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The Role Of Interleukin-18 In Myocardial Ischemia/Reperfusion, Yogesh Dhakal

Theses and Dissertations

Acute Myocardial Infarction (AMI) is one of the leading causes of morbidity for cardiovascular diseases (CVDs) in the western world. While mortality rates for AMI has reduced in the last 20 years due to advancements in clinical interventions, patients who have an AMI are significantly more likely to develop heart failure (HF) in the following years. Reperfusion of the ischemic tissue is a necessary procedure to restore blood delivery to cardiomyocytes, minimize myocardial dysfunction, and reduce infarct size. Still, the step of reperfusion itself induces myocardial damage in a phenomenon known as reperfusion injury. Considering that the degree of myocardial …

Focal Augmentation Of Somatostatin Interneuron Function And Subsequent Circuit Effects In Developmentally Malformed, Epileptogenic Cortex, Nicole Ekanem

Theses and Dissertations

Drug-resistant epilepsy (DRE) is a common clinical sequela of developmental cortical malformations such as polymicrogyria. Unfortunately, much remains unknown about the aberrant GABA-mediated circuit alterations that underlie DRE's onset and persistence in this context. To address this knowledge gap, we utilized the transcranial freeze lesion model in optogenetic mice lines (Somatostatin (SST)-Cre or Parvalbumin (PV)-Cre x floxed channelrhodopsin-2) to dissect features of the SST, PV, and pyramidal neuron microcircuit that are potentially associated with DRE. Investigations took place within developmental microgyria’s known pathological substrate, the adjoined and epileptogenic paramicrogyral region (PMR). As well, microcircuit relationships within the previously unexplored range …

Spag17 Is Important For Protein Trafficking In Mammalian Spermiogenesis, Virali Bhagat

Theses and Dissertations

Spermiogenesis is the process through which undifferentiated germ cells develop into mature spermatozoa. While spermiogenesis is a very well-regulated process, the protein-protein interactions regulating it remain poorly understood. A knockout (KO) mouse for the ciliary protein SPAG17 was generated by our lab. Loss of SPAG17 has been shown to disrupt the transport of proteins important for acrosome biogenesis and manchette functions. With this information, we hypothesized that SPAG17 plays an essential role in protein trafficking during mammalian spermiogenesis. To further investigate this, immunofluorescence (IF) studies were performed in germ cells collected from both WT and SPAG17 KO mice to visualize …

Anticholinergic Burden And Risk Of Cognitive Impairment In Older Adults, Syeda Hashimi

Theses and Dissertations

Studies reveal that 10-27% of older adults chronically use anticholinergic medications. Increased cumulative anticholinergic burden scores are associated with increased risks of dementia. The mechanisms by which anticholinergic drugs negatively impact cognition remain elusive. However, researchers speculate that the drug’s impairment of cholinergic neurons promotes neuroinflammation.

We hypothesize that drugs with anticholinergic properties will induce inflammation in the brain. MCP1 and IL 6 are chemokines that contribute to neuroinflammation. We investigated the influence of diphenhydramine (Benadryl) on the production of MCP1 and IL-6 in Normal Human Astrocytes and Paroxetine on the production of MCP1 in Normal Human Astrocytes and Normal …

A Revised Diet Matrix To Improve The Parameterization Of A West Florida Shelf Ecopath Model For Understanding Harmful Algal Bloom Impacts, Holly A. Perryman, Joseph H. Tarnecki, Arnaud Grüss, Elizabeth A. Babcock, Skyler R. Sagarese, Cameron H. Ainsworth, Alisha M. Gray Dileone

Marine Science Faculty Publications

Harmful algal blooms (HABs) are a growing concern in the West Florida Shelf (WFS) region. An Ecopath with Ecosim (EwE) model of the WFS explicitly simulating HABs was previously developed to illuminate the potential impacts of blooms of the dinoflagellate Karenia brevis (colloquially referred to as “red tides”) on the WFS ecosystem. However, the diet matrix of the Ecopath component of this EwE model (referred to as “WFS-HAB Ecopath”) was based largely on sparse, cursory information and not on local survey data. Here, we revise the diet matrix of the WFS-HAB Ecopath model using predictions of a robust statistical model …

The Synapse 23

The Synapse: Intercollegiate science magazine

No abstract provided.

Killing The Cat's Paw, Sandra F. Sperino

Faculty Publications

In federal employment discrimination law, courts apply the label "cat's paw" to describe certain cases. Judge Richard Posner first used the term cat's paw in the context of federal discrimination jurisprudence, invoking a fable about an enterprising monkey who tricks a cat into getting hot chestnuts from a fire.' As the cat removes the hot chestnuts from the fire, the monkey eats them, leaving the cat with nothing except burnt paws.

In its traditional form, a cat's paw case is one in which a biased individual passes along negative information about a worker to an "unbiased" decisionmaker. The "unbiased" decisionmaker …

The Nagoya Protocol And The Legal Structure Of Global Biogenomic Research, Sam F. Halabi, Michelle Rourke, Gian Luca Burci, Rebecca Katz

Faculty Publications

As life sciences technologies have advanced, so too has the potential for these international collaborations to lead to breakthrough medicines, enhance food security, and protect ecological systems. The linchpin of this progress is the development of high throughput genetic sequencing technologies. Researchers are now able to generate and compare large stretches of DNA - 1 million bases or more - from different sources quickly and inexpensively. Such comparisons can yield massive amounts of information about the role of inheritance in susceptibility to infection and illness as well as responses to environmental influences. In addition, the ability to sequence genomes more …

Early Access To Unapproved Medicines In The United States And France, Erika Lietzan

Faculty Publications

In 2018, President Trump signed a federal "right to try" law, claiming that it would give desperately ill patients earlier access to unapproved medicines, by allowing the patient, doctor, and drug company to arrange for access without federal oversight. Critics of the law argued that it would not meaningfully increase access to experimental medicines, because federal oversight was not the obstacle in the first place. And they were correct. U.S. law already permitted companies to provide terminally ill patients with early access to unapproved medicines. The problem was instead that companies did not take advantage of this option. This Article …

Use Of Multiple Stream Temperature Logger Models Can Alter Conclusions, Robin M. Rotman, Joanna B. Whittier, Jacob T. Westhoff, Craig P. Paukert

Faculty Publications

Remote temperature loggers are often used to measure water temperatures for ecological studies and by regulatory agencies to determine whether water quality standards are being maintained. Equipment specifications are often given a cursory review in the methods; however, the effect of temperature logger model is rarely addressed in the discussion. In a laboratory environment, we compared measurements from three models of temperature loggers at 5 to 40 °C to better understand the utility of these devices. Mean water temperatures recorded by logger models differed statistically even for those with similar accuracy specifications, but were still within manufacturer accuracy specifications. Maximum …

Phenotypic Divergence In Two Sibling Species Of Shorebird: Common Snipe And Wilson’S Snipe (Charadriiformes: Scolopacidae), Tiago M. Rodrigues, Edward H. Miller, Sergei V. Drovetski, Robert M. Zink, Jon Fjeldså, David Gonçalves

School of Biological Sciences: Faculty Publications

Natural and social selection are among the main shapers of biological diversity but their relative importance in divergence remains understudied. Additionally, although neutral evolutionary processes may promote phenotypic divergence, their potential contribution in speciation is often overlooked in studies of comparative morphology. In this study, we investigated phenotypic differentiation in two allopatric shorebirds: the Palaearctic Common Snipe Gallinago gallinago and the Nearctic Wilson’s Snipe Gallinago delicata. Specimens of Common Snipe (n = 355 skins, n = 163 skeletons) and Wilson’s Snipe (n = 403 skins, n = 141 skeletons) in natural history collections were examined to quantify differences in skeletal …

A Discrete Age Structured Model Of Hantavirus In A Rodent Reservoir In Paraguay, Megan A. Rúa

Biological Sciences Faculty Publications

Many rodent-borne hantaviruses are zoonotic pathogens that can cause disease in humans through inhalation of aerosolized rodent excreta. To evaluate the prevalence of Jaborâ virus (JABV) over time within its rodent reservoir, Akodon montensis, we formulated a mathematical model with multiple rodent age classes and unique infection class progression features. We then parameterized the model with data collected from a survey of JABV harbored by Akodon montensis in the Mbaracayú Reserve in Paraguay. Our model incorporates three types of infection over the lifetime of the rodent as well as a recovered class. A new feature of the model allows transition …

2020 Report On Giving, University Of Minnesota, Morris Office Of External Relations

Report on Giving

No abstract provided.

Educational Technology Master's Degree Academic Program Review, 2019, College Of Health, Education, And Human Services, Wright State University

Academic Program Review Reports - All

This report reviews Wright State University's Accountancy Bachelor's Degree program, specifically looking at the time from Fall 2015 to Fall 2019.

Communication Studies Bachelor's Degree Academic Program Review, 2019, College Of Liberal Arts, Wright State University

Academic Program Review Reports - All

This report reviews Wright State University's Communication Studies Bachelor's Degree program, specifically looking at the time from Fall 2015 to Fall 2019.

Motion Pictures Bachelor's Degree Academic Program Review, 2019, College Of Liberal Arts, Wright State University

Academic Program Review Reports - All

This report reviews Wright State University's Motion Pictures Bachelor's Degree program, specifically looking at the time from Fall 2015 to Fall 2019.

Biochemistry And Molecular Biology Master's Degree Academic Program Review, 2019, College Of Science And Mathematics, Wright State University

Academic Program Review Reports - All

This report reviews Wright State University's Biochemistry and Molecular Biology Master's Degree program, specifically looking at the time from Fall 2015 to Fall 2019.

Biochemistry And Molecular Biology Bachelor's Degree Academic Program Review, 2019, College Of Science And Mathematics, Wright State University

Academic Program Review Reports - All

This report reviews Wright State University's Biochemistry and Molecular Biology Bachelor's Degree program, specifically looking at the time from Fall 2015 to Fall 2019.

Biological Sciences Bachelor's Degree Academic Program Review, 2019, College Of Science And Mathematics, Wright State University

Academic Program Review Reports - All

This report reviews Wright State University's Biological Sciences Bachelor's Degree program, specifically looking at the time from Fall 2015 to Fall 2019.

Gynecology In Antiquity, Kristen Cross

Classics Ancient Science Fair

The field of Gynecology has had major shifts through its history. It began with the expansion of duties for Midwives and a wide variety of schools of thought continued to advise its growth. This presentation discusses the ancient thoughts, their origins, and its many outdated beliefs.

Technical Study: Agriculture Associate Degree Annual Program Outcomes Assessments, 2019-20, Lake Campus, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Technical Study: Agriculture Associate Degree program for the 2019-2020 academic year.

Diverse Autonomic Nervous System Stress Response Patterns In Childhood Sensory Modulation, Jacquelyn Christensen, Heather Wild, Erin S. Kenzie, Wayne Wakeland, Deborah Budding, Connie Lillas

Complex Systems Faculty Publications and Presentations

The specific role of the autonomic nervous system (ANS) in emotional and behavioral regulation—particularly in relation to automatic processes—has gained increased attention in the sensory modulation literature. This mini-review article summarizes current knowledge about the role of the ANS in sensory modulation, with a focus on the integrated functions of the ANS and the hypothalamic-pituitary-adrenal (HPA) axis and their measurement. Research from the past decade illustrates that sympathetic and parasympathetic interactions are more complex than previously assumed. Patterns of ANS activation vary across individuals, with distinct physiological response profiles influencing the reactivity underlying automatic behavioral responses. This review article advances …

The Marginalia Of The Malleus Maleficarum, Christian Stecher

Malleus Maleficarum

This paper presents a comprehensive collection of transcriptions of the marginalia found inside the Malleus maleficarum (Drach, Speier, 1490) at Portland State University and brief analyses examining the passages in which they occur, as well as English translations of the original Latin.

The marginalia consist of all occurrences of marginal annotations, underlining, or other signs of note-taking by previous owners throughout the entire book.

Nonobviousness Standard For Promoting Ongoing Drug Discovery: A Lesson From Sanofi-Aventis U.S., Llc V. Dr. Reddy’S Laboratories, Inc, 20 Uic Rev. Intell. Prop. L. 1 (2020), Ping-Hsun Chen

UIC Review of Intellectual Property Law

No abstract provided.

Harry Potter & The "Chinese" Philosopher’S Stone: Deconstructing Copyright Piracy Through Shanzhai, 19 Uic Rev. Intell. Prop. L. 101 (2020), Mark Edward Blankenship Jr.

UIC Review of Intellectual Property Law

The United States still faces a disconnect with China regarding intellectual property piracy. Particularly, with regards to shanzhai copyrightable works of art, the U.S. labels these fake works as knock-offs, rip-offs, and counterfeits. However, China views shanzhai as a unique form of copying that embraces the “Chinese spirit,” due to its constant modification and hybridization, superior quality, transformativeness, and democratic energies. By understanding the peculiarities of shanzhai, both physical and abstract, as well as China’s copyright law and tradition, this paper proposes ways on how China can improve their copyright laws to improve how shanzhai is perceived and to curb …

2020-2021 Risd Course Announcement, Risd Registrar's Office, Risd Archives

RISD Course Catalogs / Announcements

No abstract provided.

Approaches To Alleviate The Vigabatrin Induced Retinal Toxicity, Anitha Police

Electronic Theses and Dissertations

Safety of therapeutics is one of the primary concerns during the treatment of any ailments. Most of the toxic effects of drugs occurs due to accumulation of drug in organs, which is dependent on the dosage of the drug. The ideal therapy should minimize the risk of causing adverse events at the same time elicit intended therapeutic effects. Vigabatrin (VGB) is an antiepileptic drug used primarily in the treatment of infantile spasms and it acts by inhibiting gamma amino butyric acid (GABA) transaminase thereby increasing inhibitory neurotransmitter GABA levels. At therapeutic doses, VGB accumulates in retina leading to peripheral visual …

Development Of A Liposomal Formulation For Brain Targeting, Ziru Zhang

Electronic Theses and Dissertations

The blood-brain barrier (BBB), formed by the endothelial cells of the brain capillaries, inhibits the penetration of many therapeutic compounds into the brain. Liposomes, which have unique physicochemical characteristics, have been widely investigated for the drug delivery system across BBB. In the current study, FITC-dextran was used as a model drug that encapsulated in a liposomal formulation to investigated its ability to overcome the blood-brain barrier for targeted brain delivery of therapeutic agents. Here, non-targeted liposome (NT LPs) and RVG-modified liposome (RVG LPs) were prepared. The NT LPs and RVG LPs were about 97 and 101 nm in diameter with …

Labor In The Field Is Much Changed: The Chickasaws And The Civilization Plan, 1790-1837, Jeffrey D. Washburn

Electronic Theses and Dissertations

Between 1790 and 1840, the U.S. federal government instituted its so-called “civilization plan,” which encouraged Southern Indians to embrace republican values, patriarchy, yeoman farming, and individual property rights. The policies included in the civilization plan were highly influential, as the Native South transitioned from an economy built on the deerskin trade into one of cottage industries, plow-based agriculture, and ranching. Through a detailed examination of one Southern Indian community, the Chickasaws, my dissertation defines the civilization plan in terms of the ideology that the federal government envisioned and how the plan was interpreted on the ground level. My work centers …

Role Of Insulin-Like Growth Factor 1 Receptor In The Regulation Of Astrocyte Structure, Function And Cognition, Disha Prabhu

Electronic Theses and Dissertations

Levels of Insulin-like growth factor I (IGF-1) are reduced in several neurological disorders, including aging and neurodegeneration. Aged animals have reduced IGF1 signaling and exhibit impairment in cognition. Supplementing rodents with IGF-1 reverses some of the cognitive deficit, suggesting that IGF-1 signaling could potentially be targeted to ameliorate cognitive decline in older adults. For this, a thorough understanding of the mechanisms by which IGF-1 regulates the function of various cell types in the brain is needed. A majority of studies have focused on the effects of IGF-1 regulating neurons. However, astrocytes that form roughly about 40% of brain mass also …