Digital Commons Network^™

Enhanced Proteomics Resolves Kcc2 As A Novel Therapeutic Target For Traumatic Brain Injury, Pavel N. Lizhnyak

Theses and Dissertations

The development of traumatic brain injury (TBI) therapeutics and effective translation to clinic remains stubbornly elusive despite the high prevalence of TBI within the United States and across the globe. Interventions must be devised around testable targets, appropriately timed to intercede on secondary results. Here, we have utilized temporal neuroproteomics as an ideal approach to inform on the complex biochemical processing in order to address the well-recognized temporal evolution of TBI pathobiology and interrogate a novel therapeutic target in a mild-moderate rat Controlled Cortical Impact (CCI) within perilesioned somatosensory cortex. First, our findings revealed 2047 proteins significantly impacted within the …

The Role Of Syndecan-1 And Extracellular Vesicles In Breast Cancer Brain Metastasis, Megan R. Sayyad

Theses and Dissertations

Breast cancer metastasizes to the brain in 15-30% of all breast cancer cases, and metastasis is the predominant cause of breast cancer-related deaths. Patients with HER2-enriched and triple-negative breast cancers (TNBCs) are more likely to develop brain metastases. While targeted therapies exist for HER2-enriched breast cancers, there are no effective treatments for TNBCs. Thus, a greater understanding of how these cancers spread to the brain is critical. In order to spread to the brain, disseminated breast cancer cells must overcome 2 major steps—crossing the blood-brain barrier (BBB) and survival and successful colonization of the distinctive and mostly cellular brain environment. …

Indirect Relatedness, Evaluation, And Visualization For Literature Based Discovery, Sam Henry

Theses and Dissertations

The exponential growth of scientific literature is creating an increased need for systems to process and assimilate knowledge contained within text. Literature Based Discovery (LBD) is a well established field that seeks to synthesize new knowledge from existing literature, but it has remained primarily in the theoretical realm rather than in real-world application. This lack of real-world adoption is due in part to the difficulty of LBD, but also due to several solvable problems present in LBD today. Of these problems, the ones in most critical need of improvement are: (1) the over-generation of knowledge by LBD systems, (2) a …

Bending Educational Reality, Mariam Rafehi

Theses and Dissertations

Virtual reality (VR), an emergent technology, affords experiential content delivery in education by evoking emotive responses in users, which can be prohibitive via traditional media. This thesis explores VR for the development of grit – passion and perseverance, which are essential characteristics in education and long-term success. The research proposes design strategies to stimulate senses for emotional engagement and a physiological response. In the project, two interactive environments position the user in emotional states to build passion and perseverance. To develop passion, the virtual world is designed to engage in creativity using 3D-spatial audio and visual effects. In contrast, to …

The Practice Of Nonviolence: Teaching An Undergraduate Course In Nonviolent Communication, Sharon Lauricella

Journal of Communication Pedagogy

This Best Practices article outlines 10 tips relative to teaching a course in Nonviolent Communication (NVC). It outlines suggestions for readings, activities, and projects throughout a semester-long undergraduate course. The article addresses how students can learn both the theory and practice of nonviolence by means of readings and activities that address social problems such as sexism, racism, bias, and violence against oneself and the earth. Specific suggestions are provided for creative ways in which students can be engaged with readings so that they have ownership of their in-class experience. Details regarding an independent long-term project providing freedom of creativity in …

Children As Bargaining Chips, Clare Ryan

Articles

The parent- child relationship is one of the most valued and protected relationships in constitutional and family law. At the same time, the state has custodial power over children: a power that is necessary in some cases to protect vulnerable children from danger, neglect, and abandonment. But because the parent-child bond is so powerful, state actors can be tempted to exploit it for their own purposes. Custodial power over children provides state actors with the means to put pressure on the parent by threatening to remove the child. In these circumstances, the state uses the child as a bargaining chip …

Do Judges Cry? An Essay On Empathy And Fellow-Feeling, Richard Delgado, Jean Stefancic

Articles

No abstract provided.

Crime Fantasies, John Felipe Acevedo

Articles

No abstract provided.

Sonic Hedgehog Is Expressed By Hilar Mossy Cells And Regulates Cellular Survival And Neurogenesis In The Adult Hippocampus, Luis E. Gonzalez-Reyes, Chia-Chu Chiang, Mingming Zhang, Joshua Johnson, Manuel Arrillaga-Tamez, Nicholas H. Couturier, Neha Reddy, Lev Starikov, Jeffrey R. Capadona, Andreas H. Kottmann, Dominique M. Durand

Publications and Research

Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function and is implicated in hippocampal neurogenesis but the cellular source of Shh in the hippocampus remains ill defined. Here, we utilize a gene expression tracer allele of Shh (Shh-nlacZ) which allowed the identification of a subpopulation of hilar neurons known as mossy cells (MCs) as a prominent and dynamic source of Shh within the dentate gyrus. AAV-Cre mediated ablation of Shh in the adult dentate gyrus led to a marked degeneration …

John The Theologian: Towards Integrating Law And Religion, Gordon T. Butler

Faculty Articles

No abstract provided.

Not-For-Profit Entities Industry Developments - 2019; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

There Isn't Any Dumpster, Jill C. Engle

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Formative Interests And Pathways To Natural Resources Careers Among Racial And Ethnic Minorities, Laura Burmann

Dissertations, Master's Theses and Master's Reports

Land use, values, and ethics vary across cultures; however, those making natural resource (NR) management decisions are often not representative of the diversity of people who live on the land. Diversifying the workforce is a step towards ensuring management decisions and policies are inclusive of all peoples; however, few people from minority groups are pursuing degrees related to NR management. The purpose of this study is to assess factors affecting the decisions to pursue careers in NR fields among historically underrepresented groups of people, with an emphasis on the role that youth environmental education (EE) programs play in creating career …

The Effects Of Tumor Growth On Stress Response, Body Size, And Fat Content In Caenorhabditis Elegans, Reem Yassine

Senior Honors Theses and Projects

Tumorous growth affects nearby healthy tissues, as seen in wasting disease experienced by cancer patients, but the underlying mechanisms are not well understood. We studied tumor growth in C.elegans, a microscopic worm that shares many genes with humans and has the ability to grow tumors in its reproductive system. To test whether tumors cause stress in nearby tissues, we used genetic crosses to create strains containing tumors and fluorescent-based stress reporters for the following physiological stresses: endoplasmic reticulum unfolded protein response (hsp-4p::GFP), heat shock (hsp-6.2p::GFP), and infection (irg-1p::GFP). We found that expression of …

The Biocultural Evolution Of Inflammatory Bowel Diseases, Amanda Rielinger

Senior Honors Theses and Projects

Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are described as abnonnal immune responses to the gastrointestinal microbiota. The etiology of IBD is unknown; however, it is associated with Western, industrialized societies. A better understanding of the origins and treatments of IBD can lead to improved health outcomes. This paper seeks to examine IBD from a cultural, environmental, and evolutionary perspective. The effects of cultural and environmental factors, such as diagnostic practices, diet, breastfeeding practices, antibiotic use, appendectomy, and environmental radiation exposure on the risk of developing IBD are discussed. The efficacy of various treatments for IBD …

On The Brink Of Extinction: The Fate Of The Pacific Northwest's Southern Resident Killer Whales, Sabrina Wilk

Pomona Senior Theses

The killer whales that roam the northeastern Pacific Ocean have been the objects of studies since the 1970s, making them the most well-studied population of orcas in the world. Three distinct ecotypes of killer whales (Orcinus orca), known as residents, transients, and offshores, share these waters. The ecotypes are morphologically and behaviorally distinct to the extent that some scientists consider them separate species, with residents eating salmon, transients specializing on marine mammals, and offshores preferring Pacific sleeper sharks and Pacific halibut. Resident populations have endeared themselves to the region's locals with their striking black and white markings and …

Fragile Oceans, Synthetic Flotsam And Microbial Collaboration – Explorations In The Visual Communication Of The Plastic Crisis, Ivan Langesfeld

Pomona Senior Theses

Scientific evidence that the ocean plastic crisis is larger in scale and more sinister than previously thought continues to mount, but the rate of plastic production is only rising. What will it take to decisively turn the tide against plastic? We need scientists, politicians, and industry changemakers to continue producing knowledge and positive change in the industry, but we need to go further still. This thesis explores art as an alternative visual communication strategy with the capacity to encourage curiosity, empathy, and positive engagement with the issue of ocean plastics. The series of work explores bacterial bioluminescence as an artistic …

Restoring Reciprocity: Indigenous Knowledges And Environmental Education, Mireya Valencia

Pomona Senior Theses

Environmental education in the U.S. has been slow to incorporate Indigenous knowledges, with most pre-university curriculum centering around Western science. I believe incorporating Indigenous knowledges into environmental education can promote reciprocal, critical, and active human-nature relationships. While Indigenous knowledges should infiltrate all levels of environmental education, I argue that alternative forms of education which operate outside the formal school system might present the fewest immediate obstacles.

Beyond Criminal Prosecution: How Federalist Tensions In Marijuana Laws Affect State-Legal Businesses, Gabriel Roberts

University of Florida Journal of Law & Public Policy

No abstract provided.

Articulation And Transfer In Tennessee Higher Education 2018 Report, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

The Bacterial Symbionts Of Closely Related Hydrothermal Vent Snails With Distinct Geochemical Habitats Show Broad Similarity In Chemoautotrophic Gene Content, Roxanne A. Beinart, Chengwei Luo, Konstantinos T. Konstantinidis, Frank J. Stewart, Peter R. Girguis

Graduate School of Oceanography Faculty Publications

Symbiosis has evolved between a diversity of invertebrate taxa and chemosynthetic bacterial lineages. At the broadest level, these symbioses share primary function: the bacterial symbionts use the energy harnessed from the oxidation of reduced chemicals to power the fixation of inorganic carbon and/or other nutrients, providing the bulk of host nutrition. However, it is unclear to what extent the ecological niche of the host species is influenced by differences in symbiont traits, particularly those involved in chemoautotrophic function and interaction with the geochemical environment. Hydrothermal vents in the Lau Basin (Tonga) are home to four morphologically and physiologically similar snail …

Encouraging Food Safety Standard Negotiations In The One-Belt-One-Road Initiative, Yi Seul Kim

Cardozo International & Comparative Law Review

Participation and attendance in food safety negotiations such as Codex meetings are of critical importance. Common problems have existed throughout history in the area of food safety standards and their formulation regulations. First, there is a lack of interest by the public. Second, the public becomes interested only after a food safety crisis. Consequences are two-fold: with lack of public interest, governments often do not allocate enough budget and resources. Then, when the government turns to face the problem with a sudden spike in public interest, it is often too late. The situation becomes more of a crisis management, rather …

Motivating Political Participation Among Youth: An Analysis Of Factors Related To Adolescents’ Political Engagement, Brett Levy, Thomas Akiva

Educational Theory and Practice Faculty Scholarship

Prior research has identified political efficacy and political interest as strong predictors of political participation, but few studies have examined these two attitudes in tandem or compared their relative importance vis-à-vis political participation. Drawing on the expectancy-value model of motivation, we begin to address this research gap while also considering several related issues. Our sample includes a diverse group of high school students in grades 10, 11, and 12 (N=422) from the midwestern United States. Through quantitative analyses of participants’ survey data, we found that political interest (a central aspect of value) and political efficacy (closely related to expectancy) predicted …

When Archaeology Interacted With The Bible: A Study Of The Search For The City Of Raamses Of Exodus 1:11 In The Searcher's Socio Political Context, Georg Filippou

Master's Theses

The purpose of this thesis is twofold. First, I will research what a selected group of authors and scholars has stated regarding their search for the biblical city of Raamses. 3 This step will involve research of the motive of those researchers who attempted to match Raamses of Exod 1:11 with geographical locations in Egypt, to follow their search within the social and political context of these scholars. Second, based on these scholars’ research, I will attempt to discover what happened when Bible and archaeology interacted in the search for the city of Raamses.

The study begins with some pages …

A Narrative Analysis Of Genesis 3:1-7 And The Theological Significance Of The Serpent, Milton Gonzalez

Master's Theses

Problem

The Christian tradition of the Fall as it relates to Gen 3 is an interpretive construct that is foreign to the text and its immediate context. While scholars continue to view humanity and its fallen state as the central theme of the narrative, I suggest that such are but second to an even greater narrative—namely, a cosmic conflict between Elohim—the Creator of the heavens and the earth, and the serpent.

Method

The first chapter of this study considers the traditional view of the temptation narrative (i.e. Gen 3:1-7) as the Fall of Man and suggests that the story of …

A Biblical Overview Of The Concept Of Fruit With An Emphasis On The "Fruit Of The Spirit" In Galatians 5, Timothy Selinger

Master's Theses

Problem

The topic of the Holy Spirit and especially the meaning of "being filled with the Spirit" is a relevant topic. Generally, it is thought to be related to miracles, healings, and explosive church growth among Adventists or to speaking in tongues and other manifestations, especially among Charismatic Christians. Few identify the fullness of the Spirit with holiness of character. In Paul, the presence of the Spirit in the life of the believer results in the presence of the "fruit of the Spirit" (Gal 5:22). Just like an apple tree produces apples, a person filled with the Spirit will produce …

Carnarvon Rangelands Biosecurity Association Inc. Annual Report 2018/19, Carnarvon Rangelands Biosecurity Association Inc.

Recognised Biosecurity Group Annual Reports

The CRBA is a not for profit association formed under the Associations Incorporation Act 2015, providing declared pest control services for land managers throughout Shark Bay, Carnarvon, Exmouth, Murchison and Upper Gascoyne Shires. The associations’ primary purpose is the control of declared pests using funding from Declared Pest Rates paid by landholders on pastoral stations. These Declared Pest Rates funds are matched dollar for dollar by the WA Government to reflect the public benefit of controlling declared pest animals and weeds. The association is formally recognised by the Hon Minister for Agriculture and Food as a recognised biosecurity group (RBG).

Central Wheatbelt Biosecurity Association Inc. Annual Report 2018/19, Central Wheatbelt Biosecurity Association Inc.

Recognised Biosecurity Group Annual Reports

The past 12 months have been a very productive year for the CWBA. Many changes and challenges have occurred, none more so for landowners/occupiers, than the introduction of the “Declared Pest Rate’ (DPR). Generally, the pest rate has been accepted well, with most understanding the importance of an effective control of Declared Pests. While it is not a perfect solution, given that external funding sources have all but expired, and after much deliberation by the board, it is considered to be the fairest method we could use to ensure the ongoing operation of the group. The Board and EO will …

Eastern Wheatbelt Biosecurity Group Inc. Annual Report 2018/19, Eastern Wheatbelt Biosecurity Group Inc.

Recognised Biosecurity Group Annual Reports

The past 12 months has seen the Eastern Wheatbelt Biosecurity Group keep up the momentum of the past few years and contribute considerably to the betterment of the state’s landholders in controlling predominately wild dogs. With landholders funding the biosecurity groups under the BAM Act through a declared pest rate it is pleasing to note that this money is hitting the ground and making a real and tangible difference through the work of the Licensed Pest Management Technicians employed by the EWBG.

Kimberley Rangelands Biosecurity Association Invasive Species Annual Report 2018/19, Kimberley Rangelands Biosecurity Association

Recognised Biosecurity Group Annual Reports

The Kimberley Rangelands Biosecurity Association (KRBA) has an annual Large Feral Herbivore culling program that includes feral donkeys, horses and camels with other animals such as water buffalo and pigs targeted when located. The program focusses primarily on donkeys, using the radio telemetry technique with horses and camels culled opportunistically during tracking. Currently there are approximately 90 active collars throughout the region.