Digital Commons Network^™

Dosage Compensation And Gene Expression Of The X Chromosome In Sheep, Jingyue (Ellie) Duan, Kaleigh Flock, Nathanial Jue, Mingyuan Zhang, Amanda Jones, Sahar Al Seesi, Ion Mandoiu, Sambhu Pillai, Maria Hoffman, Rachel O’Neill, Steven Zinn, Kristen Govoni, Sarah Reed, Hesheng Jiang, Zongliang (Carl) Jiang, Xiuchun (Cindy) Tian

School of Natural Sciences Faculty Publications and Presentations

Ohno’s hypothesis predicts that the expression of the single X chromosome in males needs compensatory upregulation to balance its dosage with that of the diploid autosomes. Additionally, X chromosome inactivation ensures that quadruple expression of the two X chromosomes is avoided in females. These mechanisms have been actively studied in mice and humans but lag behind in domestic species. Using RNA sequencing data, we analyzed the X chromosome upregulation in sheep fetal tissues from day 135 of gestation under control, over or restricted maternal diets (100%, 140% and 60% of National Research Council Total Digestible Nutrients), and in conceptuses, juvenile, …

Celiac Disease Among At-Risk Individuals In Saudi Arabia, Mohammad-Ayman A. Safi

Saudi Medical Journal

Objectives: To perform a meta-analysis for celiac diseases (CD) among at-risk populations in Kingdom of Saudi Arabia (KSA), as well as a comparison with our previously reported meta-analysis in the normal population. Methods: In March 2018, at King Abdulaziz University, Jeddah, KSA we commenced a retrospective comprehensive database and journal search for CD among at-risk populations in SA. Data from each of the relevant articles were analyzed using the Statistical Package for Social Science Version 20 (Armonk, NY: IBM Corp.). and the comprehensive meta-analysis program (CMA). The collected data were part of a retrospective literature review and analysis. Thus, a …

Editorial Message

Saudi Medical Journal

No abstract provided.

Daxx As A Restrictor Of Tumor Initiating Cell Survival In Er+ Breast Cancer And Its Therapeutic Implications, Daniel Seamus Peiffer

Dissertations

Breast cancer overall is the second most common cause of cancer related death in women, with one in eight women being diagnosed during their lifetime. Breast cancer itself is divided into subtypes based on the expression levels of the hormone receptors including the estrogen receptor (ER) and the progesterone receptor (PR), as well as expression of the growth factor receptor epidermal growth factor receptor 2 (HER2). ER+ breast cancer is the most common breast cancer diagnosis, and these tumors are defined as being initially dependent on activation of the receptor for growth. Based on this, targeted endocrine therapies (ETs) have …

Visualization And Scientometric Mapping Of Global Agriculture Big Data Research, Guptnath Trivedi

Library Philosophy and Practice (e-journal)

The present paper is a scientometric and visualization study of global Agriculture Big Data (ABD) research. however as per the quantification is concern, very little research have performed in the area of Agriculture Big Data. The study aims to traverse the present status of Agriculture Big Data research through network analysis and visualizations study of the ABD publications. A total of 379 publication data were downloaded from Clarivate Analytics Web of Science database within the time span of "all years". VOSviewer, MS-Excel and R statistical software is used for data analysis. Various results are drawn based on annual scientific production, …

Open Access: An Overview, Javaid Wani

Library Philosophy and Practice (e-journal)

No abstract provided.

The Use And Effect Of Smartphones In Students’ Learning Activities: Evidence From The University Of Ghana, Legon, Noah Darko-Adjei

Library Philosophy and Practice (e-journal)

The use of a smartphone is gradually becoming a compelling learning tool used to enhance teaching and learning in distance education. Its usage ensures flexible course delivery, makes it possible for learners to access online learning platforms, access course resources and interact digitally. The purpose of this study was to examine the use and effects of the smartphone as a learning tool in distance education at the University of Ghana. The study was based on the Technology Acceptance Model (TAM) and included 294 total respondents. The survey research design and questionnaires were employed for the study. The major objectives of …

Librarians And Their Distinctive Personality Traits In The 21st Century Digital Era, Shohar Bano, Midhat Mehraj, Ikhlaq Ur Rehman

Library Philosophy and Practice (e-journal)

While there is a fair extension of literature in terms of core skills required by librarians but there is rareness of research on competencies that librarians should possess in terms of their personality traits that distinguish them from the rest of the professions. The role of librarians in the 21^st century has migrated from information disseminators to the talent searchers, technological experts, innovators, strategy makers, and entrepreneur. Accordingly, they cannot rely on so-called "soft skills" of primitive nature; their skills must have a touch of dynamism. The study being theoretical type describes the personality based traits of the librarians …

Critical Review Of Organization-Technology Sensemaking: Towards Technology Materiality, Discovery And Action, Mostafa Mesgari, Chitu Okoli

Information Systems and Business Analytics Faculty Works

More than two decades of sensemaking research has brought thorough knowledge of how people understand organisational phenomena and attach meaning to them. This stream of research explores varied social and cognitive aspects of the process in the context of organisations and information technology (IT). However, such a large body of literature exhibits some significant shortcomings: there is a lack of IT materiality; a neglect of the discovery aspect of perception; and a lack of action orientation. So, there is limited understanding of the role that the material artefact plays in shaping users’ sensemaking of new IT, as well as how …

Philosophy And Theology: Is Birth Ethically Relevant?, Christopher Kaczor

Philosophy Faculty Works

No abstract provided.

Virtue Epistemology, Virtue Ethics, And The Structure Of Virtue, Jason Baehr

Philosophy Faculty Works

Contemporary virtue epistemology examines the cognitive life with an eye to the epistemic excellences or "intellectual virtues" of knowing subjects (Battaly 2008). It was inspired by virtue ethics, which emphasizes moral virtues and their centrality to acting and living well. This chapter begins with an observation about an apparent structural asymmetry between virtue epistemology and virtue ethics. It considers whether, initial appearances notwithstanding, there is in fact a virtue ethical counterpart of reliabilist virtue epistemology. This leads to a somewhat narrower consideration, namely whether there is a counterpart of reliable cognitive faculties within our moral psychology. The chapter clarifies and …

Foreword Of Cow Care In Hindu Animal Ethics, Christopher Key Chapple

Theological Studies Faculty Works

No abstract provided.

A Delicate Balance For Innovation: Competition And Collaboration In R&D Consortia, Dong Chen, Li Dai

Management Faculty Works

This study examines how competitive and cooperative relationships within R&D consortia influence member firms' innovation output. We propose a U-shaped relationship between the presence of market competitors for a member firm and the firm's joint R&D output with other consortium members, and examine how the relationship is mediated by interactions with other members at the firm level and moderated by collaborative efforts at the consortium level. Using a unique sample of 320 firms from 52 R&D consortia in China, we find support for our predictions. This multi-level study extends our understanding of competition and cooperation in multi-party networks and provides …

Visual Programming Language With Natural User Interface, Matthew Britton

Williams Honors College, Honors Research Projects

One of the fastest-growing fields of interest in computer science, fueled primarily by gaming, is the Natural User Interface (NUI). NUI encompasses technologies which would replace the typical mouse-and-keyboard approach to interaction with computer systems, with the goal of making human-computer interactions more similar to face-to-face interpersonal interactions. This is done by using technologies such as gesture recognition or speech recognition and speech synthesis, which use interpersonal skills we learn and practice on a daily basis. Visual Programming Languages (VPLs) are languages that allow the creation of a program by arranging graphical representations of program behavior, rather than textual program …

Effectiveness Of Alternative Cerebral Palsy Treatments In Pediatrics: Systematic Review, Olivia Doria, Emily Fricker, Katrina Beery

Williams Honors College, Honors Research Projects

Abstract

Cerebral palsy (CP) is a multi-faceted movement disorder that affects the lives of approximately 500,000 children in America and millions across the globe. Traditional treatment involves physical and occupational therapies. The purpose of this systematic review is to identify, describe, and critically appraise the evidence about the effectiveness of alternative therapies including hippotherapy, aquatic therapy, and robotic gait training in children with CP. Researchers have found that these therapies improve gross motor function and balance. This review focuses on determining which age subpopulation would benefit most. A critical appraisal of studies is conducted and followed by recommendations for practice …

Kardía: A Choreographic Investigation Utilizing The Human Heart, Rebekah R. Mayfield

Williams Honors College, Honors Research Projects

The research project, Kardía; A Choreographic Investigation Utilizing the Human Heart, examined how findings regarding the study of the heart influences and expands choreographic options for and approaches to dance as a work of art. The heart is a unique and intricate organ that helps sustain life within a human body. Examined for this project were the structure, actions and functions of the human heart. This data informed and inspired the concepts that were applied to my choreography, culminating in the presentation of my original work entitled Kardía; The Quietest Voice. The creative process I used for this project …

A Pilot Study Comparing The Penetration Properties Of Bilobed And Trilobed Bronze Arrowhead Points Modeled From Neo-Assyrian Finds From Ziyaret Tepe, Turkey, Damon Mullen

Williams Honors College, Honors Research Projects

The aim of this project is to help understand how and why cultures implement technology. This paper specifically focuses on testing and analyzing how morphological variation in arrowhead shape affects performance attributes. As a model of variation, we have chosen to concentrate on two different types of bronze arrowhead based on Neo-Assyrian finds, bilobed and trilobed, to see if they, by virtue of morphology only, have differing penetration capabilities.

Fighting Cancer With Purpose: Best Practices For Charity Event Planning, Emily Bower

Williams Honors College, Honors Research Projects

The 2017-2018 school year was the first year The University of Akron competed in the Bateman competition, a national public relations competition. The Bateman competition challenges students to research, execute, and evaluate a public relations plan within their college campus and the surrounding community. Two teams at The University of Akron successfully created and implemented a plan that benefitted the non-profit With Purpose, an organization dedicated to increasing funding and research efforts allocated toward pediatric cancer. As a member of one of those teams, the author was responsible for planning the Bateman team’s large event during the implementation period. This …

Let's Talk About Art School!, Elise Radzialowski

Williams Honors College, Honors Research Projects

Art students have tough lives. We choose an education that is difficult to complete and a career that often trades financial security for personal fulfillment. The purpose of this project is a celebration of art students, whether it laughs at our mistakes, rejoices in our successes, or offers advice. This is a student-led critique on art school. This project intends to look seriously at the good and bad in art school, including both students and professors. The media is an experimental combination of traditional watercolor and digital painting techniques, as seen in the process images.

The limitations of this project …

Designing Classrooms For Learning, Ryan Neubauer

Williams Honors College, Honors Research Projects

The purpose of this research project was to provide a comprehensive look into what physical features of a middle school classroom that students find the most beneficial. The main question specifically was "What do students need in a classroom to meet their physical needs." In doing this, ten features of classrooms were selected and from those a set of students were asked to evaluate how they felt about these features. Over the course of a semester data was complied evaluating these features as well as classroom design and the interior space and layout.

Autonomous Vehicles, Sarah Flis

Williams Honors College, Honors Research Projects

Some research objectives to be considered in this paper will include: What are the general advantages and disadvantages of having fully autonomous vehicles? What research has been done on the safety of them and what needs to be done to improve that safety? In order to have the safest and most efficient system for autonomous vehicles, will there be a place for older vehicles that require a human to operate in this new transportation system? Where does Ohio stand in the development of autonomous vehicles and what steps are they taking to prepare for such technology?

Another important research objective …

Mobile Application: Peril, Michael Prough

Williams Honors College, Honors Research Projects

In today’s world, phones and computers are widely used for various purposes, whether it would be using social media or using it for work. As they have become more popular, these devices have improved and continue to evolve, and as such, they have a wider range of uses. One such popular use of these devices is for entertainment, which includes watching content online or playing video games. With the rise of entertainment applications, I decided that I should learn how to make these applications. I ultimately decided on creating a video game for android systems which incorporated features from platformer …

U.S. Census Explorer: A Gui And Visualization Tool For The U.S. Census Data Api, Timothy Snyder

Williams Honors College, Honors Research Projects

U.S. Census Explorer is a software application that is designed to provide tools for intuitive exploration and analysis of United States census data for non-technical users. The application serves as an interface into the U.S. Census Bureau’s data API that enables a complete workflow from data acquisition to data visualization without the need for technical intervention from the user. The suite of tools provided include a graphical user interface for dynamically querying U.S. census data, geographic visualizations, and the ability to download your work to common spreadsheet and image formats for inclusion in external works.

Prevention Of Harmful Algal Blooms By The Mitigation Of Phosphorus Nutrient Loading Via Filtration By Steel Wool And Activated Carbon, Ronald Simpson, Sara Kidd, Samantha Zidd

Williams Honors College, Honors Research Projects

Harmful Algal Blooms (HABs) are a devastating ecological and economic consequence of the abundance of nutrient-rich agricultural runoff entering aquatic ecosystems (Baker et al. 2014). Bio-available phosphorus from synthetic fertilizers is one of the major nutrients contributing to this global issue. Previous studies indicated that dissolved phosphorus can be removed from an aqueous environment when passed through a composite mixture of granular steel wool particles and activated carbon (Erickson, Gulliver, and Weiss, 2007). In this project, we conducted experiments using higher quality concentration measurements to determine what grades of steel wool (SW-0000, SW-000, SW-00) and types of activated carbon (granulated …

Letting Poetry Inside, To Stay, Erin Siegferth

Williams Honors College, Honors Research Projects

As a child, writing poetry came naturally, like learning to speak. Over time and throughout school, rigid styles of academic interpretation and an air of demographic exclusivity corrupted the genre. I came to associate poetry with historical, formal poets of history. It wasn't until my undergraduate studies introduced me to contemporary poetry that I realized poems were still being created and consumed today, by a diverse and thriving community. This realization renewed my perception of poetry and gave me permission to write in a way that felt authentic, despite the conventions and rules I had learned. In this introduction to …

Effects Of 5��-Dihydrotestosterone (Dht) On Mouse Gut Microbiome– A Study Of Sex Differences And Hormonal Effects On Gut Microbiome Composition, Bikesh Shrestha

All Master's Theses

Type 1 Diabetes (T1D) is a polygenic and multifactorial disease, traditionally attributed to genetic susceptibility and diet. Over the past decade, novel studies have placed a higher significance on the role of gut microbiome in T1D pathogenesis. Furthermore, diabetic mouse models have shown higher incidence of T1D in females compared to males, attributed to the differences in gut microbial community structure. Interestingly, female mouse models elicit male-like protection from T1D when transplanted with the male gut microbiome. In a previous study, we observed that female Non-obese diabetic (NOD) mice implanted with slow release 5��-Dihydrotestosterone(DHT) for 90 days showed improved glucose …

Regional Patterns Of Vascularity Within The Limb Bones Of Small And Large-Bodied Bats, Logan Usher

Williams Honors College, Honors Research Projects

Bats have humeri and femora that are poorly vascularized or avascular compared to birds, with only larger bats typically displaying vascular canals. Vascular canals provide passageways for blood vessels and nerves, which help maintain bone homeostasis, and support bones by resisting torsional stresses placed on them. The presence of a greater number of canals in large bats suggests that they may have a larger need for the support of nutrient and waste exchange than their dense lacunar-canalicular system can provide on its own. The focus of the current project will be to analyze SR micro-CT data from various bat humeri …

The Decision To Decentralize Good Provision In The United States: A Study In Clean Energy Policy, Whitney Michelle Davis

Theses and Dissertations--Public Policy and Administration

Normative economic theory provides justification for at least partially centralized renewable energy provision due to the large, positive externalities associated with renewable energy production. However, the United States is one of the few countries without centralized renewable energy policy. Instead, the federal government actively chooses decentralized renewable energy provision by using fiscal transfers to support subnational renewable energy development. This dissertation explores why U.S. legislators choose decentralized renewable energy provision by asking two primary questions. First, what is the motivation for using federal fiscal transfers for decentralized renewable energy output considering what we know about positive spillovers and market failure …

Redemptive Penology Vs. Exclusive Retributive Justice, Samuel Chuks Japhets

Masters Theses

Grounded on long-standing penal notions of exclusive retributivism inherited from classical theorists, Ancient Near East lex talionis, and theonomist penology, the United States federal sentencing and corrections system aims to administer just desert sentences on offenders, to curtail crimes. This exclusively retributive model of criminal sanction is, presumably transformative and innately capable of dispensing holistic justice to society, victims, and criminals. However, the preponderance of high rates of recidivism raises the question of whether this exclusively retributive doctrinal framework that drives the federal penology empirically results in a redemptive administration of penal justice, especially to the offender. Given the traditional …

The Origins Of Western Music And Its Influence On Modern Popular Music: Teaching Music Through A Musical Exploration Of Seven Countries, Johanna Katelyn Hatt

Masters Theses

The topics of music history and music appreciation cover a wide range of composers and musical contributions that at times, can be overwhelming to a student who does not have any musical knowledge. Through limiting the music appreciation course to the discussion of composers’ works from various countries, students are able to learn about the important contributions those composers and countries had to music, including modern popular music. This topic will bring value to the field of music education as it offers an alternative approach to the traditional method of teaching a music history course. With this holistic approach to …