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2018

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Accurate Vehicle Detection Using Multi-Camera Data Fusion And Machine Learning, Hao Wu Dec 2018

Accurate Vehicle Detection Using Multi-Camera Data Fusion And Machine Learning, Hao Wu

Electrical Engineering Theses and Dissertations

Computer-vision methods have recently been extensively used in intelligent transportation systems for vehicle detection. However, the detection of severely occluded or partially observed vehicles due to the limited camera fields of view remains a significant challenge. This paper presents a multi-camera vehicle detection system that significantly improves the detection performance under occlusion conditions. The key elements of the proposed method include a novel multi-view region proposal network that localizes the candidate vehicles on the ground plane. We also infer the vehicle occupancies by leveraging multi-view cross-camera context. Experiments are conducted on a dataset captured from a roadway in Richardson, TX, …


Coordination Operation Of Natural Gas And Electricity Network With Line-Pack, Junyang Mi Dec 2018

Coordination Operation Of Natural Gas And Electricity Network With Line-Pack, Junyang Mi

Electrical Engineering Theses and Dissertations

This dissertation addresses the coordinated operation of electricity and natural gas networks considering the line-pack flexibility in the natural gas pipelines. The problem is formulated as a mixed integer linear programming problem. The objective is to minimize the operation cost of the electricity and natural gas networks considering the price of the natural gas supply. Benders decomposition is used to solve the formulated problem. The master problem minimizes the startup and shutdown costs as well as the operation cost of the thermal units other than gas-fired generation units in the electricity network. The first subproblem validates the feasibility of the …


Conducting Synchronous Assessment Through Web Videoconference To Improve Online Learning: Case Outcomes With Nonparametric Analysis, Leping Liu, Li-Ting Chen Dec 2018

Conducting Synchronous Assessment Through Web Videoconference To Improve Online Learning: Case Outcomes With Nonparametric Analysis, Leping Liu, Li-Ting Chen

Journal of Educational Technology Development and Exchange (JETDE)

Online assessment has always been a challenge to online teaching. Educators have been exploring a variety of methods to perform online assessment. However, it appears that there is not enough work in the field focusing on online synchronous assessment. This paper presents two cases that demonstrate the design and implementation of using web videoconference for synchronous assessment in an educational research methods online course and an instructional video production online course. The purpose of the two cases was to explore whether or with what methods student online learning could be improved through synchronous assessment. Case outcomes were analyzed with nonparametric …


The Evolution Of Computational Propaganda: Trends, Threats, And Implications Now And In The Future, Holly Schnader Dec 2018

The Evolution Of Computational Propaganda: Trends, Threats, And Implications Now And In The Future, Holly Schnader

Senior Honors Projects, 2010-2019

Computational propaganda involves the use of selected narratives, social networks, and complex algorithms in order to develop and conduct influence operations (Woolley and Howard, 2017). In recent years the use of computational propaganda as an arm of cyberwarfare has increased in frequency. I aim to explore this topic to further understand the underlying forces behind the implementation of this tactic and then conduct a futures analysis to best determine how this topic will change over time. Additionally, I hope to gain insights on the implications of the current and potential future trends that computational propaganda has.

My preliminary assessment shows …


Theorizing Development Of Parasocial Engagement, Riva Tukachinsky, Gayle S. Stever Dec 2018

Theorizing Development Of Parasocial Engagement, Riva Tukachinsky, Gayle S. Stever

Communication Faculty Articles and Research

The article proposes a theoretical model of the development of parasocial relationships (PSRs) building on Knapp’s model of relationship development. Through synthesis of research across disciplines, the model conceptualizes the relational goals and parasocial interactions (PSIs) specific to the PSR. The model identifies variables that predict engagement at that level, describes the stage’s outcomes/effects, and considers the utility of existing measures to assess these stages. The conceptualization of PSRs as a dynamic process rather than intensity of a monolithic experience offers new directions worthy of empirical examination.


Parametric Design And Optimization Of A Pivoting S-Type Rudder For Containerships, Chen-Wei Chen, Tsung-Yueh Lin, Bo-Yen Chen, Jen-Shiang Kouh Dec 2018

Parametric Design And Optimization Of A Pivoting S-Type Rudder For Containerships, Chen-Wei Chen, Tsung-Yueh Lin, Bo-Yen Chen, Jen-Shiang Kouh

Journal of Marine Science and Technology–Taiwan

This study proposes an energy-saving S-type rudder design to deal with the inhomogeneous inflow from a rotating propeller behind a containership. The S-type rudder was modelled parametrically using four-digit NACA foils as section profiles together with Non-uniform rational B-splines (NURBS) surface formulations. A three-stage optimization process is proposed to reduce the number of design iterations necessary to achieve an optimal design. The propulsion simulations were done via CFD software, which solves the hydrodynamics of viscous flow, as governed by the Reynold-averaged Navier-Stokes (RANS) equations. Validations were performed with experimental model tests, including hull resistance, propeller open-water performance, and propulsion in …


Gardner-Webb Awards Over 200 Degrees During Commencement Exercises Dec. 15, Office Of University Communications Dec 2018

Gardner-Webb Awards Over 200 Degrees During Commencement Exercises Dec. 15, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner–Webb University hosted Fall Commencement on Saturday, Dec. 15, in the Lutz-Yelton Convocation Center. More than 200 graduates were honored during the ceremony. The ceremony featured graduates of Gardner-Webb’s traditional undergraduate program, as well as from GOAL — The Degree Completion Program (DCP), and graduate programs.


Serum Nutrient Levels And Aging Effects On Periodontitis, Jeffrey L Ebersole, Joshua Lambert, Heather Bush, Pinar Emecen Huja, Arpita Basu Dec 2018

Serum Nutrient Levels And Aging Effects On Periodontitis, Jeffrey L Ebersole, Joshua Lambert, Heather Bush, Pinar Emecen Huja, Arpita Basu

Biostatistics Faculty Publications

Periodontal disease damages tissues as a result of dysregulated host responses against the chronic bacterial biofilm insult and approximately 50% of US adults > 30 years old exhibit periodontitis. The association of five blood nutrients and periodontitis were evaluated due to our previous findings regarding a potential protective effect for these nutrients in periodontal disease derived from the US population sampled as part of the National Health and Nutrition Examination Survey (1999–2004). Data from over 15,000 subjects was analyzed for blood levels of cis-β-carotene, β-cryptoxanthin, folate, vitamin D, and vitamin E, linked with analysis of the presence and severity of periodontitis. …


Improve The Low Energy Sensitivity Of The Hawc Observatory, Zhixiang Ren Dec 2018

Improve The Low Energy Sensitivity Of The Hawc Observatory, Zhixiang Ren

Optical Science and Engineering ETDs

The high altitude water cherenkov gamma-ray observatory (HAWC) has been fully operational since March of 2015 in Mexico at 4,100 meters above sea level on the hillside of the Sierra Negra Volcano. It consists of an array of 300 water cherenkov detectors, each equipped with four photo-multiplier tubes. HAWC operates 24-hours per day with a wide field-of-view (FOV, ∼ 2 sr) and a high duty cycle (∼ 95%). These make it a powerful survey and monitoring experiment for mapping the gamma ray sky at very high energies (VHE, 100 GeV to 100 TeV) and to study sources with varying intensities. …


Stability Of A Spinning Triangle Tethered Spacecraft System In A Circular Orbit, Matthew James Heitstuman Dec 2018

Stability Of A Spinning Triangle Tethered Spacecraft System In A Circular Orbit, Matthew James Heitstuman

Mechanical Engineering ETDs

Equations of motion are derived for a spinning triangle tethered spacecraft system and are used to analyze the stability of such systems. Floquet theory is applied to the linearized, periodic coefficient, equations of motion to analyze spin stability as a function of triangle geometry and the average spin rate of the satellite relative to the angular velocity of the spacecraft orbiting around a central body. The results of the Floquet analysis show that spin stability is achievable for many combinations of spacecraft geometry and spin rate. Spacecraft engineers or operators for a triangle-shaped tethered spacecraft can use this information for …


An Analysis Of Mixed-Layer Clay Minerals And Major Element Geochemical Trends In Middle-Upper Pennsylvanian-Aged Paleosols As A Proxy For Characterizing Basin-Wide Diagenetic Patterns And The Paleoenvironment Of The Illinois Basin, U.S.A., Julia A. Mcintosh Dec 2018

An Analysis Of Mixed-Layer Clay Minerals And Major Element Geochemical Trends In Middle-Upper Pennsylvanian-Aged Paleosols As A Proxy For Characterizing Basin-Wide Diagenetic Patterns And The Paleoenvironment Of The Illinois Basin, U.S.A., Julia A. Mcintosh

Earth Sciences Theses and Dissertations

Pennsylvanian-aged paleosols from four Illinois Basin (IB) cores were sampled to characterize clay mineralogy, paleosol morphology, and major element geochemistry. This data combined with X-ray diffraction (XRD) and X-ray fluorescence (XRF) data from two other stratigraphically equivalent cores were used to better understand basin-wide diagenetic patterns. Paleosols unimpacted by diagenesis are considered reliable proxies for continued geochemical analyses and paleoclimate interpretations of middle to late Pennsylvanian (Desmoinesian-Missourian) low-latitude environments.

Reichweite Ordering, as determined from XRD analysis ofprofiles, indicates that diagenesis impacted the deep interior of the basin and the southern portion of the basin. Further investigation of illitization mechanisms derived …


Examining Environmental Hazards In Rental Homes And Habitability Laws In Clark County, Nevada, Jorge Luis Bertran Dec 2018

Examining Environmental Hazards In Rental Homes And Habitability Laws In Clark County, Nevada, Jorge Luis Bertran

UNLV Theses, Dissertations, Professional Papers, and Capstones

It is well established that home conditions are linked to the health outcomes of occupants. There are over 880,000 housing units in Clark County, Nevada; nearly half of those are renter-occupied units (ROUs). Currently, there is limited research on the characteristics of environmental hazards found in Clark County ROUs and the strength of habitability statutes created to protect tenants from substandard housing. Understanding how renters in Clark County are affected by environmental hazards in ROUs and the processes by which landlords and tenants resolve grievances related to those hazards would benefit public health. It would enhance the ability to quickly …


Literature In The World: A Critical Discourse Study Of World Literature Pedagogy, Elisa Cogbill-Seiders Dec 2018

Literature In The World: A Critical Discourse Study Of World Literature Pedagogy, Elisa Cogbill-Seiders

UNLV Theses, Dissertations, Professional Papers, and Capstones

“Literature in the World” is a critical discourse analysis of world literature pedagogy in U.S. higher education. It investigates the ways discourse communities in higher education produce and shape the field of world literature. The dissertation begins by establishing and analyzing the generic conventions of university mission statements, finding they are primarily dominated by discourse on global learning. It follows with an analysis of world literature course descriptions from the same schools. World literature course descriptions alternatively replicate, resist, or subvert global learning discourses. The last chapter uses findings from the first two chapters to trace how university and instructor …


Design And Preliminary Evaluation Of A Supercritical Carbon Dioxide Brayton Cycle For Solar Dish Concentrator Clean Energy Production, Danielle Nobles-Lookingbill Dec 2018

Design And Preliminary Evaluation Of A Supercritical Carbon Dioxide Brayton Cycle For Solar Dish Concentrator Clean Energy Production, Danielle Nobles-Lookingbill

UNLV Theses, Dissertations, Professional Papers, and Capstones

As we move toward energy independence and more ambitious clean energy goals, solar energy research must push the efficiency limits of traditional energy generation systems. Increases in efficiency can be achieved by increasing the hot temperature of the power cycle. Recent research demonstrates the potential for increased efficiency and a vastly smaller component size when supercritical carbon dioxide Brayton power cycles are used. Concentrated solar and nuclear heat sources are capable of achieving the high working fluid temperatures needed for significant efficiency gains. This NSF EPSCoR funded, experimental research system is designed to exploit the uniquely immense solar irradiance of …


Combinatorial Ant Optimization And The Flowshop Problem, Tasmin Chowdhury Dec 2018

Combinatorial Ant Optimization And The Flowshop Problem, Tasmin Chowdhury

UNLV Theses, Dissertations, Professional Papers, and Capstones

Researchers have developed efficient techniques, meta-heuristics to solve many Combinatorial Optimization (CO) problems, e.g., Flow shop Scheduling Problem, Travelling Salesman Problem (TSP) since the early 60s of the last century. Ant Colony Optimization (ACO) and its variants were introduced by Dorigo et al. [DBS06] in the early 1990s which is a technique to solve CO problems. In this thesis, we used the ACO technique to find solutions to the classic Flow shop Scheduling Problem and proposed a novel method for solution improvement. Our solution is composed of two phases; in the first phase, we solved TSP using ACO technique which …


Design, Layout, And Testing Of Sige Apds Fabricated In A Bicmos Process, Dane Laurence Gentry Dec 2018

Design, Layout, And Testing Of Sige Apds Fabricated In A Bicmos Process, Dane Laurence Gentry

UNLV Theses, Dissertations, Professional Papers, and Capstones

This Thesis is concerned with the design, layout, and testing of avalanche photodiodes (APDs). APDs are a type of photodetector and, thus, convert light signals into electrical signals (current or voltage). APDs can be fabricated using silicon (Si). In this Thesis, however, three integrated circuit (IC) chips containing various silicon-germanium (SiGe) APDs with different sizes, structures, and geometries were designed, laid out, and fabricated using the Austriamicrosystems (AMS) 0.35μm SiGe BiCMOS (S35) process. This was done in order to compare SiGe APDs to Si only APDs and investigate the hypothesis that SiGe APDs are capable of detecting longer wavelengths than …


Effects Of Ambient Air Pollution On Asthma-Related Emergency Department Visits Within The Las Vegas Metropolitan Area, Loiren E. Monardes Dec 2018

Effects Of Ambient Air Pollution On Asthma-Related Emergency Department Visits Within The Las Vegas Metropolitan Area, Loiren E. Monardes

UNLV Theses, Dissertations, Professional Papers, and Capstones

The objective of this research was to evaluate the risk for asthma-related Emergency Department visits and their association with ambient air pollution within the Las Vegas metropolitan area. All data were aggregated by date and ZIP Code. The association was analyzed by applying the distributed lag non-linear model in an attempt to identify elevated concentrations of specific air pollutants

as triggers and their delayed effects (lag days). Relative Risk (RR) and 95% confidence intervals were produced, while adjusting for socioeconomic status. This ecological population-based study analyzed daily asthma counts of Emergency Department visits from January 1st, 2009 to December 31st, …


Riding The Wave Of Microplastics In Bermuda, Molly E. Riihiluoma Dec 2018

Riding The Wave Of Microplastics In Bermuda, Molly E. Riihiluoma

Pell Scholars and Senior Theses

The presence of marine debris and microplastics in the Earth’s oceans are a global environmental issue. Bermuda’s location in the middle of the North Atlantic Gyre makes it the perfect case study for this work. As the crisis unfolds, Bermuda’s environment, economy, and population are at risk of witnessing firsthand the effects of plastic pollution. This paper relies on scholarly research as well as anecdotal evidence from retail stores and locals to compile information in order to provide necessary recommendations to benefit Bermuda’s ocean health. This research evaluates the pros and cons of policies which could mitigate the problem. Analysis …


A Simplified Two-Switching-Based Model-Free Predictive Current Controller For An Interior Permanent Magnet Synchronous Motor Drive System, Cheng-Kai Lin, Jen-Te Yu, Jyun-Ting Wang, Yen-Shin Lai, Hsing-Cheng Yu, Hao-Qun Huang Dec 2018

A Simplified Two-Switching-Based Model-Free Predictive Current Controller For An Interior Permanent Magnet Synchronous Motor Drive System, Cheng-Kai Lin, Jen-Te Yu, Jyun-Ting Wang, Yen-Shin Lai, Hsing-Cheng Yu, Hao-Qun Huang

Journal of Marine Science and Technology–Taiwan

This paper presents a simplified two-switching-based modelfree predictive current control (STSB-MFPCC) method as well as its application to interior permanent magnet synchronous motor (IPMSM) drive systems. Unlike existing model predictive current controller (MPCC) that uses 7 basic voltage vectors, STSB-MFPCC employs 19 synthesized ones, with each of which consisting of two basic voltage vectors. The new method does not require any information about the load parameters, back electromotive force, nor the system model. Compared to modelbased controllers, the proposed one has a distinctive and appealing nature in that it is much less sensitive to system parameter variations. A digital signal …


Monitoring The Impact Of Groundwater Pumping On Infrastructure Using Geographic Information System (Gis) And Persistent Scatterer Interferometry (Psi), Kirsten Deprekel, El Hachemi Bouali, Thomas Oommen Dec 2018

Monitoring The Impact Of Groundwater Pumping On Infrastructure Using Geographic Information System (Gis) And Persistent Scatterer Interferometry (Psi), Kirsten Deprekel, El Hachemi Bouali, Thomas Oommen

Department of Geological and Mining Engineering and Sciences Publications

Transportation infrastructure is critical for the advancement of society. Bridges are vital for an efficient transportation network. Bridges across the world undergo variable deformation/displacement due to the Earth’s dynamic processes. This displacement is caused by ground motion, which occurs from many natural and anthropogenic events. Events causing deformation include temperature fluctuation, subsidence, landslides, earthquakes, water/sea level variation, subsurface resource extraction, etc. Continual deformation may cause bridge failure, putting civilians at risk, if not managed properly. Monitoring bridge displacement, large and small, provides evidence of the state and health of the bridge. Traditionally, bridge monitoring has been executed through on-site surveys. …


Mercury In Big Cypress Bayou And Caddo Lake Watersheds In Marion And Harrison Counties Texas, Joseph Watkins Dec 2018

Mercury In Big Cypress Bayou And Caddo Lake Watersheds In Marion And Harrison Counties Texas, Joseph Watkins

Electronic Theses and Dissertations

Caddo Lake has been included on the Texas Commission on Environmental Quality 303(d) list for impairment due to mercury (Hg) content since 1996. One of the primary tributaries, Big Cypress Bayou, flows across Eocene-aged rocks and sediments associated with the Wilcox Group; the Wilcox is of interest because it contains lignite coal, which has a direct link to mercury. Previous research has focused on dry deposition from fossil fuel combustion as the primary source of mercury but has not addressed the potential watershed contribution to mercury concentrations in Caddo Lake.

Big Cypress Bayou flows through Harrison and Marion counties in …


Delineation Of Karst Potential Using Lidar And Gis Analyses, Fort Hood Military Installation, Texas, Colby Reece Dec 2018

Delineation Of Karst Potential Using Lidar And Gis Analyses, Fort Hood Military Installation, Texas, Colby Reece

Electronic Theses and Dissertations

ABSTRACT

Traditional karst surveys require extensive field investigations to completely characterize large areas. They are often time-consuming, requiring up to several years to collect and categorize data. Bias is given to areas that are most easily accessible and false negatives are common. The implementation of geographic information systems (GIS) has aided in the aggregation and standardization of karst data; however, these systems have also been used to develop terrain models that allow the user to remotely delineate sinkholes and other surficial features. The Fort Hood Military Installation is a karst landscape that has been altered significantly for use in military …


Bayesian Model Comparisons In Planetary Science, John Henry Boisvert Dec 2018

Bayesian Model Comparisons In Planetary Science, John Henry Boisvert

UNLV Theses, Dissertations, Professional Papers, and Capstones

Model comparison in the modern era allows us to use statistical methods that were previously difficult with older machines. I present a state-of-the-art model comparison code that uses modern Bayesian statistics to measure the Bayes factor between two competing models. The Bayes factor is the ratio of the probability of the data given one model to the probability of the data given another model. My code was used to compare models in five problems in planetary science. The first three pertain to radial velocity exoplanet data. There is a degeneracy in the radial velocity exoplanet signal between a single planet …


Employee Perceptions Of Organizational Corporate Responsibility And Their Effect On Employee Organizational Commitment, Lisa R. Davis Dec 2018

Employee Perceptions Of Organizational Corporate Responsibility And Their Effect On Employee Organizational Commitment, Lisa R. Davis

UNLV Theses, Dissertations, Professional Papers, and Capstones

The debate over whether organizations play a part in society beyond economic profit has been a major focus of research in corporate social responsibility (CSR). These debates have been mainly looked at from the macro (societal) or the meso (institutional) level. Very little research has been done on the role of the firm and looking at CSR from the micro (individual) level. Questions regarding the role of work for employees, securing economic benefits or making a difference in the world, would vary greatly depending on the individual and the importance they place on these areas in their own lives. Scholars …


A Case Study: Number Apps In Preschool, Amy Beth Adkins Dec 2018

A Case Study: Number Apps In Preschool, Amy Beth Adkins

UNLV Theses, Dissertations, Professional Papers, and Capstones

iPads are increasingly present in education. This research explores their role developing fundamental mathematics concepts. It investigates preschoolers’ interactions with mathematics apps, and affordances and constraints accessed. It was conducted over fourteen weeks; students played mathematics apps for thirty minutes a week. The qualitative case study design included participants who varied in mathematics and technological skill. Data was collected through assessments, interviews, questionnaires, videotapes, and artifacts. Results determined that students access constraints or affordances based on ability level. Findings indicate iPads are beneficial tools for preschool classrooms. Preschoolers showed an increase in math ability when using iPads.


A Distributed Real-Time Short-Term Solar Irradiation Forecasting Network For Photovoltaic Systems, Michael Adelbert Gacusan Dec 2018

A Distributed Real-Time Short-Term Solar Irradiation Forecasting Network For Photovoltaic Systems, Michael Adelbert Gacusan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Solar irradiation forecasting is essential for PV connected electrical grids to maintain reliability, stability, and effective matching of real-time demand to power distribution. This research paper develops and evaluates proposed forecasting methods using wireless sensor networks. Each node of the network is capable of monitoring illuminance data and communicate it through RF and/or WiFi. The nodes are calibrated with respect to irradiance data from an industry-standard pyranometer. Power consumption of each node type is also collected at different operating states. The proposed sensor network can estimate a cloud motion vector or a cloud shadow’s speed and direction from the data …


Community College Students’ Perceptions Of Their Academic Workload, William Neff Dec 2018

Community College Students’ Perceptions Of Their Academic Workload, William Neff

UNLV Theses, Dissertations, Professional Papers, and Capstones

One major barrier to success, for first-time, full-time college students, is course workload (Bowyer, 2012). How students respond to their situation and the barriers they face may influence decisions they make about classes in which they should enroll or those they should avoid, completing or dropping a class during the semester, and persisting from term-to-term and year-to-year. In an effort to help students succeed, colleges often give them a specified set of core courses and a specific or even prescribed pathway to complete the “general education” requirements. These core courses such as mathematics, communication, and English, among others, taken separately …


Cassava Farming Practices And Their Agricultural And Environmental Impacts: A Systematic Map Protocol, Gorm E. Shackelford, Neal R. Haddaway, Hope O. Usieta, Pieter Pypers, Silviu O. Petrovan, William J. Sutherland Dec 2018

Cassava Farming Practices And Their Agricultural And Environmental Impacts: A Systematic Map Protocol, Gorm E. Shackelford, Neal R. Haddaway, Hope O. Usieta, Pieter Pypers, Silviu O. Petrovan, William J. Sutherland

All Peer-Reviewed Publications

Background: Cassava (Manihot esculenta) is a staple crop that is important for food security in the tropics. However, cassava farming can have severe environmental impacts, such as habitat destruction and soil degradation, if it is not carefully managed. Therefore, a wide range of agricultural and environmental outcomes should be considered when cassava farming practices are recommended as "good agricultural practices". We propose a systematic map of research on cassava farming practices and their impacts on yield, quality, profitability, soil, water, wildlife, pathogens, pests, weeds, and other agricultural and environmental outcomes. This map will improve our knowledge of the multifunctionality of …


Information-Based Analysis And Control Of Recurrent Linear Networks And Recurrent Networks With Sigmoidal Nonlinearities, Deslin Menolascino Dec 2018

Information-Based Analysis And Control Of Recurrent Linear Networks And Recurrent Networks With Sigmoidal Nonlinearities, Deslin Menolascino

McKelvey School of Engineering Graduate Student Theses & Dissertations

Linear dynamical models have served as an analytically tractable approximation for a variety of natural and engineered systems. Recently, such models have been used to describe high-level diffusive interactions in the activation of complex networks, including those in the brain. In this regard, classical tools from control theory, including controllability analysis, have been used to assay the extent to which such networks might respond to their afferent inputs. However, for natural systems such as brain networks, it is not clear whether advantageous control properties necessarily correspond to useful functionality. That is, are systems that are highly controllable (according to certain …


Kcnq1/Kcne1 Interaction In The Cardiac Iks Channel And Its Physiological Consequences, Jiajing Xu Dec 2018

Kcnq1/Kcne1 Interaction In The Cardiac Iks Channel And Its Physiological Consequences, Jiajing Xu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Dynamic conformational changes of ion channel proteins during activation gating determine their function as carriers of current. The relationship between these molecular movements and channel function over the physiological timescale of the action potential (AP) has not been fully established due to limitations of existing techniques. We constructed a library of possible cardiac IKs protein conformations and applied a combination of protein segmentation and energy linearization to study this relationship computationally. Simulations reproduced the effects of the beta-subunit (KCNE1) on the alpha-subunit (KCNQ1) dynamics and function, observed in experiments. Mechanistically, KCNE1 increased the probability of “visiting” conducting pore conformations on …