Digital Commons Network^™

Liposomal Delivery Of Azithromycin Enhances Its Immunotherapeutic Efficacy And Reduces Toxicity In Myocardial Infarction, Ahmed Al-Darraji, Renée R. Donahue, Himi Tripathi, Hsuan Peng, Bryana M. Levitan, Lakshman Chelvarajan, Dalia Haydar, Erhe Gao, David Henson, John C. Gensel, David J. Feola, Vincent J. Venditto, Ahmed K. Abdel-Latif

Gill Heart & Vascular Institute Faculty Publications

A growing body of evidence shows that altering the inflammatory response by alternative macrophage polarization is protective against complications related to acute myocardial infarction (MI). We have previously shown that oral azithromycin (AZM), initiated prior to MI, reduces inflammation and its negative sequelae on the myocardium. Here, we investigated the immunomodulatory role of a liposomal AZM formulation (L-AZM) in a clinically relevant model to enhance its therapeutic potency and avoid off-target effects. L-AZM (40 or 10 mg/kg, IV) was administered immediately post-MI and compared to free AZM (F-AZM). L-AZM reduced cardiac toxicity and associated mortality by 50% in mice. We …

Detection Of Organic Free Radicals And Reactive Oxygen Substances Using Chemically-Stimulated Luminescence From Structured Compound Semiconductors, William L. Boatright

Animal and Food Sciences Faculty Patents

A method of monitoring for the presence of an oxidizing chemical species in an aqueous or non-polar environment includes steps of exposing a structured compound semiconductor material to the oxidizing chemical species in the environment and detecting electromagnetic radiation emitted by the structured compound semiconductor material upon exposure to the oxidizing chemical species. The structured compound semiconductor material is a phytate scaffold material and a metal dopant.

The Invisible Web At Work: Artificial Intelligence And Electronic Surveillance In The Workplace, Richard A. Bales, Katherine Vw Stone

AI-DR Collection

Employers and others who hire or engage workers to perform services use a dizzying array of electronic mechanisms to make personnel decisions about hiring, worker evaluation, compensation, discipline, and retention. These electronic mechanisms include electronic trackers, surveillance cameras, metabolism monitors, wearable biological measuring devices, and implantable technology. These tools enable employers to record their workers’ every movement, listen in on their conversations, measure minute aspects of performance, and detect oppositional organizing activities. The data collected is transformed by means of artificial intelligence (A-I) algorithms into a permanent electronic resume that can identify and predict an individual’s performance as well as …

Shelf-Stable Sustainable Shrimp Thermally Processed With Reciprocal Agitation, William R. Dixon, Evelyn G. Watts, John A. King, Xing Fu, Louise Wicker

Faculty Publications

Shelf-stable, ready-to-eat shrimp offer a convenient, portion-controlled option for a highly desirable seafood commodity. The perishability of shrimp requires tight cold-temperature control during distribution and handling. Thermal processing of shrimp was evaluated in a multimode retort with automated control of come-up, heat, and cool times and with addition of high-speed reciprocal agitation. Reciprocal agitation was compared with static retort for thermal process and quality parameters, including cook time, process time to achieve target lethality (F0), cook yield, texture, and appearance of shelf-stable shrimp. Total retort thermal processing times decreased from 30 min at 0 shakes per minute (SPM) to 17.1 …

Early General Hypothermia Improves Motor Function After Spinal Cord Injury In Rats; A Systematic Review And Meta-Analysis., Mahmoud Yousefifard, Mohammad Hossein Vazirizadeh-Mahabadi, Leila Haghani, Farhad Shokraneh, Alex R. Vaccaro, Vafa Rahimi-Movaghar, Mostafa Hosseini

Rothman Institute Papers

Introduction: There is still controversy about the effect of early hypothermia on the outcome of spinal cord injury (SCI). The aim of this review article is to investigate the effect of local or general hypothermia on improving the locomotion after traumatic SCI.

Methods: Electronic databases (Medline and Embase) were searched from inception until May 7, 2018. Two independent reviewers screened and summarized the relevant experimental studies on hypothermia efficacy in traumatic SCI. The data were analyzed and the findings were presented as pooled standardized mean difference (SMD) and 95% confidence interval (95% CI).

Results: 20 papers contain-ing 30 separate experiments …

Methods Of Sustaining Dietary Ketosis And Its Effects On Lipid Profile, Dominic Paul D'Agostino, Shannon Kesl

USF Patents

The ketogenic diet (KD) has therapeutic implications in many disease states. It was hypothesized ketone precursor supplementation would elevate blood ketone levels to therapeutic ranges (2-7 mM) without need for dietary restriction. The effects of ketogenic agents were tested on blood glucose, ketones, and lipids with a 28-day dose escalation study in male Sprague-Dawley rats: R,S-1,3-Butandiol (BD), acetoacetate ketone ester (KE), and control (H2O) (n≥8). Days 1-28, rats received a daily 5 g/kg intragastric gavage, based on previous toxicology studies. Once weekly, whole blood samples (10 μl) were acquired for analysis of glucose and βHB at 0, 0.5, 1, 4, …

Hydantoin Derivative Compounds, Methods Of Use And Methods Of Treatment, Jianfeng Cai, Ma Su, Alekhya Nimmagadda, Peng Teng

USF Patents

The present disclosure provides compositions including a hydantoin derivative compound, pharmaceutical compositions including a hydantoin derivative compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Method For The Treatment Of Malignancies, Richard Heller, Kenneth E. Ugen

USF Patents

A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently administering at least one high voltage, short duration pulse to the tumor. The electroporation pulses may be administered at al least 700 V/cm for a duration of less than 1 millisecond. The intratumor treatments with electroporation may be administered in at least a two-treatment protocol with the time between treatments being about 7 days. The intratumor treatments with electroporation may be administered in a three-treatment protocol with a time …

Dance And Know You Are A Part: The Instrumentality Of Performative Politics And Dance In The Configuration Of Local Social Memory And Afro-Brazilian Identity And Agency In Pelotas, Rio Grande Do Sul, Brazil, Triston R. Brown

Theses and Dissertations

The arts have been a refuge from perpetual repression and omission, and, a platform for social activism for Afro-descendants in the Americas. In Brazil this is very much the case. With performance serving as a social barometer or a looking glass, dance becomes a source of cultural knowledge, acts as preservative, and negotiates individual mobility within a given context. The Afro-Brazilian dance company, Cia de Dança Daniel Amaro in Pelotas, Brazil grants its members a means of activism and agency to challenge entrenched national narratives and reinterpret local social memory.

Most academic writings about dance or performance in Brazil, focus …

Visual Corticocortical Inputs To Ferret Area 18, Reem Khalil, Moody Roberne Jensy Saint Louis, Shaima Alsuwaidi, Jonathan B. Levitt

Publications and Research

Visual cortical areas in the adult mammalian brain are linked by a network of interareal feedforward and feedback circuits. We investigated the topography of feedback projections to ferret (Mustela putorius furo) area 18 from extrastriate areas 19, 21, and Ssy. Our objective was to characterize the anatomical organization of the extrastriate feedback pool to area 18. We also wished to determine if feedback projections to area 18 share similar features as feedback projections to area 17. We injected the tracer cholera toxin B subunit (CTb) into area 18 of adult ferrets to visualize the distribution and pattern of retrogradely labeled …

Lactate Suppresses Macrophage Pro-Inflammatory Response To Lps Stimulation By Inhibition Of Yap And Nf-Κb Activation Via Gpr81-Mediated Signaling, Kun Yang, Jingjing Xu, Min Fan, Fei Tu, Xiaohui Wang, Tuanzhu Ha, David L. Williams, Chuanfu Li

ETSU Faculty Works

Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses. Macrophages [Raw 264.7 and bone marrow derived macrophages (BMDMs)] were treated with LPS in the presence or absence of lactate. Pro-inflammatory cytokines, NF-κB and YAP activation and nuclear translocation were examined. Our results show that lactate significantly attenuates LPS stimulated macrophage TNF-α and IL-6 production. Lactate also suppresses LPS stimulated macrophage NF-κB and YAP activation and nuclear translocation in macrophages. Interestingly, YAP activation and nuclear translocation are required for LPS …

Introduction A Bold Agenda For The Next Steps In Health Reform, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

Introduction: In the aftermath of the largely failed Clinton-era health reform push and the build-up to Obamaera reforms, experts worried that another failed effort could cast a ten-year shadow. The tenth anniversary of the Affordable Care Act offered an opportunity for participants in the 2019 Next Steps in Health Reform conference to reflect. If the ACA proves resilient, what paths will it have paved for the next decade of reforms?

Executive Committee - Agenda, 10/6/2020, Academic Senate Executive Committee

Academic Senate Agendas

No abstract provided.

Comparison Of Aging Structures And Life History Of A Historical Population Of Roundtail Chub (Cyprinidae) In The Yampa River, Colorado, Stephen T. Ross, Timothy C. Modde, Derek G. Ross, David Camak

Western North American Naturalist

The Gila robusta complex includes 3 large cyprinid species native to the Colorado River drainage. All 3 members of this complex, Humpback Chub G. cypha, Bonytail Chub G. elegans, and Roundtail Chub G. robusta, historically occurred in the Yampa River Canyon of Colorado and Utah. Both Humpback Chub and Bonytail Chub are federally listed as endangered, and the Roundtail Chub is now considered either imperiled or vulnerable to extinction by all state management agencies in the Colorado River basin. In late June or early July of 1998, 1999, 2001, and 2002, we collected Roundtail Chub from the …

Med19 Regulates Adipogenesis And Maintenance Of White Adipose Tissue Mass By Mediating Pparγ-Dependent Gene Expression, John M Dean, Anyuan He, Min Tan, Jun Wang, Dongliang Lu, Babak Razani, Irfan J Lodhi

Open Access Publications

The Mediator complex relays regulatory signals from gene-specific transcription factors to the basal transcriptional machinery. However, the role of individual Mediator subunits in different tissues remains unclear. Here, we demonstrate that MED19 is essential for adipogenesis and maintenance of white adipose tissue (WAT) by mediating peroxisome proliferator-activated receptor gamma (PPARγ) transcriptional activity. MED19 knockdown blocks white adipogenesis, but not brown adipogenesis or C2C12 myoblast differentiation. Adipose-specific MED19 knockout (KO) in mice results in a striking loss of WAT, whitening of brown fat, hepatic steatosis, and insulin resistance. Inducible adipose-specific MED19 KO in adult animals also results in lipodystrophy, demonstrating its …

Isg15 Connects Autophagy And Ifn-Γ-Dependent Control Of Toxoplasma Gondii Infection In Human Cells, Jaya Bhushan, Joshua B Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J Lenschow, Herbert W Virgin, L David Sibley

Open Access Publications

The intracellular protozoan parasite

Big Data On Midwest Farms: Assessment Of Use, Concerns, And Challenges, Frederick Adomako

Theses and Dissertations

Farming is undergoing a digital revolution (Bronson & Knezevic, 2016). The advent of plant genetics, chemical inputs, and more recently guidance systems have transformed the industry into one that is increasingly technology-intense and data-rich (Stubbs, 2016). Concerns are being raised including big agricultural companies’ control of a data trove that presents privacy and business risks to farmers who do not want to share their operational data with competitors or the government (Singh & Kaskey, 2014). An overwhelming majority of agricultural producers believe farm data belongs to them (Banham, 2014). This belief of ownership has resulted in much discussion of developing …

Detecting Cognitive Decline And Dementia In Santa Cruz, Galápagos Islands, Ecuador, Patricio Espinosa Prado

All Publications

Objective: To assess the cognitive function, prevalence, and risk factors associated with cognitive decline and dementia in people above 65 years of age in Santa Cruz Island, Galápagos, Ecuador.

Methods: This is a cross-sectional observational study that was carried out in adults over 65 years of age in Santa Cruz Island, Galápagos, Ecuador. The mini-mental state examination (MMSE) and ascertain dementia eight-item informant questionnaire (AD8)-validated Ecuador Spanish versions were used to assess cognition.

Results: There were a total of 80 participants, 55 (67%) women and 25 (31.2%) men. The majority of participants were Mestizos (85.3%), with the remainder classified as …

Challenges And Opportunities For The Prevention And Treatment Of Cardiovascular Disease Among Young Adults: Report From A National Heart, Lung, And Blood Institute Working Group, Heather Johnson

All Publications

Improvements in cardiovascular disease (CVD) rates among young adults in the past 2 decades have been offset by increasing racial/ethnic and gender disparities, persistence of unhealthy lifestyle habits, overweight and obesity, and other CVD risk factors. To enhance the promotion of cardiovascular health among young adults 18 to 39 years old, the medical and broader public health community must understand the biological, interpersonal, and behavioral features of this life stage. Therefore, the National Heart, Lung, and Blood Institute, with support from the Office of Behavioral and Social Science Research, convened a 2-day workshop in Bethesda, Maryland, in September 2017 to …

Monitoring Urine Distribution By Grazing Livestock, Keith Betteridge, Coby J. Hoogendoorn, Wendy Griffiths, Des A. Costall, Mark Carter, Patrick Laube

IGC Proceedings (1977-2023)

No abstract provided.

21st Century Pastoralism--Remote Management Innovations For Sustainability In Arid Rangeland Pastoral Production, M. R. C. Ashley, A. J. Bubb, Adrian R. James, Craig D. James, C. H. James

IGC Proceedings (1977-2023)

No abstract provided.

The Effect Of Vegetative Cover In The Erosion Prevention Of A Cattle Trodden Slope Pasture, T. N. Pande, H. Yamamoto

IGC Proceedings (1977-2023)

No abstract provided.

Soil-Plant-Animal Interrelationships And The Mineral Status In Grazing Cattle With The New Agro-Ecological Conditions In Cuba, Odilia Gutiérrez, Gustavo Crespo, R. Mejias, R. Garcia, H. Fajardo

IGC Proceedings (1977-2023)

No abstract provided.

Treatment Of A Worn Mineral Oil Effluent By Electrocoagulation Using Aluminium Electrodes, Serge Raoul Tchamango Dr, God Promess Lactio, Inès Estelle Nkenmogne Kamdem, Martin Benoît Ngassoum

Karbala International Journal of Modern Science

Water pollution by oils is more and more a preoccupation because of its increasing occurrence and the hazard to human life and environment. Depollution of oily effluents can sometimes generate a secondary pollution (with chemical coagulation / flocculation processes) or be very costly (ultracentrifugation). In this work, electrocoagulation with aluminium electrodes was applied to the treatment of a worn mineral oil effluent. For this to be achieved, the influence of the pH and the current density on the turbidity and organic matter was first investigated. A liquid-liquid extraction was then carried out on the oil samples in order to isolate …

A Systematic Mapping Study On The Risk Factors Leading To Type Ii Diabetes Mellitus, Karar N. J Musafer, Fahrul Zaman Huyop, Mufeed J Ewadh, Eko Supriyanto, Mohammad Rava

Karbala International Journal of Modern Science

Diabetes is one of the most common diseases that has had devastating effects on the general population. It is also among the most popular research trends in modern medicine. Thus, due to the complexity and desirability of this particular affliction, there is a lot of demand towards understanding this disease better, so that it can pave the way towards better solutions in combating diabetes. The aim of this review is to provide a categorization of the risk factors leading to Type II Diabetes. In order to provide a justification for the type of diabetes, an explanation is provided which covers …

Prevalence Of Taeniid Eggs In The Faeces Of Domesticated And Free-Roaming Dogs In Basrah, Iraq, And The Knowledge Of Dog Owners On Cystic Echinococcosis, Mohanad Faris Abdulhameed, Ian Robertson, Suzan Abd Al-Jabbar Al-Azizz, Ihab Habib

Karbala International Journal of Modern Science

The larval stages (metacestodes) of some taeniids of carnivores, particularly Echinococcus spp., can result in severe disease for humans and livestock. The prevalence of taeniid eggs by direct examination of faecal smears in 335 free-roaming dogs (FRD) and owned domesticated dogs in Basrah Province was 10.1% (95% CI 7.1, 13.9). A structured questionnaire was administered to 86 dog owners to investigate the influence of socio-demographic factors and management and husbandry practices on their knowledge of cystic echinococcosis (CE). The results of a multivariable logistic regression analysis revealed that dog owners who fed offal had less knowledge of CE (OR=0.17, 95% …

Generation Of Fluorescent Esophageal Adenocarcinoma Cells For Lineage Tracing Within Composite 3d Culture Models, Madeline G. Linker

S.U.R.E Posters

While relatively rare, the aggressive nature and poor prognosis associated with esophageal carcinoma make it a particularly dangerous form of cancer. One approach to discovering esophageal cancer treatment options includes the development of composite 3D culture models. This method of research allows cellular interactions and responses toward interventions to be evaluated within a more complex system than 2D cultures. Additionally, a composite 3D model provides a higher throughput and is more cost-effective than in vivo animal studies. To analyze the interactions between the model’s cell types, fluorescent labeling allows each cell type to be distinguished from the others, facilitating independent …

Volume 56 - Issue 04 - Monday, October 5, 2020, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.

Effect Of Method Of Drying Piglets At Birth On Rectal Temperature Over The First 24 H After Birth, Katherine D. Vande Pol, Andres F. Tolosa, Caleb M. Shull, Catherine B. Brown, Stephan A.S. Alencar, Michael Ellis

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Piglets are born wet, and evaporation of that moisture decreases body temperature, increasing the risk of mortality. The objective of this study was to compare the effect of two commercially applicable methods for drying piglets at birth on piglet rectal temperature over 24 h after birth. The study was carried out in standard commercial farrowing facilities with 52 litters, using a completely randomized design with three Drying Treatments: Control (not dried); Desiccant (dried at birth using a cellulose-based desiccant); Paper Towel (dried at birth using paper towels). Litters were randomly allotted to treatments at the birth of the first piglet. …

Effect Of Drying And/Or Warming Piglets At Birth On Rectal Temperature Over The First 24 H After Birth, Katherine D. Vande Pol, Andres F. Tolosa, Caleb M. Shull, Catherine B. Brown, Stephan A. S. Alencar, Michael Ellis

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Piglets experience a rapid decrease in body temperature immediately after birth, increasing the risk of mortality. The objective of this study was to determine the effect of drying and/or warming piglets at birth on rectal temperature over the first 24 h after birth. The study was carried out at a commercial sow facility using a completely randomized design with four treatments (applied to piglets at birth): Control (no drying or warming), Desiccant (dried using a desiccant), Warming Box (placed in a box under a heat lamp for 30 min), and Desiccant + Warming Box (both dried and warmed as above). …