Digital Commons Network^™

Applications Of Non-Invasive Neuromodulation For The Management Of Disorders Related To Covid-19, Abrahão Fontes Baptista, Adriana Baltar, Alexandre Hideki Okano, Alexandre Moreira, Ana Carolina Pinheiro Campos, Ana Mércia Fernandes, André Russowsky Brunoni, Bashar W. Badran, Clarice Tanaka, Daniel Ciampi De Andrade, Daniel Gomes Da Silva Machado, Edgard Morya, Eduardo Trujillo, Jaiti K. Swami, Joan A. Camprodon, Katia Monte-Silva, Katia Nunes Sá, Isadora Nunes, Juliana Barbosa Goulardins, Marom Bikson, Pedro Sudbrack-Oliveira, Priscila De Carvalho, Rafael Jardim Duarte-Moreira, Rosana Lima Pagano, Samuel Katsuyuki Shinjo, Yossi Zana

Publications and Research

Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19.

Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders.

Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders.

Results: …

Asthma And Its Relationship To Mitochondrial Copy Number: Results From The Asthma Translational Genomics Collaborative (Atgc) Of The Trans-Omics For Precision Medicine (Topmed) Program, Maxwell P. Cocco, Evan White, Shujie Xiao, Donglei Hu, Angel Mak, Patrick Sleiman, Mao Yang, Kevin R. Bobbit, Hongsheng Gui, Albert M. Levin, Samantha Hochstadt, Kyle Whitehouse, Dean Rynkowski, Andrea J. Barczak, Gonçalo Abecasis, Thomas W. Blackwell, Hyun Min Kang, Deborah A. Nickerson, Soren Germer, Jun Ding, David E. Lanfear, Frank Gilliland, W. James Gauderman, Rajesh Kumar, David J. Erle, Fernando Martinez, Hakon Hakonarson, Esteban G. Burchard, Keoki L. Williams

Center for Individualized and Genomic Medicine Research Articles

BACKGROUND: Mitochondria support critical cellular functions, such as energy production through oxidative phosphorylation, regulation of reactive oxygen species, apoptosis, and calcium homeostasis.

OBJECTIVE: Given the heightened level of cellular activity in patients with asthma, we sought to determine whether mitochondrial DNA (mtDNA) copy number measured in peripheral blood differed between individuals with and without asthma.

METHODS: Whole genome sequence data was generated as part of the Trans-Omics for Precision Medicine (TOPMed) Program on participants from the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) and the Study of African Americans, Asthma, Genes, & Environment II (SAGE II). We …

A Review Of Volatile Organic Compound Contamination In Post-Industrial Urban Centers: Reproductive Health Implications Using A Detroit Lens, Carol J. Miller, Melissa Runge-Morris, Andrea E. Cassidy-Bushrow, Jennifer K. Straughen, Timothy M. Dittrich, Tracie R. Baker, Michael C. Petriello, Gil Mor, Douglas M. Ruden, Brendan F. O'Leary, Sadaf Teimoori, Chandra M. Tummala, Samantha Heldman, Manisha Agarwal, Katherine Roth, Zhao Yang, Bridget B. Baker

Public Health Sciences Articles

Volatile organic compounds (VOCs) are a group of aromatic or chlorinated organic chemicals commonly found in manufactured products that have high vapor pressure, and thus vaporize readily at room temperature. While airshed VOCs are well studied and have provided insights into public health issues, we suggest that belowground VOCs and the related vapor intrusion process could be equally or even more relevant to public health. The persistence, movement, remediation, and human health implications of subsurface VOCs in urban landscapes remain relatively understudied despite evidence of widespread contamination. This review explores the state of the science of subsurface movement and remediation …

The Effect Of Mock Code Blue Simulations And Dedicated Advanced Cardiac Life Support Didactics On Resident Perceived Competency., Dallis Q Ngo, Christina Vu, Thien Nguyen, Patricia Sotolongo, Manika Talati, Nikki Zahabi, Katrina Platt

Articles, Abstracts, and Reports

In-hospital cardiac or pulmonary arrest is associated with high mortality. In the USA, approximately 200,000 of these events occur and are associated with overall survival rates of 18%-20%. Despite advances in resuscitative methods, the probability of intact survival also remains unfavorable. Though many factors play a role, we believe a large portion of a patient's survival is dependent on the competency of the leader of the code blue or resuscitative team's efforts. Newly minted physicians who enter medical training in their respective residencies are equipped with a wide range of clinical competency in regards to hands-on experience and aptitude with …

Bullseye Snakehead Fish (Channa Marulius) Neurocranium, James A. Moss, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium had an estimated length of 11 cm, Bullseye Snakehead (Channa marulius), invasive species collected from South Florida

Assessment Of Nutrient Sources At Watershed Scale In Agro-Ecosystem Of Mississippi, Avay Risal

Theses and Dissertations

Excessive nutrient concentrations from a different point and non-point sources are the main cause of water impairment in the United States. Appropriate management practices, according to the source and quantity of pollutions, need to be implemented to control excessive nutrient influx in the water body. Various types of hydrological and water quality models with diverse function, capability and degree of complexity are employed to quantify watershed hydrologic processes and nutrient pollution. Multiple models can be applied to a watershed but the suitable model must be selected based on watershed type and simulation need. Two watershed-scale models, Soil and Water Assessment …

A Comparison Of Strawberry (Fragaria X Ananassa) Cultivars Affected By Different Cultural Practices In Two Production Systems, Geoffrey Thomas Lalk

Theses and Dissertations

Strawberry cultivar performance affected by various cultural practices was investigated in two production systems. The first study investigated strawberry yield, fruit quality, and production timing of eight cultivars when using black and red plastic mulches in a high tunnel production system. The high tunnel increased air temperatures and advanced strawberry fruiting by four to six weeks compared to local openield production. The second study investigated plant growth, yield, and fruit quality of 10 cultivars fertilized with organic or conventional fertilizer and irrigated once or twice daily with the same total irrigation volume in a container system. Strawberry cultivars varied in …

A Study On Biogeography And Floral Trait Evolution In Platanthera Subgenus Limnorchis (Orchie) Using Phylogenomic Approaches, W I W H M Eranga Hansanee Wettewa

Theses and Dissertations

Platanthera is one of the largest genera of temperate orchids and exemplifies a lineage that has adaptively radiated into diverse habitats within North America, Asia, Europe, North Africa, Borneo, and Sarawak. Major centers of diversity in this genus are western North America and eastern Asia. The diversity in floral morphological traits such as floral color, shape and the length of nectar spur is associated with numerous pollination syndromes, making Platanthera an ideal system to study the evolution of floral traits and pollination biology. Despite its diversity, a thorough phylogenetic hypothesis for the genus is lacking because no studies have yet …

Expediting Rare Disease Diagnosis: A Call To Bridge The Gap Between Clinical And Functional Genomics., Samantha N. Hartin, John C. Means, Joseph Alaimo, Scott T. Younger

Manuscripts, Articles, Book Chapters and Other Papers

Approximately 400 million people throughout the world suffer from a rare disease. Although advances in whole exome and whole genome sequencing have greatly facilitated rare disease diagnosis, overall diagnostic rates remain below 50%. Furthermore, in cases where accurate diagnosis is achieved the process requires an average of 4.8 years. Reducing the time required for disease diagnosis is among the most critical needs of patients impacted by a rare disease. In this perspective we describe current challenges associated with rare disease diagnosis and discuss several cutting-edge functional genomic screening technologies that have the potential to rapidly accelerate the process of distinguishing …

Grand Challenge In Animal Nutrition, David L. Harmon

Animal and Food Sciences Faculty Publications

No abstract provided.

Hemp Fiber – An Environmentally Friendly Fiber For Concrete Reinforcement, Brian Giltner

Theses and Dissertations

The commercial use of hemp fiber in the construction industry within the United States is non-existent. This lack of use is because of State and Federal laws forbidding the growth of hemp in the United States, which has led to a lack of research. Not having an established supply chain for hemp and coupled with limited research has put the United States behind other countries in finding viable options for these renewable resources. This is a study of the performance of raw hemp fibers and processed hemp twine in a cement past mixture subjected to tensile loading. Three water/cement ratios …

Thermographic, Behavioral, And Histological Inflammatory Analysis Of A Subconcussive, Closed-Head, Blunt Impact Rodent Model, Sonja Anne Virkus

Theses and Dissertations

Subconcussive impacts have become a growing concern particularly with respect to contact sports. It is believed that minimal head impacts can cause cerebral perturbations that initiate an immune response creating a window of vulnerability. Evidence suggests that additional head insults sustained during this window of vulnerability elicit an exaggerated inflammatory response and exacerbate cognitive deficits. Therefore, determining the lower limits of systematic perturbation resulting from low-level impacts is of critical importance in expanding our understanding of cerebral vulnerability and recovery. However, the vast majority of experimental investigations of subconcussion fail to model single impact events and instead focus on cumulative …

Martin Luther And The Jews: Passion Over Ethics, Joseph Telushkin

Consensus

No abstract provided.

A Jewish Response To Dysfunctional And Destructive Passion, Daniel Maoz

Consensus

No abstract provided.

Effects Of Noise Exposure On The Vestibular System: A Systematic Review, Courtney Elaine Stewart, Avril Genene Holt, Richard A. Altschuler, Anthony Thomas Cacace, Courtney D. Hall, Owen D. Murnane, W. Michael King, Faith W. Akin

ETSU Faculty Works

Despite our understanding of the impact of noise-induced damage to the auditory system, much less is known about the impact of noise exposure on the vestibular system. In this article, we review the anatomical, physiological, and functional evidence for noise-induced damage to peripheral and central vestibular structures. Morphological studies in several animal models have demonstrated cellular damage throughout the peripheral vestibular system and particularly in the otolith organs; however, there is a paucity of data on the effect of noise exposure on human vestibular end organs. Physiological studies have corroborated morphological studies by demonstrating disruption across vestibular pathways with otolith-mediated …

Movements And Space-Use Of Female Greater Sage-Grouse (Centrocercus Urophasianus) During Nesting And Breeding Seasons, Drew W. Retherford

Theses and Dissertations

Greater sage-grouse (Centrocercus urophasianus) are a species of conservation concern throughout their range including the state of Idaho. Little is known about the size of areas used by female sage-grouse during the breeding and nesting seasons, fidelity of females to those areas, or fidelity of female sage-grouse to specific leks or nest sites. The recent miniaturization of global positioning system (GPS) transmitting devices allows for a more thorough analysis of this behavior. We placed GPS transmitters on 234 female sage-grouse in Idaho, USA, from 2015 to 2019. We monitored 145 nest attempts, 15 of which occurred in consecutive years, from …

Proanthocyanidin Block Arrays (Pacbar) For Comprehensive Capture And Delineation Of Proanthocyanidin Structures, Shuxi Jing, Wayne E. Zeller, Daneel Ferreira, Bin Zhou, Joo-Won Nam, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Proanthocyanidins (PACs) are near-ubiquitous and chemically complex metabolites, prototypical of higher plants. Their roles in food/feed/nutrition and ethnomedicine are widely recognized but poorly understood. With the analysis of evidence that underlies this challenge, this perspective identifies shortcomings in capturing and delineating PAC structures as key factors. While several groups have forwarded new representations, a consensus method that captures PAC structures concisely and offers high integrity for electronic storage is required to reduce confusion in this expansive field. The PAC block arrays (PACBAR) system fills this gap by providing precise and human- and machine-readable structural descriptors that capture PAC metabolomic structural …

Luther Legacy Conference: Martin Luther And Antisemitism January 20, 2020

Consensus

This document contains the entire proceedings of the Luther Legacy Conference

Influence Of Promotion And Prompt Salary Payment On Job Performance Of Library Personnel In University Libraries In Nasarawa State, Nigeria., Agada Eric Ojobo, Ogbole Ibrahim, Tofi Simon Ternenge

Library Philosophy and Practice (e-journal)

ABSTRACT

The study investigated the influence promotion and prompt salary payment on job performance of library personnel in university libraries in Nasarawa State. Two (2) specific objectives with corresponding research questions guided the study and two hypotheses were formulated and tested at 0.05 level of significance. The study adopted a survey research design and was carried out in Nasarawa State, Nigeria. The population of the study was 150 library personnel in the University libraries in Nasarawa State which were made up 44 library personnel in federal university Lafia, 66 library personnel in Nasarawa State University Keffi and 40 library personnel …

Development Of The Pet-Related Events And Tasks Scale (Pets), Courtney Bolstad

Theses and Dissertations

Depression is a common, debilitating disorder that is often treated using behavioral activation (BA), which includes identification and scheduling of pleasant activities. Owning a pet appears to be a viable source of pleasant activities, though current BA tools do not extensively consider these activities. The present study aimed to develop the Pet-Related Events and Tasks Scale (PETS) to determine what activities of pet ownership are pleasant and may be used in BA. Various methods were used to generate items (i.e., focus groups, surveys, and adaptation of existing event schedule items) and revise the developing PETS (i.e., cognitive interviews and expert …

Experiential Depth: Understanding A Hindu-Muslim Relationship Through A Trinitarian Theology Of Religions, Kalpesh Bhatt

Journal of Hindu-Christian Studies

No abstract provided.

On The Secondary Nature Of Kaṁsa’S ‘Massacre Of The Innocents’ In The Bhāgavata Purāṇa, Ronald V. Huggins

Journal of Hindu-Christian Studies

No abstract provided.

Cognition In Health And Disease: Two Mouse Model Studies, Heather Lynn Mahoney

USF Tampa Graduate Theses and Dissertations

Cognitive and circadian dysfunction are common aspects of neuropsychiatric disease that are often overlooked in disease models and treatment strategies. In this work, we first evaluated the potential for cognitive enhancement in healthy adult mice by targeting a kinase involved in regulation of the molecular circadian clock. We then developed and characterized a model of neuropsychiatric disease that could present a target for rescuing circadian and cognitive deficits using this treatment.

Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of circadian rhythms impairs hippocampus-dependent learning and memory. We first asked whether casein kinase …

Office Of Research, Economic Engagement And Outreach Update, November 25, 2020, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Evolving The Narrative For Protecting A Rapidly Changing Ocean, Post‐Covid‐19, D. Laffoley, J. M. Baxter, D. J. Amon, J. Claudet, Jm Hall‐Spencer, K Grorud‐Colvert, L. A. Levin, Chris P. Reid, A. D. Rogers, M. L. Taylor, L. C. Woodall, N. F. Andersen

School of Biological and Marine Sciences

No abstract provided.

A Decade To Study Deep-Sea Life, Kerry L. Howell, Ana Hilário, A. Louise Allcock, David Bailey, Maria Baker, Malcolm R. Clark, Ana Colaço, Jon Copley, Erik E. Cordes, Roberto Danovaro, Awantha Dissanayake, Elva Escobar, Patricia Esquete, Austin J. Gallagher, Andrew R. Gates, Sylvie M. Gaudron, Christopher R. German, Kristina M. Gjerde, Nicholas D. Higgs, Bris N Le, Lisa A. Levin, Elisabetta Manea, Craig Mcclain, Lenaick Menot, Nelia C. Mestre, Anna Metaxas, Rosanna Milligan, Agnes W.N. Muthumbi, Bhavani E. Narayanaswamy, Sofia P. Ramalho, Eva Ramirez-Llodra, Laura M. Robson, Alex D. Rogers, Javier Sellanes, Julia D. Sigwart, Kerry Sink, Paul V.R. Snelgrove, Paris V. Stefanoudis, Paulo Y. Sumida, Michelle L. Taylor, Andrew R. Thurber, Rui Vieira, Hiromi K. Watanabe, Lucy C. Woodall, Joana R. Xavier

School of Biological and Marine Sciences

The United Nations Decade of Ocean Science for Sustainable Development presents an exceptional opportunity to effect positive change in ocean use. We outline what is required of the deep-sea research community to achieve these ambitious objectives.

Fishery Reforms For The Management Of Non-Indigenous Species, Periklis Kleitou, Fabio Crocetta, Sylvaine Giakoumi, Ioannis Giovos, Jason M. Hall-Spencer, Stefanos Kalogirou, Demetris Kletou, Dimitrios K. Moutopoulos, Siân Rees

School of Biological and Marine Sciences

Marine ecosystems are undergoing major transformations due to the establishment and spread of Non-Indigenous Species (NIS). Some of these organisms have adverse effects, for example by reducing biodiversity and causing ecosystem shifts. Others have upsides, such as benefits to fisheries or replacing lost ecological functions and strengthening biogenic complexity. Stopping the spread of NIS is virtually impossible and so the societal challenge is how to limit the socioeconomic, health, and ecological risks, and sustainably exploit the benefits provided by these organisms. We propose a move away from the notion that NIS have only negative effects, and suggest a turn towards …

A Blueprint For An Inclusive, Global Deep-Sea Ocean Decade Field Program, Kerry L. Howell, Ana Hilário, A. Louise Allcock, David M. Bailey, Maria Baker, Malcolm R. Clark, Ana Colaço, Jon Copley, Erik E. Cordes, Roberto Danovaro, Awantha Dissanayake, Elva Escobar, Patricia Esquete, Austin J. Gallagher, Andrew R. Gates, Sylvie M. Gaudron, Christopher R. German, Kristina M. Gjerde, Nicholas D. Higgs, Bris N Le, Lisa A. Levin, Elisabetta Manea, Craig Mcclain, Lenaick Menot, Nelia C. Mestre, Anna Metaxas, Rosanna J. Milligan, Agnes W.N. Muthumbi, Bhavani E. Narayanaswamy, Sofia P. Ramalho, Eva Ramirez-Llodra, Laura M. Robson, Alex D. Rogers, Javier Sellanes, Julia D. Sigwart, Kerry Sink, Paul V.R. Snelgrove, Paris V. Stefanoudis, Paulo Y. Sumida, Michelle L. Taylor, Andrew R. Thurber

School of Biological and Marine Sciences

The ocean plays a crucial role in the functioning of the Earth System and in the provision of vital goods and services. The United Nations (UN) declared 2021–2030 as the UN Decade of Ocean Science for Sustainable Development. The Roadmap for the Ocean Decade aims to achieve six critical societal outcomes (SOs) by 2030, through the pursuit of four objectives (Os). It specifically recognizes the scarcity of biological data for deep-sea biomes, and challenges the global scientific community to conduct research to advance understanding of deep-sea ecosystems to inform sustainable management. In this paper, we map four key scientific questions …

Altered Capicua Expression Drives Regional Purkinje Neuron Vulnerability Through Ion Channel Gene Dysregulation In Spinocerebellar Ataxia Type 1, Ravi Chopra, David D Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M Morrison, Haoran Huang, Hillary P Handler, Luke J Man, Warunee Dansithong, Daniel R Scoles, Stefan M Pulst, Harry T Orr, Vikram G Shakkottai

2020-Current year OA Pubs

Selective neuronal vulnerability in neurodegenerative disease is poorly understood. Using the ATXN1[82Q] model of spinocerebellar ataxia type 1 (SCA1), we explored the hypothesis that regional differences in Purkinje neuron degeneration could provide novel insights into selective vulnerability. ATXN1[82Q] Purkinje neurons from the anterior cerebellum were found to degenerate earlier than those from the nodular zone, and this early degeneration was associated with selective dysregulation of ion channel transcripts and altered Purkinje neuron spiking. Efforts to understand the basis for selective dysregulation of channel transcripts revealed modestly increased expression of the ATXN1 co-repressor Capicua (Cic) in anterior cerebellar Purkinje neurons. Importantly, …

Detection Rates Of Northern Bobwhite Coveys Using A Small Unmanned Aerial System-Mounted Thermal Camera, Megan Elaine Martin

Theses and Dissertations

Northern bobwhite (Colinus virginianus) monitoring (e.g., covey-call surveys) is labor-intensive and imprecise. We evaluated the influence of bobwhite covey size and cover type on covey detectability when surveyed with a thermal camera-equipped small unmanned aerial system (sUAS). We placed bobwhite groups (3, 6, and 12 individuals/cage) among three cover types (grass, shrub, forest) on a private farm in Clay County, Mississippi (3 replicates, 27 total cages). At civil twilight, the sUAS flew over cages at 30 m, capturing photographs every 5 s. We asked 31 volunteers to evaluate 57 photographs for covey presence. Overall true positive rate was 0.551, but …