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2020

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Holding Space: Learning From A Black Art Organization, Tierney Anne Bamrick Jan 2020

Holding Space: Learning From A Black Art Organization, Tierney Anne Bamrick

Electronic Theses and Dissertations

Minority-led nonprofit organizations are marginalized in the United States arts sector, analyses of which rely heavily on data from dominant, often White-led institutional arts organizations. This study seeks to understand the experience of a minority-led arts organization in that context. I ask, what does artistic practice – both creative and organizational – look like for this organization? And what are the implications of that practice for the arts sector more broadly? Drawing on over a year of ethnographic work with The Network, a Black-led arts organization in a southern U.S. city, I argue that their asset-focused treatment of place, their …


Vascular Flora Of Adobe Valley And Surrounding Hills, Mono County, California, Sophie E. Winitsky Jan 2020

Vascular Flora Of Adobe Valley And Surrounding Hills, Mono County, California, Sophie E. Winitsky

Aliso: A Journal of Systematic and Floristic Botany

Adobe Valley and the Adobe Hills lie east of the Sierra Nevada in Mono County, California, and are within the Great Basin Floristic Province. The flora of Adobe Valley and the surrounding hills is influenced by the Great Basin Desert to the east, the Sierra Nevada to the west and the northern Mojave Desert to the south. Adobe Valley is surrounded by the Adobe Hills, Benton Range and Glass Mountain region, creating a circular closed basin with many small tributaries feeding into it. This topography contributes to the creation of a rare wetland complex, including alkali meadows, marshes, and lakes …


Antitrust Regulation And The Federal-State Balance: Restoring The Original Design, Alan J. Meese Jan 2020

Antitrust Regulation And The Federal-State Balance: Restoring The Original Design, Alan J. Meese

American University Law Review

The U.S. Constitution divides authority over commerce between states and the national government. Passed in 1890, the Sherman Act (“the Act”) reflects this allocation of power, reaching only those harmful agreements that are “in restraint of . . . commerce among the several States.” This Article contends that the Supreme Court erred when it radically altered the balance between state and national power over trade restraints in 1948, abruptly abandoning decades of precedent recognizing exclusive state authority over most intrastate restraints. This revised construction of the Act contravened the statute’s apparent meaning, unduly expanded the reach of federal antitrust regulation, …


Evidence That Hindbrain Astrocytes In The Rat Detect Low Glucose With A Glucose Transporter 2-Phospholipase C-Calcium Release Mechanism, Richard C. Rogers, Susan J. Burke, J. Jason Collier, Sue Ritter, Gerlinda E. Hermann Jan 2020

Evidence That Hindbrain Astrocytes In The Rat Detect Low Glucose With A Glucose Transporter 2-Phospholipase C-Calcium Release Mechanism, Richard C. Rogers, Susan J. Burke, J. Jason Collier, Sue Ritter, Gerlinda E. Hermann

Division of Basic Science Faculty Publications

Astrocytes generate robust cytoplasmic calcium signals in response to reductions in extracellular glucose. This calcium signal, in turn, drives purinergic gliotransmission, which controls the activity of catecholaminergic (CA) neurons in the hindbrain. These CA neurons are critical to triggering glucose counter-regulatory responses (CRRs) that, ultimately, restore glucose homeostasis via endocrine and behavioral means. Although the astrocyte low-glucose sensor involvement in CRR has been accepted, it is not clear how astrocytes produce an increase in intracellular calcium in response to a decrease in glucose. Our ex vivo calcium imaging studies of hindbrain astrocytes show that the glucose type 2 transporter (GLUT2) …


Safety And Pharmacokinetics Of Naringenin: A Randomized, Controlled, Single-Ascending-Dose Clinical Trial, Candida J. Rebello, Robbie A. Beyl, Juan J.L. Lertora, Frank L. Greenway, Eric Ravussin, David M. Ribnicky, Alexander Poulev, Brandon J. Kennedy, Hector F. Castro, Shawn R. Campagna, Ann A. Coulter, Leanne M. Redman Jan 2020

Safety And Pharmacokinetics Of Naringenin: A Randomized, Controlled, Single-Ascending-Dose Clinical Trial, Candida J. Rebello, Robbie A. Beyl, Juan J.L. Lertora, Frank L. Greenway, Eric Ravussin, David M. Ribnicky, Alexander Poulev, Brandon J. Kennedy, Hector F. Castro, Shawn R. Campagna, Ann A. Coulter, Leanne M. Redman

Clinical Research Faculty Publications

Aims: To evaluate the safety and pharmacokinetics of naringenin in healthy adults consuming whole-orange (Citrus sinensis) extract. Methods and methods: In a single-ascending-dose randomized crossover trial, 18 adults ingested doses of 150 mg (NAR150), 300 mg (NAR300), 600 mg (NAR600) and 900 mg (NAR900) naringenin or placebo. Each dose or placebo was followed by a wash-out period of at least 1 week. Blood safety markers were evaluated pre-dose and 24 hours post-dose. Adverse events (AEs) were recorded. Serum naringenin concentrations were measured before and over 24 hours following ingestion of placebo, NAR150 and NAR600. Four- and 24-hour serum measurements were …


Guide To The Paul Freeman Collection, Columbia College Chicago Jan 2020

Guide To The Paul Freeman Collection, Columbia College Chicago

CBMR Collection Guides / Finding Aids

Paul Freeman was a conductor, composer, and founder of the Chicago Sinfonietta. The collection contains conductor scores, recordings, and other materials related to his conducting performances with the Chicago Sinfonietta and other orchestras.


Guide To The Patsy Ford Simms Collection, Columbia College Chicago Jan 2020

Guide To The Patsy Ford Simms Collection, Columbia College Chicago

CBMR Collection Guides / Finding Aids

Patsy Ford Simms is an internationally recognized arranger, composer and clinician who began writing and arranging out of necessity due to the lack of choral octavos for the junior high/middle school voice during the first decade of her teaching career. The collection contains original sheet music, arrangements, concert programs, press clippings, catalogues, and recordings.


Recipes For Anger Appeals: A Systematic Review, Tianen Chen Jan 2020

Recipes For Anger Appeals: A Systematic Review, Tianen Chen

Theses and Dissertations--Communication

Although there is an increasing use of anger appeals in communication research, scholars have yet to fully explore the causes of anger. Anger is elicited in situations where individuals perceive that their desired goals are blocked or needs are not fulfilled (Harmon-Jones & Harmon-Jones, 2016). Using Maslow’s hierarchy of human needs model (Maslow, 1943), the current study aims to systematically review communication studies on anger appeals to synthesize and categorize the violations of goals/needs that have been studied or utilized to elicit anger. A comprehensive literature search was conducted in eight relevant databases: ProQuest Dissertation & Thesis Global, Web of …


Squirreling Around For Science: Observing Sciurid Rodents To Investigate Animal Behavior, Patrice K. Connors, Johanna Varner, Liesl P. Erb, Laurie Dizney, Hayley C. Lanier, John D. Hanson, Christopher J. Yahnke, Jennifer M. Duggan, Elizabeth A. Flaherty Jan 2020

Squirreling Around For Science: Observing Sciurid Rodents To Investigate Animal Behavior, Patrice K. Connors, Johanna Varner, Liesl P. Erb, Laurie Dizney, Hayley C. Lanier, John D. Hanson, Christopher J. Yahnke, Jennifer M. Duggan, Elizabeth A. Flaherty

AES Faculty Publications and Presentations

Hands-on research experiences are important opportunities for students to learn about the nature of inquiry and gain confidence in solving problems. Here, we present an inquiry-based lesson plan that investigates the foraging behavior of sciurid rodents (squirrels) in local habitats. Squirrels are an ideal study system for student research projects because many species are diurnal, easy to watch, and inhabit a range of habitats including college campuses. In this activity, instructors identify appropriate field sites and focal species, while students generate questions and brainstorm predictions in small groups regarding factors that might influence behavioral trade-offs in sciurids. Students conduct observational …


An Introduction To The Squirrel-Net Teaching Modules, Laurie Dizney, Patrice K. Connors, Johanna Varner, Jennifer M. Duggan, Hayley C. Lanier, Liesl P. Erb, Elizabeth A. Flaherty, Christopher J. Yahnke, John D. Hanson Jan 2020

An Introduction To The Squirrel-Net Teaching Modules, Laurie Dizney, Patrice K. Connors, Johanna Varner, Jennifer M. Duggan, Hayley C. Lanier, Liesl P. Erb, Elizabeth A. Flaherty, Christopher J. Yahnke, John D. Hanson

AES Faculty Publications and Presentations

Although course-based undergraduate research experiences (CUREs) are gaining popularity in biology, most are designed for benchwork-based laboratory courses while few focus on field-based skills. Many barriers to implementing field CUREs exist, including the difficulty in designing authentic research that can be accomplished in a limited lab timeframe, permitting and liability issues, and problems gathering sufficient data to meaningfully analyze. Squirrel-Net (http://squirrel-net.org) is a consortium of mammalogists from eight different institutions who have worked to overcome these limitations through four field-based CUREs focused on sciurid rodents (e.g., squirrels, chipmunks, marmots, prairie dogs). Each module is linked to a national dataset, allowing …


Phylogenomics Of The Epigenetic Toolkit Reveals Punctate Retention Of Genes Across Eukaryotes, Agnes K.M. Weiner, Mario A. Cerón-Romero, Ying Yan, Laura A. Katz Jan 2020

Phylogenomics Of The Epigenetic Toolkit Reveals Punctate Retention Of Genes Across Eukaryotes, Agnes K.M. Weiner, Mario A. Cerón-Romero, Ying Yan, Laura A. Katz

Biological Sciences: Faculty Publications

Epigenetic processes in eukaryotes play important roles through regulation of gene expression, chromatin structure, and genome rearrangements. The roles of chromatin modification (e.g., DNA methylation and histone modification) and non-protein-coding RNAs have been well studied in animals and plants. With the exception of a few model organisms (e.g., Saccharomyces and Plasmodium), much less is known about epigenetic toolkits across the remainder of the eukaryotic tree of life. Even with limited data, previous work suggested the existence of an ancient epigenetic toolkit in the last eukaryotic common ancestor. We use PhyloToL, our taxon-rich phylogenomic pipeline, to detect homologs of epigenetic genes …


Dietary Fish Oil Supplement Induces Age-Specific Contractile And Proteomic Responses In Muscles Of Male Rats, David W. Russ, Kalina Dimova, Emily Morris, Marguerite Pacheco, Sean M. Garvey, Stylianos P. Scordilis Jan 2020

Dietary Fish Oil Supplement Induces Age-Specific Contractile And Proteomic Responses In Muscles Of Male Rats, David W. Russ, Kalina Dimova, Emily Morris, Marguerite Pacheco, Sean M. Garvey, Stylianos P. Scordilis

Biological Sciences: Faculty Publications

Background: Dietary fish oil (DFO) has been identified as a micronutrient supplement with the potential to improve musculoskeletal health in old age. Few data are available for effects of DFO on muscle contractility, despite the significant negative impact of muscle weakness on age-related health outcomes. Accordingly, the effects of a DFO intervention on the contractile function and proteomic profile of adult and aged in an animal model of aging were investigated.

Methods: This preliminary study evaluated 14 adult (8 months) and 12 aged (22 months) male, Sprague-Dawley rats consuming a DFO-supplemented diet or a control diet for 8 weeks (7 …


Comparative Genome Analysis Of Bifidobacterium Longum Subsp. Infantis Strains Reveals Variation In Human Milk Oligosaccharide Utilization Genes Among Commercial Probiotics, Rebbeca M. Duar, Giorgio Casaburi, Ryan D. Mitchell, Lindsey N.C. Scofield, Camila A. Ortega Ramirez, Daniela Barile, Bethany M. Henrick, Steven A. Frese Jan 2020

Comparative Genome Analysis Of Bifidobacterium Longum Subsp. Infantis Strains Reveals Variation In Human Milk Oligosaccharide Utilization Genes Among Commercial Probiotics, Rebbeca M. Duar, Giorgio Casaburi, Ryan D. Mitchell, Lindsey N.C. Scofield, Camila A. Ortega Ramirez, Daniela Barile, Bethany M. Henrick, Steven A. Frese

Department of Food Science and Technology: Faculty Publications

Dysbiosis is associated with acute and long-term consequences for neonates. Probiotics can be effective in limiting the growth of bacteria associated with dysbiosis and promoting the healthy development of the infant microbiome. Given its adaptation to the infant gut, and promising data from animal and in vitro models, Bifidobacterium longum subsp. infantis is an attractive candidate for use in infant probiotics. However, strain-level differences in the ability of commercialized strains to utilize human milk oligosaccharides (HMOs) may have implications in the performance of strains in the infant gut. In this study, we characterized twelve B. infantis probiotic strains and identified …


Online Availability Of Fish Antibiotics And Documented Intent For Self-Medication, Weiwei Zhang, Austin Williams, Nicole Griffith, Jessica Gaskins, P Brandon Bookstaver Jan 2020

Online Availability Of Fish Antibiotics And Documented Intent For Self-Medication, Weiwei Zhang, Austin Williams, Nicole Griffith, Jessica Gaskins, P Brandon Bookstaver

Faculty Publications

Self-medication and antibiotic utilization without healthcare oversight may lead to delayed appropriate treatment, transmission of communicable infections, untoward adverse events, and contribute to antimicrobial resistance. Previous data suggest people obtain over-the-counter (OTC) animal antibiotics for their personal use. This study examined the availability of OTC fish antibiotics online and the documented intent for self-medication. The authors conducted a web-based cross-sectional study using Google search engine to identify vendor websites selling fish antibiotics in the United States. Vendor websites were included if product information, consumer reviews, and comments were publicly available. Nine fish antibiotics were chosen due to their possibility of …


Analysis Of Genetic Structure And Pathogen Dynamics Of Ixodes Scapularis In Southwestern Virginia, Leemu Jackson Jan 2020

Analysis Of Genetic Structure And Pathogen Dynamics Of Ixodes Scapularis In Southwestern Virginia, Leemu Jackson

Undergraduate Honors Theses

Ixodes scapularis, or the blacklegged tick, is the primary vector of Borrelia burgdorferi. This pathogen is the causative agent of Lyme disease, the most common vector-transmitted disease in the United States. Although I. scapularis is distributed throughout the eastern U.S., Lyme disease is only considered endemic in the northeastern region of the country. Prior to 2007, Lyme disease was uncommon in Virginia, but since then cases of Lyme disease have increased dramatically with a hotspot forming in the Roanoke-Blacksburg area. The purpose of the current study was to determine whether B. burgdorferi prevalence and the genetic structure of I. …


The Coloniality Of Disaster: Race, Empire, And The Temporal Logics Of Emergency In Puerto Rico, Usa, Yarimar Bonilla Jan 2020

The Coloniality Of Disaster: Race, Empire, And The Temporal Logics Of Emergency In Puerto Rico, Usa, Yarimar Bonilla

Publications and Research

This essay uses the case of Hurricane Maria in Puerto Rico to discuss “the coloniality of disaster”: how catastrophic events like hurricanes, earthquakes, but also other forms political and economic crisis deepen the fault lines of long-existing racial and colonial histories. It argues that disaster capitalism needs to be understood as a form of racio-colonial capitalism and that this in turn requires us to question our understandings of both “resilience” and “recovery.” The article focuses on the “wait of disaster” as a temporal logic of state subjugation and on how Puerto Ricans responded to state abandonment through modes of autogesti� …


Sleep, Experiential Avoidance, And Mental Health Symptoms, Anthony Reffi Jan 2020

Sleep, Experiential Avoidance, And Mental Health Symptoms, Anthony Reffi

Graduate Research Theses & Dissertations

The explanatory mechanisms by which sleep disturbances promote psychopathology are not well understood. Given that poor sleep promotes a broad range of negative emotions the next day, sleep disturbances may increase the tendency to identify inner experiences as aversive, thereby promoting experiential avoidance (EA). Though temporarily effective, the frequent and rigid use of EA has been shown to worsen mental health. Therefore, using a seven-day ecological momentary assessment design, this study investigated momentary EA as a mechanism linking subjective sleep quality and quantity with subsequent anxiety and depressive symptoms. Undergraduate participants (N = 86, Mage = 19.72) first completed an …


The Golden Gates Of Childhood: Romantic Influences On Childhood Perspective In George Eliot's The Mill On The Floss And Charles Dickens's Oliver Twist, Tara Rosenzweig Jan 2020

The Golden Gates Of Childhood: Romantic Influences On Childhood Perspective In George Eliot's The Mill On The Floss And Charles Dickens's Oliver Twist, Tara Rosenzweig

Graduate Research Theses & Dissertations

This study explores George Eliot’s The Mill on the Floss and Charles Dickens’s Oliver Twist, specifically in terms of how these Victorian authors portray childhood. I focus on the Romantic influences of Jean-Jacques Rousseau and William Wordsworth to analyze this portrayal. I examine how Eliot and Dickens use Wordsworth’s Romantic images of nature, gates, and windows to portray Victorian adults as corruptors of childhood innocence. Further, I analyze how these authors use Rousseau’s teaching philosophies to criticize Victorian educational policies. By comparing Dickens’s Oliver Twist to Eliot’s The Mill on the Floss, I trace how both authors depend on Romanticism …


Characterization Of The Putative Polysaccharide Synthase Cpsa And Its Effects On The Virulence Of The Human Pathogen Aspergillus Fumigatus, Binita Nepal Jan 2020

Characterization Of The Putative Polysaccharide Synthase Cpsa And Its Effects On The Virulence Of The Human Pathogen Aspergillus Fumigatus, Binita Nepal

Graduate Research Theses & Dissertations

The fungus Aspergillus fumigatus is a ubiquitous opportunistic human pathogen capable of causing a life-threatening disease called invasive aspergillosis, or IA, with an associated 40–90% mortality rate in immunocompromised patients. Of the approximately 250 species known in the genus Aspergillus, A. fumigatus is responsible for up to 90% of IA infections. This study focuses on examining the role of the putative polysaccharide synthase cpsA gene in A. fumigatus virulence. Additionally, we evaluated its role in cellular processes that influence invasion and colonization of host tissue. Importantly, our results support that cpsA is indispensable for virulence in A. fumigatus infection of …


Model-Based Network Reconstruction From Cascade Dynamics, Katherine Irena Chwistek Jan 2020

Model-Based Network Reconstruction From Cascade Dynamics, Katherine Irena Chwistek

Graduate Research Theses & Dissertations

Network representation provides a natural framework for the study of real world complex systems. From social networks and animal groups to interneuronal communications and power grid systems, complex patterns of interaction can be captured and modeled using networks in a simple mathematical form. In many cases, however, a faithful network representation of the system is not readily available. For this reason, network reconstruction has become a growing topic of interest in recent years, the goal of which is to discover the hidden interaction patterns among individuals by fitting input-output data from multiple experiments to candidate network topologies.

During a cascade, …


The Role Of Prediction Error In A Behavioral Memory Reconsolidation Intervention For The Treatment Of Posttraumatic Stress Symptoms: Original Proposal And Update Due To The Covid-19 Global Pandemic, Benjamin Darnell Jan 2020

The Role Of Prediction Error In A Behavioral Memory Reconsolidation Intervention For The Treatment Of Posttraumatic Stress Symptoms: Original Proposal And Update Due To The Covid-19 Global Pandemic, Benjamin Darnell

Graduate Research Theses & Dissertations

A failure to naturally resolve posttraumatic stress symptoms (PTSS) following exposure to a traumatic event is associated with costly and debilitating consequences. Interventions for PTSS are successful for only 40%-70% of patients, and treatment drop-out and symptom relapse are common. Recent research targeting memory reconsolidation mechanisms to augment the memory may provide important information regarding possible paradigms for improving the efficacy of trauma-focused interventions. This research indicates that the use of prediction error during a memory activation cue may result in memory destabilization allowing for the destabilized memory to be updated. Considering that PTSS are inherently memory-dependent, an intervention targeting …


Engineering Ph-Dependent Antibody Interactions Through Linked Protonation Events In Interdomain Interfaces, Hyeyoung Eom Jan 2020

Engineering Ph-Dependent Antibody Interactions Through Linked Protonation Events In Interdomain Interfaces, Hyeyoung Eom

Graduate Research Theses & Dissertations

Engineered antibodies are frequently used in life science applications, such as therapeutics and clinical diagnostics. These customized antibodies typically possess enhanced binding affinity and/or specificity, yet these interactions are only one-way binding events that cannot be easily controlled without extreme changes in conditions, such as pH, denaturant, and/or temperature that likely irreversible damage the antibody and antigen. Here, we explore the design of proton-linked binding events in the context of both antibody/hapten (i.e., a low molecular weight ligand target) and antibody/antigen complexes. Specifically, this work looks to overcome the challenges of engineering pH-dependent small ligand/protein interactions, as well as develop …


The Role Of Endophytes In Conferring Salinity Tolerance In Prairie Cordgrass And The Winter Wheat Mint Variety, Jeffery Bartel Jan 2020

The Role Of Endophytes In Conferring Salinity Tolerance In Prairie Cordgrass And The Winter Wheat Mint Variety, Jeffery Bartel

Electronic Theses and Dissertations

Prairie Cordgrass (PCG) Spartina pectinata is a native grass to North America that survives saline conditions, can be harvested multiple times in a year, and can be used as biofuel. Endophytes are bacteria that reside in plant tissues and often have growthpromoting capabilities. They can assist plants by obtaining nutrients by improving the tolerance of plants against a broad range of stresses, such as plant pathogens, viruses, flooding, drought, acids, or bases. PCG can survive ocean levels of salinity. Endophytes that naturally bond with PCG may not only be able to not only help PCG but be transferred to other …


Screening Of Catalysts For The Subcritical Water Depolymerization Of Lignin, Balawanthrao Jadhav Jan 2020

Screening Of Catalysts For The Subcritical Water Depolymerization Of Lignin, Balawanthrao Jadhav

Electronic Theses and Dissertations

The current world population is completely rely on the non-renewable resources such as coal, fossils, and natural gas to get the energy, fuel and value-added chemicals. The increasing the demand of utilizing non renewable resources leads to severe problems such as global warming, climate changes, and environmental pollution. The renewable resources such as wind, solar energy, and biomass is an alternative sources to overcome these problems and to save the environment. Biomass made up with the cellulose, hemicellulose, and Lignin. Lignin is a copolymer of phenolic monomers and inexpensive naturally occurring complex material to produce the value-added chemicals and various …


Burning With Potential: Understanding The Relationship Between Biochar And Agriculture Of The Northern Glaciated Plains Ecoregion, Kaitlyn Abrahamson Jan 2020

Burning With Potential: Understanding The Relationship Between Biochar And Agriculture Of The Northern Glaciated Plains Ecoregion, Kaitlyn Abrahamson

Electronic Theses and Dissertations

Achieving global sustainable agriculture is one of the most incredible challenges of this century, yet many continue to try to solve this problem through the development of precision technologies. Biotechnologies, such as biochar, can perform like a precision technology while protecting agricultural land from soil erosion and fertility loss. The Northern Glaciated Plains ecoregion of the United States is little researched in the benefits from the use of biochar through improved soil nutrient capture and water retention, crop health improvements, and yield increases. The study plot has four sections of corn stover biochar and eight sections of control sections. This …


Fishes Of The Dakotas, Kathryn Schlafke Jan 2020

Fishes Of The Dakotas, Kathryn Schlafke

Electronic Theses and Dissertations

Biological reference materials play a critical role in studies of species biodiversity, biology, distribution, and historic diversity. Since the publications Fishes of North Dakota (Hankinson, 1929) and Fishes of South Dakota (Bailey and Allum, 1962), no new books have attempted to update the knowledge gained from the past decades of fish surveys and incorporate georeferenced collections at the state level. The last published book with the most complete accounts of fishes from North Dakota and South Dakota is the Distribution of Fishes in North and South Dakota Basins affected by the Garrison Diversion Unit (Owen et al. 1981) which includes …


Food & Culture In Greece, University Of New England Applied Nutrition Program Jan 2020

Food & Culture In Greece, University Of New England Applied Nutrition Program

All Student-Created Educational Resources

This is a fact sheet about the food culture of Greece. The purpose is to educate the audience on Greece’s traditional cuisine and eating patterns. Information includes traditional foods and dishes, traditional eating patterns, holidays and religious traditions, traditional health beliefs, and more current food practices in Greece.


Food Culture Of India, University Of New England Applied Nutrition Program Jan 2020

Food Culture Of India, University Of New England Applied Nutrition Program

All Student-Created Educational Resources

This handout informs audience of traditional foods within India. It addresses traditional eating patterns by identifying foods and beverages typically eaten, as well as how and when these foods are consumed. It also addresses traditional health beliefs and current food practices to those living in both India and the United States.


Acetaldehyde Production By Rothia Mucilaginosa Isolates From Patients With Oral Leukoplakia., Abdrazak Amer, Aine Whelan, Nezar N. Al-Hebshi, Claire M. Healy, Gary P. Moran Jan 2020

Acetaldehyde Production By Rothia Mucilaginosa Isolates From Patients With Oral Leukoplakia., Abdrazak Amer, Aine Whelan, Nezar N. Al-Hebshi, Claire M. Healy, Gary P. Moran

Articles

Rothia mucilaginosa has been found at high abundance on oral leukoplakia (OLK). The ability of clinical isolates to produce acetaldehyde (ACH) from ethanol has not been investigated. The objective of the current study was to determine the capacity of R. mucilaginosa isolates recovered from OLK to generate ACH. Analysis of R. mucilaginosa genomes (n = 70) shows that this species does not normally encode acetaldehyde dehydrogenase (ALDH) required for detoxification of ACH. The predicted OLK metagenome also exhibited reduced ALDH coding capacity. We analysed ACH production in 8 isolates of R. mucilaginosa and showed that this species is capable of …


Prognostic Role Of Homeostasis Model Assessment And Oral Glucose Tolerance Test Innondiabetic Patients With Bell's Palsy, Tuğba Karagöz, Ömer Bayir, Emel Çadalli Tatar, Erman Çakal, Ali̇ Özdek, Kemal Keseroğlu, Mustafa Şahi̇n, Mehmet Hakan Korkmaz Jan 2020

Prognostic Role Of Homeostasis Model Assessment And Oral Glucose Tolerance Test Innondiabetic Patients With Bell's Palsy, Tuğba Karagöz, Ömer Bayir, Emel Çadalli Tatar, Erman Çakal, Ali̇ Özdek, Kemal Keseroğlu, Mustafa Şahi̇n, Mehmet Hakan Korkmaz

Turkish Journal of Medical Sciences

Background/aim: We aimed to reveal the incidence and predictive role of insulin resistance and distorted oral glucose tolerance test in nondiabetic patients with Bell's Palsy (BP). Materials and methods: Eighty-six patients with BP and 28 control subjects; all with normal blood glucose levels and no history of diabetes, were enrolled in the study. We investigated insulin resistance (IR) in all subjects, in terms of HOMA-IR greater than 2.7. Sixtytwo of the patients also underwent an oral glucose tolerance test (OGTT). Results: The mean HOMA-IR value was significantly increased in patients, compared to the control group (3.2 vs 1.6; P < 0.01). IR was detected more in BP patients than in controls (P < 0.05). The patients with higher HOMA-IR values had more severe facial dysfunction at the initial presentation and complete recovery time took longer than the patients with normal HOMA-IR value (75 days vs 42 days; P < 0.05). Following a 2h-OGTT, impaired glucose tolerance and newly diagnosed DM were found in 60% of the patients. Recovery time was significantly longer in prediabetics and newly diagnosed diabetic patients than in patients with normal glycemia (68 days, 52 days, and 32 days, respectively; P < 0.01). Conclusion: There is a strong linkage between HOMA-IR value and BP prognosis so HOMA-IR value may have a significant role of predicting BP prognosis at presentation.