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2019

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Aquaporin-4 Water Channel In The Brain And Its Implication For Health And Disease., S. Mader, L. Brimberg Jan 2019

Aquaporin-4 Water Channel In The Brain And Its Implication For Health And Disease., S. Mader, L. Brimberg

Journal Articles

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer's disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication …

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Human B-1 Cells And B-1 Cell Antibodies Change With Advancing Age, N. Rodriguez-Zhurbenko, T. D. Quach, T. J. Hopkins, T. L. Rothstein, Z. M. Hernandez Jan 2019

Human B-1 Cells And B-1 Cell Antibodies Change With Advancing Age, N. Rodriguez-Zhurbenko, T. D. Quach, T. J. Hopkins, T. L. Rothstein, Z. M. Hernandez

Journal Articles

© 2019 Rodriguez-Zhurbenko, Quach, Hopkins, Rothstein and Hernandez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Age-related deficits in the immune system have been associated with an increased incidence of infections, autoimmune diseases, and cancer. Human B cell populations change quantitatively …

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Large-Scale Validation Of The Paddling Pool Task In The Clockmaze For Studying Hippocampus-Based Spatial Cognition In Mice, R. Sankowski, T. S. Huerta, R. Kalra, T. J. Klein, J. Strohl, A. Al-Abed, S. Robbiati, P. T. Huerta Jan 2019

Large-Scale Validation Of The Paddling Pool Task In The Clockmaze For Studying Hippocampus-Based Spatial Cognition In Mice, R. Sankowski, T. S. Huerta, R. Kalra, T. J. Klein, J. Strohl, A. Al-Abed, S. Robbiati, P. T. Huerta

Journal Articles

No abstract provided.

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Editorial: Recent Advances In Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, And Mild Encephalitis, K. Bechter, D. Brown, S. Najjar Jan 2019

Editorial: Recent Advances In Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, And Mild Encephalitis, K. Bechter, D. Brown, S. Najjar

Journal Articles

No abstract provided.

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Inhibition Of Hmgb1/Rage-Mediated Endocytosis By Hmgb1 Antagonist Box A, Anti-Hmgb1 Antibodies, And Cholinergic Agonists Suppresses Inflammation, H. Yang, H. Liu, Q. Zeng, G. H. Imperato, M. E. Addorisio, M. He, K. F. Cheng, Y. Al-Abed, S. S. Chavan, K. J. Tracey, +3 Additional Authors Jan 2019

Inhibition Of Hmgb1/Rage-Mediated Endocytosis By Hmgb1 Antagonist Box A, Anti-Hmgb1 Antibodies, And Cholinergic Agonists Suppresses Inflammation, H. Yang, H. Liu, Q. Zeng, G. H. Imperato, M. E. Addorisio, M. He, K. F. Cheng, Y. Al-Abed, S. S. Chavan, K. J. Tracey, +3 Additional Authors

Journal Articles

No abstract provided.

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Increased Incidence Of Thyroid Cancer Among World Trade Center First Responders: A Descriptive Epidemiological Assessment, S. Tuminello, M. A. Van Gerwen, E. Genden, M. Crane, W. Lieberman-Cribbin, E. Taioli Jan 2019

Increased Incidence Of Thyroid Cancer Among World Trade Center First Responders: A Descriptive Epidemiological Assessment, S. Tuminello, M. A. Van Gerwen, E. Genden, M. Crane, W. Lieberman-Cribbin, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = …

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An Interim Report Of The Scleroderma Clinical Trials Consortium Working Groups, M. Baron, B. Kahaleh, E. J. Bernstein, L. Chung, P. J. Clements, C. Denton, R. T. Domsic, N. Ferdowsi, S. Narain, A. Vacca, +12 Additional Authors Jan 2019

An Interim Report Of The Scleroderma Clinical Trials Consortium Working Groups, M. Baron, B. Kahaleh, E. J. Bernstein, L. Chung, P. J. Clements, C. Denton, R. T. Domsic, N. Ferdowsi, S. Narain, A. Vacca, +12 Additional Authors

Journal Articles

© The Author(s) 2018. The Scleroderma Clinical Trials Consortium represents many of the clinical researchers in the world who are interested in improving the efficiency of clinical trials in systemic sclerosis. The Scleroderma Clinical Trials Consortium has established 11 working groups to develop and validate better ways of measuring and recording multiple aspects of this heterogeneous disease. These include groups working on arthritis, disease damage, disease activity, cardiac disease, juvenile systemic sclerosis, the gastrointestinal tract, vascular component, calcinosis, scleroderma renal crisis, interstitial lung disease, and skin measurement. Members of the Scleroderma Clinical Trials Consortium may join any one or more …

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Changes In Vedolizumab Utilization Across Us Academic Centers And Community Practice Are Associated With Improved Effectiveness And Disease Outcomes., J. L. Koliani-Pace, S. Singh, M. Luo, R. Hirten, S. Aniwan, G. Kochhar, S. Chang, Y. Gao, A. Swaminath, P. S. Dulai, +25 Additional Authors Jan 2019

Changes In Vedolizumab Utilization Across Us Academic Centers And Community Practice Are Associated With Improved Effectiveness And Disease Outcomes., J. L. Koliani-Pace, S. Singh, M. Luo, R. Hirten, S. Aniwan, G. Kochhar, S. Chang, Y. Gao, A. Swaminath, P. S. Dulai, +25 Additional Authors

Journal Articles

BACKGROUND:Vedolizumab effectiveness estimates immediately after Food and Drug Administration (FDA) approval for ulcerative colitis (UC) and Crohn's disease (CD) are limited by use in refractory populations. We aimed to compare treatment patterns and outcomes of vedolizumab in 2 time frames after FDA approval. METHODS:We used 2 data sets for time trend analysis, an academic multicenter vedolizumab consortium (VICTORY) and the Truven MarketScan database, and 2 time periods, May 2014-June 2015 (Era 1) and July 2015-June 2017 (Era 2). VICTORY cumulative 12-month clinical remission, corticosteroid-free remission, and mucosal healing rates, and Truven 12-month hospitalization and surgery rates, were compared between Eras …

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Mutational Load May Predict Risk Of Progression In Patients With Barrett's Oesophagus And Indefinite For Dysplasia: A Pilot Study, A. J. Trindade, M. J. Mckinley, M. Alshelleh, G. Levi, M. Stewart, K. J. Quinn, R. M. Thomas Jan 2019

Mutational Load May Predict Risk Of Progression In Patients With Barrett's Oesophagus And Indefinite For Dysplasia: A Pilot Study, A. J. Trindade, M. J. Mckinley, M. Alshelleh, G. Levi, M. Stewart, K. J. Quinn, R. M. Thomas

Journal Articles

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Background and aims Mutational load (ML) has been shown to help risk-stratify those that may progress from non-dysplastic Barrett's oesophagus (BE) to dysplastic disease. Management of patients with BE and indefinite for dysplasia (BE-IND) is challenging and risk stratification tools are lacking. The aim of this pilot study is to evaluate the utility of ML for risk stratification in patients with BE-IND. Methods This is a single-centre, retrospective pilot study evaluating ML quantification in patients with BE-IND. Histology at …

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Radiation Recall Pneumonitis In The Setting Of Immunotherapy And Radiation: A Focused Review, K. Mcgovern, M. Ghaly, M. Esposito, K. Barnaby, N. Seetharamu Jan 2019

Radiation Recall Pneumonitis In The Setting Of Immunotherapy And Radiation: A Focused Review, K. Mcgovern, M. Ghaly, M. Esposito, K. Barnaby, N. Seetharamu

Journal Articles

© 2019 Nagashree Seetharamu. Radiation recall pneumonitis (RRP) is an entity described as pneumonitis localized to a previously irradiated field after exposure to a systemic agent. It has previously been described in the literature in the context of chemotherapeutic agents as well as certain biologics. With immunotherapy taking a more prominent role in the treatment of several different malignancies and its own baseline risk of pneumonitis, it is important to explore the likelihood of RRP, specifically in those patients who have been previously treated with radiation therapy. The current literature regarding RRP with checkpoint inhibitors is reviewed in this article. …

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A 30-Year-Old Carrier Of Gaucher Disease With Multiple Myeloma., J. Chadha, T. Sahai, J. Schwimmer, D. Shani Jan 2019

A 30-Year-Old Carrier Of Gaucher Disease With Multiple Myeloma., J. Chadha, T. Sahai, J. Schwimmer, D. Shani

Journal Articles

We are reporting a case of a 30-year-old male with no past medical history who presented with new onset of renal failure, anemia, and splenomegaly and was diagnosed with multiple myeloma. Given the splenomegaly and the patient's Jewish heritage, blood tests were done and the patient was found to be a Gaucher disease carrier. The association of Gaucher disease and multiple myeloma has previously been reported; however, we want to describe the case of a young Gaucher disease carrier who developed multiple myeloma and provide a review of the literature.

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Monoclonal Antibody Targeting Bdca2 Ameliorates Skin Lesions In Systemic Lupus Erythematosus, R. Furie, V. P. Werth, J. F. Merola, L. Stevenson, T. L. Reynolds, H. Naik, W. Wang, R. Christmann, A. Gardet, N. Franchimont, +6 Additional Authors Jan 2019

Monoclonal Antibody Targeting Bdca2 Ameliorates Skin Lesions In Systemic Lupus Erythematosus, R. Furie, V. P. Werth, J. F. Merola, L. Stevenson, T. L. Reynolds, H. Naik, W. Wang, R. Christmann, A. Gardet, N. Franchimont, +6 Additional Authors

Journal Articles

No abstract provided.

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Changes In Pulmonary Artery Pressure Before And After Left Ventricular Assist Device Implantation In Patients Utilizing Remote Haemodynamic Monitoring, A. Kilic, J. N. Katz, S. M. Joseph, M. A. Brisco-Bacik, N. Uriel, B. Lima, R. Agarwal, R. Bharmi, D. J. Farrar, S. Lee Jan 2019

Changes In Pulmonary Artery Pressure Before And After Left Ventricular Assist Device Implantation In Patients Utilizing Remote Haemodynamic Monitoring, A. Kilic, J. N. Katz, S. M. Joseph, M. A. Brisco-Bacik, N. Uriel, B. Lima, R. Agarwal, R. Bharmi, D. J. Farrar, S. Lee

Journal Articles

No abstract provided.

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Current Aats Guidelines On Surgical Treatment Of Infective Endocarditis, G. B. Pettersson, S. T. Hussain Jan 2019

Current Aats Guidelines On Surgical Treatment Of Infective Endocarditis, G. B. Pettersson, S. T. Hussain

Journal Articles

© Annals of Cardiothoracic Surgery. The 2016 American Association for Thoracic Surgery (AATS) guidelines for surgical treatment of infective endocarditis (IE) are question based and address questions of specific relevance to cardiac surgeons. Clinical scenarios in IE are often complex, requiring prompt diagnosis, early institution of antibiotics, and decision-making related to complications, including risk of embolism and timing of surgery when indicated. The importance of an early, multispecialty team approach to patients with IE is emphasized. Management issues are divided into groups of questions related to indications for and timing of surgery, pre-surgical work-up, preoperative antibiotic treatment, surgical risk assessment, …

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Quality Of Life Outcomes Following Organ-Sparing Sbrt In Previously Irradiated Recurrent Head And Neck Cancer, E. Gogineni, I. Zhang, Z. Rana, M. Marrero, G. Gill, A. Sharma, A. C. Riegel, S. Teckie, M. Ghaly Jan 2019

Quality Of Life Outcomes Following Organ-Sparing Sbrt In Previously Irradiated Recurrent Head And Neck Cancer, E. Gogineni, I. Zhang, Z. Rana, M. Marrero, G. Gill, A. Sharma, A. C. Riegel, S. Teckie, M. Ghaly

Journal Articles

No abstract provided.

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Extracellular Cold Inducible Rna-Binding Protein Mediates Binge Alcohol-Induced Brain Hypoactivity And Impaired Cognition In Mice, A. Jacob, Y. Ma, E. Nasiri, M. Ochani, J. Carrion, S. Peng, M. Brenner, P. T. Huerta, P. Wang Jan 2019

Extracellular Cold Inducible Rna-Binding Protein Mediates Binge Alcohol-Induced Brain Hypoactivity And Impaired Cognition In Mice, A. Jacob, Y. Ma, E. Nasiri, M. Ochani, J. Carrion, S. Peng, M. Brenner, P. T. Huerta, P. Wang

Journal Articles

No abstract provided.

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Neurogenesis In Neurodegenerative Diseases: Role Of Mfg-E8, C. Cheyuo, M. Aziz, P. Wang Jan 2019

Neurogenesis In Neurodegenerative Diseases: Role Of Mfg-E8, C. Cheyuo, M. Aziz, P. Wang

Journal Articles

No abstract provided.

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De Novo Interstitial Deletion Of 9q In A Pediatric Patient With Global Developmental Delay., D. Keselman, R. Singh, N. Cohen, Z. Fefer Jan 2019

De Novo Interstitial Deletion Of 9q In A Pediatric Patient With Global Developmental Delay., D. Keselman, R. Singh, N. Cohen, Z. Fefer

Journal Articles

Cytogenomic microarray (CMA) methodologies, including array comparative genomic hybridization (aCGH) and single-nucleotide polymorphism-detecting arrays (SNP-array), are recommended as the first-tier test for the evaluation of imbalances associated with intellectual disability, autism, and multiple congenital anomalies. The authors report on a child with global developmental delay (GDD) and a de novo interstitial 7.0 Mb deletion of 9q21.33q22.31 detected by aCGH. The patient that the authors report here is noteworthy in that she presented with GDD and her interstitial deletion is not inclusive of the 9q22.32 locus that includes the PTCH1 gene, which is implicated in Gorlin syndrome, or basal cell nevus …

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An Evaluation Of The Relationship Among North Carolina Reading Assessments, Sophia Latrell Crawford-Mapp Jan 2019

An Evaluation Of The Relationship Among North Carolina Reading Assessments, Sophia Latrell Crawford-Mapp

Education Dissertations and Projects

The purpose of this study was to extend the Bowles (2014) study in North Carolina to (a) determine the relationship between the scores of the North Carolina beginning-of-grade (BOG) and end-of-grade (EOG) reading assessments, the scores of the mClass Text Reading and Comprehension (TRC) assessment, and the scores of the CogAT assessment; and (b) determine the degree the TRC, CogAT, and NC BOG predict scores on the NC EOG reading assessment in third-grade classrooms of nine elementary schools. This study was conducted in two parts to best address the research questions. The first part consisted of descriptive, variance, and inferential …

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Comparing Academic Performance Data Of Students In Single-Gender Classroom: Which Gender Benefits The Most, African-American Males Or African-American Females?, Daris F. Gore Jan 2019

Comparing Academic Performance Data Of Students In Single-Gender Classroom: Which Gender Benefits The Most, African-American Males Or African-American Females?, Daris F. Gore

Education Dissertations and Projects

The purpose of this quantitative study was to determine if single-gender settings have a statistically significant effect on African-American male and/or African-American female academic achievement on English assessment from sixth through eighth grade. Social science statistics were used to determine if a statistically significant difference occurred in the performance of African-American males and/or female students in single-gender classrooms compared to African-American male and female students in coed classrooms. A two-way analysis of variance (ANOVA) was conducted to assess if differences exist on a dependent variable (student achievement) by independent variables (instructional setting and gender). A statistically significant difference occurred among …

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Impact Of Teacher Morale And School Culture On Student Achievement, Meredith Bost Jan 2019

Impact Of Teacher Morale And School Culture On Student Achievement, Meredith Bost

Education Dissertations and Projects

The purpose of this study was to examine the impact of teacher morale and school culture on student achievement. The setting for this research was a high school in a small, semi- urban school district in the Piedmont of North Carolina. For the purpose of this study, teacher morale and school culture were based on the opinion of English II and biology teachers at the study site. The study’s methodology included surveying English II and biology teachers on teacher morale and school culture. To measure teacher morale, the Purdue Teacher Opinionnaire was given to each participant. To measure the school’s …

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A Program Evaluation Of The Degree Program For Students With Behavioral Difficulties, Gail Whisnant Jan 2019

A Program Evaluation Of The Degree Program For Students With Behavioral Difficulties, Gail Whisnant

Education Dissertations and Projects

This study used a qualitative approach to explore a rural school district’s DEGREE program through parent and staff member perspectives using Stufflebeam’s (2003) CIPP model of program evaluation. Interviews and questionnaire data provided information to answer the following research questions: 1. Context: What is the context within which the DEGREE program was developed and implemented? 2. Input: What types of academic and behavioral interventions are taught? 3. Process: How are the objectives of the DEGREE program aligned with improving student academic and behavioral goals? 4. Product: What is the impact of the DEGREE program regarding student ability to transition back …

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Cyberbullying And The Middle School Adolescent: Educator Perceptions, Kalani Crognal Lafrancis Jan 2019

Cyberbullying And The Middle School Adolescent: Educator Perceptions, Kalani Crognal Lafrancis

Education Dissertations and Projects

Victimization and perpetration of cyberbullying are ongoing threats to school systems across the United States. Cyberbullying is a vast problem for adolescents, due to constant access and availability of technology via the online environment. This mixed methods study was based on the theoretical framework of Bandura’s (1989) theory. This study investigated the perceptions of middle school educators concerning cyberbullying via educator surveys, focus groups, and interviews to gather mixed methods data. This study took place in four middle schools in upstate South Carolina within District X. One hundred three educator participants took the survey, 12 educators participated in focus groups, …

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The Teacher's Role In Student Engagement, Anita Grove Jan 2019

The Teacher's Role In Student Engagement, Anita Grove

Education Dissertations and Projects

This research study examines teacher expectations and perceptions and provides an understanding of the teacher’s role in student engagement. A wide array of factors—both within and beyond the classroom—can influence student engagement. To begin the process of improving student engagement, it is essential for educators to reflect on the elements that contribute to student engagement. Research questions addressed associations between the variables of teacher expectations, teacher perceptions, and student engagement measured by a Likert Item Teacher Survey; Teacher Expectations, Perceptions and Instructional Practices Questionnaire; and a Student Engagement Observation Tool. The results indicate there is a need for resources and …

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Qualitative Analysis Of Adult Perceptions Of Their K-12 Grade Retention, Helena Sibyl King Jan 2019

Qualitative Analysis Of Adult Perceptions Of Their K-12 Grade Retention, Helena Sibyl King

Education Dissertations and Projects

This study investigated the effects that a K-12 grade retention had on adults who were retained as children. The research was motivated by three research questions: (1) How do adults aged 18-65 who have experienced grade retention describe the effect that a K-12 retention had and possibly continues to have on their lives? (2) How do adults aged 18-65 feel about having been held back in school? (3) How do adults aged 18-65 perceive grade retention overall? Previous studies neglected to examine the emotional implications that retention can have on a child and the possible long-term effects that retention may …

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Evaluation Of The Implementation Of A Secondary Transition Program For At-Risk Exceptional Children In Five High Schools, Karyn Lyndsey Herring Jan 2019

Evaluation Of The Implementation Of A Secondary Transition Program For At-Risk Exceptional Children In Five High Schools, Karyn Lyndsey Herring

Education Dissertations and Projects

Secondary transition support is an important part of the IEP requirements for high school exceptional children. Designed to help guide students toward their postschool goals, transition support should not only help identify goals but also help prepare them by teaching skills, building relationships, and imparting knowledge of the community they will join after graduation. The researcher completed a program evaluation for the FAST secondary transition support that was put into place in a large school district in North Carolina during the 2016-2017 school year to provide additional support to at-risk exceptional children on the Future Ready Course of Study graduation …

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Design Thinking In Health Sciences: Developing Solutions-Oriented Graduates Impacting Local Medical Communities Through Innovative Leadership, Tracey T. Thurnes Jan 2019

Design Thinking In Health Sciences: Developing Solutions-Oriented Graduates Impacting Local Medical Communities Through Innovative Leadership, Tracey T. Thurnes

Education Dissertations and Projects

Design Thinking in Health Sciences is a multi-year project that focuses on applying design thinking pedagogy across the health sciences in the undergraduate and graduate educational experiences through pop-ups and curriculum infusion at Elon University. In addition, the project serves to partner with local community organizations to provide “real-life” exposure on how design thinking can be implemented to serve the greater community. A convenience sample of graduate and undergraduate health science students completed a version of the INCODE-ICB-v5 survey that measures many of the same identified characteristics of The Ten Principles of Good Interdisciplinary Teamwork. Surveys were distributed pre and …

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A Descriptive Phenomenological Exploration Of Resiliency Through Math Curriculum Changes From The Perspectives Of Elementary Educators, Shanna Good Jan 2019

A Descriptive Phenomenological Exploration Of Resiliency Through Math Curriculum Changes From The Perspectives Of Elementary Educators, Shanna Good

Education Dissertations and Projects

Phenomenological research in education, especially regarding curriculum, is rare. Curriculum change in the state has occurred seven times since 2002, and more so in each district with material adoption. This descriptive phenomenological research study describes the experiences of elementary educators through changing math curriculums. To collect data, the researcher interviewed 10 elementary math teachers including a pilot interview. Using a purposeful, convenience sample, three participants from three different schools participated in this study to ensure validity and reliability. After conducting semi-structured interviews, the researcher followed protocol for descriptive phenomenological research and analyzed the data for meaning units that described how …

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Analyzing Public View Towards Vaccination Using Twitter, Mahajan Rutuja Jan 2019

Analyzing Public View Towards Vaccination Using Twitter, Mahajan Rutuja

Browse all Theses and Dissertations

Educating people about vaccination tends to target vaccine acceptance and reduction of hesitancy. Social media provides a promising platform for studying public perception regarding vaccination. In this study, we harvested tweets over a year related to vaccines from February 2018 to January 2019. We present a two-stage classifier to: (1) classify the tweets as relevant or non-relevant and (2) categorize them in terms of pro-vaccination, anti-vaccination, or neutral outlook. We found that the classifier was able to distinguish clearly between anti-vaccination and pro-vaccination tweets, but also misclassified many of these as neutral. Using Latent Dirichlet Allocation, we found that two …

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Erk3 Negatively Regulates The Il-6/Stat3 Signaling Via Socs3, Astha Shakya Jan 2019

Erk3 Negatively Regulates The Il-6/Stat3 Signaling Via Socs3, Astha Shakya

Browse all Theses and Dissertations

Mitogen activated protein kinases (MAPKs) are Ser/Thr kinases that relay the extracellular signal into intracellular responses and regulate several biological responses. They are classified into conventional MAPKs and atypical MAPKs. Extracellular signal regulated kinase 3 (ERK3) is an atypical MAPK that has a single phospho-acceptor site (Ser 189) in its activation motif instead of the canonical Thr-Xaa-Tyr (TXY) motif of conventional MAPK like ERK1/2. ERK3 comprises of a unique C terminal tail and a central C34 domain that further distinguishes it from ERK1/2. Moreover, compared to ERK1/2, much less is known about the upstream activators and the downstream targets of …

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