Digital Commons Network^™

Bridging The Gap: The Critical Next Steps For Implementing Genetic Risk Scores In Myocardial Infarction Prevention In Saudi Arabia, Ahmed Almohammadi

Journal of the Saudi Heart Association

No Abstract for this article type.

Best Practices For Interprofessional, Community-Based Interventions In Preventing Type 2 Diabetes Among Adults Aged 50 And Older, Julie Joseph Mrs

Journal of Interprofessional Practice and Collaboration

The prevalence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing among adults aged 50 years and older in the United States, posing a significant public health challenge. In 2021, an estimated 38.4 million Americans had diabetes, with adults aged 50years and above constituting a disproportionately large segment of this population. Evidence suggests that community-based lifestyle and educational interventions are effective in reducing the risk of T2DM among older adults. These interventions particularly promote dietary modification, increased physical activity, and diabetes education. Integrating the expertise of nurses, dietitians, pharmacists, physicians, and other professionals through interprofessional collaboration strengthens diabetes prevention and …

Progressivism, Democracy, And Education: A Comparative Study Of John Dewey And Mohammad Iqbal's Philosophy Of Education, Abdul Khaliq Aboya, Asad Shahzad

Dewey Studies

No abstract provided.

Dialectics Of Pragmatism, Caste(S), And The Idea Of India, Nikhil Sanjay-Rekha Adsule

Dewey Studies

No abstract provided.

Between Untouchability And Slavery: Dewey, Russell And Ambedkar On Freedom-As-Growth, Danish Hamid

Dewey Studies

No abstract provided.

John Dewey's Pragmatism And India: Past And Futures, Scott R. Stroud

Dewey Studies

No abstract provided.

Quiet Hills, Restless Hearts: An Intersectional Exploration Of Lgbtq+ Religious Journeys In Appalachia, Allison S. Monroe, Stacey L. Williams

McNair Culminating Research Projects

Many researchers have utilized Meyer’s (2003) minority stress model to examine the social factors influencing the daily lives of LGBTQ+ individuals. Previous research has looked at negative mental health outcomes for LGBTQ+ individuals (McGraw et al., 2023), the presence of religious stress for this community (Page et al., 2013), and religious journeys of these individuals (Halkitis et al, 2009).  However, few studies have examined the intersection of religion, LGBTQ+ identity, social support, and the overarching values of Appalachian culture. The proposed study seeks to add to the literature and understand the breadth of these experiences by employing qualitative semi-structured interviews. …

Synthesis And Characterization Of Organometallic Polymers And Their Cytotoxicity Towards Human Cancer Cell Lines, Paul Peter Slawek

Electronic Theses and Dissertations

This research aimed to synthesize organometallic polymers from dialkyl (methyl, ethyl, butyl, cyclohexyl, and octyl) and diaryl (phenyl) tin dichlorides and three organic monomers, dipicolinic acid (DPA), chloramphenicol (CH), and isomannide (IS), using interfacial polymerization. Structure-activity relationships were investigated through physicochemical characterization (light-scattering photometry, proton NMR, and IR spectroscopy) and cytotoxicity was evaluated against six human cancer cell lines (AsPC-1, PANC-1, MCF-7, MDA-MB-231, HT-29, PC-3), with cisplatin serving as the reference standard.

Five DPA/tin polymers were synthesized, with IC₅₀ values in the range of 0.60–0.71 μg/mL. Their cytotoxicity was significantly lower than that of cisplatin (0.0023-0.044 μg/mL), suggesting that …

Rehabvr: A Virtual Reality System For Upper-Body Orthopaedic Physical Therapy Rehabilitation, Winnie Brenda Wanjiru Waiya

Computer Science Senior Theses

Physical therapy is a central component of rehabilitation for musculoskeletal conditions, yet adherence to prescribed treatment remains persistently poor. Jack et al. identified pain, boredom, and insufficient feedback as key barriers to treatment adherence in physiotherapy outpatient settings,¹ and Rucinski et al. confirmed that non-adherence rates in orthopaedic populations remain between 50 and 70%, with patients who disengage facing elevated risk of reoperation, progressive functional decline, and poor clinical outcomes.² According to the World Health Organization, approximately 1.71 billion people globally live with musculoskeletal conditions,³ with shoulder pain specifically carrying a community prevalence ranging from 0.67 to 55.2% worldwide and …

Frontal Release Signs And Future Decline In Research Participants With Intact Cognition, Lauren G. Bojarski, Gregory A. Jicha, Elif Pinar Coskun, Frederick A. Schmitt, Linda Van Eldik, Erin L. Abner

Neurology Faculty Publications

Importance Frontal release signs (FRS) are primitive reflexes that regress with brain maturation and reappear in the setting of brain injury or neurodegeneration. Despite their association with dementia, the prognostic utility of this finding in the setting of early cognitive decline and preclinical disease is poorly understood. Objective To evaluate the association of FRS with future cognitive decline in research participants. Design, Setting, and Participants This cohort study examined the presence of FRS (from 2005-2024) among research cohort participants with intact cognition or mild impairment at study baseline. The study used single-center data collection of longitudinal research cohort data through …

Common Octopus (Octopus Vulgaris) Blooms Off The Southwest Of The Uk: History, Trends, Causes And Consequences.: Report On Work Package 2: Fisheries Independent Estimates Of Octopus Abundance And Behaviour., Bryce Stewart, Alice Hall, Tully Osmond, Keith Hiscock, Simon Thomas, Emma Sheehan

School of Biological and Marine Sciences

Since early 2025, a nearly unprecedented bloom of common octopus (Octopus vulgaris) has occurred off the southwest UK coast. Although native to UK waters, the species is usually rare, making this the largest bloom recorded in at least 75 years. While many octopus have been commercially landed, they have also preyed heavily on economically important shellfish species, including brown crab, European lobster and king scallop. Landings of these species declined sharply in 2025, causing significant hardship for many in inshore fishing communities. In response, a rapid research project was commissioned in August 2025 to investigate the history, causes and impacts …

Monoclonal Antibodies Targeting Pcdh7 Inhibit Tumor Growth And Enhance Immune Responses In Kras-Mutant Non-Small Cell Lung Cancer, Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S Padanad, Bethany Smith, Chul Ahn, John D Minna, Zhiqiang An, Ningyan Zhang, Kathryn A O'Donnell

The Brown Foundation: Institute of Molecular Medicine

We identified an important oncogenic role for protocadherin 7 (PCDH7), a cell surface protein frequently overexpressed in lung adenocarcinoma and associated with poor clinical outcome. Pcdh7 depletion reduces tumor burden and prolongs survival in KrasLSL-G12D; Tp53fl/fl mice. These findings nominate this cell surface protein as an actionable therapeutic target and highlight the therapeutic potential of PCDH7 inhibition for non–small cell lung cancer. We report the development and characterization of high-affinity anti-PCDH7 monoclonal antibodies (mAbs) that inhibit downstream mitogen-activated protein kinase (MAPK) pathway activation and suppress tumor growth in multiple mutant KRAS–driven models. A lead mAb (mAb7) sensitized tumors …

Amc-F1 Regulates Mitochondria-Autophagy Crosstalk Independent Of Nutrient Stress, Yuqin Wang, Raksha K Rao, Trung Vu, Ayano Sekine, Zhengmei Mao, Nami Mccarty

The Brown Foundation: Institute of Molecular Medicine

Mitochondria and autophagy are fundamental yet distinct regulators of cellular homeostasis. Here, we identify AMC-F1 (Autophagy-Mitochondria Coupling Factor 1; formerly TRIM44) as a central integrator of mitochondrial bioenergetics and autophagy. Using Amcf1 knockout and knock-in mouse models, we demonstrate that AMC-F1 bidirectionally regulates these pathways: its loss reduces mitochondrial respiration and autophagic flux, whereas its overexpression promotes mitochondrial elongation and increases autophagy independently of nutrient stress. Transcriptomic analyses reveal AMC-F1-dependent regulation of mitochondrial biogenesis programs that engage autophagy, involving mitochondrial respiratory chain complex genes under basal conditions and mitochondrial organization factors under starvation-induced autophagy. Although dispensable under homeostasis, this coupling …

Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes

Department of Biochemistry and Molecular Biology Faculty Papers

Chromatin insulators, a.k.a. boundary elements, separate regions of the chromosome with distinct chromatin characteristics, including distinct histone modifications. This activity affects gene expression by allowing chromatin domains to be stably regulated and maintained. Insulators also block enhancer-promoter interactions and, somewhat paradoxically, facilitate other interactions, particularly when they stitch together distant regions of the chromosome by pairing with specific partners. Here we explore how long-range interactions facilitated by insulator pairing are affected by the presence of two potentially competing partners. Our results show that when two partners are present, they can reduce each other's effects on distant gene expression, suggesting that …

Uncovering Dkk1 As A Therapeutically Relevant Target In Aggressive Er+ Breast Cancer Using A Novel Antiestrogen, Kristen Young

Dissertations

Over 70 percent of breast cancers are estrogen receptor-positive (ERα+), meaning that the hormone estrogen drives tumor growth. Although first-line targeted therapies that directly block ERα from hormone-dependent pathologies are initially effective, almost half of patients ultimately progress. These patients show high mutational rates to the ESR1 gene that encodes for ERα. A hotspot missense tyrosine to serine mutation at position 537 (Y537S) initiates hormone-independent, allele-specific transcriptional programs that increase metastasis. While next-generation ERα-targeted therapies show promise, benefits are often limited compared to standard-of-care. Understanding the mechanisms of action used by the Y537S ESR1 breast cancer cells to evade therapeutic …

Discovery Of Bmi-Associated Gut Microbiome Signatures In The Awi-Gen 2 Cohort, Meriem Yagoubi

Theses and Dissertations

Obesity is increasing across sub-Saharan Africa amid rapid dietary, environmental, and urbanization transitions, yet the gut microbiome features associated with adiposity in African populations remain under-characterized. This study investigated whether species-level gut microbiome composition is associated with body mass index (BMI) in the AWI-Gen 2 cohort, and whether BMI-associated microbial signals remain detectable after accounting for the dominant geographic structure of the microbiome. Gut microbiome community structure and diversity were characterized across 1,665 participants, and differential abundance analysis was used to identify taxa associated with BMI after controlling for study site. Machine learning models were then trained to assess how …

Ambivalence, Foremourning, And Displacement In The German Translation Of Marie Bonaparte's Topsy, Kooper Wilson

University Honors Theses

This paper offers a reading of Sigmund Freud’s German translation of Marie Bonaparte’s book, Topsy: The Golden-Haired Chow, in which the author attempts to both delay the death of her dog and mourn it in advance through what I call foremourning. I argue that the manifest subject matter of Topsy should not be interpreted away as a projection of merely human concerns, but rather that close attention to Freud’s translation introduces themes from his analytic experience which engender an appreciation of Topsy’s atopia (intractability). I draw from recent psychoanalytic theory, literary criticism, and deconstruction, especially Jacques Derrida’s seminars …

Foundations' Deep, Emily Williams, Morgan Williams

University Honors Theses

Most historic buildings do not survive as they were built, yet preservation frameworks still tend to evaluate them as if they did.

Foundations' Deep begins with a structure located in Helena, Montana 59602, a building that sits uneasily within the categories it has been asked to meet. Built in the early twentieth century, it has persisted through alteration, abandonment, and use. What remains is not a stable artifact but a record of accumulated decisions, some careful and many indifferent, now embedded in the fabric of the building itself.

The thesis grows from this condition and from the limits of the …

Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients (L248H and M376V MFN2 mutations) and wild-type mouse embryonic fibroblasts expressing these variants, we studied how MFN2 mutations impact mitochondrial dynamics beyond fusion. We analyzed mitochondrial morphology and dynamics by live-cell confocal microscopy and tested fusion/fission protein levels, oxygen consumption rate (OCR), extracellular …

Synthesis And Characterization Of Synergistic Bioactive– Organometallic Condensation Polymers, Francesca Isabel Mosca

Electronic Theses and Dissertations

This research focuses on the synthesis and structural characterization of polymers with anticipated anticancer and antiviral properties by combining metal-containing Lewis acids, organotin dichlorides (R2SnCl2), Group 4 metallocene dichlorides (Cp2TiCl2, Cp2ZrCl2 and Cp2HfCl2), and triphenyl Group 15 metal dichlorides (Ph3AsCl2, Ph3SbCl2 and Ph3BiCl2), with biologically active Lewis bases, lamivudine, a synthetic nucleoside, and camphoric acid, a dicarboxylic acid, to achieve synergistic effect.

Five classes of polymers were synthesized using interfacial polymerization: lamivudine and organotin dichlorides, lamivudine and Group 4 metallocene dichlorides, camphoric acid and triphenyl Group 15 metal dichlorides, camphoric acid and organotin dichlorides, and camphoric acid and Group 4 …

Histone Deacetylase Enzyme Activity Is Not The Universal Anticancer Target Of Hdac Inhibitors, Chaitra Rai, Hang Ruan, Xue Li, Wenbo Li, Hyun-Hwan Jeong, Chengchuang Song, Panpan Liu, Yingjie Chang, Hao Fang, Udhaya Kumar S, Yuxiang Sun, M James You, Dongyin Guan, Zhandong Liu, Leng Han, Xuben Hou, Zheng Sun

Faculty, Staff and Students Publications

Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, our unbiased bioinformatics analyses found that, for most cancer types, expression levels or genetic variants of histone deacetylase (HDACs) do not consistently correlate with carcinogenesis, do not predict cancer patient survival, and do not associate with cellular responses to HDIs. Whole-genome CRISPR library screens did not identify HDACs as genes affecting cellular responses to HDIs. Overexpression of dominant-negative Class I HDACs causes similar protein hyperacetylation …

Entre La Lucha: Familismo And Well-Being Of Latino Immigrant Families Navigating Manual Labor And Anti-Immigrant Sentiment, Faviola Robles Saenz

Dissertations and Theses

The United States' history of treatment toward Latino immigrants has been shaped by anti-immigrant sentiment and exploitative labor practices, creating psychological violence that harms their families' well-being. Although previous research has examined anti-immigrant sentiment, labor conditions, and familismo among Latinos, these areas are often studied in isolation, with limited attention to their intersections and how they are experienced across generations. Informed by history, prior research, and my lived experiences, this study qualitatively explored the intersections of anti-immigrant sentiment and parents' manual labor to understand how these contexts shape familismo and well-being among Latino immigrant families. This work was grounded in …

Imaging And Non-Imaging Approaches For The Diagnosis And Monitoring Of Necrotizing Enterocolitis-What Lies Ahead?, Indrani Bhattacharjee, Catalina Le Cacheux, Eric B. Ortigoza, Jonathan Dillman, Sherwin S. Chan, Alain Cuna

Manuscripts, Articles, Book Chapters and Other Papers

Necrotizing enterocolitis (NEC) remains one of the most serious gastrointestinal emergencies in preterm infants, and imaging plays a central role in diagnosis and clinical management. Historically, evaluation has relied primarily on abdominal radiography, which remains widely available and embedded in established diagnostic frameworks. However, the hallmark radiographic signs of NEC (i.e., pneumatosis intestinalis, portal venous gas, and free air) reflect relatively advanced manifestations of intestinal injury that indicate established mucosal disruption or transmural necrosis. Bowel ultrasound has increasingly complemented radiography by enabling real-time assessment of bowel wall integrity, perfusion, motility, and intra-abdominal fluid, providing physiologic information that may refine clinical …

Stress-Activated Pathways Mediate Pfas Effects On Human Placental Syncytiotrophoblast Cells., Keisuke Kozai, Kaela Varberg

Manuscripts, Articles, Book Chapters and Other Papers

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants associated with placenta-mediated pregnancy complications, including preeclampsia, fetal growth restriction, and preterm birth. The syncytiotrophoblast (STB), which forms the placental barrier at the maternal-fetal interface and is directly exposed to maternal blood, is a primary site of PFAS exposure. Although PFAS induce STB apoptosis, the upstream stress-signaling pathways involved remain poorly defined. Here, we investigated stress-responsive signaling mechanisms mediating PFAS-induced STB cell death. STB differentiated from human trophoblast stem cells were exposed to vehicle or an environmentally relevant mixture of 5 PFAS (perfluorooctanoic acid, perfluorooctanesulfonic acid, perfluorohexane sulfonate, perfluorononanoic acid, and …

Declination Of Groundwater Potential Zones Of Nashik, Maharashtra Using Geographic Information System With Analytic Hierarchy Process-Fuzzy Techniques, Madhusudhan M. Reddy, Bhogayya G. Naidu, Bharat N. Mulay, Ramanjaneyulu B, Ravi K. Kumar, Mirzi L. Betasolo, Praveen U. Goud, Snehal N. Chaudhari

Mansoura Engineering Journal

Groundwater is a critical resource for agriculture and domestic use in the semi-arid region of Nashik District, Maharashtra, where overexploitation and erratic climatic conditions have led to declining groundwater availability. This study integrates Geographic Information System (GIS) with Analytic Hierarchy Process (AHP) and Fuzzy-AHP techniques to delineate groundwater potential zones (GWPZs) and identify suitable sites for artificial recharge. A total of ten thematic layers drainage density, rainfall, geomorphology, elevation, distance from river, geology, slope, land use/land cover, topographic wetness index (TWI), and curvature were derived from SRTM DEM, Landsat-8, and IMD datasets, representing key controls on groundwater recharge, infiltration, and …

Using Ai-Assisted Programming To Develop Research Services Tools For Research Impact, Open Access Publishing & More, Gary Lee

FORCE 2026

Academic libraries play a vital role in scholarly communication, As research practices become more data‑driven and interdisciplinary, librarians can help scholars by creating and sharing flexible, customizable tools that align with local workflows and user needs.

AI Assisted programming (sometimes called “vibe coding”) offers a new way for librarians without extensive programming knowledge to develop such tools . This allows previously non-expert librarians to go from conceptual goals to working applications by rapid prototyping, experimentation, and roll-out, resulting in service innovation and improvement.

This presentation illustrates how librarians at HKUST have explored vibe coding with tools like GROK, POE, and …

[2026 Honorable Mention] Chumash Heritage National Marine Sanctuary, Daylyn R. Reese

Ethnic Studies Research Paper Award

This research offers unique insights into the creation and development of the Chumash Heritage National Marine Sanctuary (N.M.S.) with a focus on indigenous populations’ roles (primarily Chumash and Costanoan). In this episode, I analyze what makes this NMS different from every NMS precluding it, how it recognizes a new goal in conservation (thrivability), and the areas in which improvements still must be made to authentically include and honor indigenous voices.

Current Status Of Anthelmintic Resistance In Meat Goats: A Comparative Efficacy Study Of Albendazole And Fenbendazole In Maha Sarakham, Thailand, Minta Pipatsakulpak, Usanisa Boonum, Kotchakorn Roongruang, Benjawan Sae-Chue, Sukanya Leethongdee, Songsak Chumpawadee, Nattaya Watwiengkam, Pongphol Pongthaisong

The Thai Journal of Veterinary Medicine

Anthelmintic resistance in gastrointestinal nematodes threatens sustainable goat production globally. While resistance is well-documented in many regions, data from Thailand remain limited. This study determined the prevalence of gastrointestinal nematodes and assessed the efficacy of albendazole and fenbendazole in meat goats in Maha Sarakham province, northeastern Thailand. A two-stage cross-sectional study was conducted on 10 meat goat farms between August 2021 and March 2022. In Stage 1, fecal samples from 150 goats were examined using simple flotation and sedimentation techniques to identify parasite morphology. In Stage 2, the McMaster technique was employed to quantify fecal egg counts (FEC). Twenty-six goats …

Exploring The Halal Perspectives On Animal Excrement And Its Renewable Energy Products, Ahmad Munjin Nasikh, Nur Faizin, Eli Hendrik Sanjaya, Achmad Sultoni, Cecep Soleh Kurniawan

Nusantara Halal Journal

Energy consumption continues to increase following the escalation of economic growth worldwide. The U.S. Energy Information Administration predicts global energy consumption will increase by 50% from 2018 to 2050, with the highest increase in Asia. But up to recently, coal and oil are still the primary sources of energy. Thus, a novel and renewable alternative energy is a necessity. Biomass is one of the most abundant renewable energy sources that come from various sources. However, the Muslim world population feels the need for an answer to the halal status of this energy source. This paper examines Islamic classical and modern …

Potential Protective Effects Of Okra (Abelmoschus Esculentus) Seed Oil Against Cadmium-Induced Oxidative Lipid Damage In Male Rats, Amani Ahmad Rifai Filimban, Nada Abdulkareem Batais

The Journal of King Abdulaziz University: Science

Objectives: To investigate the protective effect of okra seed oil against cadmium-induced toxicity in male Wistar rats.

Methods: Twenty-four male Wistar rats (8-weeks old, average 120g) were divided into four groups (n=6): Control/ Received deionized water. Cadmium/ Received 5 mg/kg/day of cadmium chloride (CdCl₂) orally. Okra Seed Oil/ Treated with 800 mg/kg/day of okra seed oil. Okra Seed Oil + Cadmium/ Received okra seed oil followed three hours later by CdCl₂. Treatments were given daily. Lipid profiles and antioxidant markers were measured to assess metabolic effects.

Results: Cadmium exposure caused significant dyslipidemia, characterized by elevated levels …