Digital Commons Network^™

Baseball Media Guide 2019, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

Daily Announcements February 2019, Wofford College. Office Of Marketing And Communications

Communications Office Daily Announcements

No abstract provided.

Employee Salary Report. [University Of Missouri—St. Louis] 2018-2019, University Of Missouri-St. Louis

UMSL Salary Report

No abstract provided.

Mole Street Journal, February 2019, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

February 2019 Quicknotes, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. February 2019 features the article "Student Week of Prayer: 'Bare Feet, Holy Ground'".

Peer Writing Tutors And The On-Going Conversation About Student Engagement, Kevin Dvorak, Russell Carpenter, Jacqueline Lytle

CAHSS Faculty Presentations, Proceedings, Lectures, and Symposia

The presenters -- directors and a student-leader of two writing and communication centers -- will take the ongoing conversation of student engagement and writing centers in a new direction. Building on the conversation Kail, Gillespie, and Hughes initiated on assessing peer tutor alumni, presenters will examine how centers create the types of learning experiences that engage staff members within their centers, universities, and communities. Using student engagement research as a foundation, the two centers developed “engagement surveys” that measured how working in the writing center influenced their tutors’ experiences as students. Presenters analyze results and implications for the role writing …

Identification Of The Alternative Oxidase Gene And Its Expression In The Copepod Tigriopus Californicus, Allison Mcdonald, Carly E. Tward, Willie Cygelfarb, Jaspreet Singh

Biology Faculty Publications

In addition to the typical electron transport system (ETS) in animal mitochondria responsible for oxidative phosphorylation, in some species there exists an alternative oxidase (AOX) pathway capable of catalyzing the oxidation of ubiquinol and the reduction of oxygen to water. The discovery of AOX in animals is recent and further investigations into its expression, regulation, and physiological role have been hampered by the lack of a tractable experimental model organism. Our recent DNA database searches using bioinformatics revealed an AOX sequence in several marine copepods including Tigriopus californicus. This species lives in tidepools along the west coast of North …

Extending The Osmometer Method For Assessing Drought Tolerance In Herbaceous Species, Robert J. Griffin-Nolan, Troy W. Ocheltree, Kevin E. Mueller, Dana M. Blumenthal, Julie A. Kray, Alan K. Knapp

Biological, Geological, and Environmental Faculty Publications

Community-scale surveys of plant drought tolerance are essential for understanding semi-arid ecosystems and community responses to climate change. Thus, there is a need for an accurate and rapid methodology for assessing drought tolerance strategies across plant functional types. The osmometer method for predicting leaf osmotic potential at full turgor ((o)), a key metric of leaf-level drought tolerance, has resulted in a 50-fold increase in the measurement speed of this trait; however, the applicability of this method has only been tested in woody species and crops. Here, we assess the osmometer method for use in herbaceous grassland species and test whether …

Spera: 2019, Hope College

Spera

Yearly publication that serves as a "spotlight on faculty research and scholarly work".

Escaping The Perils Of Sensationalist Television Reduction, Michelle Mueller

Religious Studies

Mormon polygamy has become a popular subject for contemporary reality television shows. TLC’s polygamy reality shows center around Mormon polygamist families from the families’ points of view. In contrast from these, Lifetime/A&E Networks’ Escaping Polygamy (2014–) centers around three twenty-something ex-members of a Mormon fundamentalist sect known as the Kingston group. The show depicts the ex-members as heroines who rescue other young adults as they are leaving Mormon polygamist sects. In this article, Escaping Polygamy is interpreted as an “atrocity tale” that relies on a history of moral panic around Mormon polygamy and perpetuates reductive stereotypes about Mormon fundamentalist groups. …

A Small Survey Of Uv-Bright Stars Around The Northern Ecliptic Pole: Seeking New P-Mode Sdb Variables For The Tess Mission, Saskia Prins, John Telting, Roy H. Østensen

College of Natural and Applied Sciences

Starting in 2019, the TESS mission will monitor the northern ecliptic pole for 1 year. Data will be collected at 30-minute and 2-minute cadences, and only a limited amount of slots will be reserved for targets requiring a 20- second cadence. Only the 20-second cadence is sufficient to sample p-mode oscillations in sdB stars. From the seismic measurements obtained with the Kepler spacecraft we have gained a wealth of new insights in structural and rotational aspects of mainly g-mode variable sdB stars. Unfortunately only one traditional p-mode sdB variable was found in the main Kepler field. The TESS mission offers …

Enhanced Il-1Β Production Is Mediated By A Tlr2-Myd88-Nlrp3 Signaling Axis During Coinfection With Influenza A Virus And Streptococcus Pneumoniae, Angeline E. Rodriguez, Christopher Bogart, Christopher M. Gilbert, Jonathan A. Mccullers, Amber M. Smith, Thirumala Devi Kanneganti, Christopher Lupfer

College of Natural and Applied Sciences

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. It is well known that the host response has an important role in disease. Interleukin-1β (IL-1β) is an important immune signaling cytokine responsible for inflammation and has been previously shown to contribute to disease severity in numerous infections. Other studies in mice indicate that IL-1β levels are dramatically …

Identification-Method Research For Open-Source Software Ecosystems, Zhifang Liao, Ningwei Wang, Shengzong Liu, Yan Zhang, Hui Liu, Qi Zhang

College of Natural and Applied Sciences

In recent years, open-source software (OSS) development has grown, with many developers around the world working on different OSS projects. A variety of open-source software ecosystems have emerged, for instance, GitHub, StackOverflow, and SourceForge. One of the most typical social-programming and code-hosting sites, GitHub, has amassed numerous open-source-software projects and developers in the same virtual collaboration platform. Since GitHub itself is a large open-source community, it hosts a collection of software projects that are developed together and coevolve. The great challenge here is how to identify the relationship between these projects, i.e., project relevance. Software-ecosystem identification is the basis of …

Divergent Cytotoxic And Metabolically Stimulative Functions Of Sigma-2 Receptors: Structure-Activity Relationships Of 6-Acetyl-3-(4-(4-(4-Fluorophenyl)Piperazin-1-Yl)Butyl)Benzo[D]Oxazol-2(3h)-One (Sn79) Derivatives, Hilary E. Nicholson, Walid F. Alsharif, Anthony B. Comeau, Christophe Mesangeau, Sebastiano Intagliata, Marco Mottinelli, Christopher R. Mccurdy, Wayne D. Bowen

Faculty and Student Publications

© 2019 by the authors. Astragalus is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic A. aitosensis (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of A. aitosensis extract to obtain seven phenolic compounds (1–7), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analyses and HR-MS allowed us to resolve the structures of known compounds …

Minimally Manipulative Method For The Expansion Of Human Bone Marrow Mesenchymal Stem Cells To Treat Osseous Defects, Logan M. Lawrence, Andrew Cottrill, Amrita Valluri, Gaetano Marenzi, Krista L. Denning, Jagan Valluri, Pier Paolo Claudio, James B. Day

Faculty and Student Publications

Copyright © 2019 Hamerly, Tweedell, Hritzo, Nyasembe, Tekwani, Nanayakkara, Walker and Dinglasan. Malaria is a major global health threat, with nearly half the world's population at risk of infection. Given the recently described delayed clearance of parasites by artemisinincombined therapies, new antimalarials are needed to facilitate the global effort toward elimination and eradication. NPC1161 is an 8-aminoquinoline that is derived from primaquine with an improved therapeutic profile compared to the parent compound. The (R)-(-) enantiomer (NPC1161B) has a lower effective dose that results in decreased toxic side effects such as hemolysis compared to the (S)-(+)-enantiomer, making it a promising compound …

The Chemical Characterization Of Eleutherococcus Senticosus And Ci-Wu-Jia Tea Using Uhplc-Uv-Qtof/Ms, Yan Hong Wang, Yonghai Meng, Chunmei Zhai, Mei Wang, Bharathi Avula, Jimmy Yuk, Kerri M. Smith, Giorgis Isaac, Ikhlas A. Khan

Faculty and Student Publications

© 2019, The Author(s). Hu antigen R (HuR) is indeed one of the most studied RNA-binding protein (RBP) since its fundamental role both in tumorigenesis and cancer progression. For this reason, downregulation in HuR protein levels or inhibition of HuR biological function are, nowadays, attractive goals in cancer research. Here, we examined the antitumor effects of CMLD-2 in four thyroid cancer cell lines (SW1736, 8505 C, BCPAP and K1). Indeed, CMLD-2 competitively binds HuR protein disrupting its interaction with RNA-targets. 35 μM CLMD-2 produced a significant downregulation in thyroid cancer cell viability, coupled to an increase in apoptosis. Moreover, CMLD-2 …

Shifts In Leukocyte Counts Drive The Differential Expression Of Transcriptional Stroke Biomarkers In Whole Blood, Grant C. O'Connell, Madison B. Treadway, Connie S. Tennant, Noelle Lucke-Wold, Paul D. Chantler, Taura L. Barr

Clinical and Translational Science Institute

Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution of the ten genes across the peripheral immune system by measuring their expression levels on isolated neutrophils, monocytes, B-lymphocytes, CD-4+ T-lymphocytes, CD-8+ T-lymphocytes, and NK-cells generated from the blood of healthy donors (n = 3). Then, we examined the relationship between the whole-blood expression levels of the ten genes and white blood …

Alkaline Phosphatase: A Potential Biomarker For Stroke And Implications For Treatment, A L. Brichacek, C M. Brown

Clinical and Translational Science Institute

Stroke is the fifth leading cause of death in the U.S., with more than 100,000 deaths annually. There are a multitude of risks associated with stroke, including aging, cardiovascular disease, hypertension, Alzheimer’s disease (AD), and immune suppression. One of the many challenges, which has so far proven to be unsuccessful, is the identification of a cost-effective diagnostic or prognostic biomarker for stroke. Alkaline phosphatase (AP), an enzyme first discovered in the 1920s, has been evaluated as a potential biomarker in many disorders, including many of the co-morbidities associated with stroke. This review will examine the basic biology of AP, and …

Endoplasmic Reticulum Stress Is Transmissible In Vitro Between Cells Of The Central Nervous System, Neil T. Sprenkle, Anirudhya Lahiri, James W. Simpkins, Gordon P. Meares

Clinical and Translational Science Institute

Improper protein folding and trafficking are common pathological events in neurodegenerative diseases that result in the toxic accumulation of misfolded proteins within the lumen of the endoplasmic reticulum (ER). While low‐level stimulation of the unfolded protein response (UPR) is protective, sustained UPR activation resulting from prolonged ER stress can promote neurotoxicity. The cell‐autonomous mechanisms of the UPR have been extensively characterized. However, the cell‐extrinsic role of the UPR under physiological and pathological states in the CNS remains to be elucidated. To begin to address this, we evaluated if transferring conditioned media between ER‐stressed astrocytes and neurons could modulate their functional …

Surgical Parameters For Minimally Invasive Trans- Eustachian Tube Csf Leak Repair: A Cadaveric Study And Literature Review, Erik C. Brown, Brandon Lucke-Wold, Justin S. Cetas, Aclan Dogan, Sachin Gupta, Timothy E. Hullar, Timothy L. Smith, Jeremy N. Ciporen

Clinical and Translational Science Institute

Background Cerebrospinal fluid rhinorrhea from a lateral skull base defect refractory to spontaneous healing and/or conservative management is most commonly managed via open surgery. Approach for repair is dictated by location of the defect, which may require surgical exploration. The final common pathway is the eustachian tube (ET). Endoscopic ET obliteration via endonasal and lateral approaches is under development. Whereas ET anatomy has been studied, surgical landmarks have not been previously described or quantified. We aimed to define surgical parameters of specific utility to endoscopic ET obliteration. Methods A literature review was performed of known ET anatomic parameters. Next, using …

The Thinker February, Jennifer Jacobs

Library Newsletters

No abstract provided.

Faculty Achievements, February 2019, Otterbein University

Faculty Achievement Reports

No abstract provided.

Testing The Utility Of Geochemical Proxies To Reconstruct Holocene Coastal Environments And Relative Sea Level: A Case Study From Hungry Bay, Bermuda, Andrew C. Kemp, Christopher H. Vane, Nicole S. Khan, Joanna C. Ellison, Simon E. Engelhart, Benjamin P. Horton, Daria Nikitina, Struan R. Smith, Lisa J. Rodrigues, Ryan P. Moyer

Geosciences Faculty Publications

On low-lying, tropical and sub-tropical coastlines freshwater marshes may be replaced by salt‑tolerant mangroves in response to relative sea-level rise. Pollen analysis of radiocarbon‑dated sediment cores showed that such a change occurred in Hungry Bay, Bermuda during the late Holocene. This well-established paleoenvironmental trajectory provides an opportunity to explore if geochemical proxies (bulk-sediment δ¹³C and Rock-Eval pyrolysis) can reconstruct known environmental changes and relative sea level. We characterized surface sediment from depositional environments in Bermuda (freshwater wetlands, saline mangroves, and wrack composed of Sargassum natans macroalgae) using geochemical measurements and demonstrate that a multi-proxy approach can objectively distinguish …

Iris-Eda: An Integrated Rna-Seq Interpretation System For Gene Expression Data Analysis, Brandon Monier, Adam Mcdermaid, Cankun Wang, Jing Zhao, Allison Miller, Anne Fennell, Qin Ma

Agronomy, Horticulture and Plant Science Faculty Publications

Next-Generation Sequencing has made available substantial amounts of large-scale Omics data, providing unprecedented opportunities to understand complex biological systems. Specifically, the value of RNA-Sequencing (RNA-Seq) data has been confirmed in inferring how gene regulatory systems will respond under various conditions (bulk data) or cell types (single-cell data). RNA-Seq can generate genome-scale gene expression profiles that can be further analyzed using correlation analysis, co-expression analysis, clustering, differential gene expression (DGE), among many other studies. While these analyses can provide invaluable information related to gene expression, integration and interpretation of the results can prove challenging. Here we present a tool called IRIS-EDA, …

Prostate Cancer Disparity, Chemoprevention, And Treatment By Specific Medicinal Plants, Clement G. Yedjou, Ariane T. Mbemi, Felicite Noubissi, Solange S. Tchounwou, Nole Tsabang, Marinelle Payton, Lucio Miele, Paul B. Tchounwou

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Prostate cancer (PC) is one of the most common cancers in men. The global burden of this disease is rising. Its incidence and mortality rates are higher in African American (AA) men compared to white men and other ethnic groups. The treatment decisions for PC are based exclusively on histological architecture, prostate-specific antigen (PSA) levels, and local disease state. Despite advances in screening for and early detection of PC, a large percentage of men continue to be diagnosed with metastatic disease including about 20% of men affected with a high mortality …

Library Quarterly - February/March 2019, Lea Iadarola, Jordan Chussler, Jared Wellman, Leecy Barnett, Alison Leonard, Gabrell Tannis, Maria Vega, Stacy Alesi, Christelle Mehu, Amy Filiatreau, Tsukasa Cherkaoui, Sabine Dantus

Library Newsletter

In this issue:

• Enter the ACE Awards!
• Third Annual Creative Writing Contest
• 2018 in Review
• A Gem of a Database
• New Year, New You: Magazines from the Lynn Library Website!
• The Creative Mind
• Meet Maria Vega
• Meet Stacy Alesi
• Quarterly Funnies
• Create a Textbook for Your Students & Defeat the Textbook Publishing Cartel
• Commissioned Music by the Lynn Conservatory
• Events

A Coalescent Sampler Successfully Detects Biologically Meaningful Population Structure Overlooked By F‐Statistics, Eric D. Crandall, Robert J. Toonen, Tobo Laboratory, Kimberly A. Selkoe

School of Natural Sciences Faculty Publications and Presentations

Assessing the geographic structure of populations has relied heavily on Sewell Wright's F‐statistics and their numerous analogues for many decades. However, it is well appreciated that, due to their nonlinear relationship with gene flow, F statistics frequently fail to reject the null model of panmixia in species with relatively high levels of gene flow and large population sizes. Coalescent genealogy samplers instead allow a model‐selection approach to the characterization of population structure, thereby providing the opportunity for stronger inference. Here, we validate the use of coalescent samplers in a high gene flow context using simulations of a stepping‐stone model. …

February 2019, Volume 15, Number 1, Winthrop University Archives And Special Collections

Retrospect: News from the Louise Pettus Archives and Special Collections at Winthrop University

No abstract provided.

Evaluation Of Volatile Metabolites Emitted In-Vivo From Cold-Hardy Grapes During Ripening Using Spme And Gc-Ms: A Proof-Of-Concept, Somchai Rice, Devin L. Maurer, Anne Fennell, Murlidhar Dharmadhikari, Jacek A. Koziel

Agronomy, Horticulture and Plant Science Faculty Publications

In this research, we propose a novel concept for a non-destructive evaluation of volatiles emitted from ripening grapes using solid-phase microextraction (SPME). This concept is novel to both the traditional vinifera grapes and the cold-hardy cultivars. Our sample models are cold-hardy varieties in the upper Midwest for which many of the basic multiyear grape flavor and wine style data is needed. Non-destructive sampling included a use of polyvinyl fluoride (PVF) chambers temporarily enclosing and concentrating volatiles emitted by a whole cluster of grapes on a vine and a modified 2 mL glass vial for a vacuum-assisted sampling of volatiles from …

Word Ways V.52 No.1 Complete Issue

Word Ways

All of the articles in this issue in one complete document.