Digital Commons Network^™

Annual Report, Aurora Health Care Metro Region Cancer Program, 2005, Advocate Aurora Health

Aurora Health Care Books, Documents, and Pamphlets

Aurora Health Care, Milwaukee, WI: Annual report of the cancer services at the Vince Lombardi Cancer Clinics and five Aurora hospitals in the Milwaukee metro region: Aurora St. Luke’s Medical Center, St Luke's South Shore, Aurora Sinai Medical Center, West Allis Memorial Hospital, and Aurora Medical Center in Washington County. Includes statistics and a special section on non-small cell lung cancer.

Guide To Aurora Health Care Libraries, 1995, Advocate Aurora Health

Aurora Health Care Books, Documents, and Pamphlets

Aurora Health Care Libraries, Wisconsin: Aurora Libraries guide from 1995 describing library staff, locations, services, policies, and resources.

Guide To Aurora Health Care Libraries, 1996, Advocate Aurora Health

Aurora Health Care Books, Documents, and Pamphlets

Aurora Health Care Libraries, Wisconsin: Aurora Libraries guide from 1996 describing library staff, locations, services, policies, and resources.

Guide To Aurora Health Care Libraries, 1997, Advocate Aurora Health

Aurora Health Care Books, Documents, and Pamphlets

Aurora Health Care Libraries, Wisconsin: Aurora Libraries guide from 1997 describing library staff, locations, services, policies, and resources.

The Past, Present, And Future Of The Hemlock Woolly Adelgid (Adelges Tsugae) And Its Ecological Interactions With Eastern Hemlock (Tsuga Canadensis) Forests, Aaron M. Ellison, David A. Orwig, Matthew C. Fitzpatrick, Evan L. Preisser

Biological Sciences Faculty Publications

The nonnative hemlock woolly adelgid is steadily killing eastern hemlock trees in many parts of eastern North America. We summarize impacts of the adelgid on these forest foundation species; review previous models and analyses of adelgid spread dynamics; and examine how previous forecasts of adelgid spread and ecosystem dynamics compare with current conditions. The adelgid has reset successional sequences, homogenized biological diversity at landscape scales, altered hydrological dynamics, and changed forest stands from carbon sinks into carbon sources. A new model better predicts spread of the adelgid in the south and west of the range of hemlock, but still under-predicts …

Mitochondrial Metabolism In Major Neurological Diseases, Zhengqiu Zhou, Grant L. Austin, Lyndsay E. A. Young, Lance A. Johnson, Ramon Sun

Molecular and Cellular Biochemistry Faculty Publications

Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular physiology. They are responsible for producing the majority of a cell’s ATP, thus supplying energy for a variety of key cellular processes, especially in the brain. Although energy production is a key aspect of mitochondrial metabolism, its role extends far beyond energy production to cell signaling and epigenetic regulation–functions that contribute to cellular proliferation, differentiation, apoptosis, migration, and autophagy. Recent research on neurological disorders suggest a major metabolic component in disease pathophysiology, and mitochondria have been shown to be in the center of metabolic dysregulation and possibly …

Minimal Information For Studies Of Extracellular Vesicles 2018 (Misev2018): A Position Statement Of The International Society For Extracellular Vesicles And Update Of The Misev2014 Guidelines, Clotilde Théry, Kenneth W. Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D. Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K. Atkin-Smith, D. Craig Ayre, Jean-Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie N. Bauer, Amy A. Baxter, Mary Bebawy, Carla Beckham, Apolonija Bedina Zavec, Adberrahim Benmoussa, Anna C. Berardi, Paolo Bergese, Ewa Bielska, Cherie Blenkiron, Sylwia Bobis-Wozowicz, Eric Boilard, Wilfred Boireau, Antonella Bongiovanni, Ivan Vechetti

Physiology Faculty Publications

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines …

Sodalis Glossinidius Presence In Wild Tsetse Is Only Associated With Presence Of Trypanosomes In Complex Interactions With Other Tsetse-Specific Factors 06 Biological Sciences 0604 Genetics, Manun Channumsin, Marc Ciosi, Dan Masiga, C. Michael R. Turner, Barbara K. Mable

All Peer-Reviewed Publications

Background: Susceptibility of tsetse flies (Glossina spp.) to trypanosomes of both humans and animals has been associated with the presence of the endosymbiont Sodalis glossinidius. However, intrinsic biological characteristics of the flies and environmental factors can influence the presence of both S. glossinidius and the parasites. It thus remains unclear whether it is the S. glossinidius or other attributes of the flies that explains the apparent association. The objective of this study was to test whether the presence of Trypanosoma vivax, T. congolense and T. brucei are related to the presence of S. glossinidius in tsetse flies when other factors …

The Age Of Ambergris., Steven John Rowland, Paul Andrew Sutton, Timothy D.J. Knowles

More Faculty of Science and Engineering Research

Ambergris, which is a coprolith originating from the sperm whale, has been found only rarely, but for centuries, as jetsam on beaches all over the world. There are no reliable data indicating how long such samples may have remained at sea, with unsubstantiated accounts suggesting maybe decades. Here, we obtained over forty jetsam samples, many collected on known dates, from mostly known beach locations across the globe. Such an inventory of verified jetsam ambergris is unprecedented. Each sample was characterised by analytical methods such as gas chromatography-mass spectrometry (GC-MS). We then determined the radiocarbon ages of some of the samples …

Flux Of Particulate Elements In The North Atlantic Ocean Constrained By Multiple Radionuclides, Christopher T. Hayes, Erin E. Black, Robert F. Anderson, Mark Baskaran, Ken O. Buesseler, Matthew A. Charette, Hai Cheng, J. Kirk Cochran, R. Lawrence Edwards, Patrick Fitzgerald, Phoebe J. Lam, Yanbin Lu, Stephanie O. Morris, Daniel C. Ohnemus, Frank J. Pavia, Gillian Stewart, Yi Tang

Environmental Science and Geology Faculty Research Publications

Sinking particles strongly regulate the distribution of reactive chemical substances in the ocean, including particulate organic carbon and other elements (e.g., P, Cd, Mn, Cu, Co, Fe, Al, and 232Th). Yet, the sinking fluxes of trace elements have not been well described in the global ocean. The U.S. GEOTRACES campaign in the North Atlantic (GA03) offers the first data set in which the sinking flux of carbon and trace elements can be derived using four different radionuclide pairs (238U:234Th ;210Pb:210Po; 228Ra:228Th; and 234U:230Th) at stations co-located with sediment trap fluxes for comparison. Particulate organic carbon, particulate P, and particulate Cd …

Conditional Knockout Of Shp2 In Erbb2 Transgenic Mice Or Inhibition In Her2-Amplified Breast Cancer Cell Lines Blocks Oncogene Expression And Tumorigenesis, Hua Zhao, Elisha Martin, Fatimah Matalkah, Neal Shah, Alexey Ivanov, J. Michael Ruppert, Paul R. Lockman, Yehenew M. Agazie

Clinical and Translational Science Institute

Overexpression of the human epidermal growth factor receptor 2 (HER2) is the cause of HER2- positive breast cancer (BC). Although HER2-inactivating therapies have benefited BC patients, development of resistance and disease recurrence have been the major clinical problems, pointing to a need for alternative therapeutic strategies. For that to happen, proteins that play critical roles in the biology of HER2-induced tumorigenesis have to be identified and characterized. Here, we show that the Src homology phosphotyrosyl phosphatase 2 (Shp2) encoded by the Ptpn11 gene is a requisite for ErbB2-induced tumorigenesis. We report that conditional knockout of Shp2 alleles in the ErbB2 …

Giant Tortoise Genomes Provide Insights Into Longevity And Age-Related Disease, Vı́Ctor Quesada, Sandra Freitas‐Rodríguez, Joshua M. Miller, José G. Pérez-Silva, Zi-Feng Jiang, Washington Tapia, Olaya Santiago‐Fernández, Diana Campos-Iglesias, Lukas F. K. Kuderna, Maud C. Quinzin, M. Alvarez, Dido Carrero, Luciano B. Beheregaray, James P. Gibbs, Ylenia Chiari, Scott Glaberman, Claúdio Ciofi, Miguel Araujo‐Voces, Pablo Mayoral, Javier R. Arango

Faculty and Student Publications (Open Access)

No abstract provided.

Identification And Characterization Of Early Photoreceptor Cis-Regulatory Elements And Their Relation To Onecut1, Nathalie Jean-Charles, Diego F. Buenaventura, Mark M. Emerson

Publications and Research

Background: Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors or to generate new functional photoreceptors to replace those lost in the diseased retina. Cis-regulatory elements specific to cones, rods, or both types of photoreceptors are critical components of successful implementation of these two strategies. The purpose of this study was to identify and characterize the cell type specificity and activity of cis-regulatory elements active in developing photoreceptors.

Methods: Cis-regulatory elements were introduced into the developing chicken …

Cryptic Diversity In The Mexican Highlands: Thousands Of Uce Loci Help Illuminate Phylogenetic Relationships, Species Limits And Divergence Times Of Montane Rattlesnakes (Viperidae: Crotalus ), Christopher Blair, Robert W. Bryson Jr, Charles W. Linkem, David Lazcano, John Klicka, John E. Mccormack

Publications and Research

With the continued adoption of genome‐scale data in evolutionary biology comes the challenge of adequately harnessing the information to make accurate phylogenetic inferences. Coalescent‐based methods of species tree inference have become common, and concatenation has been shown in simulation to perform well, particularly when levels of incomplete lineage sorting are low. However, simulation conditions are often overly simplistic, leaving empiricists with uncertainty regarding analytical tools. We use a large ultraconserved element data set (>3,000 loci) from rattlesnakes of the Crotalus triseriatus group to delimit lineages and estimate species trees using concatenation and several coalescent‐based methods. Unpartitioned and partitioned maximum …

Counter Anion Effect On The Photophysical Properties Of Emissive Indolizine-Cyanine Dyes In Solution And Solid State, Jacqueline Gayton, Shane Autry, Ryan C. Fortenberry, Nathan I. Hammer, Jared H. Delcamp

Faculty and Student Publications (Open Access)

Near-infrared emissive materials with tunable Stokes shifts and solid-state emissions are needed for several active research areas and applications. To aid in addressing this need, a series of indolizine-cyanine compounds varying only the anions based on size, dipole, and hydrophilicity were prepared. The effect of the non-covalently bound anions on the absorption and emission properties of identical π-system indolizine-cyanine compounds were measured in solution and as thin films. Interestingly, the anion choice has a significant influence on the Stokes shift and molar absorptivities of the dyes in solution. In the solid-state, the anion choice was found to have an effect …

Cherenkov Excited Short-Wavelength Infrared Fluorescence Imaging In Vivo With External Beam Radiation, Xu Cao, Shudong Jiang, Mengyu Jeremy Jia, Jason R. Gunn, Tianshun Miao, Scott C. Davis, Petr Bruza, Brian W. Pogue

Dartmouth Scholarship

Cherenkov emission induced by external beam radiation therapy from a clinical linear accelerator (LINAC) can be used to excite phosphors deep in biological tissues. As with all luminescence imaging, there is a desire to minimize the spectral overlap between the excitation light and emission wavelengths, here between the Cherenkov and the phosphor. Cherenkov excited short-wavelength infrared (SWIR, 1000 to 1700 nm) fluorescence imaging has been demonstrated for the first time, using long Stokes-shift fluorophore PdSe quantum dots (QD) with nanosecond lifetime and an optimized SWIR detection. The 1  /  λ2 intensity spectrum characteristic of Cherenkov emission leads to low overlap …

Factors Influencing Recruitment And Appearance Of Bull Kelp, Nereocystis Luetkeana (Phylum Ochrophyta), Katie Dobkowski, K. Darby Flanagan, Jessica R. Nordstrom

All Faculty Scholarship

The dynamics of annual species are strongly tied to their capacity for recruitment each year. We examined how competition and propagule availability influence recruitment and appearance and tracked survivorship of an annual species of marine macroalgae, the bull kelp (Nereocystis luetkeana), which serves as major biogenic habitat in the Salish Sea of Washington State. We hypothesized that 1) juvenile N. luetkeana would exhibit a seasonal appearance as a cohort in the spring and 2) competition for space would be more limiting than propagules (spores) to recruitment at sites adjacent to established N. luetkeana beds. We tagged N. luetkeana …

Morphological Assessment Of Cultivated And Wild Amaranth Species Diversity, Ranjita Thapa, Matthew W. Blair

Agricultural and Environmental Sciences Faculty Research

Amaranthus L. is genus of C4 dicotyledonous herbaceous plants comprising approximately 70 species, with three subgenera, which contains both cultivated and wild types, where cultivated ones are used for food grains, leafy vegetables, potential forages and ornamentals. Grain amaranth are pseudocereals from three species domesticated in North and South America and are notable for containing high amount of protein and minerals and balanced amino acid in their small seeds. Genetic diversity analysis of amaranths is important for development of core set of germplasm with widely diverse population and effective utilization of plant genetic resources. In this study, we evaluated a …

Pymol Plugin To Build Protein Structures Based On Natural Term Overlaps, Noah T. Paravicini

Dartmouth College Undergraduate Theses

This project is a continuation of the Grigoryan Lab's exploration of TERMs. A TERM is a tertiary structural motif, which is a fragment of a protein that includes the secondary, tertiary, and quaternary environments around a certain residue. As displayed in past publications discussing TERMs, they are a useful way of decomposing proteins into smaller components that help in understanding design and prediction of protein structures. The Grigoryan Lab developed a database that keeps track of naturally occurring overlaps between TERMs, which gives a user the information they would need to put these TERMs together into complex structures. These events …

Volume 56, Number 15: November 21, 2018, University Of North Dakota

University Letter Archive

No abstract provided.

Phylogeny And Population Genetic Analyses Reveals Cryptic Speciation In The Bombus Fervidus Species Complex (Hymenoptera: Apidae), Jonathan B. Koch, Juanita Rodriguez, James P. Pitts, James P. Strange

Ecology Center Publications

Bumble bees (Bombus Latrielle) are significant pollinators of flowering plants due to their large body size, abundant setae, and generalist foraging strategies. However, shared setal coloration patterns among closely and distantly related bumble bee species makes identification notoriously difficult. The advent of molecular genetic techniques has increased our understanding of bumble bee evolution and taxonomy, and enables effective conservation policy and management. Individuals belonging to the North American Bombus fervidus species-complex (SC) are homogenous in body structure but exhibit significant body color phenotype variation across their geographic distribution. Given the uncertainty of the genealogical boundaries within the SC, some …

U–Pb-Dated Flowstones Restrict South African Early Hominin Record To Dry Climate Phases, Robyn Pickering, Andy I.R. Herries, Jon D. Woodhead

KIP Articles

The Cradle of Humankind (Cradle) in South Africa preserves a rich collection of fossil hominins representing Australopithecus, Paranthropus and Homo1. The ages of these fossils are contentious2,3,4 and have compromised the degree to which the South African hominin record can be used to test hypotheses of human evolution. However, uranium–lead (U–Pb) analyses of horizontally bedded layers of calcium carbonate (flowstone) provide a potential opportunity to obtain a robust chronology5. Flowstones are ubiquitous cave features and provide a palaeoclimatic context, because they grow only during phases of increased effective precipitation6,7, ideally in closed caves. Here we show that flowstones from eight …

Association Of Exposure To Police Violence With Prevalence Of Mental Healthsymptoms Among Urban Residents In The United States, Jordan E. Devylder, Hyun-Jin Jun, Lisa Fedina, Daniel Coleman, Deidre Anglin, Courtney Cogburn, Bruce Link, Richard P. Barth

Publications and Research

Importance Police violence is reportedly widespread in the United States and may pose a significant risk to public mental health.

Objective To examine the association between 12-month exposure to police violence and concurrent mental health symptoms independent of trauma history, crime involvement, and other forms of interpersonal violence exposure.

Design, Setting, and Participants This cross-sectional, general population survey study of 1221 eligible adults was conducted in Baltimore, Maryland, and New York City, New York, from October through December 2017. Participants were identified through Qualtrics panels, an internet-based survey administration service using quota sampling.

Exposures Past 12-month exposure to police violence, …

Palaeohistology And Life History Evolution In Cave Bears, Ursus Spelaeus Sensu Lato, Kristof Veitschegger, Christian Kolb, Eli Amson, Torsten M. Scheyer, Marcelo R. Sánchez-Villagra

KIP Articles

No abstract provided.

Student Entrepreneurs Win Big At Blazer Innovation Challenge, Alicia Rohan

Browse All News

No abstract provided.

Expanded Genetic Screening In Caenorhabditis Elegans Identifies New Regulators And An Inhibitory Role For Nad+ In Axon Regeneration, Kyung Won Kim, Ngana Heok Tang, Christopher A. Piggott, Matthew G. Andrusiak, Seungmee Park, Ming Zhu, Naina Kurup, Salvatore J. Cherra Iii, Zilu Wu, Andrew D. Chisholm, Yishi Jin

Neuroscience Faculty Publications

The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans mechanosensory neuron axotomy model. We identify an unexpected role of the nicotinamide adenine dinucleotide (NAD⁺) synthesizing enzyme, NMAT-2/NMNAT, in axon regeneration. NMAT-2 inhibits axon regrowth via cell-autonomous and non-autonomous mechanisms. NMAT-2 enzymatic activity is required to repress regrowth. Further, we find differential requirements for proteins in membrane contact site, components and regulators of the …

Sexually-Relevant Visual And Chemosensory Signals Induce Distinct Behaviors And Neural Activation Patterns In The Social African Cichlid, Astatotilapia Burtoni, Karen E. Field, Christopher T. Mcvicker, Karen P. Maruska

Faculty Publications

© 2018 Field, McVicker and Maruska. Across vertebrates, the use of multimodal (multiple sensory modalities) signals has evolved to convey important information to receivers. Information content of multimodal signals can be the same as or different from information in each unimodal signal, and are classified as redundant or non-redundant, respectively, based on receivers’ behavioral responses. Despite the prevalence and importance of multimodal signaling across taxa, relatively little is known about how and where these signals are processed in the brains of receivers. We used the social African cichlid fish, Astatotilapia burtoni, to investigate how sexually-relevant visual and chemosensory uni- and …

Grounds Services Helps Preserve Habitat For Monarchs And Other Pollinators (November 21, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Backpack Pcr: A Point-Of-Collection Diagnostic Platform For The Rapid Detection Of Brugia Parasites In Mosquitoes, Weam I. Zaky, Francesca R. Tomaino, Nils Pilotte, Sandra J. Laney, Steven A. Williams

Biological Sciences: Faculty Publications

No abstract provided.

Altered Expression Of Phox2 Transcription Factors In The Locus Coeruleus In Major Depressive Disorder Mimicked By Chronic Stress And Corticosterone Treatment In Vivo And In Vitro, Yan Fan, Ping Chen, Muhammad U. Raza, Attila Szebeni, Katalin Szebeni, Gregory A. Ordway, Craig A. Stockmeier, Meng Yang Zhu

ETSU Faculty Works

Phox2a and Phox2b are two homeodomain transcription factors playing a pivotal role in the development of noradrenergic neurons during the embryonic period. However, their expression and function in adulthood remain to be elucidated. Using human postmortem brain tissues, rat stress models and cultured cells, this study aimed to examine the alteration of Phox2a and Phox2b expression. The results show that Phox2a and Phox2b are normally expressed in the human locus coeruleus (LC) in adulthood. Furthermore, the levels of Phox2a protein and mRNA and protein levels of Phox2b were significantly elevated in the LC of brain donors that suffered from the …