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Articles 19681 - 19710 of 732790
Full-Text Articles in Entire DC Network
Is Poverty The Root Of All Crime? Rethinking Criminality Amid Institutional Failure In Madagascar, Ramalina Ranaivo Mikea Manitra
Is Poverty The Root Of All Crime? Rethinking Criminality Amid Institutional Failure In Madagascar, Ramalina Ranaivo Mikea Manitra
Jurnal Kriminologi Indonesia
Madagascar continues to grapple with high levels of poverty and weak institutional capacity, creating conditions conducive to widespread and persistent criminality. This paper aims to examine how structural poverty, institutional failure, and state fragility interact to shape patterns of crime through the lens of criminological theories such as strain theory, social disorganisation, and state-centred criminology. Using a qualitative methodology based on a comprehensive literature review of empirical studies, policy documents, and international reports, the paper explores the socio-economic and institutional dynamics underpinning crime in Madagascar. The findings reveal that poverty-driven crime often arises as a rational response to unmet needs, …
Facilitation Of Focus Groups Towards Conflict Resolution Among Pastoralists And Farmers In Northern Uganda: An Indigenous Relational Approach, Francis Akena Adyanga Dr., Norma Ra Romm Prof., Ambrose Dbins Toolit
Facilitation Of Focus Groups Towards Conflict Resolution Among Pastoralists And Farmers In Northern Uganda: An Indigenous Relational Approach, Francis Akena Adyanga Dr., Norma Ra Romm Prof., Ambrose Dbins Toolit
The Qualitative Report
In this article we discuss how we explored with participants in a district of Northern Uganda certain land-related conflicts between pastoralists (herdsmen) and farmers. Following the end of the conflict in the civil war in Northern Uganda (1986-2006/7), many pastoralists moved from Central and Western Uganda to Northern Uganda in search for pastures for their animals. This has resulted in tension with the host community of farmers. In recognition of these long-standing conflicts and wishing to contribute to their addressal, in 2021 we set up four focus groups drawing on Indigenous relational practices of conflict resolution. We invoked storytelling and …
Identification, Abundance, And Behavior Of North American Bobcat (Lynx Rufus) Along Road Mitigation Structures Designed For Endangered Species In South Texas, Victoria Hanley, Kevin W. Ryer, Md. Saydur Rahman, John H. Young Jr., Richard J. Kline
Identification, Abundance, And Behavior Of North American Bobcat (Lynx Rufus) Along Road Mitigation Structures Designed For Endangered Species In South Texas, Victoria Hanley, Kevin W. Ryer, Md. Saydur Rahman, John H. Young Jr., Richard J. Kline
School of Integrative Biological & Chemical Sciences Faculty Publications
Endangered species are increasingly used as the target species in implementing and constructing new wildlife crossing structures (WCS). Highways in South Texas fragment the landscape and result in high road mortality for endangered species such as ocelots (Leopardus pardalis, a medium-sized spotted wild cat). In response, the Texas Department of Transportation constructed nine WCS on Farm-to-Market 106 (FM 106), a road which bisects Laguna Atascosa National Wildlife Refuge in Cameron County, Texas. With ocelots being rare and elusive, bobcats (Lynx rufus) are often used as a surrogate species to study felid behavior at road mitigation structures …
Molecular Mechanisms Of Iron Metabolism And Overload, Aditi Tayal, Jasmeen Kaur, Robert W. Maitta
Molecular Mechanisms Of Iron Metabolism And Overload, Aditi Tayal, Jasmeen Kaur, Robert W. Maitta
Faculty Scholarship
Iron represents an essential element required for normal physiologic processes throughout organ systems. A vast network of transporters is involved not only in uptake of this element but in processing, oxidation, and recycling to maintain it in a tight balance to avoid excess storage. This complex network of transporters, including heme and ferroportin, among many others, are responsible for facilitating inter-organ tissue iron exchange and availability, contributing to overall heme homeostasis. However, exposure to high levels of iron can overwhelm compensatory mechanisms that result in its accumulation and toxicity. This is the case of patients with genetic diseases such as …
Progressive Respiratory Failure In A Term Neonate With Abca3 Surfactant Deficiency: Beyond The Common Causes Of Respiratory Distress, Andrew M Beverstock, Hillary C Lee, David S Moreno Mcneill, Morcos Hanna
Progressive Respiratory Failure In A Term Neonate With Abca3 Surfactant Deficiency: Beyond The Common Causes Of Respiratory Distress, Andrew M Beverstock, Hillary C Lee, David S Moreno Mcneill, Morcos Hanna
Faculty, Staff and Students Publications
Background
Most cases of respiratory distress in term neonates are due to transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), or air leak syndromes. Genetic surfactant deficiencies are rare causes of respiratory distress. Among these, mutations in the ABCA3 gene disrupt surfactant metabolism and can lead to severe, treatment-refractory respiratory failure. While commonly considered in preterm infants, surfactant dysfunction should also be considered in term infants with unexplained and persistent hypoxemia.Case
We present a case of a 38-weeks term female infant with fetal growth restriction who developed respiratory distress shortly after birth. She initially responded to continuous …"The Cake Is A Lie:" Locating Loot Boxes In Indian Gaming Framework, Aman Gupta, Samriddh Sharma
"The Cake Is A Lie:" Locating Loot Boxes In Indian Gaming Framework, Aman Gupta, Samriddh Sharma
Indian Journal of Law and Technology
Lootboxes have become endemic in modern video games. These microtransactions allow users to purchase virtual containers without knowing their content, which is determined by chance. There have been increasing concerns about the negative impact of loot-box purchases on mental health and whether these amount to gambling under various laws. In response, several countries have started applying existing gambling laws or legislating new measures to regulate lootboxes. This raises questions about the present state of regulations in the Indian context and whether they are adequate in meeting the risks posed by lootboxes. In the present article, the authors explain the concept …
The Potential Of Protection System Of Curator And Administrator Profession In Indonesia (Comparative Analysis Of Curator And Notary Profession In Indonesia), Banat Aghniya Ghassani Yudistira
The Potential Of Protection System Of Curator And Administrator Profession In Indonesia (Comparative Analysis Of Curator And Notary Profession In Indonesia), Banat Aghniya Ghassani Yudistira
Technology and Economics Law Journal
This thesis explores the potential need for a protection system for curators and administrators in Indonesia’s bankruptcy proceedings, highlighting their vulnerability to criminalization despite fulfilling roles mandated by law. The study begins by outlining the duties and responsibilities of curators and administrator under Law No. 37 of 2004 on Bankruptcy and Suspension of Debt Payment Obligations (UU KPKPU), emphasizing their legal obligation to manage and settle bankrupt assets independently and without conflict of interest. However in practice, curators and administrators often face legal threats and being criminalized, including police reports and criminal charges, merely for executing duties outlined in the …
Comparative Analysis Between The United States And Indonesia Regarding Product Liability Of Food And Beverage Tenants Within The Tourism Industry, Shadrina R. T. Utomo, Henny Marlyna, Ayu Galuh Anggraini
Comparative Analysis Between The United States And Indonesia Regarding Product Liability Of Food And Beverage Tenants Within The Tourism Industry, Shadrina R. T. Utomo, Henny Marlyna, Ayu Galuh Anggraini
Technology and Economics Law Journal
This research analyzes on how the laws in Indonesia and Florida, United States (U.S.) regulate the product liability of tourism entrepreneurs, whether as the food and beverage tenant within the tourism area or as the tourism operator, who have caused tourists to suffer from food poisoning. The Law Number 10 Year 2009 concerning Tourism the obligation for tourism entrepreneurs in providing insurance is only for high-risk tourism businesses. Tourism entrepreneurs in Indonesia have made various safety measures by fulfilling the sanitation and hygiene requirements, and preparing medical protocols. Meanwhile in Florida, tourism entrepreneurs have added accessibility efforts for tourists with …
State Of New York Cannabis Testing, University Of Mississippi – National Center For Cannabis Research And Education, Yasha Kahn, Mcr Labs
State Of New York Cannabis Testing, University Of Mississippi – National Center For Cannabis Research And Education, Yasha Kahn, Mcr Labs
New York
No abstract provided.
A Mini Review On Rodent Models Of Autism Spectrum Disorder (Asd), Rachel Zeller
A Mini Review On Rodent Models Of Autism Spectrum Disorder (Asd), Rachel Zeller
Research from the Berry Summer Thesis Institute, 2025
Autism spectrum disorder (ASD) is a neurodevelopmental disorder typically diagnosed at a young age. ASD symptoms include deficits in social behavior, repetitive and restrictive behaviors, anxiety, as well as alterations in sensory gating and sensitivity, learning, memory, and attention performance. Since ASD emerges from a combination of genetic and environmental factors, clinical treatment of these conditions presents with challenges. Being able to model behavioral and neurobiological aspects of this disorder at the preclinical level using rodents allows for further investigation of the pathophysiological basis of this disorder. This mini review will focus on selected genetic and pharmacological rodent models of …
Evaluating The Environmental Determinants Of Tadpole Mouthpart Deformities, Nicholas J. Canfield
Evaluating The Environmental Determinants Of Tadpole Mouthpart Deformities, Nicholas J. Canfield
Research from the Berry Summer Thesis Institute, 2025
Amphibians are among the most threatened group of animals on the planet, with over 40% of living species facing an extinction risk. These organisms are highly sensitive to environmental change due to their highly permeable skin and complex life cycle that exposes them to stressors in both aquatic and terrestrial ecosystems. Amphibian populations that are closely monitored can serve as valuable bioindicators of environmental health because they typically respond rapidly to habitat degradation, decreased water quality, and changes in climate. Tadpoles in particular may act as a “canary in a coal mine” for aquatic ecosystems because they easily develop anatomical …
Astrocytes Expressing Mutant Hnrnpa1 Induce Non-Cell-Autonomous Motor Neuron Death, Qinxue Wu, Xionghao Liu, Tingting Zhang, Shiquan Cui, Bo Huang, Cao Huang, Qilin Cao, Xu-Gang Xia, Hongxia Zhou
Astrocytes Expressing Mutant Hnrnpa1 Induce Non-Cell-Autonomous Motor Neuron Death, Qinxue Wu, Xionghao Liu, Tingting Zhang, Shiquan Cui, Bo Huang, Cao Huang, Qilin Cao, Xu-Gang Xia, Hongxia Zhou
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Pathogenic mutation of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is causative to amyotrophic lateral sclerosis (ALS). Neuron death resulting from pathogenic hnRNPA1 may not require its presence across all pertinent cells types, including neurons, glia, and muscles. Rather, the exclusive presence of pathogenic hnRNPA1 in a specific cell type, such as astrocytes, may suffice to substantially alter cellular functions. Consequently, this alteration initiates abnormal interaction within intricate neuron-glia networks, culminating in non-cell-autonomous motor neuron death. To investigate the pivotal role of non-cell-autonomous neuron death in hnRNPA1-associated ALS, we developed transgenic rats overexpressing mutant hnRNPA1 in specifically astrocytes. The confined overexpression of …
A Comparison Of Diving Behavior Of Goose-Beaked And Dense-Beaked Whales From Tagging Studies In Multiple Ocean Basins, Jay Barlow, Robin W. Baird, Janelle Badger, Gregory S. Schorr, Erin A. Falcone, Shannon N. Coates, Peter L. Tyack, Andrew J. Read, Leigh S. Hickmott, John W. Durban, Diane Claridge, Natacha Aguilar De Soto, Daniel Miranda Gonzalez, Fleur Visser, Machiel G. Oudejans, Stacy L. De Ruiter, David A. Sweeney, Brenda K. Rone, Stephanie L. Watwood
A Comparison Of Diving Behavior Of Goose-Beaked And Dense-Beaked Whales From Tagging Studies In Multiple Ocean Basins, Jay Barlow, Robin W. Baird, Janelle Badger, Gregory S. Schorr, Erin A. Falcone, Shannon N. Coates, Peter L. Tyack, Andrew J. Read, Leigh S. Hickmott, John W. Durban, Diane Claridge, Natacha Aguilar De Soto, Daniel Miranda Gonzalez, Fleur Visser, Machiel G. Oudejans, Stacy L. De Ruiter, David A. Sweeney, Brenda K. Rone, Stephanie L. Watwood
University Faculty Publications and Creative Works
Studies of cetacean diving behavior in multiple locations in different ocean basins allow for an assessment of variability within and among populations. We examine foraging dive behaviors of goose-beaked whales (Ziphius cavirostris) and dense-beaked whales (Mesoplodon densirostris) using data from 132 tagged whales in seven locations in the Pacific and Atlantic Oceans and the Mediterranean Sea. Acoustic recording tags are used to identify foraging dives by the presence of echolocation. For other tag types, foraging dives are identified based on maximum dive depth. Five parameters are used to characterize foraging dives: maximum dive depth, foraging dive duration, dive cycle duration, …
Analysis Of Linguistic Issues In Audiovisual Translation - Subtitling, Marwah Abdullah Hilabi, Ahmad Khuddro Dr
Analysis Of Linguistic Issues In Audiovisual Translation - Subtitling, Marwah Abdullah Hilabi, Ahmad Khuddro Dr
Effat Undergraduate Research Journal
Audiovisual Translation (AVT) is a term used for the translation which appears on screen. This product can be written in the form of subtitles, or spoken as in dubbing and it could be also done as a voiceover. This study discusses the AVT with subtitling as an example. Due to the massive growth of media, the need for professional translators and good translation is high. This study used an animated TV series called Fruits Basket as the main example of subtitling. This TV show is an English dubbed version of the Japanese series consisting of 26 episodes. Therefore, the first …
Swahili And English Sell, But What About Iraqw And Sukuma? Tanzanian Native Languages And Ethnic Affiliations In Bottom-Up Commercial Signage, Adventina Buberwa
Swahili And English Sell, But What About Iraqw And Sukuma? Tanzanian Native Languages And Ethnic Affiliations In Bottom-Up Commercial Signage, Adventina Buberwa
Journal of Humanities and Social Sciences
Policy statements in Tanzania forbid the use of ethnic community languages but permits Swahili and English in the public space. In this paper, we question the total absence of ethnic community languages in signposts in which previous studies of linguistic landscape attested the presence of unpermitted languages of Arabic, Chinese and Hindi. Under the auspices of the social identity theory, we envisaged the investigation and analysis of personal and place names on privately-owned commercial signposts. It has come out clearly that owners of the businesses represented would no doubt hope that the names they include in their signage would appeal …
Harmonizing Technological Advancement With Ethical And Safe Ai Deployment By Bridging The Innovation–Regulation Divide, Majd A. Ali, Wadii Ali, Hussein Abbas Hameed
Harmonizing Technological Advancement With Ethical And Safe Ai Deployment By Bridging The Innovation–Regulation Divide, Majd A. Ali, Wadii Ali, Hussein Abbas Hameed
Al-Farahidi Expert Systems Journal
The development of technology, especially artificial intelligence (AI), has revolutionized various fields like business, healthcare, and even security. Unfortunately, examining the ethical and legal ramifications associated with such sophisticated technology is often left behind. This paper delves into the most pressing issues related to AI and its innovation; specifically, it covers issues such as governance frameworks, the legal gap of coordination, international relations, and ethical problems like discrimination by algorithms, lack of clarity on who is being held responsible, and transparency deficiency. The study focuses on the global strategies for AI governance, from the stringent AI regulations of the European …
Emotional Armor: An Exploration Of Emotion Regulation On Race-Related Stress And Well-Being, Jibri Khalia Parker
Emotional Armor: An Exploration Of Emotion Regulation On Race-Related Stress And Well-Being, Jibri Khalia Parker
Doctoral Dissertations
Scholars have examined at length the impact of stress on well-being. However, people of color experience an additional stressor called racism. Increased experiences with chronic discrimination and racism have been associated with increased hypertension, heart disease, anxiety and depression to name a few (Williams, 2018). Chronic experiences with racism leads to a phenomenon called race-related stress (Utsey & Ponterotto, 1996). The research has shown the impact of race-related stress on physical and mental health outcomes, particularly on individuals from an ethnic background (Williams, 2018). However, not much research has focused on potential moderators in this relationship. This study poses emotion …
Sleep, Emotion Regulation, And Relationship Satisfaction: A Moderation Analysis, Lakyn Boone
Sleep, Emotion Regulation, And Relationship Satisfaction: A Moderation Analysis, Lakyn Boone
Doctoral Dissertations
Sleep plays a pivotal role in overall health and well-being, influencing mental health, cognitive abilities, memory, emotional balance, and physical well-being (Luyster et al., 2012; Mukherjee et al., 2015). Emotions constitute a natural and indispensable element of human existence but necessitate proper regulation, as any disruption in emotion control has been associated with various mental health disorders (Gross & Jazaieri, 2014; Kring & Gordon, 1998; Phelps, 2006). Furthermore, human connections and relationships are fundamental aspects of the human experience, contributing to emotional support, personal growth, a sense of belonging, and even influencing one's physical health outcomes (Baumeister & Leary, 1995; …
Advancing Rfid Systems: From Head Orientation To Robotic Localization Using Passive Tags, Guilherme Ricardo Mendes Da Silva Barreto De Figueiredo
Advancing Rfid Systems: From Head Orientation To Robotic Localization Using Passive Tags, Guilherme Ricardo Mendes Da Silva Barreto De Figueiredo
Doctoral Dissertations
No abstract provided.
Vitamin B12 Deficiency: Confidence, Perspectives, And Practices Among Registered Dietitian Nutritionists, Avery Miller Adams
Vitamin B12 Deficiency: Confidence, Perspectives, And Practices Among Registered Dietitian Nutritionists, Avery Miller Adams
Master's Theses
Vitamin B12 deficiency is common in the United States, occurring in 20% of adults aged 60 and above (Andres et al., 2004). Veterans are susceptible to B12 deficiency due to tobacco product usage, alcohol consumption, and poor diet quality. Megaloblastic anemia is the second most prevalent vitamin deficiency disorder recorded in military personnel from 1997 to 2015 (Knapik et al., 2021). This exploratory, analytic research aims to assess registered dietitian RDN nutritionists’ (RDN) knowledge, perceptions, and intentions regarding treating vitamin B12 deficiency in a clinical setting. Due to population prevalence differences, responses from VA and non-VA practicing registered dietitian-nutritionists (RDNs) …
State Of Hawaii Cannabis Testing, University Of Mississippi – National Center For Cannabis Research And Education, Yasha Kahn, Mcr Labs
State Of Hawaii Cannabis Testing, University Of Mississippi – National Center For Cannabis Research And Education, Yasha Kahn, Mcr Labs
Hawaii
No abstract provided.
The Covid-19 Pandemic As An Environmental Jolt And Its Impact On Firms And Essential Workers, Kimberly Kay Hyett Nehls
The Covid-19 Pandemic As An Environmental Jolt And Its Impact On Firms And Essential Workers, Kimberly Kay Hyett Nehls
Electronic Theses and Dissertations
Environmental jolts are sudden, large-scale disruptions that challenge organizational and societal stability and demand new ways of understanding adaptation across individuals and firms. This two-paper dissertation explores the human and organizational dimensions of such jolts through the empirical context of the COVID-19 pandemic. Paper 1 examines how global tourism firms navigated the crisis, introducing the constructs of global stakeholder interconnectedness and stakeholder prioritization fluidity to refine stakeholder theory. The findings show how international exposure shaped communication strategies under duress. Paper 2 turns to the lived experiences of low-wage essential workers, extending sensemaking theory through the concept of constrained sensemaking, highlighting …
Building An Interdisciplinary Workforce In Geroscience: Aligning Perspectives And Educational Goals, Iman M Al-Naggar, Miranda E Orr, Et Al.
Building An Interdisciplinary Workforce In Geroscience: Aligning Perspectives And Educational Goals, Iman M Al-Naggar, Miranda E Orr, Et Al.
2020-Current year OA Pubs
The National Institute on Aging-funded Geroscience Education and Training Network held the "Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals" preconference workshop at the 2023 Gerontological Society of America's Annual Meeting. Parties involved in geroscience education and interested stakeholders addressed the development of didactic educational materials, training, and career development opportunities to equip learners with the skills to meet the demands of the emerging field of geroscience, from research to clinic and industry. Recent successes were presented, existing opportunities, gaps, and challenges identified and discussed, and solutions and future directions described.
Unleashing Nk Cells For Cancer Immunotherapy In Lung Cancer: Biologic Challenges And Clinical Advances, Quinlan Mclaughlin, Dorothy K Sojka, Kathleen Kennedy, Sytse J Piersma, Nan Sethakorn
Unleashing Nk Cells For Cancer Immunotherapy In Lung Cancer: Biologic Challenges And Clinical Advances, Quinlan Mclaughlin, Dorothy K Sojka, Kathleen Kennedy, Sytse J Piersma, Nan Sethakorn
2020-Current year OA Pubs
Natural killer (NK) cells are a crucial part of the innate immune system and serve as an important effector for killing tumor cells through direct cytolytic activity or immunomodulatory signaling to T cells and antigen presenting cells. NK cells are correlated with increased tumor control and better overall patient survival across various types of cancers including non-small cell lung cancer (NSCLC). Despite their promising potential for anti-tumor killing, NK cell function is often diminished within the tumor microenvironment. There are many factors that lead to decreased tumor-infiltrating NK cell killing, including immunoinhibitory factors from tumor cells and resident tissues, acquired …
Alameda Song Sparrow Habitat Use Of Salt Pond Restoration Sites In South San Francisco Bay, Bradley A. Speno
Alameda Song Sparrow Habitat Use Of Salt Pond Restoration Sites In South San Francisco Bay, Bradley A. Speno
Master's Theses
Restoration is acknowledged worldwide as a conservation need to return ecosystem functions. However, projects require monitoring to track system changes and assess restoration progress. In the San Francisco Bay, several large restoration projects are implementing plans to return salt-producing ponds to the historical ecosystem, tidal salt marsh. The Alameda song sparrow (Melospiza melodia pusillula), a California species of special concern, has been documented to use restored and historic marshes, but their use of restored salt ponds is not fully understood. The birds’ use of restored marshes may be a useful measure of restoration progress. This research investigated the relationships comparing …
Centrosomal And Non-Centrosomal Microtubule Networks Coordinate To Drive Nuclear Dynamics In Developing Epithelium, Rashmi Budhathoki
Centrosomal And Non-Centrosomal Microtubule Networks Coordinate To Drive Nuclear Dynamics In Developing Epithelium, Rashmi Budhathoki
Electronic Theses and Dissertations
The morphogenesis of developing tissues relies on extensive cellular rearrangements in shape, position, and identity. A key process in reshaping tissues is cell intercalation-driven elongation, where epithelial cells align and intercalate along a common axis. Typically, analyses focus on how peripheral cortical forces influence cell shape changes. Less attention is given to how inhomogeneities in internal structures, particularly the nucleus, impact cell shaping. Here, we examine how pulsed contractile and extension dynamics interact with the nucleus in elongating Drosophila embryos. Our data show that tightly packed nuclei in apical layers hinder tissue remodeling/oscillatory behaviors. We identify two mechanisms for resolving …
Trainee Countertransference And Competency In Bereavement Therapy: Strengths And Limitations Of The Wounded Healers, Meghan Paynter
Trainee Countertransference And Competency In Bereavement Therapy: Strengths And Limitations Of The Wounded Healers, Meghan Paynter
Electronic Theses and Dissertations
Countertransference is a common experience in therapy, happening among clinicians of all stages of their career and the outcomes of this experience hinge largely on how countertransference is managed. Challenging topics, such as grief, only make countertransference harder to manage effectively and the management of this experience improves with practice and time—something trainees have not yet ascertained. Given the pervasiveness of grief as a human experience, also indiscriminate in nature, the experiences of trainees experiencing countertransference are important to understand, including what is experienced, how they experience it, and how it impacts their process and self-perception of confidence and competence …
Behavioral Neuroscience Of Drug Addiction And Mental Disorder, Mona Muzammil, Muzammil Arshad, Washain Muzammil
Behavioral Neuroscience Of Drug Addiction And Mental Disorder, Mona Muzammil, Muzammil Arshad, Washain Muzammil
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)
This book explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of …
Prolonged Exposure To Food Odors Suppresses Feeding Via An Olfactory Bulb-To-Hypothalamus Circuit, Yao Liu, Hailan Liu, Huey-Xian Kelly Wong, Niccole Auld, Kristine M Conde, Yongxiang Li, Meng Yu, Yue Deng, Qingzhuo Liu, Xing Fang, Mengjie Wang, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Longlong Tu, Hesong Liu, Jonathan C Bean, Junying Han, Megan E Burt, Sanika V Jossy, Yongjie Yang, Chunmei Wang, Qingchun Tong, Benjamin R Arenkiel, Hongjie Li, Yong Xu, Yang He
Prolonged Exposure To Food Odors Suppresses Feeding Via An Olfactory Bulb-To-Hypothalamus Circuit, Yao Liu, Hailan Liu, Huey-Xian Kelly Wong, Niccole Auld, Kristine M Conde, Yongxiang Li, Meng Yu, Yue Deng, Qingzhuo Liu, Xing Fang, Mengjie Wang, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Longlong Tu, Hesong Liu, Jonathan C Bean, Junying Han, Megan E Burt, Sanika V Jossy, Yongjie Yang, Chunmei Wang, Qingchun Tong, Benjamin R Arenkiel, Hongjie Li, Yong Xu, Yang He
The Brown Foundation: Institute of Molecular Medicine
Olfactory perception of food odors is a key determinant of eating behavior, including triggering appetite, facilitating food seeking and influencing food choice. While transient food-related olfactory cues stimulate appetite and provoke cravings in states of hunger, emerging evidence implies that prolonged and sustained exposure to food-derived odor (FO) suppresses feeding. However, the mechanisms by which olfaction induces hypophagia remain elusive. In this study, we show that prolonged FO exposure significantly suppresses food intake in male mice. We identified a subset of neurons in the ventral subiculum (vSub) that are specifically activated by FO. We further discovered that these FO-activated neurons …
Targeting Sting To Disrupt Macrophage-Mediated Adhesion In Encapsulating Peritoneal Sclerosis, Juan Sun, Yuxiang Sun, Dandan Guo, Huolin Ye, Qiang Huang, Hu Zhou, Canming Li, Mei Liao, Yujia You, Hongli Shang, Pan Zhou, Dongxuan Wu, Janusz Witowski, Zhaoyong Hu, Hui Peng
Targeting Sting To Disrupt Macrophage-Mediated Adhesion In Encapsulating Peritoneal Sclerosis, Juan Sun, Yuxiang Sun, Dandan Guo, Huolin Ye, Qiang Huang, Hu Zhou, Canming Li, Mei Liao, Yujia You, Hongli Shang, Pan Zhou, Dongxuan Wu, Janusz Witowski, Zhaoyong Hu, Hui Peng
Faculty, Staff and Students Publications
Encapsulating peritoneal sclerosis (EPS) is a life-threatening fibrotic condition characterized by severe abdominal adhesions, chronic inflammation, and significant morbidity. The lack of effective treatments for EPS stems from a limited understanding of its underlying mechanisms. In this study, we developed a modified mouse model of PD-induced EPS and investigated the role of the STING signaling pathway in disease progression. Our findings reveal that STING activation in peritoneal mesothelial cells significantly increases the secretion of the macrophage chemokine CCL2, leading to enhanced macrophage infiltration and the formation of pathological adhesions. Notably, pharmacological inhibition of STING using the inhibitor H151 effectively reduced …