Digital Commons Network^™

Academic Senate - Agenda, 12/04/2018, Academic Senate

Academic Senate Agendas

No abstract provided.

Reducing Protected Lands In A Hotspot Of Bee Biodiversity: Bees Of Grand Staircase-Escalante National Monument, Joseph S. Wilson, Matt Kelly, Olivia Messinger Carril

Biology Faculty Publications

Grand Staircase-Escalante National Monument is a federally protected area found in central southern Utah. Designated in 1996 by President William J. Clinton, it was recently reduced in size by President Donald J. Trump in a proclamation that turned the one large monument into three smaller ones. A long-term, standardized study of the bees had been conducted from 2000–2003, revealing 660 species. The bee communities of the area are characterized by being spatially heterogeneous; most of the bees occur in isolated areas, with only a few being both abundant and widespread. Here we examine what affect the recent resizing of the …

Notch Signaling Regulates Mitochondrial Metabolism And Nf-Κb Activity In Triple-Negative Breast Cancer Cells Via Ikkα-Dependent Non-Canonical Pathways, Fokhrul Hossain, Claudia Sorrentino, Deniz A. Ucar, Yin Peng, Margarite Matossian, Dorota Wyczechowska, Judy Crabtree, Jovanny Zabaleta, Silvana Morello, Luis Del Valle, Matthew Burow, Bridgette Collins-Burow, Antonio Pannuti, Lisa M. Minter, Todd E. Golde, Barbara A. Osborne, Lucio Miele

School of Medicine Faculty Publications

Triple negative breast cancer (TNBC) patients have high risk of recurrence and metastasis, and current treatment options remain limited. Cancer stem-like cells (CSCs) have been linked to cancer initiation, progression and chemotherapy resistance. Notch signaling is a key pathway regulating TNBC CSC survival. Treatment of TNBC with PI3K or mTORC1/2 inhibitors results in drug-resistant, Notch-dependent CSC. However, downstream mechanisms and potentially druggable Notch effectors in TNBC CSCs are largely unknown. We studied the role of the AKT pathway and mitochondrial metabolism downstream of Notch signaling in TNBC CSC from cell lines representative of different TNBC molecular subtypes as well as …

Dexamethasone For Adult Patients With A Symptomatic Chronic Subdural Haematoma (Dex-Csdh) Trial: Study Protocol For A Randomised Controlled Trial, Angelos G. Kolias, Ellie Edlmann, Eric P. Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z. Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A. Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J. Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J. Hutchinson

Peninsula Medical School

No abstract provided.

Ecosystem Shake Up: An Environmental Change Adaptation Project, Hannah E. Morgan, Dana Atwood-Blaine, Audrey C. Rule

Journal of STEM Arts, Crafts, and Constructions

This practical article reports an intriguing diorama project for third grade elementary students (ages 8-9 years). Students worked as partners to create dioramas of given ecosystems made in pizza boxes. Then, students rolled a die to determine a change in some environmental factor that affected the ecosystem. The students discussed how this change affected the ecosystem and made a second part of their diorama showing the ecosystem after the change. Finally, students made class presentations concerning their dioramas and ideas. A rubric for assessing the projects is included. Results of this science project indicate that students became deeply engrossed in …

Modeling The Effect Of Seasonality On The Transmission Of Antibiotic Resistance Bacteria In Hospitals With Environmental Contamination, Qimin Huang

Open Access Dissertations

Nosocomial infections caused by antibiotic resistant bacteria are a major threat to global public health today. In order to understand the diverse factors contributing to hospital acquired antibiotic resistant infections, we develop some mathematical models and address the theoretical, numerical and stochastic aspects of such models. In Chapter 2, both deterministic and stochastic mathematical models are developed to explore the roles that antibiotic exposure and environmental contamination play in the transmission dynamics of nosocomial infections in hospitals. Uncolonized patients without or with antibiotic exposure, colonized patients without or with antibiotic exposure, uncontaminated and contaminated health-care workers, and free-living Methicillin-resistant {\it …

Automobility And The Future Of Transport, Lukas Koch

English Department: Traveling American Modernism (ENG 366, Fall 2018)

This article explores the history of automobility as ideology, its effect on individuals and its possible future. In the USA in the early 20th century the automobile served to solve the crisis of individualism, created by Taylorism and the rise of the scientific method. To the people of the time the car was associated with freedom and individuality. Freedom through the automobile however was and would never be universally accessible. Furthermore examining the real life consequences of increasing mobility reveals unforeseen effects, mainly pollution, traffic and fragmentation of society. This paper proposes adoption of programs favoring sustainable modes of transportation …

Analyzing Self-Care Initiative Of Nursing Students, Lawren Murray Tachias

Honors Capstone Projects and Theses

No abstract provided.

Stress Management And Cardiovascular Health: Perceptions Of University Employees, Janki Rashmikant Patel

Honors Capstone Projects and Theses

No abstract provided.

Grand Valley Forum, Volume 043, Number 08, December 3, 2018, Grand Valley State University

2018-2019, Volume 43

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Increasing Knowledge And Awareness About Dating Violence Among College Students Through A Smartphone Application, Sarah Michelle Willis

Honors Capstone Projects and Theses

No abstract provided.

The Statesman, V. 62, I. 14, Stony Brook University

Stony Brook Statesman-Sucolian

v. 62, i. 14;

Ordich Uses Background In Forensics To Excel In Master’S In Law, Justice & Culture, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Post Quotes Thompson On Why Poinsettias Are Red, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Alumni News | Food Studies Student Reunion At Lecture With Alum, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Effect Of Social Stories On The Positive Play Behaviors And Social Interactions Of Preschool Students With Developmental Disabilities, Lauren Lee Divittorio

Theses and Dissertations

The purpose of this single subject design study was to determine the effectiveness of social stories on the positive play behaviors and social interactions of preschool students with developmental disabilities. The satisfaction of staff members with the implementation of social stories in the classroom was also examined. Preschool students in the study showed an increase in positive social interactions including turn-taking, using verbal and non-verbal communication to express their feelings during play, and overall positive play behaviors after implementation of social stories. Staff members reported positive social validity of the intervention. Implications for using social stories with preschool students with …

Uncovering The Role Of Propagule Pressure In Determining Establishment Success Using A Synthetic Biology Approach, Michael D. Dressler

HCNSO Student Theses and Dissertations

The spread of invasive species poses a major ecological and economical threat. Consequently there are ongoing efforts to develop a generalizable mechanism to predict establishment success of non-native species. One proposed mechanism to predict establishment success is propagule pressure, which is defined as the number of individuals introduced at a given time. Although some studies have demonstrated a positive correlation between propagule pressure and establishment success, others have not, and the effect of propagule pressure on establishment success remains unclear. To address this challenge, a strain of bacteria engineered with an Allee effect, a growth dynamic that is often associated …

The Rider (2018-12-03), Victor G. Ramirez

The Rider Archives

Vol.4 No.14

Recoupling Fire And Grazing Reduces Wildland Fuel Loads On Rangelands, Heath D. Starns, Samuel D. Fuhlendore, R. Dwayne Elmore, Dirac L. Twidwell Jr, Eric T. Thacker, Torre J. Hovick, Barney Luttbeg

Department of Agronomy and Horticulture: Faculty Publications

Fire suppression and exclusion, the historically dominant paradigm of fire management, has resulted in major modifications of fire-dependent ecosystems worldwide. These changes are partially credited with a recent increase in wildfire number and extent, as well as more extreme fire behavior. Fire and herbivory historically interacted, and research has shown that the interaction creates a unique mosaic of vegetation heterogeneity that each disturbance alone does not create. Because fire and grazing have largely been decoupled in modern times, the degree to which the interaction affects fuels and fire regimes has not yet been quantified. We evaluated effects of fire-only and …

Frost450, A Novel Microtubule Targeting Agent: Resistance And Cross-Resistance In An Ovarian Cancer Cell Line, Jonathan Chancellor Fox

Undergraduate Honors Theses

Drug resistance remains problematic for chemotherapy treatments. As primary treatment strategies tend to lose potency against cancer, there is a need for treatment options that overcome drug resistance mechanisms. FROST450, a novel microtubule destabilizing agent, has proven anticancer effects that overcome taxane and multidrug resistance. However, to better understand the clinical potential of FROST450, in this study we examine the mechanisms and implications of acquired FROST450 resistance in an A2780 ovarian cancer cell line. Results indicate FROST450 resistance is associated with increased mitochondrial respiration and with changes in gene sequence or expression level of proteins associated with microtubules, and that …

Cartographies Of Power: Unequal Urban Development And The Racialization Of Space In São Paulo, Jessica Hyman

Undergraduate Honors Theses

This work aims first and foremost to add to the literature on urban politics and race in Brazil. Where other scholars have not so explicitly addressed the ever present ideology of whiteness in regards to spatial organization and displacement in Brazil, this piece aims to do so. I build off of the work of past scholars in reinforcing that the belief in the racial democracy of Brazil is in fact a myth. I do so by illustrating the processes of the racialization of space that occur in São Paulo’s favelas and their development. The right to the city —a Brazilian …

Supportive Resources For Teaching Healthy Sexuality And Body Maturation During Trauma-Focused Cognitive Behavioral Therapy, Jennifer Davis

Honors Capstone Projects and Theses

No abstract provided.

Preface: Workshop On Pesticide Exposure Assessment Paradigm For Non-Apis Bees, Richard Bireley, Shannon Borges, Karina Cham, David Epstein, Kristina Garber, Connie Hart, Wayne Hou, Alessio Ippolito, Jens Pistorius, Veronique Poulsen, Keith Sappington, Thomas Steeger

United States Environmental Protection Agency: Publications

Since the mid-2000s, increased annual losses of honey bee (Apis mellifera L., Hymenoptera: Apidae) colonies and declines in some species of non-Apis bees have been reported (Biesmeijer et al. 2006, NRC 2007). These losses, particularly with respect to honey bees, have been associated with multiple factors including pesticides, pathogens (viruses, fungi, bacteria), pests (primarily the parasitic mite Varroa destructor Anderson and Trueman [Arachnida: Parasitiformes: Varroidae]), poor nutrition, and bee management practices acting in combination (vanEngelsdorp et al. 2008, 2009; Ratnieks et al. 2010). Because of the role that bees play in providing pollination services to natural and agricultural-based ecosystems, …

Transition Metal Dichalcogenide For High-Performance Electrode Of Supercapacitor, Saifful Kamaluddin Muzakir, Ahmad Salihin Samsudin, Bouchta Sahraoui

Makara Journal of Technology

Molybdenum dichalcogenides have been reviewed from the perspectives of bandgap, conductivity, and oxidation states of transition metal. Researchers have concluded that a narrow-bandgap transition metal dichalcogenide with high conductivity could be achieved for the high-performance electrode of a supercapacitor.

Calcareous Nannofossil Biostratigraphy And Paleoecology Of The Fort Hays Limestone Of Western Kansas, Western Interior Basin (Wib), Bryan Hermosillo

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Investigations of Upper Cretaceous hemi-pelagic sediments from the Western Interior Basin suggest that high surface water fertility caused increased production of biogenic carbonate, resulting in the deposition of limestone. We examined calcareous nannofossils from the Turonian/Coniacian Fort Hays Member of the Niobrara Formation to evaluate the correlation between nannofossil surface water fertility proxies and associated lithology. Our paleoecology results indicate that oligotrophic surface water conditions were present during limestone deposition. This stands at odds with existing depositional models for the Western Interior Seaway (WIS). Paleoecological data within the interbedded marls was artificially skewed due to the prevalence of etching caused …

The Bg News December 03, 2018, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. December 03, 2018. Volume 98-Issue 27.

Autoimmune Hyperphosphatemic Tumoral Calcinosis In A Patient With Fgf23 Autoantibodies., Mary Scott Roberts, Peter D. Burbelo, Daniela Egli-Spichtig, Farzana Perwad, Christopher J. Romero, Shoji Ichikawa, Emily G. Farrow, Michael J. Econs, Lori C. Guthrie, Michael T. Collins, Rachel I. Gafni

Manuscripts, Articles, Book Chapters and Other Papers

Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating mutations in FGF23, N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO (KL) have been reported as causing HFTC/HHS. We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy. In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. However, no mutations in FGF23, KL, or FGF receptor 1 …

Long-Term Experimental Hybridisation Results In The Evolution Of A New Sex Chromosome In Swordtail Fish, Paolo Franchini, Julia C. Jones, Peiwen Xiong, Susanne Kneitz, Zachariah Gompert, Wesley C. Warren, Ronald B. Walter, Axel Meyer, Manfred Schartl

Biology Faculty Publications

The remarkable diversity of sex determination mechanisms known in fish may be fuelled by exceptionally high rates of sex chromosome turnovers or transitions. However, the evolutionary causes and genomic mechanisms underlying this variation and instability are yet to be understood. Here we report on an over 30-year evolutionary experiment in which we tested the genomic consequences of hybridisation and selection between two Xiphophorus fish species with different sex chromosome systems. We find that introgression and imposing selection for pigmentation phenotypes results in the retention of an unexpectedly large maternally derived genomic region. During the hybridisation process, the sex-determining region of …

Natural Negative Allosteric Modulators Of 5-Ht3 Receptors, Lina T. Al Kury, Mohamed Mahgoub, Frank Christopher Howarth, Murat Oz

All Works

© 2018 by the authors Chemotherapy-induced nausea and vomiting (CINV) remain the most common and devastating side-effects associated with cancer chemotherapy. In recent decades, several lines of research emphasize the importance of 5-hydroxytryptamine3 (5-HT3; serotonin) receptors in the pathogenesis and treatment of CINV. 5-HT3 receptors are members of ligand-gated ion channels that mediate the rapid and transient membrane-depolarizing effect of 5-HT in the central and peripheral nervous system. These receptors play important roles in nausea and vomiting, as well as regulation of peristalsis and pain transmission. The development of antagonists for 5-HT3 receptor dramatically improved the treatment of CINV in …

Medical School Watercooler Newsletter - December 2, 2018, Lindsey Lyle

Watercooler Newsletter

This is the December 2, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Welcomes New Critical Care and Burn Surgeon
• Basic Medical Sciences Student Receives AHA Predoctoral Fellowship
• Tammi Milton Named Employee of the Month for December
• USA Welcomes Dr. Brett Martin to Radiology