Digital Commons Network^™

Maternal Childhood And Lifetime Traumatic Life Events And Infant Bronchiolitis, Margaret A. Adgent, Omar Elsayed-Ali, Tebeb Gebretsadik, Frances A. Tylavsky, Mehmet Kocak, Stephania A. Cormier, Rosalind J. Wright, Kecia N. Carroll

Faculty Publications

© 2019 John Wiley & Sons Ltd Background: Viral bronchiolitis is a common respiratory infection that often affects term, otherwise healthy infants. A small literature suggests maternal stress during pregnancy is associated with bronchiolitis. However, the association between maternal exposure to lifetime traumatic stress, including traumatic events occurring in childhood or throughout the life course, and bronchiolitis has not been studied previously. Objectives: To investigate the association between maternal exposure to total lifetime and childhood traumatic stress events and infant bronchiolitis. Methods: We studied mother-infant dyads enrolled in a prospective prenatal cohort, recruited 2006-2011, and Tennessee Medicaid. During pregnancy, we …

2019 Stamps Scholars Setting Records, Edwin B. Smith

University of Mississippi News

Thirteen new arrivals are second-largest group; Ole Miss has nation's fourth-largest program

Genetically Distinct Behavioral Modules Underlie Natural Variation In Thermal Performance Curves, Gregory W. Stegeman, Scott E. Baird, William S. Ryu, Asher D. Cutter

Biological Sciences Faculty Publications

Thermal reaction norms pervade organismal traits as stereotyped responses to temperature, a fundamental environmental input into sensory and physiological systems. Locomotory behavior represents an especially plastic read-out of animal response, with its dynamic dependence on environmental stimuli presenting a challenge for analysis and for understanding the genomic architecture of heritable variation. Here we characterize behavioral reaction norms as thermal performance curves for the nematode Caenorhabditis briggsae, using a collection of 23 wild isolate genotypes and 153 recombinant inbred lines to quantify the extent of genetic and plastic variation in locomotory behavior to temperature changes. By reducing the dimensionality of the …

Examining The Effects Of Stress And Age On Neural Reward Processing: Considerations For The Role Of Individual Differences In Autonomic Reactivity, William Mccuddy

Dissertations (1934 -)

Acute stress is unavoidable and may hinder basic reward processing underlying adaptive decision-making. Additionally, older adults may be at an increased risk of poor decision-making after exposure to acute stress due to age-related changes in cognitive and autonomic functioning. The current study assessed the influence of acute stress, autonomic reactivity, and age on a simple behavioral task during fMRI. Specifically, old and young adults completed a basic reward processing paradigm (i.e., where participants received monetary rewards and punishments) after exposure to acute stress (i.e., social evaluative cold pressor) or control procedure between-subjects. In the young group, differential responses for monetary …

Metastatic Breast Cancer In Kenya: Presentation, Pathologic Characteristics, And Patterns-Findings From A Tertiary Cancer Center, Etoroabasi Ekpe, Asim Jamal, Jasmit Shah, Judith S. Jacobson, Shahin Sayed

Internal Medicine, East Africa

Purpose: The purpose of this research was to describe the sociodemographic and clinical characteristics of Kenyan women with metastatic breast cancer diagnosed and treated at Aga Khan University Hospital in Nairobi, Kenya from 2012 to 2018.

Patients and Methods: We reviewed charts of Kenyan women with metastatic breast cancer and analyzed sociodemographic data, breast cancer risk factors, and tumor characteristics associated with stage at diagnosis, receptor status (ie, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 [HER2]), and site of metastasis using χ2, analysis of variance, two-sample t tests, and logistic regressions.

Results: A total of 125 …

Effects Of Movement On Student Achievement, Nicole Davidson

Master's Theses & Capstone Projects

This literature review explores the effect that movement has on the achievement of elementary aged students. The research provided through scholarly articles, journals, and books, explains why there is a need for movement activities in the classroom and how physical activity effects the engagement and success of children in a positive way. This literature review examines the constructive impact that movement plays on the brain activity of young children in their early developmental stages of life. Studies also provide research that examine how the overall health of children can benefited by the amount of movement that their body receives daily. …

Hydrologic And Biologic Responses Of Anthropogenically Altered Lentic Springs To Restoration In The Great Basin, Leah Nicole Knighton

Theses and Dissertations

Water is a limited and highly valued resource in the semi-arid Great Basin. Surface water sources are often small and widely spaced apart, comprising only 1-3% of the surface area of the overall landscape. Despite their small size, these springs and surrounding wet meadows have a substantial effect on the surrounding environment. Springs provide drinking water, forage and cover for livestock and wildlife, habitat for diversity of plant species and a resource for human-related activities. In recent years, many of these springs have become dewatered due to diversions of groundwater for municipal water and agriculture, and climatic shifts in precipitation …

Louisiana Agriculture Summer, 2019, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

Northwest- Summer 2019, Lsu Agcenter

Horticulture Hints

No abstract provided.

Northeast- Summer 2019, Lsu Agcenter

Horticulture Hints

No abstract provided.

Central- Summer 2019, Lsu Agcenter

Horticulture Hints

No abstract provided.

Southwest- Summer 2019, Lsu Agcenter

Horticulture Hints

No abstract provided.

Southeast- Summer 2019, Lsu Agcenter

Horticulture Hints

No abstract provided.

A Phylogenomic Supertree Of Birds, R T. Kimball, C H. Oliveros, N Wang, N D. White, R T. Kimball, D J. Field, D T. Ksepka, R T. Chesser, R G. Moyle, M J. Braun, R T. Brumfield, B C. Faircloth, B T. Smith, E L. Braun

Faculty Publications

It has long been appreciated that analyses of genomic data (e.g., whole genome sequencing or sequence capture) have the potential to reveal the tree of life, but it remains challenging to move from sequence data to a clear understanding of evolutionary history, in part due to the computational challenges of phylogenetic estimation using genome-scale data. Supertree methods solve that challenge because they facilitate a divide-and-conquer approach for large-scale phylogeny inference by integrating smaller subtrees in a computationally efficient manner. Here, we combined information from sequence capture and whole-genome phylogenies using supertree methods. However, the available phylogenomic trees had limited overlap …

Resetting The Table For People And Plants: Botanic Gardens And Research Organizations Collaborate To Address Food And Agricultural Plant Blindness, Sarada Krishnan, Tara Moreau, Jeff Kuehny, Ari Novy, Stephanie L. Greene, Colin K. Khoury

Faculty Publications

Societal Impact Statement: Food and agricultural plants are integral to human well-being. Due to their universal importance, such plants would appear to represent an ideal entryway by which to address plant blindness. However, with limited opportunities for direct contact with agriculture, many people cannot appreciate the flora that feed us every day. We provide examples of informal education initiatives aimed at increasing public awareness and appreciation of food and agricultural plants, made possible through collaborations between botanic gardens, academic institutions, nonprofits, and agricultural research organizations. We hope these examples encourage and inspire organizations to further utilize food and agricultural plants …

Elemental Composition, Phosphorous Uptake, And Characteristics Of Growth Of A Sar11 Strain In Batch And Continuous Culture, Scott R. Grant, Matthew J. Church, Sara Ferrón, Edward A. Laws, Michael S. Rappé

Faculty Publications

In this study, a strain of SAR11 subgroup IIIa (termed HIMB114) was grown in seawater-based batch and continuous culture in order to quantify cellular features and metabolism relevant to SAR11 ecology. We report some of the first direct measurements of cellular elemental quotas for nitrogen (N) and phosphorus (P) for SAR11, grown in batch culture: 1.4 0.9 fg N and 0.44 0.01 fg P, respectively, that were consistent with the small size of HIMB114 cells (average volume of 0.09 m³). However, the mean carbon (C) cellular quota of 50 47 fg C was anomalously high, but variable. The …

Hole Filling In 3d Scans For Digital Anthropometric Applications, Sima Sobhiyeh, Marcelline Dechenaud, Alexander Dunkel, Margarite Laborde, Samantha Kennedy, John Shepherd, Steven Heymsfield, Peter Wolenski

Faculty Publications

Anthropometric measurements have been used to assess an individual's body composition, disease risk, and nutritional status. Three-dimensional (3D) optical devices can rapidly acquire body surface scans in the form of a triangular mesh which can then be used to obtain anthropometric measurements such as body volume, limb lengths, and circumferences; however, the meshes provided by some scanners may include missing data patches known as holes. These need to be repaired in order to obtain correct landmark detection and automatic calculation of anthropometric measurements -especially body volume. In this study, we present ScReAM (Scan Reconstruction for Anthropometric Measurements) which is a …

Labrad : Vol 45, Issue 2 - July 2019, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• Novel Molecular Technique for Identifying Respiratory Tract Pathogens
• Role of Serum Galactomannan (GM) Assay in Diagnosing Invasive Aspergillosis (IA)
• Factor VIII Inhibitor – A Diagnostic Approach
• PET/CT Hybrid Imaging Technology at Aga Khan University Hospital
• Diagnostic Tests for Von Willebrand Disease
• Iron Deficiency Anemia
• Sweat Testing for Diagnosis of Cystic Fibrosis
• Flow Cytometric Identification of Abnormal B-Cells
• Direct Immunofluorescence in Bullous Skin Disorders
• Radiology-Pathology Correlation; Orthopedic Pathology
• Fecal Elastase: A Marker For Exocrine Pancreatic Function
• Edward Syndrome: Rare Autosomal Aneuploidy
• Sirolimus in Renal Transplant
• Latest Trends in Clinical Laboratory Science Technology
• Radiology-Neuropathology Correlation
• Nuchal Translucency Scan
• Bio-risk Management System in …

Summer 2019, University Of North Dakota Alumni Association

ALL: UND Alumni Review Master List

Summer 2019 issue of "The University of North Dakota Alumni Review." 60 pages

Volume 102, Number 2

Guidelines For Aspen Restoration In Utah With Applicability To The Intermountain West, Stanley G. Kitchen, Patrick N. Behrens, Sherel K. Goodrich, Ashley Green, John Guyon, Mary O'Brien, David Tart

Aspen Bibliography

As highly productive and biologically diverse communities, healthy quaking aspen (Populus tremuloides; hereafter aspen) forests provide a wide range of ecosystem services across western North America. Western aspen decline during the last century has been attributed to several causes and their interactions, including altered fire regimes, drought, excessive use by domestic and wild ungulates, and conifer encroachment. Today’s managers need science-based guidance to develop and implement strategies and practices to restore structure, processes, and resilience to the full range of aspen functional types across multiple spatial scales. In these guidelines, we detail a process for making step-by-step decisions …

A Corporate Duty To Rescue: Biopharmaceutical Companies And Access To Medications, Rebecca E. Wolitz

Indiana Law Journal

Controversies regarding the pricing of biopharmaceutical products are pervasive. Patients must choose between treatment and rent, prescriptions go unfilled, and health systems are forced to restrict access to life-saving medications— all because of cost. Though there is often consensus that these issues are problematic, there is disagreement as to what are appropriate solutions and who has responsibility to bring about those solutions. Most efforts to address biopharmaceutical pricing concerns focus on governmental regulation. This Article has a different focus. It provides a legal and normative analysis of a form of corporate self-regulation that could help address access and pricing concerns—a …

A Dangerous Concoction: Pharmaceutical Marketing, Cognitive Biases, And First Amendment Overprotection, Cynthia M. Ho

Indiana Law Journal

Is more information always better? First Amendment commercial speech jurisprudence takes this as a given. However, when information is only available from a self-interested and marketing-savvy pharmaceutical company, more information may simply lead to more misinformation. Notably, doctors are also misled. This can result in public health harms when companies are promoting unapproved uses of prescription drugs that the Food and Drug Administration (FDA) has approved for other purposes—commonly referred to as “off-label” uses. Contrary to judicial presumptions, as well as the presumptions of some doctors and scholars, doctors are not sophisticated enough to always discern what is true versus …

Bioaerosols Associated With Evaporative Cooler Use In Low-Income Homes In Semi-Arid Climates, Ashlin Elaine Cowger

Theses and Dissertations

Asthma is the leading chronic illness in children in the United States. Since children in the U.S. spend a majority of their time indoors there is an increased need to understand key sources of daily asthma triggers in the home. Bacterial endotoxin, dust mite allergens and β-D-glucan have been shown to be potent inducers of asthma attacks, and high levels of these allergens in homes can trigger attacks in those with asthma. We aim to better understand the risks to those with asthma that might be associated with evaporative cooler (EC) use in low-income homes. ECs are often promoted because …

Quantitative Systems Pharmacology Model Of Chimeric Antigen Receptor T-Cell Therapy, Deni Hardiansyah, Chee Meng Ng

Pharmaceutical Sciences Faculty Publications

Chimeric antigen receptor T‐cell (CART) therapy is a new and promising cancer therapy. However, severe toxicity due to cytokine release syndrome (CRS) in CART‐treated patients highlighted the possible danger of this new therapy. Disease burden and CART doses are the potential factors associated with CRS but the detail relationships between these factors and the severity of the CRS remain largely unknown. In this study, the quantitative systems pharmacology (QSP) approach is used to quantify the complex relationships among CART doses, disease burden, and pro inflammatory cytokines in human subjects and to gain relevant insights into the determinant of clinical toxicity/efficacy …

Full Issue

BYU Studies

No abstract provided.

Part I: Complete Dentures And Diabetes Correlation, Ibeth Erazo

Publications and Research

Diabetes is one of the most frequent pathologies that dentists encounter, due to its high prevalence worldwide. The aim of this study is to present the correlation between diabetes and complete denture wearers, intending to emphasize the importance of proper control and denture adaptation to oral environment for this type of patient. Within the sphere of the dental office, one of the main complications to consider in this type of patient is periodontal disease, which is their most frequent complication. Other important oral manifestations considered in the research are fungal infections, xerostomia, and burning mouth syndrome. It is common for …

Creating Tools For Studying Dna Uptake In Bacteria, Tamara Zaza

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Tlr9 Agonist Mgn1703 Enhances B Cell Differentiation And Function In Lymph Nodes, Mariane H. Schleimann, Maria-Louise Kobberø, Line K. Vibholm, Katherine Kjær, Leila B. Giron, Kathleen Busman-Sahay, Chi Ngai Chan, Michael Nekorchuk, Manuel Schmidt, Burghardt Wittig, Tine E. Damsgaard, Peter Ahlburg, Michel B. Hellfritzsch, Kaja Zuwala, Frederik H. Rothemejer, Rikke Olesen, Phillipp Schommers, Florian Klein, Harsh Dweep, Andrew Kossenkov, Jens R. Nyengaard, Jacob D. Estes, Mohamed Abdel-Mohsen, Lars Østergaard, Ole S. Søgaard, Paul W. Denton

Biology Faculty Publications

Background

TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important for B cell activity in lymph nodes but little is known about the in vivo impact of TLR9 agonism on human lymph node B cells. As a pre-defined sub-study within our clinical trial investigating TLR9 agonist MGN1703 (lefitolimod) treatment in the context of developing HIV cure strategies (NCT02443935), we assessed TLR9 agonist-mediated effects in lymph nodes.

Methods

Participants received MGN1703 for 24 weeks concurrent with antiretroviral therapy. Seven …

The Paradox Of Source Code Secrecy, Sonia K. Katyal

Cornell Law Review

In Lear v. Adkins, the Supreme Court precipitously wrote, "federal law requires that all ideas in general circulation be dedicated to the common good unless they are protected by a valid patent." Today, it is clear that trade secrecy's dominance over source code has been a significant cause for concern in cases involving the public interest. To protect civil rights in the age of automated decision making, I argue, we must limit opportunities for seclusion in areas of intellectual property, criminal justice, and governance more generally. The solution, therefore, does not require a complete overhaul of the existing system, but …

In Vivo Proteomics Identifies The Competence Regulon And Alib Oligopeptide Transporter As Pathogenic Factors In Pneumococcal Meningitis., Frank Schmidt, Niamatullah Kakar, Tanja C Meyer, Maren Depke, Ilias Masouris, Gerhard Burchhardt, Alejandro Gómez-Mejia, Vishnu Dhople, Leiv S Håvarstein, Zhi Sun, Robert L Moritz, Uwe Völker, Uwe Koedel, Sven Hammerschmidt

Articles, Abstracts, and Reports

Streptococcus pneumoniae (pneumococci) is a leading cause of severe bacterial meningitis in many countries worldwide. To characterize the repertoire of fitness and virulence factors predominantly expressed during meningitis we performed niche-specific analysis of the in vivo proteome in a mouse meningitis model, in which bacteria are directly inoculated into the cerebrospinal fluid (CSF) cisterna magna. We generated a comprehensive mass spectrometry (MS) spectra library enabling bacterial proteome analysis even in the presence of eukaryotic proteins. We recovered 200,000 pneumococci from CSF obtained from meningitis mice and by MS we identified 685 pneumococci proteins in samples from in vitro filter controls …