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Comparing Methods For Clinical Investigator Site Inspection Selection: A Comparison Of Site Selection Methods Of Investigators In Clinical Trials, Nicholas Hein, Elena Rantou, Paul Schuette

United States Food and Drug Administration: Publications

Background During the past two decades, the number and complexity of clinical trials have risen dramatically increasing the difficulty of choosing sites for inspection. FDA’s resources are limited and so sites should be chosen with care.

Purpose To determine if data mining techniques and/or unsupervised statistical monitoring can assist with the process of identifying potential clinical sites for inspection.

Methods Five summary-level clinical site datasets from four new drug applications (NDA) and one biologics license application (BLA), where the FDA had performed or had planned site inspections, were used. The num- ber of sites inspected and the results of the …

Multifocal Necrotizing Myopathy In Northern Elephant Seal (Mirounga Angustirostris) Pups, San Miguel Island, California, Terry R. Spraker, Tetiana A. Kuzmina, Eugene T. Lyons, Robert L. Delong, Claire Simeone, D. N. Rao Veeramachaneni

United States Department of Commerce: Staff Publications

A field study addressing causes of mortality in freshly dead northern elephant seals (Mirounga angustirostris, Gill, 1866) was conducted on San Miguel Island, California, in February 2015. Necropsies were performed on 18 pups ranging in age from stillbirths to approximately 7 to 8 weeks. The primary gross diagnoses in these pups included trauma, myopathy, starvation/ emaciation, infections, congenital anomalies, and perinatal mortality. However, 6 (33%) had a previously unrecognized myopathy characterized by multiple white streaks that were most obvious within the inner layer of the abdominal wall and the small innermost ventral intercostal muscles. Following histological examination, 2 …

The Peptide Hormone Adropin Regulates Signal Transduction Pathways Controlling Hepatic Glucose Metabolism In A Mouse Model Of Diet-Induced Obesity, Su Gao, Sarbani Ghoshal, Liyan Zhang, Joseph R. Stevens, Kyle S. Mccommis, Brian N. Finck, Gary D. Lopaschuk, Andrew A. Butler

Open Access Publications

No abstract provided.

Phytochemical Investigation And Drug Interaction Potential Of Cyanotis Vaga, Ibrahim Almarabi

Electronic Theses and Dissertations

Cyanotis. vaga (Lour.) Schult, & Schult. f. (C. vaga) previously called Tradescantia vaga and Cyanotis barbata, is a perennial herb. It is native to Eastern Asia and Tropical Africa. It has been reported that its decoction reduces fever and enhances well-being. Recently, C. vaga has been used widely for its anabolic effects, due to its richness of ecdysteroids. Even though C. vaga is a commedicinal plant (dietary supplement), there are no reports about its effect on the drug metabolizing enzyme Cytochromes P450 to predict its interaction with concomitantly used medications. In this study, eight ecdysteroids were isolated …

การเปรียบเทียบการเกิดภาวะเอียงของกระดูกเชิงกรานขณะวิ่งที่ระดับความหนักปานกลางในกลุ่มนักวิ่งมือใหม่และนักวิ่งสันทนาการเพศหญิง, หทัยภัทร ทิพยุทธ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อศึกษาผลของการวิ่งที่ระดับความหนักปานกลางต่อระยะเวลาการเกิดภาวะเอียงของกระดูกเชิงกราน (pelvic drop) ในนักวิ่งมือใหม่ และนักวิ่งสันทนาการเพศหญิง และศึกษาความสัมพันธ์ระหว่างแนวการเอียงของกระดูกเชิงกราน (pelvic alignment)กับอัตราการเต้นของหัวใจ (heart rate; HR), การใช้ออกซิเจน (VO2 uptake), ค่าความรู้สึกเหนื่อย (Rating of Perceived Exertion; RPE), ค่าความรู้สึกล้าของขา (Rating of Perceived Exertion for legs; RPElegs) และความล้าของกล้ามเนื้อ Gluteus medius และ Gluteus maximus กลุ่มตัวอย่างในงานวิจัยครั้งนี้อายุระหว่าง 18 - 35 ปี เป็นนักวิ่งมือใหม่ (ประสบการณ์น้อยกว่า 1 ปี) 27 คน และนักวิ่งสันทนาการ (ประสบการณ์ 2 - 4 ปี) 27 คน ซึ่งทั้งสองกลุ่มได้รับการทดสอบประสิทธิภาพการใช้ออกซิเจนสูงสุด (VO2max) และวิ่งบนลู่วิ่ง 30 นาที ที่ระดับความหนักปานกลางที่อัตราเร็วที่เลือกเอง (นักวิ่งมือใหม่; 5.87 ± 0.62 กม./ชม. vs. นักวิ่งสันทนาการเพศหญิง; 6.44 ± 0.58 กม./ชม.) โดยอยู่ในช่วงอัตราการเต้นหัวใจที่ 40 - 59% ของอัตราการเต้นหัวใจสำรองสูงสุด (heart rate reserve; HRR) ขณะทดสอบบนลู่วิ่ง 30 นาที นักวิ่งทั้งสองกลุ่มจะถูกบันทึกค่าอัตราการเต้นของหัวใจ, การใช้ออกซิเจน, ค่าความรู้สึกเหนื่อย, ค่าความรู้สึกล้าของขา และวัดการทำงานของกล้ามเนื้อ (muscle activity) จากสัญญาณไฟฟ้า (electromyography; EMG) ที่กล้ามเนื้อ Gluteus medius และ Gluteus maximus ทุก ๆ …

Development Of Riceberry Cracker Supplementation With Unripe Papaya Flour, Napassorn Payantakom

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this study was to investigate the effect of partial replacement of wheat flour with riceberry flour and unripe papaya flour on the physicochemical, functional properties and sensory evaluation of crackers. In the current study found that partial substitution of wheat flour with 5, 10, 15 and 20% riceberry flour (5, 10, 15 and 20%RBF) resulted in significantly increased in hardness and redness together with a decreased fracturability, lightness and yellowness of crackers. Researcher also found that substitution of wheat flour with riceberry flour resulted in an increase phenolic content from 2.03±0.36 (control cracker) to 8.78±0.19 (20%RBF) mg …

Disaster Legal Tech: Strategies For Providing Legal Information To Survivors, Jeanne Ortiz-Ortiz, Jessica Penkoff

Touro Law Review

No abstract provided.

Proceedings Of The 2019 Undergraduate Research Conference, Ryan C. Winters, Courtney A. Suire, Dillard University, Grambling State University, Louisiana State University, Loyola University New Orleans, Mcneese State University, Nicholls State University, Northwestern State University Of Louisiana, Southeastern Louisiana University, Southern University And A&M College, University Of Louisiana At Lafayette

Advance: Student Research Experience

Proceedings of the 2019 Undergraduate Research Conference, University of Louisiana at Lafayette, November 22-23, 2019

Effects Of Commercial Feed Additives On The Gut Microbiota Of Food Animals, Prakash Poudel

Electronic Theses and Dissertations

Weaning is a stressful event of newborn animals which can lead to dysbiosis in the GIT causing invasion of pathogens, retarded growth, high incidence of diarrhea, and increased neonatal mortality. Since antibiotics use in livestock production have been regulated, various feed additives have been designed as antibiotic alternatives to use in newborn animal during weaning. This thesis investigated the dynamics of bacterial composition of GIT in weaned animals fed commercial feed additives by analysis of high throughput sequencing data generated from PCR-amplified DNA targeting V1-V3 region of 16S rRNA gene. Experiment 1 investigated the rumen environment of neonatal calves fed …

Consumer Perceptions And Demand For Locally-Grown Vegetables In South Dakota, Richard Mulder

Electronic Theses and Dissertations

An increasingly popular topic in the food labeling field over the last 15 years has been the increasing body of research for food that is locally produced. Consumers’ definition of, attitudes toward, and willingness-to-pay (WTP) for local food have been areas of interest for researchers. To the best of our knowledge, this is the first study that contributes to the current body of local foods’ research for vegetables by providing information on these areas of interest for the state of South Dakota. This study acquires data through a consumer-intercept survey conducted in grocery stores throughout South Dakota with a sample …

Optimization Of Canola Co-Product Utilization In Swine, Jung Wook Lee

Electronic Theses and Dissertations

Canola co-products have a high content of fiber and glucosinolates. Fiber reduces nutrient utilization in pigs, whereas glucosinolates are degraded to toxic products, which interfere with liver, kidney and thyroid functions. Negative effects of fiber can potentially be alleviated by fiber-degrading enzymes, whereas negative effects of glucosinolates in pigs can potentially be alleviated through reduction in hindgut pH. However, there is a lack of information on effects of supplemental fiberdegrading enzymes on digestion and fermentation characteristics of canola coproducts for pigs. Also, there is limited information on effects of reducing hindgut pH on toxicity of glucosinolates in pigs. Four experiments …

Staff Education On Metabolic Syndrome In Patients Taking Antipsychotic Medications, Juliana Ifeoma Omile

Walden Dissertations and Doctoral Studies

Second-generation antipsychotics (SGAs) are prescribed for treatment of psychosis. A major side effect of SGAs is an increased risk of metabolic syndrome (MetS) with symptoms of hypertension, hyperlipidemia, hyperglycemia, and truncal obesity. A clinic in the northeastern United States was not screening patients for MetS when being treated with SGAs. The purpose of this project was to educate staff on MetS risk factors, signs, symptoms, and patient management with a goal to improve their knowledge of MetS. Lewin's change theory provided a conceptual framework for the project. The project question explored the development and evaluation of an educational module on …

Growth Performance, Metabolic And Rumen Profile, Nutrient Utilization, And Health Of Calves Fed Condensed Whey Solubles With Starter Pellets, Michaela Joy Della

Electronic Theses and Dissertations

A study was conducted for this thesis to evaluate the effectiveness of a new product’s ability to improve calf health and growth performance. In addition to the results from the study, this thesis also includes a literature review of immune and rumen maturation in calves and a discussion of ways to protect and encourage those fundamental progressions. For the main research project 48 dairy calves were used in a randomized complete block design study to evaluate the growth performance, rumen fermentation and metabolic profiles, nutrient utilization, and health scores when calves were supplemented Condensed Whey Solubles (CWS) with their starter …

Eat Smart, Play Hard The Oyate Way: Impact Of A Culturally Tailored Nutrition And Physical Activity Curriculum On Elementary Youth, Abbey Hillestad

Electronic Theses and Dissertations

Objective: To assess changes in nutrition and physical activity (PA) knowledge and behavior in elementary-age participants from school districts with high American Indian enrollment after completion of a culturally tailored education curriculum.
Design: Pre-post intervention study assessing knowledge and behavior using quantitative methods. Participants: A total of 248 participants (Kindergarten through 5th grade, n=248) throughout 13 elementary classrooms in tribal communities participated in Eat Smart. Play Hard.: The Oyate Way. Intervention(s): Baseline and post intervention data from a culturally tailored nutrition and PA knowledge and behavior curriculum.
Main Outcome Measure(s): Dependent variables were nutrition and PA knowledge, and nutrition and …

Diagnosis And Rehabilitation Of Multiple Hip Pathologies In A Division I Football Player: A Case Study, Kelsey E. Sanders

Electronic Theses and Dissertations

Objective: To present a diagnosis and rehabilitation plan for femoroacetabular impingement (FAI), labral tear, and sports hernia in a Division I college football player. Background: A 21-year-old NCAA Division I college football player experienced a rare combination diagnosis of hip FAI, labral tear and sports hernia. Overlapping signs and symptoms proved difficult to conclude a diagnosis. The patient underwent three months of conservative treatment with no relief before electing to undergo surgery. Differential Diagnosis: Hip flexor strain, osteitis pubis. Treatment: A combination of conservative treatment such as activity modification, anti-inflammatories, therapeutic modalities, injections, and rehabilitation were unsuccessful in relieving symptoms …

Analysis Of Factors Influencing College Choice Decisions Of Mid-Major Ncaa Division I Swimmers, Kaden Huntrods

Electronic Theses and Dissertations

Student-athletes face an ever-increasing challenge of selecting a higher education institution that meets their desired criteria academically and athletically. Coaches and recruiters have sought to discover how to best recruit student-athletes over the history of college athletics. Understanding these factors can assist coaches and athletes to create athletic programs to best fit the desired student-athletes. This study examined the factors that influence the college selection process of mid-major NCAA Division I, male and female swimmers. The instrument utilized in this study was the Student Athlete College Choice Profile Survey (SACCPS). The participants included 141 student-athletes from seven mid-major NCAA Division …

Receiving And Backgrounding Phase Management: The Effects Of Receiving Diet Roughage Source And Backgrounding Phase Rate Of Gain On Performance Of Feedlot Cattle, Ethan J. Blom

Electronic Theses and Dissertations

Management of cattle during the receiving and backgrounding phases can influence the performance of feedlot cattle. The receiving phase is a stressful time for cattle entering the feedlot and quickly adapting cattle to milled feed can impact their productivity. Silages are often viewed as less desirable feedstuffs in receiving diets for newly-weaned calves. The objective of this 2-yr study was to evaluate effects of roughage source in receiving diets on cattle performance, diet mixing, and diet integrity. Steer calves (yr 1, n = 180; yr 2, n = 210) were weaned and immediately transported 580 km. Calves were allotted to …

Brassica Carinata Growth And Yield Response To Nitrogen And Sulfur Fertilizers And Impacts On Selected Soil Parameters And Ghg Fluxes, Dwarika Bhattarai

Electronic Theses and Dissertations

Carinata (Brassica carinata A. Braun), a non-food oilseed crop and an alternative bio-jet fuel feedstock, has received attention for its potential as a low-input option for production in the semi-arid regions of the Northern Great Plains of USA. The crop has a lower N fertilizer requirement as compared to the other oilseeds, suggesting less negative impact on soils and GHGs emissions. Carinata is a new crop to South Dakota (SD), thus, the best management practices have yet to be developed. In addition, no sufficient research to address the impact of growing carinata on soils and GHG emissions has been …

Implementation Of A Transcultural Nursing Education Program To Improve Nurses' Cultural Competence, Ann Marie Elizabeth Edwards

Walden Dissertations and Doctoral Studies

The exponential growth of culturally diverse populations in the United States has led to a multicultural patient population while the nursing workforce remains predominantly White. At the project site, managers identified that staff nurses struggled to deliver culturally competent care. The purpose of this project was to improve the cultural competence of registered nurses (RNs) through a transcultural nursing education program. Leininger's transcultural nursing theory guided the project. Sources of evidence used to develop a face-to-face educational program included peer-reviewed journals, credible websites, and the Inventory for Assessing the Process of Cultural Competence Among Healthcare Professionals-R tool. Aggregate pretest and …

Mean Nutrition And Physical Activity Knowledge Score Of Children Ages 3-5 Years In The Igrow Readers Intervention, Mollie Loes

Electronic Theses and Dissertations

The prevalence of childhood obesity remains high within the United States, which can lead to long-term harmful effects. During the first five years of children’s lives, healthy eating habits and physical activity patterns are formed, so the preschool years are a critical time to begin obesity prevention (4). Because the preschool years are crucial for providing healthy eating habits and physical activity patterns, there is the need for childhood obesity interventions. iGrow Readers is a cluster-randomized control study concentrated on children 3-5 years of age recruited from childcare centers from South Dakota, Nebraska, and Minnesota. Fourteen child care centers with …

Interactions Of Arbuscular Mychorrhizal Fungi And Bacterial Endophytes On Disease Resistance Of Common Root Pathogens In Wheat, Janice L. Eibensteiner

Electronic Theses and Dissertations

Arbuscular mycorrhiza, a symbiosis between plants and fungi, help plants to capture nutrients such as phosphorus (P), nitrogen (N) and other micronutrients from the aggre in exchange for up to 20% of the fixed carbon (C) from the plant. In addition, arbuscular mycorrhizal (AM) fungi can improve the resistance against abiotic (drought, salinity), and also biotic (pathogen) stresses. Bacterial endophytes promote plant growth and yield by fixing N2 from the atmosphere, assimilating N and transfer it to the plant. Bacterial endophytes can also solubilize phosphate and stimulate plant defense responses, suppressing pathogens. The host plant provides sucrose and a favorable …

Integration Of Molecular Techniques For The Investigation Of Bovine Respiratory Disease, Amy Abrams

Electronic Theses and Dissertations

Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in the cattle industry. The complexity of host, pathogen, and environmental factors contributing to the incidence of BRD necessitate a multifaceted approach to investigate BRD. A greater understanding of pathogenic and genetics factors associated with BRD would improve prevention and treatment of BRD. Due to the complexity of BRD, genetic technologies have been limited in their ability to identify a genetic basis for BRD. Pooling of DNA samples prior to extraction can increase the ability to conduct genotyping studies of complex traits. Once generated, new information and management …

Using Isoconversional Methods To Study The Effect Of Antioxidants On The Oxidation Kinetics Of Milk Fat, Khalid Ahmed Alsaleem

Electronic Theses and Dissertations

Milk fat is a versatile ingredient because of its nutritional value, functionality, and flavor. During processing and storage, milk fat may undergo oxidation resulting in many undesirable changes such as unpleasant flavor and aroma, and formation of toxic compounds. A common practice to prevent the oxidation of milk fat is by the addition of antioxidants. It is worth to mention that little is known on the effect of antioxidants on the oxidation kinetics. In this work, the effect of selected antioxidants on the oxidation kinetics of anhydrous milk fat (AMF) under non-isothermal conditions was investigated. AMF with an addition of …

Increasing Accumulation Of Glyceollins In Soybeans Via Optimization Of The Fungal Incubation Process, Stephanie Wootton

Electronic Theses and Dissertations

Continual use of antibiotics in the feed of food animals was viewed a solution to the problem of disease outbreaks in livestock produced in confinement operations. This practice also improved animal performance, likely due to the reduction in sub-clinical infections. Unfortunately, this practice led to a new problem, the development of antibiotic resistant microbes. This increase in antibiotic resistance reduced the direct benefits of antibiotics in animal production. Moreover, as antibiotic resistance spread from animal to human pathogens, this practice created a major public health concern. This led the FDA to enact the Veterinary Feed Directive in 2017 that greatly …

Is It Racism, Colorism, Or A Pigment Of Your Imagination? A Study On The Invisible Color Line, Yolanda Rodriguez

Electronic Theses and Dissertations

Participants were 324 self-identified ethnic/racial minority adults recruited from a southern university in the United States and an online community (MTurk workers) primarily ranging in age from 18-30 (78.4%). Participants completed a demographic questionnaire and a measure for each of the variables of interest. A moderated mediation analysis was conducted using PROCESS (Hayes 2013) model 8. It was hypothesized that acculturation modality (X) would predict skin lightening behaviors and attitudes (Y) through three mediators (M1: Discrepancy scores M2: Satisfaction with Skin Color and M3: Desire to Change Skin Color). Psychological well-being was predicted to be a moderator (W) of the …

Cultural Influences On Body Size Ideals Among African American Women In The Mississippi Delta, Lois Marie Coleman

Electronic Theses and Dissertations

Results: One-on-one interviews yielded 25 cognitive maps. The maps contained a total of 169 concepts with 294 connections among them. The lowest number of variables identified on a participant’s map was 4 and the highest was 11. The lowest number of connections made on a participant’s map was 4 and the highest was 39. Through qualitative condensing and matrix addition, the 169 concepts were used to create 27 variables with 134 connections. Feedback from focus group participants resulted in the addition of 3 variables and 9 connections.

Service Provider Promising Practice - The Arc Of Westchester: Creative Partnership With Mercy College, Jaimie Ciulla Timmons, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

The Arc of Westchester benefits from an agency culture that values innovative partnerships. In fact, an agency leader explained that the organization “will work with anybody who is willing to sit and talk.” This collaborative spirit led to a creative endeavor with Mercy College, a four-year school offering degrees in Business, Education, Liberal Arts, Health and Natural Sciences, and Social and Behavioral Sciences. Within Health and Natural Sciences are departments such as nursing, speech therapy, occupational therapy, physical therapy, and nutrition. The Arc of Westchester partnered with these departments to form a mutually beneficial relationship, creating opportunities for both college …

The History And Influence Of The National Association Of Counsel For Children—An Alternative Perspective, Martin Guggenheim

Faculty Articles

This article reviews and critiques the public statements and positions taken by the National Association of Counsel for Children (NACC) as part of a symposium celebrating the 40th anniversary of its founding. The article suggests that for too many years after it was founded in 1977, NACC ignored glaring problems in the child welfare arena, including the ease with which children were separated from their families and placed into foster and the exponential growth of terminating parental rights. In addition, the article shows that for too many years NACC's focus was on winning the intramural fight with the Court Appointed …

Concerns Of Female Adolescents About Menarche And First Sexual Intercourse: Mixed Methods Analysis Of Social Media Questions, Nikkie Saldivar Hodgson, Elad Yom-Tov, William F. Strong, Priscilla L. Flores, Giselle N. Ricoy

Communication Faculty Publications

Background: Adolescents use social media for information on medical and social aspects of maturation.

Objective: The aim of this study was to investigate the concerns and information needs of adolescents regarding menarche and first sexual intercourse.

Methods: Questions about menarche or first sexual intercourse were obtained from Yahoo Answers, a community-based social media question-and-answer website. A total of 1226 questions were analyzed. We focused on 123 question pairs made by users who asked questions on both topics and reported their ages at each. Quantitative and qualitative analyses were performed on these question pairs.

Results: Qualitative analysis identified uncertainty as a …

Reference Guide: Identifying Policy Levers To Improve The Massachusetts System Of Public Supports For Low-Income Families, Jason Wright, Uchenna Nwangwu, Caitlin A. Carey, Susan Crandall

Center for Social Policy Publications

The goal of this reference guide is to provide background information on eligibility requirements for public assistance programs available to low-income families in the state of Massachusetts to demonstrate the inconsistencies and complexities that arise from those eligibility requirements. In order to better understand these complex systems, the policy levers are identified in the form of information about the associated legislation and government agencies for each public support program. This information can be used to develop more effective and efficient policies and better serve the needs of low-income families.