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2019

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Obesity Perception Survey Among Youth In Turkey: Instrument Development And Test-Retest Reliability, Wasantha Jayawardene, Sali̇h Pinar, Mohammad Torabi, Pengcheng Xun, Mustafa Kami̇l Özer Jan 2019

Obesity Perception Survey Among Youth In Turkey: Instrument Development And Test-Retest Reliability, Wasantha Jayawardene, Sali̇h Pinar, Mohammad Torabi, Pengcheng Xun, Mustafa Kami̇l Özer

Turkish Journal of Medical Sciences

Background/aim: We aimed to develop an instrument that can assess the perceptions and opinions of young people regarding the causes and consequences of obesity and the role of individuals, families, communities, and government in addressing obesity.Materials and methods: A 36-question (101-item) survey was developed by adopting, translating, and revising multiple-choice or Likert-scale questions from existing surveys to assure construct cross-cultural validity. A two-factor mixed-effects model estimated the intraclass correlation coefficient (ICC) to measure the test-retest reliability of questions administered 2 weeks apart to a convenient sample of İstanbul high school and university students, aged 15?25 years (n = 122).Results: The …

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Intensive Care Psychological Assessment Tool (Ipat): Turkish Validity And Reliability Study, Berker Duman, Zeynep Kotan, Vahap Ozan Kotan, Nevzat Mehmet Mutlu, Beyza Doğanay Erdoğan, Damla Sayar Akaslan, Safi̇ye Zeynep Tatli, Hakan Kumbasar Jan 2019

Intensive Care Psychological Assessment Tool (Ipat): Turkish Validity And Reliability Study, Berker Duman, Zeynep Kotan, Vahap Ozan Kotan, Nevzat Mehmet Mutlu, Beyza Doğanay Erdoğan, Damla Sayar Akaslan, Safi̇ye Zeynep Tatli, Hakan Kumbasar

Turkish Journal of Medical Sciences

Background/aim: It is of crucial importantance to be able to detect acute psychological distress in patients. The Intensive Care Psychological Assessment Tool (IPAT) was developed for this purpose in intensive care units. This study aims to evaluate the validity and reliability of the Turkish version of IPAT.Materials and methods: In total, 98 patients were included. To assess concurrent validity, the Intensive Care Experiences Scale (ICES) and the Hospital Anxiety Depression Scale were performed. Cronbach?s alpha coefficient was used to estimate internal consistency. Interitem and item-total score correlations were also performed. Sensitivity and specificity were derived for concurrent anxiety and depression.Results: …

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Validity And Reliability Study Of The Turkish Version Of The Hand20 Questionnaire, Nurten Gi̇zem Tore, Deran Oskay Jan 2019

Validity And Reliability Study Of The Turkish Version Of The Hand20 Questionnaire, Nurten Gi̇zem Tore, Deran Oskay

Turkish Journal of Medical Sciences

Background/aim: This study aimed to translate and validate the Turkish version of the Hand20 questionnaire.Materials and methods: Patients who had upper extremity involvement and stable symptoms for the previous 4 weeks in their upper extremities were included in the study. Patients who were illiterate or used a splint during the day were excluded from the study. Participants completed the Turkish version of the Disabilities of the Arm, Shoulder, and Hand (DASH-T) questionnaire once and the final version of the Hand20 questionnaire twice in a 7-day interval. Internal consistency and reliability of the questionnaire was assessed. Moreover, correlations between Hand20 and …

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Risk Factors For Community-Onset Urinary Tract Infections Caused By Extended-Spectrum Ss-Lactamase-Producing Escherichia Coli, Türkan Tüzün, Selda Sayin Kutlu, Murat Kutlu, İlknur Kaleli̇ Jan 2019

Risk Factors For Community-Onset Urinary Tract Infections Caused By Extended-Spectrum Ss-Lactamase-Producing Escherichia Coli, Türkan Tüzün, Selda Sayin Kutlu, Murat Kutlu, İlknur Kaleli̇

Turkish Journal of Medical Sciences

Background/aim: Community-onset urinary tract infections(UTIs) caused by extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli have increased in many parts of the world. This study aimed to determine the prevalence and risk factors for community-onset UTI caused by ESBL-producing E. coli.Materials and methods: This prospective cohort study was conducted between January 2012 and March 2014 in cases of community-onset UTI caused by E. coli. Patients with UTI due to ESBL-producing E. coli and patients with UTI due to non-ESBL-producing E. coliwere compared to identify risk factors for ESBL-producing E. coli in the community.Results: A total of 305 patients (116 males [46.4%]; mean age: …

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Additional Effects Of Erythropoietin Pretreatment, Ischemic Preconditioning, And N-Acetylcysteine Posttreatment In Rat Kidney Reperfusion Injury, Mohammed Elshiekh, Mehri Kadkhodaee, Behjat Seifi, Mina Ranjbaran Jan 2019

Additional Effects Of Erythropoietin Pretreatment, Ischemic Preconditioning, And N-Acetylcysteine Posttreatment In Rat Kidney Reperfusion Injury, Mohammed Elshiekh, Mehri Kadkhodaee, Behjat Seifi, Mina Ranjbaran

Turkish Journal of Medical Sciences

Background/aim: Since the nature of ischemia/reperfusion (IR)-induced tissue damage is multifactorial and complex, in the current study, the effects of multiple treatment strategies via concomitant administration of erythropoietin (EPO) and N-acetylcysteine (NAC) with an ischemic preconditioning (IPC) regimen on renal IR injury were examined.Materials and methods: Thirty male Wistar rats were subjected to bilateral occlusion of the renal pedicles for 50 min followed by reperfusion. EPO (1000 IU/kg) was administered for 3 days, as well as IPC before the IR and NAC (150 mg/kg) administration for 4 days after IR. The animals were randomly allocated into 6 groups (n = …

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Does Smoking Increase The Anesthetic Requirement?, Erdoğan Öztürk, Mustafa Sai̇d Aydoğan, Kazim Karaaslan, Zafer Doğan, Ufuk Topuz Jan 2019

Does Smoking Increase The Anesthetic Requirement?, Erdoğan Öztürk, Mustafa Sai̇d Aydoğan, Kazim Karaaslan, Zafer Doğan, Ufuk Topuz

Turkish Journal of Medical Sciences

Background/aim:To examine the effects of active and passive smoking on perioperative anesthetic and analgesic consumption. Materials and methods: Patients were divided into three groups: group S, smokers; group PS, passive smokers; and group NS, individuals who did not have a history of smoking and were not exposed to smoke. All patients underwent the standard total intravenous anesthesia method. The primary endpoint of this study was determination of the total amount of propofol and remifentanil consumed. Results: The amount of propofol used in induction of anesthesia was significantly higher in group S compared to groups PS and NS. Moreover, the total …

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Profiling Of 17 Y-Str Loci In Mazandaran And Gilan Provinces Of Iran, Minoo Sayyari, Ali Salehzadeh, Mohamad Amin Tabatabaiefar, Ali Abbasi Jan 2019

Profiling Of 17 Y-Str Loci In Mazandaran And Gilan Provinces Of Iran, Minoo Sayyari, Ali Salehzadeh, Mohamad Amin Tabatabaiefar, Ali Abbasi

Turkish Journal of Medical Sciences

Background/aim: TheY-chromosome mainly consists of heterochromatin regions that have a father-to-son inheritance. Short tandem repeat polymorphic (STRP) markers distributed all over the chromosome provide the opportunity for investigations in forensic medicine and ancestral lineage studies. Due to the existence of wide varieties of geographical and ethnic groups in Iran, studying Y-STRP markers is necessary for further applications. Here we investigated the provinces of Mazandaran and Gilan for the first time. Materials and methods: Samples included 119 and 90 unrelated males from Mazandaran and Gilan, respectively. Using a PCR amplification kit, 17 Y-STRP markers were amplified and genotyping was conducted by …

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Relationship Between Headache And Internet Addiction In Children, İlknur Böyükbaş Tepeci̇k, Ayşegül Neşe Çitak Kurt, Selma Tural Hesapçioğlu, Mehmet Uğurlu Jan 2019

Relationship Between Headache And Internet Addiction In Children, İlknur Böyükbaş Tepeci̇k, Ayşegül Neşe Çitak Kurt, Selma Tural Hesapçioğlu, Mehmet Uğurlu

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate Internet addiction in pediatric patients with migraine- and tension-type headache in this study. Materials and methods: Among our 200 subjects, 103 had migraine-type headache and 97 had tension-type headache. Results: Headache triggered by computer use was more common in the migraine-type headache group. There was no difference between the Internet addiction scale score of the two groups. The Internet addiction scale scores of the patients were found to differ depending on the aim and duration of computer use. Internet addiction was found in six (6%) patients. Internet addiction prevalence was 3.7% and 8.5% in the …

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Capillaroscopic Findings In Turkish Takayasu Arteritis Patients, Ali̇ Akdoğan, Abdulsamet Erden, Esra Firat Şentürk, Levent Kiliç, Alper Sari, Berkan Armağan, Ömer Karadağ, Sedat Ki̇raz Jan 2019

Capillaroscopic Findings In Turkish Takayasu Arteritis Patients, Ali̇ Akdoğan, Abdulsamet Erden, Esra Firat Şentürk, Levent Kiliç, Alper Sari, Berkan Armağan, Ömer Karadağ, Sedat Ki̇raz

Turkish Journal of Medical Sciences

Background/aim: Abnormal capillaroscopic findings have been reported in vasculitic syndromes such as Behçet's disease, Henoch-Schönlein purpura, and Wegener's granulomatosis. This study was conducted to define the capillaroscopic changes in patients with Takayasu arteritis (TA). Materials and methods: We studied 28 TA patients (27 females). The nail folds from the 2nd to 5th fingers on both hands were examined with video capillaroscopy for all. A patient was defined as having an abnormal capillaroscopic examination if more than 1 morphologic abnormality was present in at least 2 nail folds. Results: The median capillary density of TA patients was 9 (range: 9-11). There …

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Review Of The Effect Of 3d Medical Printing And Virtual Reality On Urology Training With `Medtrain3dmodsim' Erasmus + European Union Project, İlkan Tatar, Emre Huri̇, İlker Selçuk, Young Lee Moon, Alberto Paoluzzi, Andreas Skolarikos Jan 2019

Review Of The Effect Of 3d Medical Printing And Virtual Reality On Urology Training With `Medtrain3dmodsim' Erasmus + European Union Project, İlkan Tatar, Emre Huri̇, İlker Selçuk, Young Lee Moon, Alberto Paoluzzi, Andreas Skolarikos

Turkish Journal of Medical Sciences

Background/aim: It is necessary to incorporate novel training modalities in medical education, especially in surgical fields, because of the limitations of cadaveric training. Traditional medical education has many drawbacks, such as residency working hour restrictions, patient safety conflicts with the learning needs, and the lack of hands-on workshops. The MedTRain3DModsim Project aimed to produce 3-dimensional (3D) medical printed models, simulations, and innovative applications for every level of medical training using novel worldwide technologies. It was aimed herein to improve the interdisciplinary and transnational approaches, and accumulate existing experience for medical education, postgraduate studies, and specialty training. Materials and methods: This …

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The Combination Of Fatty Liver And Increased Gamma-Glutamyl Transpeptidase Levels As A Risk Factor For Atherosclerotic Plaque Development In Apparently Healthy People, Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi Jan 2019

The Combination Of Fatty Liver And Increased Gamma-Glutamyl Transpeptidase Levels As A Risk Factor For Atherosclerotic Plaque Development In Apparently Healthy People, Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi

Turkish Journal of Medical Sciences

Background/aim: To elucidate how the combination of fatty liver and increased serum gamma-glutamyl transpeptidase (GGT) levels influences atherosclerotic plaque development in apparently healthy people.Materials and methods: The study population included people who had received an annual health checkup for more than 7 years and had no evidence of carotid plaque at baseline. We investigated the risk factors for carotid plaque occurrence using the Cox proportional hazards model.Results: A total of 107 people (76 men and 31 women; median age, 49 years) were enrolled. At baseline, fatty liver and a serum GGT level ≥50 U/L were observed in 13 and 38 …

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Comparison Of Atrial Fibrillation Predictors In Patients With Acute Coronary Syndrome Using Ticagrelor Or Clopidogrel, Engi̇n Algül, Hamza Sunman, Muhammet Dural, İlki̇n Guli̇yev, Mert Aker, Mehmet Ali̇ Felekoğlu, Mehmet Erat, Murat Tulmaç, Sadik Açikel, Tolga Çi̇men Jan 2019

Comparison Of Atrial Fibrillation Predictors In Patients With Acute Coronary Syndrome Using Ticagrelor Or Clopidogrel, Engi̇n Algül, Hamza Sunman, Muhammet Dural, İlki̇n Guli̇yev, Mert Aker, Mehmet Ali̇ Felekoğlu, Mehmet Erat, Murat Tulmaç, Sadik Açikel, Tolga Çi̇men

Turkish Journal of Medical Sciences

Background/aim: Ticagrelor is a drug widely used in patients with acute coronary syndromes (ACS) that specifically increases the plasma level of adenosine, which is likely to cause atrial fibrillation (AF). Therefore, in this study we aimed to investigate the electrocardiographic and echocardiographic predictors of AF development after P2Y12 receptor antagonists in ACS patients.Materials and methods: This cross-sectional study included 831 patients with ACS (486 [58.5%] with ST elevated myocardial infarction [STEMI] and 345 [41.5%] with non-ST elevated myocardial infarction [NSTEMI]). Patients were divided into ticagrelor (n = 410) and clopidogrel (n = 421) groups. P wave properties including P wave …

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The Relationship Between Serum Nt-Probnp Levels And Severity Of Coronary Artery Disease Assessed By Syntax Score In Patients With Acute Myocardial Infarction, Taner Sarak, Muhammed Karadeni̇z Jan 2019

The Relationship Between Serum Nt-Probnp Levels And Severity Of Coronary Artery Disease Assessed By Syntax Score In Patients With Acute Myocardial Infarction, Taner Sarak, Muhammed Karadeni̇z

Turkish Journal of Medical Sciences

Background/aim: In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is a measure of the complexity of coronary artery disease. Materials and methods: We enrolled 405 consecutive patients with myocardial infarction who underwent coronary angiographic examination. Patients were divided into 3 groups according to their SYNTAX scores. Those with SYNTAX score ≤22 were included in the low SYNTAX score group (LSTX), those with a score of 23-32 were included in the intermediate SYNTAX score group (ISTX), and those with a score of ≥33 were included in the high SYNTAX score group (HSTX). Results: …

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Prognostic Value Of Blood Gas Parameters And End-Tidal Carbon Dioxide Values In Out-Of-Hospital Cardiopulmonary Arrest Patients, Ayça Çalbay, Zeynep Çakir, Atif Bayramoğlu Jan 2019

Prognostic Value Of Blood Gas Parameters And End-Tidal Carbon Dioxide Values In Out-Of-Hospital Cardiopulmonary Arrest Patients, Ayça Çalbay, Zeynep Çakir, Atif Bayramoğlu

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the usefulness of blood gas and end-tidal carbon dioxide (EtCO2) measurements for predicting return of spontaneous circulation (ROSC) and for evaluating post-ROSC neurological survival.Materials and methods: This was a prospective case control study utilizing Atatürk University's database of adult nontraumatic patients (over 18 years old) with out-of-hospital cardiac arrest (OHCA) over the course of a year. The neurological status of the patients was evaluated after 1 h at ROSC and at hospital discharge, as defined by the cerebral performance category score. The blood gas parameters pH, PO2, PCO2, lactate, and BE were compared with …

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Stage 1 Hybrid Palliation Of Hypoplastic Left Heart Syndrome: An Initial Experience In Pulmonary Trunk Approach, Procedural Modifications, And Complication Management, Emrah Akay, Onur Işik, Ayşen Yaprak Engi̇n, Volkan Çakir Jan 2019

Stage 1 Hybrid Palliation Of Hypoplastic Left Heart Syndrome: An Initial Experience In Pulmonary Trunk Approach, Procedural Modifications, And Complication Management, Emrah Akay, Onur Işik, Ayşen Yaprak Engi̇n, Volkan Çakir

Turkish Journal of Medical Sciences

Background/aim: Hypoplastic left heart syndrome (HLHS) is a rare pathology with a very high mortality rate. The present study aimed to share our initial experience with the ductus arteriosus stenting procedure using the pulmonary trunk approach in the treatment of HLHS, as well as provide some technical suggestions and discuss complications and their management.Materials and methods: The medical records of 9 neonates (age range: 1-8 days) with HLHS, who were operated on within a 12-month period, were reviewed retrospectively. Preprocedural planning was performed by computed tomography angiography and echocardiography. The operations were performed in a hybrid surgery room by interventional …

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Plasma Thrombin-Activatable Fibrinolysis Inhibitor (Tafi) Antigen Levels In Acromegaly Patients In Remission, Mehmet Erdoğan, Mustafa Özbek, Erdem Akbal, Kemal Üreten Jan 2019

Plasma Thrombin-Activatable Fibrinolysis Inhibitor (Tafi) Antigen Levels In Acromegaly Patients In Remission, Mehmet Erdoğan, Mustafa Özbek, Erdem Akbal, Kemal Üreten

Turkish Journal of Medical Sciences

Background/aim: Acromegaly is associated with increased morbidity andmortality, mostly due to cardiovascular complications.Plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels are associated with coagulation/fibrinolysis and inflammation. Plasma TAFI may play a role in arterial thrombosis in cardiovascular diseases. In this study, it was aimed to evaluate the thrombin-activatable fibrinolysis inhibitor (TAFI) antigen and homocysteine levels in patients with acromegaly and healthy control subjects.Materials and methods: Plasma TAFI antigen and homocysteine levels in 29 consecutive patients with acromegaly and 26 age-matched healthy control subjects were measured. All patients included in the study were in remission. The TAFIa/ai antigen in the plasma samples …

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Timely Identification Of Atypical Acute Aortic Dissection In The Emergency Department:A Study From A Tertiary Hospital, Youjin Jiang, Zhengfang Zhang, Zhiming Gu, Hengdi Zou, Wenhui Fan, Xiaojun Chen, Hongyou Wang Jan 2019

Timely Identification Of Atypical Acute Aortic Dissection In The Emergency Department:A Study From A Tertiary Hospital, Youjin Jiang, Zhengfang Zhang, Zhiming Gu, Hengdi Zou, Wenhui Fan, Xiaojun Chen, Hongyou Wang

Turkish Journal of Medical Sciences

Background/aim: Acute aortic dissection (AAD) is a rare but fatal disease if left untreated. Symptoms are often similar to common conditions; therefore, the diagnostic strategy is important. We aimed to identify the atypical symptoms in a timely manner without putting patients at greater risk for undetected AAD.Materials and methods: We conducted a retrospective observational study of 59 AAD patients with both atypical and typical symptoms from January 2012 to December 2016. Patients with atypical symptoms continuing more than 30 min underwent a D-dimer test and computed tomography (CT) or computed tomographic angiography (CTA).Results: Of the 59 AAD patients, 22 were …

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Is The Version Angle Of The Glenoid Different In Bone And Cartilage? An Mri Study, Alper Deveci̇, Yahya Can Dura, Deni̇z Sözmen Ciliz, Güzelali̇ Özdemi̇r, Enver Kiliç, Erman Ceyhan, Burak Kulakoğlu, Sualp Turan Jan 2019

Is The Version Angle Of The Glenoid Different In Bone And Cartilage? An Mri Study, Alper Deveci̇, Yahya Can Dura, Deni̇z Sözmen Ciliz, Güzelali̇ Özdemi̇r, Enver Kiliç, Erman Ceyhan, Burak Kulakoğlu, Sualp Turan

Turkish Journal of Medical Sciences

Background/aim: To determine whether or not there is a difference between the version of the bone and cartilage surfaces of the glenoid. Axial magnetic resonance imaging (MRI) slices were examined in order to evaluate the measurements taken based on both the cartilage and bone joint surfaces.Materials and methods: A retrospective evaluation was made of the MRI scans of 182 patients. All of the reviewers independently measured the glenoid version angles of all of the patients from 1-182. The process was then repeated, with each reviewer taking second measurements of the angles from 1-182. Pearson correlation coefficient analysis was applied to …

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Il-1rn Vntr, Il-2(-330), And Il-4 Vntr Gene Polymorphisms In Patients With Chronic Rhinosinusitis With Sinonasal Polyposis, Gökhan Kuran, Hüseyi̇n Aslan, Süheyl Haytoğlu, Özge Özalp Yüreği̇r, Sevcan Tuğ Bozdoğan Jan 2019

Il-1rn Vntr, Il-2(-330), And Il-4 Vntr Gene Polymorphisms In Patients With Chronic Rhinosinusitis With Sinonasal Polyposis, Gökhan Kuran, Hüseyi̇n Aslan, Süheyl Haytoğlu, Özge Özalp Yüreği̇r, Sevcan Tuğ Bozdoğan

Turkish Journal of Medical Sciences

Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmental factors. In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease. Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, were analyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction.Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036, respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between …

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Canal Wall Down Versus Canal Wall Up Surgeries In The Treatment Of Middle Ear Cholesteatoma, Recep Karamert, Faki̇h Ci̇hat Eravci, Süleyman Cebeci̇, Mehmet Düzlü, Mehmet Ekrem Zorlu, Nagi̇han Gülhan Yaşar, Hakan Tutar, Mehmet Bi̇rol Uğur, Ayşe İri̇z, Yildirim Ahmet Bayazit Jan 2019

Canal Wall Down Versus Canal Wall Up Surgeries In The Treatment Of Middle Ear Cholesteatoma, Recep Karamert, Faki̇h Ci̇hat Eravci, Süleyman Cebeci̇, Mehmet Düzlü, Mehmet Ekrem Zorlu, Nagi̇han Gülhan Yaşar, Hakan Tutar, Mehmet Bi̇rol Uğur, Ayşe İri̇z, Yildirim Ahmet Bayazit

Turkish Journal of Medical Sciences

Background/aim: To compare outcomes of canal wall up (CWU) and canal wall down (CWD) techniques in the treatment of middle ear cholesteatoma.Materials and methods: Medical records of 76 patients who had a primary surgery due to middle ear cholesteatoma between July 2015 and November 2017 were reviewed retrospectively. Hearing thresholds, speech discrimination scores (SDS), recurrences, and revision surgeries of CWU and CWD surgeries were compared. Results: Of 76 cholesteatoma cases, 40 (52.6%) had a CWU and 36 (47.4%) had a CWD operation. Postoperatively, the mean air conduction thresholds were significantly better in CWU compared to CWD surgeries (P = 0.016). …

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Effect Of Variation In Mirna-Binding Site (Rs8176318) Of The Brca1 Gene In Breast Cancer Patients, Mushtaq Ahmad, Fazal Jalil, Muti Ul Haq, Aftab Shah Jan 2019

Effect Of Variation In Mirna-Binding Site (Rs8176318) Of The Brca1 Gene In Breast Cancer Patients, Mushtaq Ahmad, Fazal Jalil, Muti Ul Haq, Aftab Shah

Turkish Journal of Medical Sciences

Background/aim: A variation in the 3 prime untranslated regions (3?-UTRs) affects the binding of microRNA (miRNA) to the breast cancer (BC) susceptibility gene 1 (BRCA1) gene, and thus regulate its expression. In this study, the consequences of a variation in the miRNA-binding site (rs8176318G>T) in the 3?-UTRs of BRCA1 and its association with the risk of BC were investigated.Materials and methods: The selected variation (rs8176318G>T) was genotyped in BC patients (n = 300) and healthy controls (n = 300) using allele-specific polymerase chain reaction (PCR) [tetra-primer amplification refractory mutation system-PCR (T-ARMS-PCR)]. The results of the T-ARMS-PCR were further …

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The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin Jan 2019

The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin

Turkish Journal of Medical Sciences

Background/aim: This study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearing function by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease (CPOD).Materials and methods: The study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD, according to spirometry and PaO2 values, and who did not show pathology upon autoscopic examination. The control group consisted of 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group. Results: …

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Comparison Of Ultrasound-Guided Transversus Abdominis Plane Block, Quadratus Lumborum Block, And Caudal Epidural Block For Perioperative Analgesia In Pediatric Lower Abdominal Surgery, Celal Bulut İpek, Deni̇z Kara, Si̇nan Yilmaz, Serdar Yeşi̇ltaş, Asim Esen, Shai̇naaz Dooply Su Sander Lwi̇n, Kazi̇m Karaaslan, Ayda Türköz Jan 2019

Comparison Of Ultrasound-Guided Transversus Abdominis Plane Block, Quadratus Lumborum Block, And Caudal Epidural Block For Perioperative Analgesia In Pediatric Lower Abdominal Surgery, Celal Bulut İpek, Deni̇z Kara, Si̇nan Yilmaz, Serdar Yeşi̇ltaş, Asim Esen, Shai̇naaz Dooply Su Sander Lwi̇n, Kazi̇m Karaaslan, Ayda Türköz

Turkish Journal of Medical Sciences

Background/aim: Despite different regional anesthesia techniques used to provide intraoperative and postoperative analgesia in pediatric patients, the analgesic effectiveness of peripheral nerve blockades with minimal side effect profiles have not yet been fully determined.We aimed to compare the efficacy of ultrasound-guided transversus abdominis plane (TAP) block, quadratus lumborum (QL) block, and caudal epidural block on perioperative analgesia in pediatric patients aged between 6 months and 14 years who underwent elective unilateral lower abdominal wall surgery.Materials and methods: Ninety-four patients classified under the American Society of Anesthesiologists physical status classification system as ASA I or ASA II were randomly divided into …

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Normative Hippocampal Volumetric Measurements Using Magnetic Resonance Imaging, Meltem Özdemi̇r, Handan Soysal, Önder Eraslan, Alper Di̇lli̇ Jan 2019

Normative Hippocampal Volumetric Measurements Using Magnetic Resonance Imaging, Meltem Özdemi̇r, Handan Soysal, Önder Eraslan, Alper Di̇lli̇

Turkish Journal of Medical Sciences

Background/aim: A wide variety of neurological and psychiatric disorders have been shown to be closely related to changes in hippocampal volume (HV). It appears that hippocampal volumetry will be an indispensable part of clinical practice for a number of neuropsychiatric disorders in the near future. The aim of this study was to establish a normative data set for HV according to age and sex in the general population.Materials and methods: Hippocampal magnetic resonance imaging scans of 302 healthy volunteers were obtained using a 1.5 T unit with a 20-channel head coil. The hippocampal volumetric assessment was conducted using the volBrain …

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Evaluation Of Interleukin-23 Receptor (Il-23r) Gene Polymorphisms And Serum Il-23 Levels In Patients With Psoriasis, Başak Fi̇li̇z, Mehmet Yildirim, Kuyaş Heki̇mler Öztürk, Fevzi̇ye Burcu Şi̇ri̇n, Seda Çeli̇k, İjlal Erturan, Selma Korkmaz, Hi̇kmet Orhan Jan 2019

Evaluation Of Interleukin-23 Receptor (Il-23r) Gene Polymorphisms And Serum Il-23 Levels In Patients With Psoriasis, Başak Fi̇li̇z, Mehmet Yildirim, Kuyaş Heki̇mler Öztürk, Fevzi̇ye Burcu Şi̇ri̇n, Seda Çeli̇k, İjlal Erturan, Selma Korkmaz, Hi̇kmet Orhan

Turkish Journal of Medical Sciences

Background/aim: IL-23R gene polymorphisms and the association of these polymorphisms with serum IL-23 levels were investigated in patients with psoriasis in the current study. Materials and methods: Sixty-seven patients with psoriasis who were admitted to our dermatology outpatient clinic and 67 healthy controls were included in the study. Polymorphisms of the IL-23R gene were determined by KASP-PCR method, and serum IL-23 levels were determined by ELISA method.Results: The distribution of IL-23R gene polymorphisms rs2201841, rs11209026, rs7530511, rs1343152, and rs11465804 was not significantly different in the patient and control groups. The AA genotype of the rs2201841 locus in males and the …

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Pyogenic Granuloma And Nodular Kaposi?S Sarcoma: Dermoscopic Clues For The Differential Diagnosis, Ömer Faruk Elmas, Necmetti̇n Akdeni̇z, Emi̇ne Müge Acar, Asuman Ki̇li̇tçi̇ Jan 2019

Pyogenic Granuloma And Nodular Kaposi?S Sarcoma: Dermoscopic Clues For The Differential Diagnosis, Ömer Faruk Elmas, Necmetti̇n Akdeni̇z, Emi̇ne Müge Acar, Asuman Ki̇li̇tçi̇

Turkish Journal of Medical Sciences

Background/aim: Pyogenic granuloma (PG)-like nodular Kaposi?s sarcoma (KS) has been previously demonstrated in several studies. However, to the best of our knowledge, no original study investigating the dermoscopic differential diagnosis of PG and KS exists in the relevant literature. In this study we aimed to identify dermoscopic findings providing useful clues to differential diagnosis between the two entities.Materials and methods: Patients with histopathologically confirmed PG or nodular KS were included in the study. Demographic, clinical, dermoscopic, and histopathological findings of the cases were retrospectively reviewed. Results: The most common finding observed in PG was red structureless areas (80.00%), followed by …

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Importance Of 14-3-3eta, Anti-Carp, And Anti-Sa In The Diagnosis Of Seronegative Rheumatoid Arthritis, Emrah Salman, Sali̇h Çeti̇ner, Bariş Boral, Fi̇li̇z Ki̇bar, Eren Erken, Emi̇ne Duygu Ersözlü, Suade Özlem Badak, Reyhan Bi̇li̇ci̇ Salman, Yaşar Sertdemi̇r, Alev Çeti̇n Duran, Akgün Yaman Jan 2019

Importance Of 14-3-3eta, Anti-Carp, And Anti-Sa In The Diagnosis Of Seronegative Rheumatoid Arthritis, Emrah Salman, Sali̇h Çeti̇ner, Bariş Boral, Fi̇li̇z Ki̇bar, Eren Erken, Emi̇ne Duygu Ersözlü, Suade Özlem Badak, Reyhan Bi̇li̇ci̇ Salman, Yaşar Sertdemi̇r, Alev Çeti̇n Duran, Akgün Yaman

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation. The study aimed to assess serum 14-3-3eta, anti-CarP, and anti-Sa in seronegative RA (SNRA) patients who were treatment-naïve as well as in healthy subjects. This is the first study in the literature to examine these autoantibodies together in SNRA patients. Materials and methods: Forty-five treatment-naïve SNRA patients and 45 healthy subjects were recruited. Drugs change the levels of autoantibodies; therefore, patients who took any medication had been excluded from our study. Anti-carbamylated protein, anti-Sa, and 14-3-3eta were measured by using three different ELISA kits.Results: Median serum concentration of …

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Comparison Of 2-Year Clinical And Radiological Outcomes Between Volar Plating And External Fixation With Additional K-Wires For Ao Type C Distal Radius Fractures, Özgür Çi̇çekli̇, Erhan Şükür, Alauddi̇n Kochai̇, Levent Bayam, İzzet Bi̇ngöl, Uğur Özdemi̇r Jan 2019

Comparison Of 2-Year Clinical And Radiological Outcomes Between Volar Plating And External Fixation With Additional K-Wires For Ao Type C Distal Radius Fractures, Özgür Çi̇çekli̇, Erhan Şükür, Alauddi̇n Kochai̇, Levent Bayam, İzzet Bi̇ngöl, Uğur Özdemi̇r

Turkish Journal of Medical Sciences

Background/aim: Surgical treatment of distal intraarticular radius fractures remains controversial. Our aim was to compare the clinical and radiological outcomes between volar plating (VP) and external fixation (EF) for distal intraarticular radius fractures two years postoperatively. Materials and methods: This retrospective study included 59 patients with 62 intraarticular AO Type C distal radius fractures. We distinguished two groups: patients treated with internal fixation (volar locking plate, VP group: 41 fractures), and patients treated with an external fixator and K-wires (EF group: 21 fractures). The clinical assessment included range of motion, grip strength, disability of the arm, shoulder, and hand (DASH), …

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Quantitative Analysis Of The Optic Nerve Head Parameters In Patients With Age-Related Macular Degeneration, Mert Şi̇mşek, Mehmet Çitirik, Serdar Özateş, Tülay Şi̇mşek Jan 2019

Quantitative Analysis Of The Optic Nerve Head Parameters In Patients With Age-Related Macular Degeneration, Mert Şi̇mşek, Mehmet Çitirik, Serdar Özateş, Tülay Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: To evaluate the topographic parameters of the optic disc of patients with age-related macular degeneration (AMD) by performing confocal scanning laser ophthalmoscopy.Materials and methods: This prospective study included 41 eyes of 41 patients with neovascular AMD, 56 eyes of 56 patients with nonneovascular AMD, and 48 eyes of 48 healthy control subjects. Images of the optic nerve head of all of the participants were obtained using Heidelberg retinal tomography III software 3.1. The following stereometric parameters were measured for each participant: disc area, cup area, rim area, cup volume, rim volume, cup-to-disc ratio, mean cup depth, maximum cup depth, …

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The Frequency Of Raynaud?S Phenomenon In Patients With Methylenetetrahydrofolate Reductase Gene Mutation And Hyperhomocysteinemia, Kadi̇r Serkan Yalçin, Ali̇ Koşar Jan 2019

The Frequency Of Raynaud?S Phenomenon In Patients With Methylenetetrahydrofolate Reductase Gene Mutation And Hyperhomocysteinemia, Kadi̇r Serkan Yalçin, Ali̇ Koşar

Turkish Journal of Medical Sciences

Background/aim: Raynaud?s phenomenon (RP) is not a rare health problem; global prevalence is about 3%?20%. Etiology and pathophysiology of this pathology has not been clarified. There are many precipitating factors resulting in RP. Hyperhomocysteinemia resulting from methylenetetrahydrofolate reductase (MTHFR) gene mutationmay have a role in its etiology. The aim of this study was to observe the frequency of RP in patients with MTFHR gene mutation and hyperhomocysteinemia. Possible relationships among vitamin B12, folic acid, complete blood count (leukocytes and platelets), and c-reactive protein levels and RP were also analyzed. Materials and methods: A total of 388 patients admitted to the …

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