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Master Of Science In Anesthesia Fort Lauderdale, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physical Therapy, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Just A Chemical Imbalance: Exploring The Absence Of The Social Etiology Of Depression In Common Medical Websites, Zoe Folsom

Conspectus Borealis

In recent decades, depression has received increased attention in the United States. As diagnosed instances of depression rise, and as it has usurped all other conditions in both national and global disability costs, pressure continues to mount to address and mitigate the societal impacts of this seemingly unstoppable disease. While this has taken various forms, from campaigns to destigmatize mental illness to government entities devoting to reducing social costs of depression, the prevailing narrative proves incomplete. Despite a wealth of research supporting a direct link between social factors (such as life satisfaction and relational satisfaction) and instances of clinical depression, …

2018 Touro College & University System Faculty Publications, Touro College & University System

Faculty Publications Books

This is the 2018 edition of the Faculty Publications Book of the Touro College & University System. It includes all eligible 2018 publication citations of faculty within the Touro College & University System, including New York Medical College (NYMC). It was produced as a joint effort of the Touro College Libraries and the Health Sciences Library at NYMC.

The Falcon 2019-2020, Seattle Pacific University

Seattle Pacific Student Newspapers

No abstract provided.

Sarcoid-Like Reaction Associated With Renal Cell Carcinoma - A Case Report., Asma Iftikhar, Muhammad A I Cheema, Preethi Ramachandran, Sonu Sahni

Touro College of Osteopathic Medicine (New York) Publications and Research

Renal cell carcinoma (RCC) is a highly vascular tumor, which may spread to the lungs and other organs. It often presents with localized or systemic manifestation, including paraneoplastic syndromes. Sarcoidosis is a systemic granulomatous inflammatory disease characterized by non-caseating granulomas that typically afflicts the respiratory system. In the absence of any evidence of systemic sarcoidosis they are referred to as sarcoid-like reactions. Non-caseating epithelioid granulomas, also regarded to sarcoid-like granulomas have been described in association with certain malignancies such as carcinomas of the breast, colon, seminoma, and Hodgkin's lymphoma. However, sarcoid like reaction associated with renal cell carcinoma is uncommon. …

Basal Cell Carcinoma Originating In A Tattoo: Case Report And Review Of An Uncommon Complication In Tattoo Recipients., Boya Abudu, Christof P. Erickson, Antoanella Calame, Philip R. Cohen

Touro College of Osteopathic Medicine (New York) Publications and Research

No abstract provided.

Is There A Correlation Between Epstein - Barr Virus (Mononucleosis) And Hodgkin’S Lymphoma?, Rooth Cohen

The Science Journal of the Lander College of Arts and Sciences

Symptoms of acute Infectious Mononucleosis (IM), which develops after Epstein-Barr virus (EBV) in half the cases, is strikingly like those of Hodgkin’s Lymphoma (HL). This, combined with the findings that many patients with HL had a history of EBV and/or IM, triggered an interest in scientists to learn if the two were biochemically related. Many studies in this field unanimously concluded that the development of IM after EBV infection presented a higher risk of developing HL. However, whether this relationship is coincidental or pathological remains a matter of controversy until this day. In the last decade, there has been a …

Biological Evaluation Of Dna Biomarkers In A Chemically Defined And Site-Specific Manner, Ke Bian, James C. Delaney, Xianhao Zhou, Deyu Li

Biomedical and Pharmaceutical Sciences Faculty Publications

As described elsewhere in this Special Issue on biomarkers, much progress has been made in the detection of modified DNA within organisms at endogenous and exogenous levels of exposure to chemical species, including putative carcinogens and chemotherapeutic agents. Advances in the detection of damaged or unnatural bases have been able to provide correlations to support or refute hypotheses between the level of exposure to oxidative, alkylative, and other stresses, and the resulting DNA damage (lesion formation). However, such stresses can form a plethora of modified nucleobases, and it is therefore difficult to determine the individual contribution of a particular modification …

2019-2020 Lindenwood University Accelerated Degree Program Course Catalog, Lindenwood University

Course Catalogs

Lindenwood University Accelerated Degree Program Course Catalog

Development Of A Cx46 Targeting Strategy For Cancer Stem Cells, Erin E. Mulkeans-Hubert, Luke A. Torre-Healy, Daniel J, Silver, Jennifer T. Eurich, Defne Bayik, Emily Serbinowski, Masahiro Hitomi, John Zhou, Bartlomiej Przychodzen, Renliang Zhang, Samuel A. Sprowls, James S. Hale, Tyler J. Alban, Artem Berezovsky, Brent A. Bell, Paul R. Lockman, Babal K. Jha, Justin D. Lathia

Faculty & Staff Scholarship

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. To develop a Cx46 targeting strategy, we screen a clinically relevant small molecule library and identify clofazimine as an inhibitor of Cx46-specific cell-cell communication. Clofazimine attenuates proliferation, self-renewal, and …

In Vivo Gene Essentiality And Metabolism In Bordetella Pertussis, Laura A. Gonyar, Patrick E. Gelbach, Dennis G. Mcduffe, Alexander F. Koeppel, Qing Chen, Gloria Lee, Louise M. Temple, Scott Stibitz, Erik L. Hewlwtt, Jason A. Papin, F. Heath Damron, Joshua C. Eby

Faculty & Staff Scholarship

Bordetella pertussis is the causative agent of whooping cough, a serious respiratory illness affecting children and adults, associated with prolonged cough and potential mortality. Whooping cough has reemerged in recent years, emphasizing a need for increased knowledge of basic mechanisms of B. pertussis growth and pathogenicity. While previous studies have provided insight into in vitro gene essentiality of this organism, very little is known about in vivo gene essentiality, a critical gap in knowledge, since B. pertussis has no previously identified environmental reservoir and is isolated from human respiratory tract samples. We hypothesize that the metabolic capabilities of B. pertussis …

Machine-Learning To Stratify Diabetic Patients Using Novel Cardiac Biomarkers And Integrative Genomics, Quincy A. Hathaway, Skyler M. Roth, Mark V. Pinti, Daniel C. Sprando, Amina Kunovac, Andrya J. Durr, Chris C. Cook, Garret K. Fink, Tristen B. Cheuvront, Jasmine H. Grossman, Ghadah A. Aljahli, Andrew D. Taylor, Andrew P. Giromini, Jessica L. Allen, John M. Hollander

Faculty & Staff Scholarship

Background: Diabetes mellitus is a chronic disease that impacts an increasing percentage of people each year. Among its comorbidities, diabetics are two to four times more likely to develop cardiovascular diseases. While HbA1c remains the primary diagnostic for diabetics, its ability to predict long-term, health outcomes across diverse demographics, ethnic groups, and at a personalized level are limited. The purpose of this study was to provide a model for precision medicine through the implementation of machine-learning algorithms using multiple cardiac biomarkers as a means for predicting diabetes mellitus development. Methods: Right atrial appendages from 50 patients, 30 non-diabetic and 20 …

Systemic Inhibition Of Tissue-Nonspecific Alkaline Phosphatase Alters The Brain-Immune Axis In Experimental Sepsis, Allison L. Brichacek, Stanely A. Benkovic, Sreeparna Chakraborty, Divine C. Nwafor, Wei Wang, Sujung Jun, Duaa Dakhlallah, Werner Geldenhuys, Anthony B. Pinkerton, José Luis Millán, Candice M. Brown

Faculty & Staff Scholarship

Tissue-nonspecific alkaline phosphatase (TNAP) is a ubiquitous enzyme present in many cells and tissues, including the central nervous system. Yet its functions at the brain-immune axis remain unclear. The goal of this study was to use a novel small molecular inhibitor of TNAP, SBI-425, to interrogate the function of TNAP in neuroimmune disorders. Following intraperitoneal (IP) administration of SBI-425, mass spectrometry analysis revealed that the SBI-425 does not cross the blood-brain barrier (BBB) in healthy mice. To elucidate the role of TNAP at the brain-immune axis, mice were subjected to experimental sepsis and received either vehicle or SBI-425 (25 mg/kg, …

Enhancement Of Immune Response Against Bordetella Spp. By Disrupting Immunomodulation, Monica C. Gestal, Laura K. Howard, Kalyan Dewan, Hannah M. Johnson, Mariette Barbier, Clare Bryant, Illiassou Hamidou Soumana, Israel Rivera, Bodo Lina, Uriel Blas-Machado, Eric T. Harvill

Faculty & Staff Scholarship

Well-adapted pathogens must evade clearance by the host immune system and the study of how they do this has revealed myriad complex strategies and mechanisms. Classical bordetellae are very closely related subspecies that are known to modulate adaptive immunity in a variety of ways, permitting them to either persist for life or repeatedly infect the same host. Exploring the hypothesis that exposure to immune cells would cause bordetellae to induce expression of important immunomodulatory mechanisms, we identified a putative regulator of an immunomodulatory pathway. The deletion of btrS in B. bronchiseptica did not affect colonization or initial growth in the …

The Regulatory Landscape Of A Core Maize Domestication Module Controlling Bud Dormancy And Growth Repression, Zhaobin Dong, Yuguo Xiao, Rajanikanth Govindarajulu, Regina Feil, Muriel L. Siddoway, Torrey Nielsen, John E. Lunn, Jennifer Hawkins, Clinton Whipple, George Chuck

Faculty & Staff Scholarship

Many domesticated crop plants have been bred for increased apical dominance, displaying greatly reduced axillary branching compared to their wild ancestors. In maize, this was achieved through selection for a gain-of-function allele of the TCP transcription factor teosinte branched1 (tb1). The mechanism for how a dominant Tb1 allele increased apical dominance, is unknown. Through ChIP seq, RNA seq, hormone and sugar measurements on 1 mm axillary bud tissue, we identify the genetic pathways putatively regulated by TB1. These include pathways regulating phytohormones such as gibberellins, abscisic acid and jasmonic acid, but surprisingly, not auxin. In addition, metabolites involved in sugar …

Middle Ear Choristoma Presenting As Cholesteatoma With Conductive Hearing Loss, Phillip R. Purnell, Erik Interval, H James Williams, Adam M. Cassis

Faculty & Staff Scholarship

A 6-year-old male was seen for evaluation of middle ear polyp with associated hearing loss and otorrhea. CT scan revealed canal polyp with a stalk extending to the middle ear with malformation of the malleus and incus. The patient underwent exploratory tympanotomy which revealed a fistula from the bony-cartilaginous junction connecting to a middle ear mass which had eroded the incus. Intraoperative pathology suggested columnar epithelium without cholesteatoma or muscle. Final pathologic diagnosis reported dense fibrous tissue as well as ectopic salivary gland tissue, consistent with salivary gland choristoma. After removal of the mass, a partial prosthesis was successfully placed. …

Cardiovascular Risk Factor Control And Lifestyle Factors In Young To Middle-Aged Adults With Newly Diagnosed Obstructive Coronary Artery Disease, M. S. Garshick, G. D. Vaidean, A. Vani, J. A. Underberg, J. D. Newman, J. S. Berger, E. A. Fisher, E. Gianos

Journal Articles

No abstract provided.

A Fluorescent, [F-18]-Positron-Emitting Agent For Imaging Prostate-Specific Membrane Antigen Allows Genetic Reporting In Adoptively Transferred, Genetically Modified Cells, H. Guo, H. Kommidi, Y. Vedvyas, J. E. Mccloskey, W. Zhang, N. Chen, F. Nurili, A. P. Wu, H. B. Sayman, R. Ting, +4 Additional Authors

Journal Articles

No abstract provided.

Shorter Disease Duration Is Associated With Higher Rates Of Response To Vedolizumab In Patients With Crohn's Disease But Not Ulcerative Colitis., D. M. Faleck, A. Winters, S. Chablaney, P. Shashi, J. Meserve, A. Weiss, V. Kesar, K. Sultan, A. Swaminath, R. Ungaro, +24 Additional Authors

Journal Articles

BACKGROUND & AIMS: Patients with Crohn's disease (CD), but not ulcerative colitis (UC), of shorter duration have higher rates of response to tumor necrosis factor (TNF) antagonists than patients with longer disease duration. Little is known about the association between disease duration and response to other biologic agents. We aimed to evaluate response of patients with CD or UC to vedolizumab, stratified by disease duration.

METHODS: We analyzed data from a retrospective, multicenter, consortium of patients with CD (n = 650) or UC (n = 437) treated with vedolizumab from May 2014 through December 2016. Using time to event analyses, …

Metabolic And Microstructural Alterations In The Sle Brain Correlate With Cognitive Impairment, M. Mackay, A. Vo, C. C. Tang, W. Anderson, N. J. Ploran, C. Aranow, P. Watson, B. T. Volpe, B. Diamond, D. Eidelberg, +5 Additional Authors

Journal Articles

No abstract provided.

Forebrain Cholinergic Signaling Regulates Innate Immune Responses And Inflammation, K. R. Lehner, H. A. Silverman, M. E. Adorissio, A. Roy, A. Al-Onaizi, S. S. Chavan, Y. Al-Abed, C. N. Metz, K. J. Tracey, V. A. Paviov, +6 Additional Authors

Journal Articles

No abstract provided.

Influence Of Genetic Copy Number Variants Of The Human Glut3 Glucose Transporter Gene Slc2a3 On Protein Expression, Glycolysis And Rheumatoid Arthritis Risk: A Genetic Replication Study, K. R. Simpfendorfer, W. Li, A. Shih, H. Wen, N. P. Kothari, A. Einsidler, A. Wuster, J. Hunkapiller, T. W. Behrens, P. K. Gregersen, +5 Additional Authors

Journal Articles

No abstract provided.

Patterns Of Ana(+) B Cells For Sle Patient Stratification, J. Suurmond, Y. Atisha-Fregoso, A. N. Barlev, S. A. Calderon, C. Mackay, Z. Aranow, B. Diamond

Journal Articles

No abstract provided.

Tissue-Specific Metabolic Profiles After Prolonged Cardiac Arrest Reveal Brain Metabolome Dysfunction Predominantly After Resuscitation, J. Choi, M. Shoaib, T. Yin, G. Nayyar, Shinozaki, G. F. Stevens, L. B. Becker, J. Kim

Journal Articles

No abstract provided.

Challenges And Inconsistencies In Using Lysophosphatidic Acid As A Biomarker For Ovarian Cancer, T. Yagi, M. Shoaib, C. E. Kuschner, M. Nishikimi, B. Becker, Z. T. Lee, J. Kim

Journal Articles

No abstract provided.

Assessment Of Pain Symptoms And Quality Of Life Using The International Spinal Cord Injury Data Sets In Persons With Chronic Spinal Cord Injury, K. Gibbs, A. Beaufort, A. Stein, T. M. Leung, N. Sison, Z. Bloom

Journal Articles

Introduction: Traumatic spinal cord injury (SCI) triggers complex changes that can negatively impact health and quality of life. The International SCI Data Sets were developed to enable more comparable data collection on the complex sequelae of SCI across studies. This should facilitate progress in mechanistic understanding and improving treatments of SCI. Study design: Prospective observational pilot study. Objectives: To collect data on pain symptoms and quality of life (QoL) in adults living with chronic SCI. Setting: Academic medical center, New York, USA. Methods: The International SCI Basic Pain and Qol Data Sets were used to collect data from participants with …

Aquaporin-4 Water Channel In The Brain And Its Implication For Health And Disease., S. Mader, L. Brimberg

Journal Articles

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer's disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication …

Human B-1 Cells And B-1 Cell Antibodies Change With Advancing Age, N. Rodriguez-Zhurbenko, T. D. Quach, T. J. Hopkins, T. L. Rothstein, Z. M. Hernandez

Journal Articles

© 2019 Rodriguez-Zhurbenko, Quach, Hopkins, Rothstein and Hernandez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Age-related deficits in the immune system have been associated with an increased incidence of infections, autoimmune diseases, and cancer. Human B cell populations change quantitatively …

Large-Scale Validation Of The Paddling Pool Task In The Clockmaze For Studying Hippocampus-Based Spatial Cognition In Mice, R. Sankowski, T. S. Huerta, R. Kalra, T. J. Klein, J. Strohl, A. Al-Abed, S. Robbiati, P. T. Huerta

Journal Articles

No abstract provided.