Digital Commons Network^™

Creating A Community Of Breastfeeding Support At Texas Woman's University, Becky Spencer, Amy O'Keefe, Angela Cagle

Creating Healthy Work Environments (CHWE)

In 2017 Texas Woman's University (TWU) formed a lactation committee comprised of students, staff, and faculty members to evaluate and develop breastfeeding support on campus. The purpose of this presentation is to present the work of the committee in creating a community of breastfeeding support at TWU.

The Many Benefits Of Urban Green Spaces, Junainah Abu Kasim, Mohd Johari Mohd Yusof, Helmi Zulhaidi Mohd Shafri

CSID Journal of Infrastructure Development

Recently, the ideology of greenery city has received global attention which aimed to address the issues of rapid urbanization, population growth and climate change. Urban green spaces (UGS) seem as the most essential asset that could help cities to mitigate the adverse effects of rapid urbanization and urban sprawl in a sustainable way. It plays a vital role in our cities as an urban lung, discharging oxygen to reduce the city’s heat, the wall for harmful air pollution and offer greatest benefits in term of environment, social and economy to a city. However, the presence of UGS as one of …

Optimizing Gastrointestinal Integrity In Poultry: The Role Of Nutrients And Feed Additives, Sunday A. Adedokun, Opeyemi C. Olojede

Animal and Food Sciences Faculty Publications

Immunomodulation of the immune system by stimulating or suppressing one or both arms, is an emerging concept driven by the understanding of the host defense system. In particular, the gastrointestinal tract (GIT) functions not only as a site for digestion and absorption of nutrients but also acts as a metabolic and immunological organ. This serves as a barrier against abnormal presentation of luminal constituents, caused by dysfunctional intestinal epithelial barrier, to the mucosal immune system. Invasion by pathogens in the case of disease or stress or a massive influx of commensal bacteria overcomes the defensive mechanisms, resulting in the full …

The Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University

Global Access To Antibiotics Without Prescription In Community Pharmacies: A Systematic Review And Meta-Analysis, Asa Auta, Muhammad A. Hadi, Enoche Oga, Emmanuel O. Adewuyi, Samirah N. Abdu-Aguye, Davies Adeloye, Barry Strickland-Hodge, Daniel J. Morgan

Research outputs 2014 to 2021

Objective To estimate the proportion of over-the-counter antibiotic requests or consultations that resulted in non-prescription supply of antibiotics in community pharmacies globally. Methods We systematically searched EMBASE, Medline and CINAHL databases for studies published from January 2000 to September 2017 reporting the frequency of non-prescription sale and supply of antibiotics in community pharmacies across the world. Additional articles were identified by checking reference lists and a Google Scholar search. A random effects meta-analysis was conducted to calculate pooled estimates of non-prescription supply of antibiotics. Results Of the 3302 articles identified, 38 studies from 24 countries met the inclusion criteria and …

Daptomycin Dosing In Obese Patients: Analysis Of The Use Of Adjusted Body Weight Versus Actual Body Weight, Ashley N. Fox, Winter J. Smith, Katherine E. Kupiec, Stephanie J. Harding, Beth H. Resman-Targoff, Stephen B. Neely, Bryan P. White, Ryan E. Owens

Pharmacy Faculty Publications and Presentations

Background: Food and Drug Administration-approved daptomycin dosing uses actual body weight, despite limited dosing information for obese patients. Studies report alterations in daptomycin pharmacokinetics and creatine phosphokinase elevations associated with higher weight-based doses required for obese patients. Limited information regarding clinical outcomes with alternative daptomycin dosing strategies in obesity exists. Objective: This study evaluates equivalency of clinical and safety outcomes in obese patients with daptomycin dosed on adjusted body weight versus a historical cohort using actual body weight. Methods: This retrospective, single center study compared equivalency of outcomes with two onesided tests in patients with body mass index >30 kg/m2 …

Candidemia Following Ureteric Stent Placement In A Patient With Type 2 Diabetes Treated With Canagliflozin, Rishi Raj, Jon Hendrie, Aasems Jacob, Derick Adams

Internal Medicine Faculty Publications

A 38-year-old female patient with well-controlled type 2 diabetes mellitus treated with canagliflozin underwent ureteral stent placement for obstructive renal calculi. Ten days following ureteroscopy and ureteral stenting, she developed fevers and blood cultures grew Candida glabrata (C. glabrata). The patient was successfully treated with an extended course of broad-spectrum antibiotics and antifungal agents. The clinical presentation of candidemia is indistinguishable from bacteremia resulting in delay in diagnosis and treatment. Candiduria is commonly seen in patients with type 2 diabetes, however it rarely leads to candidemia in an otherwise healthy person following a relatively simple urologic procedure. Sodium-glucose …

4-O-Methylhonokiol Influences Normal Cardiovascular Development In Medaka Embryo, Santu K. Singha, Ilias Muhammad, Mohamed Ali Ibrahim, Mei Wang, Nicole M. Ashpole, Zia Shariat-Madar

Faculty and Student Publications

© 2019 The Author(s). With an increasing number of antimicrobial stewardship-related articles published each year, attempting to stay current is challenging. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship-related peer-reviewed literature that detailed an actionable intervention for 2018. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training as well as to identify potential intervention opportunities within one's institution.

Knowledge And Awareness Of Human Papillomavirus Among College Students In South Carolina, Salima Kasymova, Sayward Harrison, Caroline Pascal

Faculty Publications

Despite the existence of a safe and effective vaccine, human papillomavirus (HPV) remains prevalent in the United States, with late adolescence and early adulthood being periods of increased risk. Thus, targeting college-aged individuals for HPV prevention and vaccination promotion is critical—particularly in regions such as the Deep South where vaccination rates remain low. This study sought to examine awareness and knowledge of HPV as well as experiences and attitudes regarding HPV vaccination among college students in the Deep South. Specifically, we completed a cross-sectional survey of 256 undergraduate students from a large public university in South Carolina. Although a majority …

Little Race Or Gender Bias In An Experiment Of Initial Review Of Nih R01 Grant Proposals, Patrick S. Forscher, William T.L. Cox, Markus Brauer, Patricia G. Devine

Psychological Science Faculty Publications and Presentations

Many granting agencies allow reviewers to know the identity of a proposal’s Principal Investigator (PI), which opens the possibility that reviewers discriminate on the basis of PI race and gender. We investigated this experimentally with 48 NIH R01 grant proposals, representing a broad spectrum of NIH-funded science. We modified PI names to create separate White male, White female, Black male, and Black female versions of each proposal, and 412 scientists each submitted initial reviews for three proposals. We find little to no race or gender bias in initial R01 evaluations, and additionally find that any bias that might have been …

Exploring Mortality Rates For Major Causes Of Death In Korea, Hyo Jung Oh, Donng Min Yang, Chong Hyuck Kim, Jae Gyu Jeon, Nam Hyung Jung, Chan Young Kim, Jurgen Symanzik, Hyo Won Oh, Akugizibwe Edwin, Seong Ii Jo, Jeong Yong Ahn

Mathematics and Statistics Faculty Publications

Background: The trends and patterns of the mortality rates for causes of death are meaningful information. They can provide a basis for national demographic and health care policies by identifying the number, causes, and geographical distribution of deaths.

Objective: To explore and analyze the characteristics of the mortality rates for major causes of death in Korea.

Methods: Some common data analysis methods were used to describe the data. We also used some visualization techniques such as heat maps and line plots to present mortality rates by gender, age, and year.

Results: Our analysis shows the crude …

Diabetes, Undernutrition, Migration And Indigenous Communities: Tuberculosis In Chiapas, Mexico, H. A. Rashak, H. J. Sánchez-Pérez, Bassent Abdelbary, A. Bencomo-Alerm, N. Enriquez-Ríos, A. Gómez-Velasco, A. Colorado, M. Castellanos-Joya, M. H. Rahbar, Blanca I. Restrepo

Physician Assistant Studies Faculty Publications

We investigated the distribution of comorbidities among adult tuberculosis (TB) patients in Chiapas, the poorest Mexican state, with a high presence of indigenous population, and a corridor for migrants from Latin America. Secondary analysis on 5508 new adult TB patients diagnosed between 2010 and 2014 revealed that the most prevalent comorbidities were diabetes mellitus (DM; 19.1%) and undernutrition (14.4%). The prevalence of DM in these TB patients was significantly higher among middle aged (41–64 years) compared with older adults (⩾65 years) (38.6% vs. 23.2%; P < 0.0001). The prevalence of undernutrition was lower among those with DM, and higher in communities with high indigenous presence. Immigrants only comprised 2% of all TB cases, but were more likely to have unfavourable TB treatment outcomes (treatment failure, death and default) when compared with those born in Chiapas (29.5% vs. 11.1%; P < 0.05). Unfavourable TB outcomes were also more prevalent among the TB patients with undernutrition, HIV or older age, but not DM (P < 0.05). Our study in Chiapas illustrates the challenges of other regions worldwide where social (e.g. indigenous origin, poverty, migration) and host factors (DM, undernutrition, HIV, older age) are associated with TB. Further understanding of these critical factors will guide local policy makers and health providers to improve TB management.

Biosynthetic And Synthetic Strategies For Assembling Capuramycin-Type Antituberculosis Antibiotics, Ashley L. Biecker, Xiaodong Liu, Jon S. Thorson, Zhaoyong Yang, Steven G. Van Lanen

Pharmaceutical Sciences Faculty Publications

Mycobacterium tuberculosis (Mtb) has recently surpassed HIV/AIDS as the leading cause of death by a single infectious agent. The standard therapeutic regimen against tuberculosis (TB) remains a long, expensive process involving a multidrug regimen, and the prominence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and totally drug-resistant (TDR) strains continues to impede treatment success. An underexplored class of natural products—the capuramycin-type nucleoside antibiotics—have been shown to have potent anti-TB activity by inhibiting bacterial translocase I, a ubiquitous and essential enzyme that functions in peptidoglycan biosynthesis. The present review discusses current literature concerning the biosynthesis and chemical synthesis of capuramycin …

$3.25 Million R01 Grant Will Explore The Long-Term Impact Of Diet, Exercise On Symptoms Of Adults With Hiv, Staff

Browse All News

No abstract provided.

Leading Researcher Returns To Discuss Origins Of Human Aids And Malaria At Uab's Darwin Day, Staff

Browse All News

No abstract provided.

Synthesis And Encapsulation Of A New Zinc Phthalocyanine Photosensitizer Into Polymeric Nanoparticles To Enhance Cell Uptake And Phototoxicity, Nahid Mehraban, Phillip R. Musich, Harold S. Freeman

ETSU Faculty Works

Efforts to enhance the utility of photodynamic therapy as a non-invasive method for treating certain cancers have often involved the design of dye sensitizers with increased singlet oxygen efficiency. More recently, however, sensitizers with greater selectivity for tumor cells than surrounding tissue have been targeted. The present study provides an approach to the modification of the known photosensitizer zinc phthalocyanine (ZnPc), to enhance its solubility and delivery to cancer cells. Targeting a photosensitizer to the site of action improves the efficacy of the sensitizer in photodynamic therapy. In this work we used PLGA-b-PEG to encapsulate a new zinc phthalocyanine derivative, …

Recurring Episodes Of Thermal Stress Shift The Balance From A Dominant Host-Specialist To A Background Host-Generalist Zooxanthella In The Threatened Pillar Coral, Dendrogyra Cylindrus, Cynthia Lewis, Karen L. Neely, Mauricio Rodriguez-Lanetty

Marine & Environmental Sciences Faculty Articles

Most scleractinian corals form obligate symbioses with photosynthetic dinoflagellates (family Symbiodiniaceae), which provide differential tolerances to their host. Previously, research has focused on the influence of symbiont composition and the dynamic processes of symbiont repopulation during single episodes of hyperthermal events, followed by years of less-stressful conditions. In contrast, this study characterized for the first time, the role of Symbiodiniaceae species changes in response to annually recurring hyperthermal events, a scenario soon expected to become the norm. Consecutive hyperthermal events during summer 2014 and 2015 along the Florida Reef Tract offered a unique opportunity to study bleaching susceptibility and recovery …

Elopre Named Director Of Diversity And Inclusion For Graduate Medical Education, Brit Blalock

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No abstract provided.

Effect Of Cooled Perches On Performance, Plumage Condition, And Foot Health Of Caged White Leghorn Hens Exposed To Cyclic Heat, J Y. Hu, P Y. Hester, M M. Makagon, Y Xiong, R S. Gates, H W. Cheng

Department of Animal Science: Faculty Publications

We examined the effects of water-chilled perches as cooling devices on hen performance during 2 summers using daily cyclic heat. White Leghorns, 17 wk of age, were assigned to 36 cages arranged into 6 banks. The banks were assigned to cooled perches, air perches, and no perches resulting in 2 replicate banks and 12 cages per treatment. Chilled water (10^◦C) was circulated through the cooled perches during heat episodes. Daily cyclic heat of 35^◦C was applied from 0600 to1800 h with a lowering of temperature to 28^◦C from 1800 to 0600 h during the …

Human Polyclonal Antibodies Produced From Transchromosomal Bovine Provides Prophylactic And Therapeutic Protections Against Zika Virus Infection In Stat2 Ko Syrian Hamsters, Venkatraman Siddharthan, Jinxin Miao, Arnaud J. Van Wettere, Rong Li, Hua Wu, Eddie Sullivan, Jinan Jiao, Jay W. Hooper, David Safronetz, John D. Morrey, Justin G. Julander, Zhongde Wang

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain–Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZIKV infection. Here, we report that ZIKV-specific human polyclonal antibodies (SAB-155), elicited in transchromosomal bovine (TcB), provide significant protection from infection by ZIKV in STAT2 knockout (KO) golden Syrian hamsters both prophylactically and therapeutically. These antibodies also prevent testicular lesions in this hamster model. Our data indicate that antibody-mediated immunotherapy is effective in treating ZIKV infection. Because suitable …

Upregulation Of The Wnk4 Signaling Pathway Inhibits Epithelial Sodium Channels Of Mouse Tracheal Epithelial Cells After Influenza A Infection, Yapeng Hou, Yong Cui, Zhiyu Zhou, Hongfei Liu, Hongfei Zhang, Yan Ding, Hongguang Nie, Hong-Long Ji

Cellular and Molecular Biology Faculty Publications and Presentations

Influenza virus has a significant impact on the respiratory system. The mechanism of how influenza virus impairs the fluid transport in airway is not fully understood. We examined its effects on epithelial sodium channels (ENaC), which are very important for water and salt transport in the respiratory system. We focused on the impacts of influenza virus on ENaC activity in mouse tracheal epithelial cells (MTECs) and applied Ussing chamber apparatus for recording the short-circuit currents in primary cultured MTECs. Expressions of α and γ-ENaC were measured at the protein and mRNA levels by western blot and quantitative real-time polymerase chain …

Faculty Senate Executive Committee Minutes, January 22, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Academic Freedom and Tenure
• Council on Teacher Education
• Greenhouse Gas Resolution
• USUSA Annual Report
• Professional Responsibilities and Procedures Committee
• Scholarship Advisory Board
• USUSA Recommendations

Faculty Senate Executive Committee Agenda, January 22, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – January 10, 2019
• Academic Freedom and Tenure Annual Report
• 405.7.2 – External Reviewers
• Greenhouse Gas Resolution
• 403.3.1 – Standards of Conduct – Faculty Responsibilities to Students
• 403.3.2 – Standards of Conduct – Professional Obligations
• 405.2.1 – 405.3.2 – 405.5.1 – 405.10.1 Community Engagement Inclusion
• 407.1.1 – Non Punitive Measure
• 407.11.2(2) - Notification of Faculty Member
• 407.11.3(2) – Protection of Complainant and Others

Medical School Watercooler Newsletter - January 20, 2019, Lindsey Lyle

Watercooler Newsletter

This is the January 20, 2019 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

New Members Elected into USA Chapter of GHHS

February Med School Café – “Personalized Medicine: The Future is Now”

USA Health Expands Obstetrics and Gynecology Care

Five USA Medical Students Match in Ophthalmology Residency Programs

Dr. Kristie Burch Joins University Urology

USA Health Welcomes Gary Mans as Associate Vice President for Marketing and Communications

USA Health Hosts Symposium on Pediatric Care

Laurie Wilson Named January Employee of the Month

Retracted: The Epidemiology Of Stroke In A Developing Country (Pakistan), M Ishaq Khan, Junaid I. Khan, Sheikh I. Ahmed, Sajjad Ali

Pakistan Journal of Neurological Sciences (PJNS)

Retraction Notice

Khan MI, Khan JI, Ahmed SI, Ali S. The epidemiology of stroke in a developing country (Pakistan).

Pak J Neurol Sci. 2018;13(3):30-44.

A reader brought to our attention that the article titled “The epidemiology of stroke in a developing country (Pakistan)”, published in Volume 13, Issue 3, of Pakistan Journal of Neurological Sciences (PJNS) was a redundant (duplicate) publication. We investigated this complaint and found out that prior to its submission to PJNS on February 11 2018, this article had already been published almost verbatim in Journal of Neurology & Stroke on January 23, 2018.

Reference of the …

Er Pilot Leads To Hospital-Wide Implementation Of Blood Culture Device, Karen Stonecypher, Jennifer Noble

General Submissions: Presentations (Oral and Poster)

Session G presented Friday, September 28, 1:00-2:00 pm Purpose: Blood culture (BC) collection plays a primary role in the diagnosis of infections. False-positive cultures can lead to unnecessary antibiotic treatment, untoward consequences, ELOS, and increased costs. The blood culture contamination (BCC) rate in the emergency room (ER) has remained greater than 3% despite repeated training on antisepsis techniques at the venipuncture site. The ENA Clinical Practice Guideline: Prevention of Blood Culture Contamination (2016) identified the Steripath (SP) blood culture collection device (Magnolia Medical Technologies) as an effective method for decreasing BCC. Skin fragments and skin-residing bacteria have been shown to …

Nursing Subject Matter Experts To Care For Emerging Infectious Diseases, Paula Justice, Jennifer Andonian

General Submissions: Presentations (Oral and Poster)

Session I presented Saturday, September 29, 10:00-11:00 am

Purpose: As our world becomes ever-more interconnected, the transmission of infectious diseases is happening quicker and more widely than ever before. Highly infectious diseases, such as Ebola, Middle East Respiratory Syndrome and multi-drug resistant tuberculosis have changed the way we screen patients for communicable disease, and how we maintain the well-being of our healthcare workforce. Emergency department nurses are the frontline staff that receive and treat patients with suspected exposures to these deadly diseases. Personal Protective Equipment (PPE) is designed to prevent patient to healthcare worker transmission, yet requires proper donning and …

Developing And Assessing The Feasibility Of A Home-Based Preexposure Prophylaxis Monitoring And Support Program, Aaron J Siegler, Kenneth H Mayer, Albert Y Liu, Rupa R Patel, Lauren M Ahlschlager, Colleen S Kraft, Rossi Fish, Sarah E Wiatrek, Patrick S Sullivan

2010-2019 OA Pubs

We piloted PrEP@Home, a preexposure prophylaxis system of remote laboratory and behavioral monitoring designed to replace routine quarterly follow-up visits with home care to reduce the patient and provider burden. The system was highly acceptable and in-demand for future use, and more than one-third of participants reported greater likelihood of persisting in care if available.

Non-Invasive Analysis Of The Sputum Transcriptome Discriminates Clinical Phenotypes Of Asthma, Xiting Yan

Yale Day of Data

Whole transcriptome wide gene expression profiles in the sputum and circulation from 100 asthma patients were measured using the Affymetrix HuGene 1.0ST arrays. Unsupervised clustering analysis based on pathways from KEGG were used to identify TEA clusters of patients from the sputum gene expression profiles. The identified TEA clusters have significantly different pre-bronchodilator FEV1, bronchodilator responsiveness, exhaled nitric oxide levels, history of hospitalization for asthma and history of intubation. Evaluation of TEA clusters in children from Asthma BRIDGE cohort confirmed the identified differences in intubation and hospitalization. Furthermore, evaluation of the TH2 gene signatures suggested a much lower prevalence of …

Microbiome And Immune Alterations In Young And Old Non-Human Primates And The Impact Of Siv Infection, Kyle Blaine Russell

Open Access Theses

Aging and chronic HIV infection are known to independently affect the immune system and the microbiome, but what effect both have together is unknown. To investigate this effect we infected young and old Rhesus Macaques with simian immunodeficiency virus (SIV) and started on antiretroviral therapy (ART) at 84 days post infection. Blood and fecal samples were collected at pre SIV infection and various timepoints post-SIV infection. PBMCs were used for flow cytometry analysis of immune cell subsets, serum was used to determine influenza antibody titers and metabolites, and fecal samples were used for microbiome analysis. Analysis of samples before SIV …