, even as the decline in vocations means fewer Marianists and more laypeople filling the offices on campus. From the beginning, the …

Bisphenol-A (Bpa) And Breast Cancer: Utilizing Risk Assessment And Education To Improve Preventative Care, Ashley Catherine Babcock

Doctor of Nursing Practice (DNP) Projects

Breast cancer places a large burden on many communities, causing mortalities, and lasting physical, mental, and financial damage. The majority of cases are not caused by a genetic risk factor, which speaks to the importance of addressing environmental risk factors to reduce disease burden. Bisphenol-A (BPA) is linked to increase risk for and metastasis of breast cancer. BPA is widely used in plastics, exposing a huge portion of the United States population. This project used the model developed for the Green Choices program to trial response to the use of an environmental risk survey and education tool that can be …

Recent Advances In The Management Of Gastrointestinal Stromal Tumor., Monjur Ahmed

Division of Gastroenterology and Hepatology Faculty Papers

Gastrointestinal stromal tumor (GIST) is a rare but an important clinical entity seen in our clinical practice. It is the most common mesenchymal tumor of the gastrointestinal tract and most common malignancy of the small intestine. Although the exact prevalence of GIST is not known, the incidence of GIST has been increasing. GISTs arise from interstitial cells of Cajal. Most of the GISTs occur due to mutation in c-kit gene or platelet derived growth factor receptor alpha gene. 15% of GISTs do not have these mutations and they are called wild-type GISTs. Almost all GISTs express KIT receptor tyrosine kinase. …

Exploiting Somatic Pirnas In Bemisia Tabaci Enables Novel Gene Silencing Through Rna Feeding, Mosharrof Mondal, Judith K. Brown, Alex Flynt

Faculty Publications

© This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). RNAi promises to reshape pest control by being nontoxic, biodegradable, and species specific. However, due to the plastic nature of RNAi, there is a significant variability in responses. In this study, we investigate small RNA pathways and processing of ingested RNAi trigger molecules in a hemipteran plant pest, the whitefly Bemisia tabaci. Unlike Drosophila, where the paradigm for insect RNAi technology was established, whitefly has abundant somatic piwi-associated RNAs (piRNAs). Long regarded as germline restricted, piRNAs are common in the …

Mentors International Microfinance Curriculum Design, Jessica Wilkinson

Instructional Psychology and Technology Graduate Student Projects

Mentors International is a non-profit that seeks to empower the world’s poor to grow in self-reliance through personal and business mentoring and access to financial services. Their goal was to create training curriculum that empowers clients of all education levels to start and grow their business, standardizes their training programs across the globe, and ultimately reduces repeat loan clients. This paper describes the design process of creating the curriculum, and the final product delivered.

Molecular Pathways Elicited By Toll-Like Receptor 2 (Tlr2) Signaling During Staphylococcus Aureus Craniotomy Infection, Chinyere Agba, Cortney E. Heim, Christopher M. Horn, Tammy Kielian

Posters: 2020 Summer Undergraduate Research Program

A craniotomy is required to access the brain during neurosurgery for tumor resection or epilepsy treatment and despite extensive precautionary measures, infectious complications occur at a frequency of 1-3% (1-3). Approximately half of craniotomy infections are caused by S. aureus, which forms a biofilm on the bone flap. Our laboratory has developed a mouse model of S. aureus craniotomy-associated biofilm infection that shares important ultrastructural and MRI attributes with human disease (4). Toll-like receptor 2 (TLR2) is expressed by cells of the innate immune system and is critical for recognizing pathogen-associated molecular patterns (PAMPs) in the cell wall of gram-positive …

Bioenergetic And Proteomic Analysis Of Striatal Synaptosomes From Pink1/Parkin Double Knockout Rats, Jacob Shomali, Steven Totusek, Kelly Stauch

Posters: 2020 Summer Undergraduate Research Program

Parkinson’s disease (PD) patients exhibit dopaminergic (DA) neuron degeneration in the substantia nigra pars compacta (SNpc) and loss of associated terminals in the striatum, which results in motor deficits. Loss-of-function gene mutations in PINK1 and Parkin (proteins relevant to mitochondrial quality control) have been identified in hereditary PD patients and show promise for PD animal models. Without a reproducible PD mammalian model, previous studies have failed to observe the mechanisms of progressive neurodegeneration. Therefore, we created and characterized a PINK1/Parkin double knockout (DKO) rat that reproducibly (100% of males) exhibits PD-relevant pathology, including striatal nerve terminal bioenergetic deficits prior to …

The Investigation Of Surface Structures On Various Pathogens And Their Interactions With The Human Immune System, Carmen M. Villalobos

Biomedical Engineering ETDs

The cell surface is the first interface the host immune system encounters and

its investigation has led to a better understanding of cellular biology and types of

pathways that pathogens target in a host cell. The cell surface has evolved to include

many functions such as manipulation of the cytoskeleton, cell signaling, membrane

trafficking, adhesion, and integration into host tissue. The pathogens of interest are

the pathogenic fungus, Candida albicans, and the parasite, Giardia lamblia and we

investigate the consequences of drug treatments on the cell surface, leading to

promising new targets.

Dating, Dining, And Ducks: Continued Recovery Of Campus Lakes After Dredging, Hannah E. Cohen, Emily A. Kane, Christian Cox

Sustainability Showcase (2014-2022)

Proposed by Hannah Cohen, GS Student, and Drs. Emily Kane and Christian Cox , Department of Biology. ($19,000.00)

Assessing Sex Differences In The Effects Of Short-Term Rem Sleep On Anxiety- And Depressive-Like Behaviors In Rats, Nadia Meshkati

Seton Hall University Dissertations and Theses (ETDs)

Findings from both human and animal studies suggest rapid eye movement (REM) sleep disturbances following a traumatic event can lead to inability to extinguish the fear association, and eventually influence the development of post-traumatic stress disorder (PTSD). Additionally, research has demonstrated that sleep disruptions, including REM sleep deprivation (RSD), increases anxiety- and depressive-like behaviors and states in animals and people, with evidence of sex differences. Furthermore, it has yet to be determined whether short-term RSD, a more natural animal model of PTSD, can influence affective state of subjects. The present study applied short-term RSD to investigate sex differences in the …

Potential Of Resampled Multispectral Data For Detecting Desmodium-Brachiaria Intercropped With Maize In A 'Push-Pull' System, B. T. Mudereri, E. M. Abdel-Rahman, T. Dube, T. Landmann, S. Niassy, H. E.Z. Tonnang, Z. R. Khan

All Peer-Reviewed Publications

Poor crop yields remain one of the main causes of chronic food insecurity in Africa. This is largely caused by insect pests, weeds, unfavourable climatic conditions and degraded soils. Weed and pest control, based on the climate-adapted g'push-pull' system, has become an important target for sustainable intensification of food production adopted by many small-holder farmers. However, essential baseline information using remotely sensed data is missing, specifically for the g'push-pull' companion crops. In this study, we investigated the spectral uniqueness of two of the most commonly used g'companion' crops (i.e. greenleaf Desmodium (i Desmodium intortum/i) and Brachiaria (i Brachiaria/i cv Mulato) …

Pilot Project For Future Fast And Accurate Detection Of The Human Fecal Marker Hf183 For Presence Of Human Pollution In The New River, Angie Louis

All HCAS Student Capstones, Theses, and Dissertations

One type of pollution that has a negative impact on the environmental waters originates from fecal contamination. Identifying the source of pollution is an important step in effective resource management, mitigation, and reducing risk to human health. Microbial source tracking (MST) can be used to identify fecal pollution and to identify specific microbes in the environment and the quantitative polymerase chain reaction (qPCR) can be utilized in this analysis. In this pilot study the New River waterway, running through the City of Fort Lauderdale, was tested for a human specific bacteria Bacteroids, using the TaqMan HF183 qPCR assay (HF183/BFDrev). …

Synchronization Of Mothers And Offspring Promotes Tolerance And Limits Allergy, Kathryn A Knoop, Keely G Mcdonald, Paige E Coughlin, Devesha H Kulkarni, Jenny K Gustafsson, Brigida Rusconi, Vini John, I Malick Ndao, Avraham Beigelman, Misty Good, Barbara B Warner, Charles O Elson, Chyi-Song Hsieh, Simon P Hogan, Phillip I Tarr, Rodney D Newberry

Open Access Publications

Allergic disorders, characterized by Th2 immune responses to environmental substances, are increasingly common in children in Western societies. Multiple studies indicate that breastfeeding, early complementary introduction of food allergens, and antibiotic avoidance in the first year of life reduces allergic outcomes in at-risk children. Why the benefit of these practices is restricted to early life is largely unknown. We identified a preweaning interval during which dietary antigens are assimilated by the colonic immune system. This interval is under maternal control via temporal changes in breast milk, coincides with an influx of naive T cells into the colon, and is followed …

Selective Inhibition Of Mtorc1 In Tumor Vessels Increases Antitumor Immunity, Shan Wang, Ariel Raybuck, Eileen Shiuan, Sung Hoon Cho, Qingfei Wang, Dana M Brantley-Sieders, Deanna Edwards, Margaret M Allaman, James Nathan, Keith T Wilson, David Denardo, Siyuan Zhang, Rebecca Cook, Mark Boothby, Jin Chen

Open Access Publications

A tumor blood vessel is a key regulator of tissue perfusion, immune cell trafficking, cancer metastasis, and therapeutic responsiveness. mTORC1 is a signaling node downstream of multiple angiogenic factors in the endothelium. However, mTORC1 inhibitors have limited efficacy in most solid tumors, in part due to inhibition of immune function at high doses used in oncology patients and compensatory PI3K signaling triggered by mTORC1 inhibition in tumor cells. Here we show that low-dose RAD001/everolimus, an mTORC1 inhibitor, selectively targets mTORC1 signaling in endothelial cells (ECs) without affecting tumor cells or immune cells, resulting in tumor vessel normalization and increased antitumor …

Ancestral Pueblo Pottery: Cataloguing, Curation, Mount-Making And More, Elizabeth A. Jennings

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Ancestral Pueblo pottery is some of the most renowned pottery of its kind in North America, yet outside of the archaeology and art history communities its beauty and complexity is not well known. The University of Northern Colorado has a vast and remarkable collection of artifacts, predominately comprised of Native American pottery and ceramics. This collection was not previously widely accessible, partially because it was not published. The purpose of my research was to create an exhibition highlighting this collection of Ancestral Pueblo pottery in Michener Library at University of Northern Colorado, as well as an interactive touch screen kiosk …

We Are...Marshall, August 5, 2020, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Comparative Gene Expression Profiling Between Optic Nerve And Spinal Cord Injury In Xenopus Laevis Reveals A Core Set Of Genes Inherent In Successful Regeneration Of Vertebrate Central Nervous System Axons, Morgan A. Sammons, Jamie L. Belrose, Aparna Prasad, Kurt M. Gibbs, Ben G. Szaro

Biological Sciences Faculty Scholarship

Background

The South African claw-toed frog, Xenopus laevis, is uniquely suited for studying differences between regenerative and non-regenerative responses to CNS injury within the same organism, because some CNS neurons (e.g., retinal ganglion cells after optic nerve crush (ONC)) regenerate axons throughout life, whereas others (e.g., hindbrain neurons after spinal cord injury (SCI)) lose this capacity as tadpoles metamorphose into frogs. Tissues from these CNS regions (frog ONC eye, tadpole SCI hindbrain, frog SCI hindbrain) were used in a three-way RNA-seq study of axotomized CNS axons to identify potential core gene expression programs for successful CNS axon regeneration.

Results …

Transcriptome Analysis And Expression Of Selected Cationic Amino Acid Transporters In The Liver Of Broiler Chicken Fed Diets With Varying Concentrations Of Lysine, Collins N. Khwatenge, Boniface M. Kimathi, Samuel N. Nahashon

Agricultural and Environmental Sciences Faculty Research

Amino acids are known to play a key role in gene expression regulation. Amino acid signaling is mediated via two pathways: the mammalian target of rapamycin complex 1 (mTORC1) and the amino acid responsive (AAR) pathways. Cationic amino acid transporters (CATs) are crucial in these pathways due to their sensing, signaling and transport functions. The availability of certain amino acids plays a key role in the intake of other amino acids, hence affecting growth in young birds. However, the specific mechanism for regulating lysine transport for growth is not clear. In this study, we analyze the transcriptome profiles and mRNA …

Punishment Feedback Impairs Memory And Changes Cortical Feedback-Related Potentials During Motor Learning, Christopher M. Hill, Mason Stringer, Dwight E. Waddell, Alberto Del Arco

Faculty and Student Publications

© Copyright © 2020 Hill, Stringer, Waddell and Del Arco. Reward and punishment have demonstrated dissociable effects on motor learning and memory, which suggests that these reinforcers are differently processed by the brain. To test this possibility, we use electroencephalography to record cortical neural activity after the presentation of reward and punishment feedback during a visuomotor rotation task. Participants were randomly placed into Reward, Punishment, or Control groups and performed the task under different conditions to assess the adaptation (learning) and retention (memory) of the motor task. These conditions featured an incongruent position between the cursor and the target, with …

Characterization Of The Biogeography And Temporal Dynamics Of The Trachymyrmex Septentrionalis Fungus Garden Microbiome, Kevin Lee

Doctoral Dissertations

Like all fungus-growing ants, Trachymyrmex septentrionalis engages in an obligate mutualism with a Basidiomycete fungus that it raises as its primary nutrition source. Therefore, the success of the symbiosis is dependent upon the health of the fungus garden containing this fungus, which may be affected by the composition of its microbiome. Most of what is known about fungus garden microbiomes comes from studies of the Neotropical fungus growing ants, especially the most evolutionarily derived and economically impactful “leaf-cutting” species. Although fungus-farming ants inhabit a vast range, little is known about how dispersal of microbes from their biogeographically and temporally distinct …

Moving Up And On, Karrington Tabor

The Mall

No abstract provided.

Good/Bad, Natalie Shaffer

The Mall

No abstract provided.

When The Last Light Fades, Kaitlyn Graham

The Mall

No abstract provided.

Improving Medication Communication Of Nurses To Patients In The Cardiac Procedure Unit, Jose Abrogar

Master's Projects and Capstones

Abstract

Problem: Effective communication about medications and their potential side effects is a significant indicator of safe patient care and improved health outcomes. The Cardiac Procedure Unit (CPU) of a large medical center in California recently received a low HCAHPS (CMS, 2019) score of one star (out of five) in the area of medication communication.

Context: The CPU is a microsystem that provides pre and post cardiac procedure care for patients of diverse backgrounds. It has a highly competent staff administering patient care. Current patient medication education faces challenges that hinder patient receptivity and thus understanding.

Intervention: The proposed project …