Digital Commons Network^™

Gen-1 Immunotherapy For The Treatment Of Ovarian Cancer, Premal H Thaker, Nicholas Borys, Jason Fewell, Khursheed Anwer

2010-2019 OA Pubs

GEN-1 is a gene-based immunotherapy, comprising a human IL-12 gene expression plasmid and a synthetic plasmid delivery system, delivered intraperitoneally (ip.) to produce local and persistent levels of a pleiotropic immunocytokine, IL-12, at the tumor site in patients with advanced ovarian cancer. The goal of local and persistent IL-12 delivery is to remodel the highly immunosuppressive tumor microenvironment to favor immune stimulation while avoiding serious systemic toxicities, a major limitation of recombinant IL-12 therapy. Safe and sustained local production of IL-12 and related immunocytokines at the tumor site could produce potentially more favorable immunological changes in the tumor microenvironment and …

Hillslope Hydrology In Global Change Research And Earth System Modeling, A. Flores, J. Mcnamara

Geosciences Faculty Publications and Presentations

Earth System Models (ESMs) are essential tools for understanding and predicting global change, but they cannot explicitly resolve hillslope‐scale terrain structures that fundamentally organize water, energy, and biogeochemical stores and fluxes at subgrid scales. Here we bring together hydrologists, Critical Zone scientists, and ESM developers, to explore how hillslope structures may modulate ESM grid‐level water, energy, and biogeochemical fluxes. In contrast to the one‐dimensional (1‐D), 2‐ to 3‐m deep, and free‐draining soil hydrology in most ESM land models, we hypothesize that 3‐D, lateral ridge‐to‐valley flow through shallow and deep paths and insolation contrasts between sunny and shady slopes are the …

Accounting For Unintended Consequences Of Resource Policy: Connecting Research That Addresses Displacement Of Environmental Impacts, Rebecca L. Lewison, Andrew F. Johnson, Jianbang Gan, Robin Pelc, Katie Westfall, Mark Helvey

School of Natural Sciences Faculty Publications and Presentations

Natural resource policies enacted to protect environmental integrity play an important role in promoting sustainability. However, when resources are shared ecologically, economically, or through a common, global interest, policies implemented to protect resource sustainability in one domain can displace, and in some cases magnify, environmental degradation to other domains. Although such displacement has been recognized as a fundamental challenge to environmental and conservation policy within some resource sectors, there has been little cross‐disciplinary and cross‐sectoral integration to address the problem. This suggests that siloed knowledge may be impeding widespread recognition of the ubiquity of displacement and the need for mitigation. …

Agricultural Safety Education: Formative Assessment Of A Curriculum Integration Strategy, Michael L. Pate, Rebecca G. Lawver, Scott W. Smalley, Dustin K. Perry, Lorann Stallones, Alyx Shultz

Applied Sciences, Technology and Education Faculty Publications

The purpose of this study was to assess an agricultural tractor and machinery safety curriculum for teacher training that focused on hands-on integration activities to assist with training youth in machinery safety skills. Teachers attended a single ten-hour summer training seminar hosted in Montana, South Dakota, or Utah during 2017. Teachers completed the National Tractor and Machinery Safe Operation (NSTMOP) exam to measure their existing knowledge prior to beginning the training. Upon seminar completion, teachers took an NSTMOP post-test to measure their knowledge gain of agricultural safety practices and hazard recognition associated with machinery and tractors. A total of 116 …

The Ethics Of Eliminating Harmful Species: The Case Of The Tsetse Fly, Jérémy Bouyer, Neil H. Carter, Chelsea Batavia, Michael Paul Nelson

Human-Environment Systems Research Center Faculty Publications and Presentations

Wildlife species harmful to humans are often targets of control and elimination programs. A contemporary example is the tsetse fly, a vector of sleeping sickness and African animal trypanosomosis. Tsetse flies have recently been targeted by a pan-African eradication campaign. If it is successful, the campaign could push the entire tsetse family to extinction. With the emergence of effective and efficient elimination technologies, ethical assessment of proposed elimination campaigns is urgently needed. We examine the ethics of tsetse fly elimination by considering arguments predicated on both the instrumental and the intrinsic values of the species at local and global scales. …

Perceptual Lateralization Of Vocal Stimuli In Goats, Luigi Baciadonna, Christian Nawroth, Elodie F. Briefer, Alan G. Mcelligott

Communication Skills Collection

Functional asymmetries, for example, the preferential involvement of 1 brain hemisphere to process stimuli, may increase brain efficiency and the capacity to carry out tasks simultaneously. We investigated which hemisphere was primarily involved in processing acoustic stimuli in goats using a head-orienting paradigm. Three playbacks using goat vocalizations recorded in different contexts: food anticipation (positive), isolation (negative), food frustration (negative), as well as 1 playback involving dog barks (negative) were presented on the left and right sides of the test subjects simultaneously. The head-orienting response (left or right) and latency to resume feeding were recorded. The direction of the head-orienting …

Perceptual Lateralization Of Vocal Stimuli In Goats, Luigi Baciadonna, Christian Nawroth, Elodie F. Briefer, Alan G. Mcelligott

Social Cognition Collection

Functional asymmetries, for example, the preferential involvement of 1 brain hemisphere to process stimuli, may increase brain efficiency and the capacity to carry out tasks simultaneously. We investigated which hemisphere was primarily involved in processing acoustic stimuli in goats using a head-orienting paradigm. Three playbacks using goat vocalizations recorded in different contexts: food anticipation (positive), isolation (negative), food frustration (negative), as well as 1 playback involving dog barks (negative) were presented on the left and right sides of the test subjects simultaneously. The head-orienting response (left or right) and latency to resume feeding were recorded. The direction of the head-orienting …

Canine Endogenous Oxytocin Responses To Dog-Walking And Affiliative Human–Dog Interactions, Lauren Powell, Kate M. Edwards, Adrian Bauman, Adam J. Guastella, Bradley Drayton, Emmanuel Stamatakis, Paul Mcgreevy

Human-Animal Interactions Collection

Several studies suggest human–dog interactions elicit a positive effect on canine oxytocin concentrations. However, empirical investigations are scant and the joint influence of human–dog interaction and physical activity remains unexplored. The aims of the current study were to (a) examine the canine endogenous oxytocin response to owner-led dog-walking and affiliative human–dog interactions and (b) investigate the moderating effect of the owner-reported strength of the human–dog bond on such responses. Twenty-six dogs took part in a random order cross-over trial, involving dog-walking and human–dog interactions. Urinary samples were collected before and after each condition. The data were analyzed using linear mixed …

Isu Today- February 19, 2019, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Interaction And Regulation Between Lipid Mediator Phosphatidic Acid And Circadian Clock Regulators, Sang-Chul Kim, Sang-Chul Kim, Dmitri Nusinow, Maria Sorkin, Maria Sorkin, Jose Pruneda-Paz, Xuemin Wang, Xuemin Wang

Biology Department Faculty Works

Circadian clocks play important roles in regulating cellular metabolism, but the reciprocal effect that metabolism has on the clock is largely unknown in plants. Here we show that the central glycerolipid metabolite and lipid mediator phosphatidic acid (PA) interacts with and modulates the function of the core clock regulators LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) in Arabidopsis thaliana. PA reduced the ability of LHY and CCA1 to bind the promoter of their target gene TIMING OF CAB EXPRESSION1. Increased PA accumulation and inhibition of PA-producing enzymes had opposite effects on circadian clock outputs. Diurnal change in levels …

Isu Today- February 26, 2019, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Transcriptomic Response Is More Sensitive To Water Deficit In Shoots Than Roots Of Vitis Riparia (Michx.), Vedbar Singh Khada, Kimberly Vaughn, Juan Xie, Padmapriya Swaminathan, Qin Ma, Grant Cramer, Anne Y. Fennell Dr

Agronomy, Horticulture and Plant Science Faculty Publications

Background: Drought is an important constraint on grapevine sustainability. Vitis riparia, widely used in rootstock and scion breeding, has been studied in isolated leaf drying response studies; however, it is essential to identify key root and shoot water deficit signaling traits in intact plants. This information will aid improved scion and rootstock selection and management practices in grapevine. RNAseq data were generated from V. riparia roots and shoots under water deficit and well-watered conditions to determine root signaling and shoot responses to water deficit.
Results: Shoot elongation, photosynthetic rate, and stomatal conductance were significantly reduced in water deficit (WD) treated …

The History And Future Of Digital Health In The Field Of Behavioral Medicine., Danielle Arigo, Danielle E Jake-Schoffman, Kathleen Wolin, Ellen Beckjord, Eric B Hekler, Sherry L Pagoto

College of Science & Mathematics Departmental Research

Since its earliest days, the field of behavioral medicine has leveraged technology to increase the reach and effectiveness of its interventions. Here, we highlight key areas of opportunity and recommend next steps to further advance intervention development, evaluation, and commercialization with a focus on three technologies: mobile applications (apps), social media, and wearable devices. Ultimately, we argue that future of digital health behavioral science research lies in finding ways to advance more robust academic-industry partnerships. These include academics consciously working towards preparing and training the work force of the twenty first century for digital health, actively working towards advancing methods …

Kentucky Warbler (Vol. 95, No. 1), Kentucky Library Research Collections

The Kentucky Warbler

No abstract provided.

Development Of An Industry-Based Habitat Mapping/Monitoring System Frdc Project No 2011/021, Simon De Lestang, Matthew B. Pember, Dirk Slawinski

Fisheries Research Reports

Mapping / monitoring in the marine environment can be a very costly exercise. Scientists from the Department of Primary Industries and Regional Development; Fisheries Division (FD) and the Commonwealth Scientific and Industrial Research Organisation (CSIRO) have developed a small, low-cost automated camera system that, when fitted to commercial fishing gear, can achieve this at minimal cost. The POTBot (Pictures Of The Bottom) system is a cheap, small “smart” camera that can track its position globally and the date and time, and can record high-definition video and water temperature readings when it determines it has been deployed into the ocean.

Ecolunch | Thermal Properties Of Pushup Displays In Urosaurus Ornatus, March 20, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Biology Colloquium | The New World Justicioid Lineage, Feb 8, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Isu Today- February 25, 2019, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Isu Today- February 21, 2019, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Isu Today- February 28, 2019, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Why The Duty To Self-Censor Requires Social-Media Users To Maintain Their Own Privacy, Earl W. Spurgin

2019 Faculty Bibliography

Revelations of personal matters often have negative consequences for social-media users. These consequences trigger frequent warnings, practical rather than moral in nature, that social-media users should consider carefully what they reveal about themselves since their revelations might cause them various difficulties in the future. I set aside such practical considerations and argue that social-media users have a moral obligation to maintain their own privacy that is rooted in the duty to self-censor. Although Anita L. Allen provides a paternalist justification of the duty that supports my position that social-media users are obligated to self-censor what they reveal about themselves, I …

Association Between Perceived Physical Activity And Cognitive Function In Older Adults, Paul D. Loprinzi, Emily Frith

Faculty and Student Publications

© The Author(s) 2018. There is irrefutable evidence that regular participation in physical activity is favorably associated with numerous positive health outcomes, including cognitive function. Emerging work suggests that perceived physical activity, independent of actual physical activity behavior, is inversely associated with mortality risk. In this study, we evaluate whether perceived physical activity, independent of actual physical activity, is associated with cognitive function, a robust indicator of mortality risk. Data from the cross-sectional 1999–2002 National Health and Nutrition Examination Survey were employed (N = 2352; 60+ years of age). Actual physical activity was assessed via a validated survey. Perceived physical …

February 2019, Marci Grant

The CETL Correspondent

New Teaching and Learning Coordinator has been hired!

Mr. Steve Ray has joined the ranks of the Center for Excellence in Teaching and Learning, please contact Steve and give him a warm SWOSU welcome.

Why Do This And What Do I Need?: A Workshop For Preparing Swca Certification Proposals, Scott Whiddon, Russell Carpenter, Courtnie Morin, Kevin Dvorak, Joy Bracewell

CAHSS Faculty Presentations, Proceedings, Lectures, and Symposia

In this workshop, participants will gain a detailed sense of the benefits for writing center certification via SWCA. After reviewing the process for certification design, current SWCA Research & Development committee members will guide workshop participants through a series of brainstorming activities to help directors begin to develop materials for application packets. The goal of this workshop is to help demystify the process of application, to prompt reflection on materials that centers might already have, and to encourage participation in the SWCA certification program.

The Promise And Purpose Of Love And Belonging In Shaping The Spiritual Destiny Of Sixth Graders, Jim Newby

Doctor of Ministry

The consilience of interpersonal neurobiology and theology is the template for the viscidity of faith throughout one’s lifetime. The congruence of disciplines conclude that what is experienced and believed before the age of thirteen determines how one will live their life. The loss of connection to parents at home and adults within the faith community, is cultivating isolation, loneliness, and the loss of love and belonging in each emerging generation.

Chapter One introduces the deprecating beliefs that are practiced during the first twelve years of one’s life that ultimately lead young believers away from homes and communities of faith and …

The Birch Creek Canids And Dogs As Transport Labor In The Intermountain West, Martin H. Welker, David A. Byers

Sociology, Social Work and Anthropology Faculty Publications

Historically, domestic dogs (Canis familiaris) have been documented as central features of Intermountain West and Great Plains Native American camps. Some of these dogs were bred specifically for largeness and stamina to haul travois and to carry pannier-style packs. Ethnographic accounts frequently highlight the importance of dogs in moving through the Intermountain West and the plains, reporting loads as heavy as 45 kg (100 lbs). We calculated body mass from skeletal morphometric data and used these to estimate prehistoric and historic dog load capacities for travois and pannier-style packs in the Intermountain West, Great Plains, and Great Basin. Specimens of …

Fluctuation Of Primary Motor Cortex Excitability During Cataplexy In Narcolepsy, Bei Huang, Zhenying Qian, Zongwen Wang, Jihui Zhang, Kun Chen, Tao Xu, Jijun Wang, David F. Cechetto, Zhongxin Zhao, Huijuan Wu

Anatomy and Cell Biology Publications

Objective Cataplexy is a complicated and dynamic process in narcolepsy type 1 (NT1) patients. This study aimed to clarify the distinct stages during a cataplectic attack and identify the changes of the primary motor cortex (PMC) excitability during these stages. Methods Thirty-five patients with NT1 and 29 healthy controls were recruited to this study. Cataplectic stages were distinguished from a cataplectic attack by video-polysomnogram monitoring. Transcranial magnetic stimulation motor-evoked potential (TMS-MEP) was performed to measure the excitability of PMC during quiet wakefulness, laughter without cataplexy, and each cataplectic stage. Results Based on the video and electromyogram observations, a typical cataplectic …

Environmental Temperature Effects On Adipose Tissue Growth In A Hibernator, Amanda D.V. Maccannell, Kevin J. Sinclair, Charles A. Mckenzie, James F. Staples

Paediatrics Publications

Obligate hibernators express circannual patterns of body mass and hibernation, which persist under constant laboratory conditions. Brown adipose tissue (BAT) is important for thermogenesis during arousals from hibernation, whereas white adipose tissue (WAT) serves as energy storage and thermal insulation. The goal of this study was to investigate the effects of environmental temperature on BAT and WAT. We hypothesized that changes to environmental temperature would not influence the pattern of mass gain or BAT and WAT volume in the thirteen-lined ground squirrel (Ictidomys tridecemlineatus). To test this, we housed animals at thermoneutral 25°C (warm-housed) or 5°C (cold-housed), with the same …

Identification Of A Lipid-Rich Depot In The Orbital Cavity Of The Thirteen-Lined Ground Squirrel, Amanda D.V. Maccannell, Kevin J. Sinclair, Glenn J. Tattersall, Charles A. Mckenzie, James F. Staples

Paediatrics Publications

We discovered a previously undescribed orbital lipid depot in the thirteen-lined ground squirrel during the first ever magnetic resonance image (MRI) of this common experimental model of mammalian hibernation. In animals housed at constant ambient temperatures (5°C or 25°C, 12 h:12 h light:dark photoperiod), the volume of this depot increased in the autumn and decreased in the spring, suggesting an endogenous circannual pattern. Water-fat MRI revealed that throughout the year this depot is composed of ∼40% lipid, similar to brown adipose tissue (BAT). During arousal from torpor, thermal images showed higher surface temperatures near this depot before the rest of …

Dynamics Of Spontaneous Alpha Activity Correlate With Language Ability In Young Children., Elaine Yuen Ling Kwok, Janis Oram Cardy, Brian L Allman, Prudence Allen, Björn Herrmann

Health and Rehabilitation Sciences Publications

Early childhood is a period of tremendous growth in both language ability and brain maturation. To understand the dynamic interplay between neural activity and spoken language development, we used resting-state EEG recordings to explore the relation between alpha oscillations (7-10 Hz) and oral language ability in 4- to 6-year-old children with typical development (N = 41). Three properties of alpha oscillations were investigated: a) alpha power using spectral analysis, b) flexibility of the alpha frequency quantified via the oscillation's moment-to-moment fluctuations, and c) scaling behavior of the alpha oscillator investigated via the long-range temporal correlation in the alpha-amplitude time course. …