Making Space For Makerspace: How Adding A Makerspace Can Benefit Art Museum Education Programming, Kaeleigh Thorp

Master's Projects and Capstones

In this capstone project, I advocate for adding makerspaces to art museum education programming. I review the foundational educational concepts of a makerspace which help explain why it is a modern strategy to increasing visitor learning. This includes John Dewey’s theories of experience and education, Howard Gardner’s multiple intelligences theory, George Hein’s studies of museum visitor behavior, and the physiological science of learning. I then propose four key terms essential for visitor learning, and explain how makerspaces successfully incorporate them. The four key terms are: 1. multiple intelligences, 2. direct experience, 3. inquiry based and open ended learning, and 4. …

The Dominican Liberator: Father Edward Paul Doyle, O.P.’S Response To The Holocaust, Jacqueline Michels

History & Classics Undergraduate Theses

Individual survivors and witnesses to the Holocaust each remember and reflect on their experiences differently. Some are angry at the Nazis for their inhumane actions. Some are angry at God for allowing these evils to take place. Others learned from their experience. Edward Paul Doyle, O.P. was one of the latter. A Dominican Friar at Providence College, he served as an army chaplain for the United States Army in Germany during World War II. While in Germany, Father Doyle helped to liberate Nordhausen concentration camp where he witnessed the horrors of the Holocaust. Father Doyle recorded his experience and reflections …

Scheduling Two Machines With Dissimilar Costs, Madhurupa Moitra

UNLV Theses, Dissertations, Professional Papers, and Capstones

We consider two devices, which has states ON and OFF. In the ON state, the devices use their full power whereas in the OFF state the devices consume no energy but a constant cost is associated with switching back to ON. Such two devices are configured with different run and power-up costs on which a sequence of jobs must be processed. The object is to minimize the cost. Such systems are widely used to conserve energy, for example, to speed scale CPUs, to control data centers, or to manage renewable energy.

The problems are studied in the framework of online …

A Framework To Capture Dynamic Traffic Trends From Historical Sensor Data, Carlos Gaviria

UNLV Theses, Dissertations, Professional Papers, and Capstones

The typical approach of increasing infrastructure to alleviate traffic issues such as congestion is becoming unviable due to limited space, high cost, and associated externalities. Control and management strategies using Intelligent Transportation Systems (ITS) seek to maximize the use of existent infrastructure. Many ITS strategies, such as the deployment of information, require or benefit from knowledge about traffic patterns and trends. This study proposes a mathematical programming formulation and solution algorithm that considers multiple time intervals for the estimation of network-wide traffic states and calculation of the corresponding transition probabilities. The proposed solution enables the determination of sections of the …

Optimization Of Useful Hard X-Ray Photochemistry, David Lewis Goldberger

UNLV Theses, Dissertations, Professional Papers, and Capstones

X-ray induced damage is generally considered a nuisance, but in the field of Useful Hard X-ray Photochemistry we harness the highly ionizing and penetrating properties of hard X-rays (> 7 keV) to initiate novel photochemical decomposition and synthesis at ambient and extreme conditions. Preliminary experiments suggest that the energy of irradiating photons and the sample pressure play roles in determining the nature of X-ray induced damage. Here, we present the X-ray energy dependence of damage induced in strontium oxalate, strontium nitrate, and barium nitrate, as well as the pressure dependence of X-ray induced damage of strontium oxalate. Our results indicate …

Doing Business In America: A Jewish History, Purdue University Press

The Jewish Role in American Life: An Annual Review

American and Jewish historians have long shied away from the topic of Jews and business. Avoidance patterns grew in part from old, often negative stereotypes that linked Jews with money, and the perceived ease and regularity with which they found success with money, condemning Jews for their desires for wealth and their proclivities for turning a profit. A new, dauntless generation of historians, however, realizes that Jewish business has had and continues to have a profound impact on American culture and development, and patterns of immigrant Jewish exploration of business opportunities reflect internal, communal, Jewish-cultural structures and their relationship to …

Accurate Vehicle Detection Using Multi-Camera Data Fusion And Machine Learning, Hao Wu

Electrical Engineering Theses and Dissertations

Computer-vision methods have recently been extensively used in intelligent transportation systems for vehicle detection. However, the detection of severely occluded or partially observed vehicles due to the limited camera fields of view remains a significant challenge. This paper presents a multi-camera vehicle detection system that significantly improves the detection performance under occlusion conditions. The key elements of the proposed method include a novel multi-view region proposal network that localizes the candidate vehicles on the ground plane. We also infer the vehicle occupancies by leveraging multi-view cross-camera context. Experiments are conducted on a dataset captured from a roadway in Richardson, TX, …

Coordination Operation Of Natural Gas And Electricity Network With Line-Pack, Junyang Mi

Electrical Engineering Theses and Dissertations

This dissertation addresses the coordinated operation of electricity and natural gas networks considering the line-pack flexibility in the natural gas pipelines. The problem is formulated as a mixed integer linear programming problem. The objective is to minimize the operation cost of the electricity and natural gas networks considering the price of the natural gas supply. Benders decomposition is used to solve the formulated problem. The master problem minimizes the startup and shutdown costs as well as the operation cost of the thermal units other than gas-fired generation units in the electricity network. The first subproblem validates the feasibility of the …

Clinical Pharmacology Of Tisagenlecleucel In B-Cell Acute Lymphoblastic Leukemia., Karen Thudium Mueller, Edward Waldron, Stephan A. Grupp, John E. Levine, Theodore W. Laetsch, Michael A. Pulsipher, Michael W. Boyer, Keith August, Jason Hamilton, Rakesh Awasthi, Andrew M. Stein, Denise Sickert, Abhijit Chakraborty, Bruce L. Levine, Carl H. June, Lori Tomassian, Sweta S. Shah, Mimi Leung, Tetiana Taran, Patricia A. Wood, Shannon L. Maude

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL).

PATIENTS AND METHODS: We evaluated the cellular kinetics of tisagenlecleucel, the effect of patient factors, humoral immunogenicity, and manufacturing attributes on its kinetics, and exposure-response analysis for efficacy, safety and pharmacodynamic endpoints in 79 patients across two studies in pediatric B-ALL (ELIANA and ENSIGN).

RESULTS: Using quantitative polymerase chain reaction to quantify levels of tisagenlecleucel transgene, responders (N = 62) had ≈2-fold higher tisagenlecleucel expansion in peripheral blood than nonresponders ( …

The Evolution Of Computational Propaganda: Trends, Threats, And Implications Now And In The Future, Holly Schnader

Senior Honors Projects, 2010-2019

Computational propaganda involves the use of selected narratives, social networks, and complex algorithms in order to develop and conduct influence operations (Woolley and Howard, 2017). In recent years the use of computational propaganda as an arm of cyberwarfare has increased in frequency. I aim to explore this topic to further understand the underlying forces behind the implementation of this tactic and then conduct a futures analysis to best determine how this topic will change over time. Additionally, I hope to gain insights on the implications of the current and potential future trends that computational propaganda has.

My preliminary assessment shows …

Parametric Design And Optimization Of A Pivoting S-Type Rudder For Containerships, Chen-Wei Chen, Tsung-Yueh Lin, Bo-Yen Chen, Jen-Shiang Kouh

Journal of Marine Science and Technology–Taiwan

This study proposes an energy-saving S-type rudder design to deal with the inhomogeneous inflow from a rotating propeller behind a containership. The S-type rudder was modelled parametrically using four-digit NACA foils as section profiles together with Non-uniform rational B-splines (NURBS) surface formulations. A three-stage optimization process is proposed to reduce the number of design iterations necessary to achieve an optimal design. The propulsion simulations were done via CFD software, which solves the hydrodynamics of viscous flow, as governed by the Reynold-averaged Navier-Stokes (RANS) equations. Validations were performed with experimental model tests, including hull resistance, propeller open-water performance, and propulsion in …

Collision Avoidance Path Planning For Ships By Particle Swarm Optimization, Yu-Tao Kang, Wei-Jiong Chen, Da-Qi Zhu, Jin-Hui Wang, Qi-Miao Xie

Journal of Marine Science and Technology–Taiwan

Ship collision avoidance is a key consideration in maritime systems. Collision avoidance maneuvers depend on navigators’ experience and skill levels. Because both maritime traffic densities and average ship speeds are increasing, the times available for decision-making are decreasing, which elevates the risk of human errors in the collision avoidance process. To reduce the effect of human factors and efficiently prevent collisions between ships navigating in open water with effective visibility, a particle swarm optimization (PSO) algorithm can be used to plan ship paths. An improved ship domain dynamic model can assess collision risks in close-range encounters. Several marine traffic scenarios …

A Pilot Study On Real-Time Monitoring Of Heart Rate And Movement Speed In Middle-Distance Race Of Physical Education Classes, Daqing Zhu, Xingui Zhang, Lanying Fu, Peiyong Wang, Shaohong Zhai

Journal of Educational Technology Development and Exchange (JETDE)

In Chinese universities, students need to participate in the middle-distance-race. Normally, female students are required to participate in the race of 800 meters, while male students are required to participate in the race of 1000 meters. However, it is difficult for teachers to grasp the real time information of students during the race. And there is a lack of timely communications between the teachers and students. Focusing on this issue, this study, with the use of POLAR heart rate sensor and other modern information technologies, expands the original function of the sensor to achieve a concurrent operation of detecting heart …

Grammar And Variation: Understanding How Cis-Regulatory Information Is Encoded In Mammalian Genomes, Dana Michele King

Arts & Sciences Graduate Student Theses and Dissertations

Understanding how genotype leads to phenotype is key to understand both the development and dysfunction of complex organisms. In the context of regulating the gene expression patterns that contribute to cell identity and function, the goal of my thesis research is to how changes in genome sequence may impact impact gene expression by determining how sequence features contribute to regulatory potential. To accomplish this goal, I first leveraged the key regulatory role of pluripotency transcription factors (TFs) in mouse embryonic stem cells (mESCs) and tested synthetically generated and genomic identified combinations of binding site for four TFs, OCT4, SOX2, KLF4, …

Fast Objective Coupled Planar Illumination Microscopy, Cody Jonathan Greer

Arts & Sciences Graduate Student Theses and Dissertations

Among optical imaging techniques light sheet fluorescence microscopy stands out as one of the most attractive for capturing high-speed biological dynamics unfolding in three dimensions. The technique is potentially millions of times faster than point-scanning techniques such as two-photon microscopy. This potential is especially poignant for neuroscience applications due to the fact that interactions between neurons transpire over mere milliseconds within tissue volumes spanning hundreds of cubic microns. However current-generation light sheet microscopes are limited by volume scanning rate and/or camera frame rate. We begin by reviewing the optical principles underlying light sheet fluorescence microscopy and the origin of these …

The Splice Is Not Right: Splice-Site-Creating Mutations In Cancer Genomes, Reyka Glencora Jayasinghe

Arts & Sciences Graduate Student Theses and Dissertations

Accurate interpretation of cancer mutations in individual tumors is a prerequisite for precision medicine. Large-scale sequencing studies, such as The Cancer Genome Atlas (TCGA) project, have worked to address the functional consequences of genomic mutations, with the larger goal of determining the underlying mechanisms of cancer initiation and progression. Many studies have focused on characterizing non-synonymous somatic mutations that alter amino acid sequence, as well as splice disrupting mutations at splice donors and acceptors. Current annotation methods typically classify mutations as disruptors of splicing if they fall on the consensus intronic dinucleotide splice donor, GT, the splice acceptor, AG. Splice …

Modeling The Bioactivation And Subsequent Reactivity Of Drugs, Tyler Brian Hughes

Arts & Sciences Graduate Student Theses and Dissertations

Metabolism can convert drugs to harmful reactive metabolites that conjugate to DNA and off-target proteins. Reactive metabolites are a significant driver of both drug candidate attrition and withdrawal from the market of already approved drugs. Unfortunately, reactive metabolites are difficult to study in vivo, because they are transitory and generally do not circulate. Instead, this work computationally models both metabolism and reactivity. Using deep learning, predictive models were developed for the metabolic formation of quinones and epoxides, which together account for about half of known reactive metabolites. Additionally, an accurate model of DNA and protein reactivity was constructed, which predicts …

Protein Structure-Guided Approaches To Identify Functional Mutations In Cancer, Sohini Sengupta

Arts & Sciences Graduate Student Theses and Dissertations

Distinguishing driver mutations from passenger mutations within tumor cells continues to be a major challenge in cancer genomics. Many computational tools have been developed to address this challenge; however, they rely heavily on primary protein sequence context and frequency/mutation rate. Rare driver mutations not found in many cancer patients may be missed with these traditional approaches. Additionally, the structural context of mutations on tertiary/quaternary protein structures is not taken into account and may play a more prominent role in determining phenotype and function. This dissertation first presents a novel computational tool called HotSpot3D, which identifies regions of protein structures that …

Skiing At Martin The Northern Pacific Stop At Stampede Pass, John W. Lundin

Works by Local Authors

Martin is a stop on the Northern Pacific Railroad at the east portal of its tunnel under Stampede Pass, going through the Cascade Mountains, named for the nearby Martin Creek. Since the 1920s, Northwest skiers took the Northern Pacific Railroad to Martin to take advantage of the deep snow that fell there. The story of skiing at Martin is virtually unknown these days, and Martin is one of the Lost Ski Areas of Washington.

The Future Of Innovation: How Libraries Support Entrepreneurs, Ilana Stonebraker, Heather A. Howard, Joe Collier, Saira Raza

Libraries Faculty and Staff Scholarship and Research

This paper highlights the ways that three different libraries are working to support entrepreneurs in their community: a public librarian connected with city government to support a small business development center; a librarian from a private university worked with social entrepreneurs that want to transform the world with business; a librarian from a large public land-grant works with entrepreneurs across the campus including business incubators and business competitions. The work these librarians do highlights the many ways libraries support entrepreneurs through collaboration, vision, and partnership.

Design And Preliminary Evaluation Of A Supercritical Carbon Dioxide Brayton Cycle For Solar Dish Concentrator Clean Energy Production, Danielle Nobles-Lookingbill

UNLV Theses, Dissertations, Professional Papers, and Capstones

As we move toward energy independence and more ambitious clean energy goals, solar energy research must push the efficiency limits of traditional energy generation systems. Increases in efficiency can be achieved by increasing the hot temperature of the power cycle. Recent research demonstrates the potential for increased efficiency and a vastly smaller component size when supercritical carbon dioxide Brayton power cycles are used. Concentrated solar and nuclear heat sources are capable of achieving the high working fluid temperatures needed for significant efficiency gains. This NSF EPSCoR funded, experimental research system is designed to exploit the uniquely immense solar irradiance of …

Analysis And Design Of Analog Front-End Circuitry For Avalanche Photodiodes (Apd) And Silicon Photo-Multipliers (Sipm) In Time-Of-Flight Applications, Vikas Vinayaka

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis reports the analysis and design of analog front-end circuitry for reading out signals from avalanche photodiodes (APD) or silicon photomultiplier (SiPM) in time-of-flight (ToF) applications. An integrated circuit was designed using AMS SiGe 0.35 um BiCMOS process. The chip measured 2 mm x 2 mm (2000 umx2000 um). The chip mainly contains the following circuits: an APD with photoactive area measuring 24 umx24 um, an SiPM with 8x8 APDs with 236 k ohm quench resistors, a transimpedance amplifier (TIA), a comparator and a R-2R digital to analog converter (DAC). The TIA is based on the shunt-shunt feedback topology. …

Effects Of Ambient Air Pollution On Asthma-Related Emergency Department Visits Within The Las Vegas Metropolitan Area, Loiren E. Monardes

UNLV Theses, Dissertations, Professional Papers, and Capstones

The objective of this research was to evaluate the risk for asthma-related Emergency Department visits and their association with ambient air pollution within the Las Vegas metropolitan area. All data were aggregated by date and ZIP Code. The association was analyzed by applying the distributed lag non-linear model in an attempt to identify elevated concentrations of specific air pollutants

as triggers and their delayed effects (lag days). Relative Risk (RR) and 95% confidence intervals were produced, while adjusting for socioeconomic status. This ecological population-based study analyzed daily asthma counts of Emergency Department visits from January 1st, 2009 to December 31st, …

Riding The Wave Of Microplastics In Bermuda, Molly E. Riihiluoma

Pell Scholars and Senior Theses

The presence of marine debris and microplastics in the Earth’s oceans are a global environmental issue. Bermuda’s location in the middle of the North Atlantic Gyre makes it the perfect case study for this work. As the crisis unfolds, Bermuda’s environment, economy, and population are at risk of witnessing firsthand the effects of plastic pollution. This paper relies on scholarly research as well as anecdotal evidence from retail stores and locals to compile information in order to provide necessary recommendations to benefit Bermuda’s ocean health. This research evaluates the pros and cons of policies which could mitigate the problem. Analysis …

Brand Loyalty In The Cruise Sector: Age Cohorts, Gender, And Travel Attributes As Key Moderators For Relationship Marketing Theory, Stephen Wen-Hung Wang, Maxwell Kuo-Hsuan Hsu, Angeline Close Scheinbaum, Feng-Ming Tsai

Journal of Marine Science and Technology–Taiwan

Testing established theory in relationship marketing, we examine the impact of customer relationship management on customer satisfaction and brand loyalty in the context of the cruise industry. Individual differences such as age cohort (e.g., millennials, Gen X, baby boomers), gender, and consumers’ desired travel attributes are examined as moderators. Cruise vacation consumers at an international cruise harbor were approached to complete an in-person survey (n = 226). Empirical findings support extant theory in relationship marketing in that consumers’ perception of relationship investment raises satisfaction and, in turn, brand loyalty. Notably, when customer relationship investment is degenerated into a second order …

A Simplified Two-Switching-Based Model-Free Predictive Current Controller For An Interior Permanent Magnet Synchronous Motor Drive System, Cheng-Kai Lin, Jen-Te Yu, Jyun-Ting Wang, Yen-Shin Lai, Hsing-Cheng Yu, Hao-Qun Huang

Journal of Marine Science and Technology–Taiwan

This paper presents a simplified two-switching-based modelfree predictive current control (STSB-MFPCC) method as well as its application to interior permanent magnet synchronous motor (IPMSM) drive systems. Unlike existing model predictive current controller (MPCC) that uses 7 basic voltage vectors, STSB-MFPCC employs 19 synthesized ones, with each of which consisting of two basic voltage vectors. The new method does not require any information about the load parameters, back electromotive force, nor the system model. Compared to modelbased controllers, the proposed one has a distinctive and appealing nature in that it is much less sensitive to system parameter variations. A digital signal …

Monitoring The Impact Of Groundwater Pumping On Infrastructure Using Geographic Information System (Gis) And Persistent Scatterer Interferometry (Psi), Kirsten Deprekel, El Hachemi Bouali, Thomas Oommen

Department of Geological and Mining Engineering and Sciences Publications

Transportation infrastructure is critical for the advancement of society. Bridges are vital for an efficient transportation network. Bridges across the world undergo variable deformation/displacement due to the Earth’s dynamic processes. This displacement is caused by ground motion, which occurs from many natural and anthropogenic events. Events causing deformation include temperature fluctuation, subsidence, landslides, earthquakes, water/sea level variation, subsurface resource extraction, etc. Continual deformation may cause bridge failure, putting civilians at risk, if not managed properly. Monitoring bridge displacement, large and small, provides evidence of the state and health of the bridge. Traditionally, bridge monitoring has been executed through on-site surveys. …

Mercury In Big Cypress Bayou And Caddo Lake Watersheds In Marion And Harrison Counties Texas, Joseph Watkins

Electronic Theses and Dissertations

Caddo Lake has been included on the Texas Commission on Environmental Quality 303(d) list for impairment due to mercury (Hg) content since 1996. One of the primary tributaries, Big Cypress Bayou, flows across Eocene-aged rocks and sediments associated with the Wilcox Group; the Wilcox is of interest because it contains lignite coal, which has a direct link to mercury. Previous research has focused on dry deposition from fossil fuel combustion as the primary source of mercury but has not addressed the potential watershed contribution to mercury concentrations in Caddo Lake.

Big Cypress Bayou flows through Harrison and Marion counties in …

Delineation Of Karst Potential Using Lidar And Gis Analyses, Fort Hood Military Installation, Texas, Colby Reece

Electronic Theses and Dissertations

ABSTRACT

Traditional karst surveys require extensive field investigations to completely characterize large areas. They are often time-consuming, requiring up to several years to collect and categorize data. Bias is given to areas that are most easily accessible and false negatives are common. The implementation of geographic information systems (GIS) has aided in the aggregation and standardization of karst data; however, these systems have also been used to develop terrain models that allow the user to remotely delineate sinkholes and other surficial features. The Fort Hood Military Installation is a karst landscape that has been altered significantly for use in military …

Information-Based Analysis And Control Of Recurrent Linear Networks And Recurrent Networks With Sigmoidal Nonlinearities, Deslin Menolascino

McKelvey School of Engineering Graduate Student Theses & Dissertations

Linear dynamical models have served as an analytically tractable approximation for a variety of natural and engineered systems. Recently, such models have been used to describe high-level diffusive interactions in the activation of complex networks, including those in the brain. In this regard, classical tools from control theory, including controllability analysis, have been used to assay the extent to which such networks might respond to their afferent inputs. However, for natural systems such as brain networks, it is not clear whether advantageous control properties necessarily correspond to useful functionality. That is, are systems that are highly controllable (according to certain …