Digital Commons Network^™

Electric Load Forecasting Using Long Short-Term Memory Algorithm, Tianshu Yang

Theses and Dissertations

Abstract

Power system load forecasting refers to the study or uses a mathematical method to process

past and future loads systematically, taking into account important system operating

characteristics, capacity expansion decisions, natural conditions, and social impacts, to

meet specific accuracy requirements. Dependence of this, determine the load value at a

specific moment in the future. Improving the level of load forecasting technology is

conducive to the planned power management, which is conducive to rationally arranging

the grid operation mode and unit maintenance plan, and is conducive to formulating

reasonable power supply construction plans and facilitating power improvement, and

improve the …

Cellular Mechanisms By Which Alcohol Promotes Hiv Protease Inhibitor-Induced Hepatotoxicity, Michael Hinton

Theses and Dissertations

CELLULAR MECHANISMS BY WHICH ALCOHOL PROMOTES HIV PROTEASE INHIBITOR-INDUCED HEPATOTOXICITY

Michael Hinton, B.S.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University

Virginia Commonwealth University, 2019

Major Director: Huiping Zhou

Professor, Department of Microbiology and Immunology

The development of highly-active-antiretroviral therapy(HAART) has allowed management of HIV and extended the lives of those infected. Alcohol abuse, which is very common in HIV-1 infected patients, is one of the most important co-morbid risk factors for liver injury and has been associated with the occurrence of serious metabolic syndrome and subsequent discontinuation …

Characterization Of The Roles Of Ppp1r15a (Gadd34) And Ppp1r15b (Crep) In Er Stress-Induced Apoptosis In Vivo, Danielle Hicks

University of the Pacific Theses and Dissertations

Failure to balance synthesis, folding and degradation of secreted proteins results in the accumulation of unfolded proteins in the endoplasmic reticulum, termed ER stress. Cells respond to ER stress by activating a signaling pathway known as the unfolded protein response (UPR). The UPR induces phosphorylation of eIF2α to attenuate global protein translation, allowing the ER to clear misfolded proteins. Opposing this function, eIF2α phosphatases contain a catalytic subunit, Protein Phosphatase 1, and either of two homologous scaffolding subunits, GADD34 and CReP. Inhibition of eIF2α phosphatases has been shown to prolong UPR signaling and promote survival in many cells types and …

Attention Deficit Hyperactivity Disorder And Psychopathy In The General Adult Population, Kathryn Richelle Wilson

Walden Dissertations and Doctoral Studies

Attention deficit hyperactivity disorder (ADHD) is one of the fastest growing mental disorders in the United States. More children are being diagnosed than ever before, and many of these individuals are finding that at least one other emotional, behavioral, or mental disorder often accompanies ADHD (including psychopathy). The number of individuals in the prison population with both ADHD and psychopathy is on the rise. Because of these increases, including what is being seen in the prison population, this study aimed to identify if there was a relationship between ADHD and psychopathy in the general population, and if there were specific …

Body Cameras Effectiveness In A Large Police Department In The Southeast, Jason D. Armstrong

Walden Dissertations and Doctoral Studies

Several recent high profile incidents involving law enforcement officers have resulted in the death of a citizen. In some of these cases, the use of deadly force by police was ruled as justified only to learn later that one or more officers were not truthful about what occurred. These incidents have called into question law enforcement's legitimacy and created a demand for greater transparency by equipping officers with body-worn cameras. Body cameras can act as independent, reliable witnesses with no bias or agenda. Federal, state, and local governments have pledged millions of taxpayer dollars to implement body-worn camera programs in …

Corporate Environmental Strategies For Balancing Profitability With Environmental Stewardship, Stephen I. Carmer

Walden Dissertations and Doctoral Studies

In the United States, citizens concerned with climate change and income inequity scrutinize the activities of corporations. Sustainability and corporate social responsibility (CSR) have a critical role in business management, because stakeholders demand transparency in a company's operations. This correlation study, grounded in stakeholder theory, examined the relationship between environmental initiatives, CSR, and net profit for U.S. corporations. Participants included 96 companies with listing on either National Association of Securities Dealers Automated Quotations, or the New York Stock Exchange, or both, with and without evidence of CSR and environmental disclosures. The multiple regression analysis significantly predicted higher net profit for …

Measuring Regulatory And Noncompliance Prevalence Among Maryland Commercial Blue Crab Fishers, Jacquelyn Lee Rachor Hornsby

Walden Dissertations and Doctoral Studies

Few empirical studies exist that compare regulation (R) and fishing crime (VL). The lack of information about R and VL effects stakeholder decision-making. Crime weakens conservation efforts and creates false baseline data. This furthers R and the cycle repeats. The purpose of this correlational study was to determine the statistical association between the number and type of annual commercial blue crab R and VL of the same. The Pearson's R correlation was used to analyze the data because it demonstrated the strength of each relationship. This quantitative study was grounded in enforcement theory. The data was public record and consisted …

Predicting Maritime Pilot Selection With Personality Traits, Tara Brook Barca

Walden Dissertations and Doctoral Studies

Maritime pilots provide a vital service in facilitating the safe and efficient passage of vessels into and out of ports and waterways worldwide. Lack of effective selection of maritime pilots can jeopardize the welfare of people, property, and marine ecosystems. Based on Edwards' conceptualization of person-job fit theory, this quantitative, ex post facto study was an examination of whether personality traits, as measured by the Personality Research Form E (PRF-E), could predict maritime pilot selection. The research questions were: (a) Is there a significant relationship between respondents' PRF-E scale ratings and selection for a maritime pilot job and (b) How …

An Exploration Of The Experiences Of Equine Therapy Specialists, Jaime Lyn Battestella-Williams

Walden Dissertations and Doctoral Studies

Horses have been an integral part of human history and progress for centuries. Horses and humans have united in diverse ways, including farming, war, construction, racing, and other areas of sports. Researchers have indicated that the use of horses for mental health and wellness is a growing trend that continues to lack strong, empirical evidence. Currently, there is limited research available on the experiences of certified equine specialists incorporating horses into mental health and wellness. It is essential to gain further insight into the incorporation of horses into psychology and counseling for therapists, as well as potential clients, interested in …

Social Anxiety, Quality Of Life, And Healthy Lifestyle Behaviors Of Women With Infertility Problems, Esra Savaş

Walden Dissertations and Doctoral Studies

Not having a child has significant psychosocial effects on women experiencing infertility problems. There is a gap in research on social anxiety, quality of life, and healthy lifestyle behaviors of women during infertility, fertility treatment, and subsequent pregnancy. The purpose of this quantitative comparative study was to investigate the social anxiety, quality of life, and healthy lifestyle behaviors of Turkish women with infertility issues and Turkish women who conceived after infertility treatment, as measured by the Liebowitz Social Anxiety Scale, the Fertility Quality of Life Questionnaire, and the Healthy Lifestyle Behavior Scale II. The social support and stress buffering theory …

Bat Species Diversity And Habitat Use Assessment With Focus On Endangered Indiana Bats In The Wright State University Woods, Megan R. Rude

Browse all Theses and Dissertations

The goals of my thesis are to: 1) identify species of bats in Wright State University’s (WSU) campus woods via acoustic surveys to compare to detections from previous years (Chapter 1) (2) analyze occupancy and detection probabilities of Indiana bats in different areas throughout the woods (Chapter 1), and 3) create an acoustical approach to analyze habitat use through bat social calls (Chapter 2). In Chapter 1, I conducted stationary acoustic surveys in the Wright State University woods in hydric (riparian), edge, and old growth habitats to record bat vocalizations. The WSU woods have a diverse bat community as ten …

Geographic Profiling: Contributions To The Investigation Of Serial Murders, Beth Nichols

Browse all Theses and Dissertations

Most research studies have focused on profiling serial killers but have not heavily utilized geographic profiling to complete this work. The purpose of this study is to determine whether geographic profiling software programs can assist in serial murder cases. The study will utilize CrimeStat geographical profiling software to look at the significance of disposal or dump sites, the residence of the killer, and the distance between the dumpsite and the serial killer’s residence. This research utilizes a mix -methods approach (case studies and GIS analysis) to analyze five solved case studies of male serial murderers to determine whether they live …

Agent-Based Simulation Of Artificial-Intelligence-Assisted Transfer Of Care, Paul B. Stone

Browse all Theses and Dissertations

This study demonstrates the application of Agent-Based Simulation as a potential training aid for Transfer of Care (ToC) between EMS and a hospital triage department. The specific aim was to develop a simulation to increase the efficiency and accountability of information communication during ToC to test the suitability of Agent-Based Simulation to address training requirements in complex, health provision settings. This paper focuses on the design of the training simulation, including the development of individual agents within the simulation through the user interface elements and the evaluation and verification of the prototype simulator. The primary objective is for the simulation …

Type 2 Diabetes Leads To Impairment Of Cognitive Flexibility And Disruption Of Excitable Axonal Domains In The Brain, Leonid M. Yermakov

Browse all Theses and Dissertations

Type 2 diabetes is a metabolic disease affecting millions of people around the world. Cognitive and mood impairments are among its many debilitating complications, but disease mechanism(s) remain elusive. Here, we present a series of behavioral tasks that demonstrate impairment of cognitive flexibility in db/db mice, a commonly used type 2 diabetes model. Using immunohistochemistry, we demonstrate disruption of axon initial segments (AIS) and nodes of Ranvier, excitable axonal domains regulating neuronal output, in brain regions associated with cognitive and mood impairments. Finally, we present results of exercise treatment that ameliorates AIS disruption in these animals. Establishing cognitive flexibility deficits …

Classism, Ableism, And The Rise Of Epistemic Injustice Against White, Working-Class Men, Sarah E. Bostic

Browse all Theses and Dissertations

In this thesis, I illustrate how epistemic injustice functions in the divide between white working-class men and the educated elite by discussing the discursive ways in which working-class knowledge and experience are devalued as legitimate sources of knowledge. I demonstrate this by using critical discourse analysis to interpret the underlying attitudes and ideologies in comments made by Clinton and Trump during their 2016 presidential campaigns. I also discuss how these ideologies are positively or negatively perceived by Trump’s working-class base. Using feminist standpoint theory and phenomenology as a lens of interpretation, I argue that white working-class men are increasingly alienated …

Effect Of Hybrid/Complex N-Glycosylation On Cardiac Voltage-Gated Ion Channel Expression, Austin R. Parrish

Browse all Theses and Dissertations

Dilated cardiomyopathy (DCM) is one the most common forms of heart failure, with the majority of cases being idiopathic. Dr. Bennett’s laboratory previously showed that deletion of the Mgat1 gene in cardiomyocytes only (Mgat1KO) is sufficient to cause DCM leading to heart failure and early death. The Mgat1 gene product, GlcNAcT1, is responsible for initiating the formation of hybrid/complex N-glycosylation. These data suggest a link between abnormal glycosylation and heart disease; however, there is a mystery of how the specific changes in glycosylation contribute to heart disease etiology and progression. The proper function and gating of voltage-gated Na+ channels (Nav) …

Recognition Of Incomplete Objects Based On Synthesis Of Views Using A Geometric Based Local-Global Graphs, Michael Christopher Robbeloth

Browse all Theses and Dissertations

The recognition of single objects is an old research field with many techniques and robust results. The probabilistic recognition of incomplete objects, however, remains an active field with challenging issues associated to shadows, illumination and other visual characteristics. With object incompleteness, we mean missing parts of a known object and not low-resolution images of that object. The employment of various single machine-learning methodologies for accurate classification of the incomplete objects did not provide a robust answer to the challenging problem. In this dissertation, we present a suite of high-level, model-based computer vision techniques encompassing both geometric and machine learning approaches …

∆Np63Α Positively Regulates Erk3 Expression In Non-Melanoma Skin Cancer, Eid Salem Alshammari

Browse all Theses and Dissertations

Non-melanoma skin cancer (NMSC) is a group of skin cancer that includes basal cell carcinoma of the skin (BCC), squamous cell carcinoma of the skin (SCC), actinic keratoses, a precursor to SCC, and other rare cutaneous carcinomas. p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α, a main isoform of p63, is highly expressed in NMSC and plays essential roles in NMSCs development. Extracellular signal-regulated kinase 3 (ERK3) is an atypical member of the MAPK family. It possesses a single phosphorylation site (serine 189) in its activation loop, which makes …

Learned Helplessness In Industrial-Organizational Psychology: Relationships With Locus Of Control, Self-Efficacy, And Feedback-Seeking Behavior, Nicholas Kovacs

Browse all Theses and Dissertations

Researchers have suggested that self-efficacy and feedback-seeking behavior (FSB) are effective in enhancing performance. To improve performance in the workplace, research should focus on how psychologists can enhance these constructs in employees. Though locus of control (LOC) relates to self-efficacy and increased FSB, research has revealed issues in LOC (e.g., failure to predict performance, range restriction, failure to predict behaviors). The current study examined the effects of perceived “lack of control”, learned helplessness, over LOC on both self-efficacy and FSB in two different samples: a student sample (N = 321) and a work sample (N = 794). Learned helplessness accounted …

Rebel Motivations During The Social War And Reasons For Their Actions After Its End, Mark Louis Howard

Browse all Theses and Dissertations

Modern scholarship has fiercely contested the motivations of Italian rebels during the Social War. Generally speaking, three camps have formed concerning this issue: those who strictly follow the sources in arguing that the allies fought against Rome to obtain full citizenship under her rule, those who believe the rebels sought independence rather than citizenship, and those who believe that rebel actions were inspired by differing motivations. By building upon the scholarship of Dart and Salmon, I believe we will see that many of the allies were willing to fight against the empire for a place of privilege within it. Many …

A Graphene/Rf Gas Sensor, Kathleen Louise Brockdorf

Browse all Theses and Dissertations

Toxic chemicals have been used as chemical warfare agents since ancient times, but World War 1 saw the beginning of modern chemical proliferation. There are many methods of detecting these agents, but the combination of high sensitivity, specificity, fast response, and small form factor is difficult to achieve. More recently, graphene has been identified as a possible sensing material for ammonia and other substances. This research documents a novel method of using graphene as a chemical sensor, utilizing a radio-frequency approach to sensing. This approach utilizes all available information from the material, such as permittivity and conductivity, instead of simply …

Silver Nanoparticles: An Effective Antibacterial Agent Against Gram-Negative Bacteria, Ashley M. Wilcox

Browse all Theses and Dissertations

A fourth of the world’s population lack access to safe water, thus the need for a more effective water treatment is imperative. Interest in silver nanoparticles (AgNPs) has grown in the last decade. Unlike chlorine, AgNPs do not form disinfection by products (DBPs), making them a prime candidate for drinking water treatment. The main aim of this study was to compare the antibacterial activity of electrochemical silver nanoparticles (eAgNPs-f) of ~5 nm in diameter against well-established pathogens: Escherichia coli (E. coli), Klebsiella variicola (K. variicola), and Pseudomonas aeruginosa (P. aeruginosa) to chlorine and Ag+ for drinking water. This was achieved …

Chondroitin Sulfate Hydrogels For Total Wound Care Devices, Tushar Goswami

Browse all Theses and Dissertations

Chondroitin sulfate (CS) is a naturally occurring bio-polymer found in areas of high cartilage in mammals. In directed applications, such as hydrogels, CS can be used to impact keratinocyte growth cycles. In this work, CS based hydrogels were utilized to accelerate wound healing and, in conjunction with a graphene sensor, monitor wound fluid pH. The hydrogels were cast onto a graphene field effect transistor (GFET) to obtain the benefits of the hydrogel wound healing capabilities, while also utilizing the pH sensitivity of the graphene. Results showed that the hydrogel caused a fivefold increase in cell size over the course of …

The Development Of A Lexicon For The Communication Of Action In Cooperative Work, Claire Supriya Shah

Browse all Theses and Dissertations

This research expands upon the research conducted by Clark and Wilkes-Gibbs (1986) on how individuals collaborate and reach common ground in the domain of objects into the domain of action. Pairs of participants (N = 22) were asked to complete a set of six maneuvers with a remote-control car. Dialogue was transcribed and analyzed for total word count, verb phrase count, number of turns taken, number of errors committed, and selected other linguistic characteristics. Total word count, verb phrase count, number of turns taken, and number of errors committed all significantly decreased over time, either linearly or logarithmically. This research …

Leveraging Blockchain To Mitigate The Risk Of Counterfeit Microelectronics In Its Supply Chain, Aman Ali Pogaku

Browse all Theses and Dissertations

System on Chip (SoC) is the backbone component of the electronics industry nowadays. ASIC and FPGA-based SoCs are the two most popular methods of manufacturing SoCs. However, both ASIC and FPGA industries are plagued with risks of counterfeits due to the limitations in Security, Accountability, Complexity, and Governance of their supply chain management. As a result, the current practices of these microelectronics supply chain suffer from performance and efficiency bottlenecks. In this research, we are incorporating blockchain technology into the FPGA and ASIC microelectronic supply chain to help mitigate the risk of counterfeit microelectronics through a secure and decentralized solution …

Design And Development Of An Immersive Simulation For Social Determinants Of Health Training, Lahari Surapaneni

Browse all Theses and Dissertations

This thesis research project focuses on design and development of an immersion simulation-based training tool that help raise the social determinants of health (SDOH) awareness among the health care providers. Compared to existing classroom lecture and/or role-play based SDOH education approach, our immersion-simulation based approach provides an easy access and highly realistic experience to such training curriculum at anytime and anywhere with an Internet connection. Such an interactive and immersive exposure is critical to raise SDOH awareness and maintain long-lasting empathy towards actual patients in practice, and thus help providers to be better prepared when encountering with those patients. Particularly, …

Using Eeg To Examine The Top Down Effects On Visual Object Processing, Joseph D. Borders

Browse all Theses and Dissertations

Object recognition entails a complex interplay between top-down and bottom-up signals. Yet, limited research has investigated the mechanisms through which top-down processes, such as task context and behavioral goals impact the neural basis of visual object processing. Using electroencephalography (EEG), we studied the temporal dynamics of task and object processing to identify how early the impact of task can be observed. We recorded ERPs from participants as they viewed object images from four categories spanning animacy (Inanimate: roller-skate, motorbike; Animate: cow, butterfly) and size (Large: motorbike, cow; Small: roller-skate, butterfly) dimensions under four task conditions comprising conceptual (naturalness, size) and …

Identification Of A Hybrid Lethal Gene On The X Chromosome Of Caenorhabditis Briggsae, John Kelly Dougherty

Browse all Theses and Dissertations

Two closely related Caenorhabditis species, C. briggsae and C. nigoni are cross fertile and produce viable adult progeny. From C. nigoni mothers, F1 adult females are viable and fertile, F1 males are viable but sterile. In crosses that utilize C. nigoni males and C. briggsae hermaphrodites produce viable adult F1 females but F1 males arrest during embryogenesis. A mutation in the Cbr-him-8 gene is a recessive maternal-effect suppressor of male-specific lethality. Hybrid crosses with cbr-him-8 mutant mothers produce viable adult male progeny. The HIM-8 protein in C. elegans is required for the pairing of X-chromosomes during meiosis. This function is …

Phylogenetic, Genomic, And Biogeographic Characterization Of Anovel And Ubiquitous Marine Invertebrate-Associated Rickettsiales Parasite,Candidatus Aquarickettsia Rohweri, Gen. Nov., Sp. Nov, J. Grace Klinges, Stephanie M. Rosales, Ryan Mcminds, Koty H. Sharp

Arts & Sciences Faculty Publications

Bacterial symbionts are integral to the health and homeostasis of invertebrate hosts. Notably, members of the Rickettsiales genus Wolbachia influence several aspects of the fitness and evolution of their terrestrial hosts, but few analogous partnerships have been found in marine systems. We report here the genome, phylogenetics, and biogeography of a ubiquitous and novel Rickettsiales species that primarily associates with marine organisms. We previously showed that this bacterium was found in scleractinian corals, responds to nutrient exposure, and is associated with reduced host growth and increased mortality. This bacterium, like other Rickettsiales, has a reduced genome indicative of a parasitic …

Examination Of Strain-Dependent Differences In S. Sanguinis Virulence And Growth, Shannon Baker

Theses and Dissertations

Streptococcus sanguinis, an abundant and benign inhabitant of the oral cavity, is an important etiologic agent of infective endocarditis, particularly in people with pre-disposing cardiac valvular damage. Although commonly isolated from patients with IE, little is known about the factors that make any particular S. sanguinis isolate more virulent than another or, indeed, whether significant differences in virulence exist among isolates. To investigate the virulence of multiple isolates, a variation of the Bar-seq (barcode sequencing) method was employed. A conserved chromosomal site was identified for subsequent insertion of a barcode identifier, unique for each strain. Barcode insertion did not …