Digital Commons Network^™

Towards Engineering Advanced Nanomaterials: Elucidating Fundamental Particle Behavior In Water And Critical Sorption Dynamics, Changwoo Kim

McKelvey School of Engineering Graduate Student Theses & Dissertations

As advanced nanomaterials, inorganic-organic nano composites have received great interest as potential platform (nano) structures for sensor, catalyst, sorbent, and environmental applications. Here, my Ph.D. research has focused on the design, synthesis, and characterization of advanced water-stable engineered metal-oxide nanoparticles functionalized by organic frames for environmental applications. For the environmental applications, I have evaluated particleoptimized sorption processes for the remediation and separation of arsenic, chromium, and uranium under environmentally relevant conditions. More specifically, I have explored the critical role of organic coating on sorption mechanisms and performances using engineered iron oxide -based, manganese oxide -based, and manganese ferrite -based (core) …

Modeling The Bioactivation And Subsequent Reactivity Of Drugs, Tyler Brian Hughes

Arts & Sciences Graduate Student Theses and Dissertations

Metabolism can convert drugs to harmful reactive metabolites that conjugate to DNA and off-target proteins. Reactive metabolites are a significant driver of both drug candidate attrition and withdrawal from the market of already approved drugs. Unfortunately, reactive metabolites are difficult to study in vivo, because they are transitory and generally do not circulate. Instead, this work computationally models both metabolism and reactivity. Using deep learning, predictive models were developed for the metabolic formation of quinones and epoxides, which together account for about half of known reactive metabolites. Additionally, an accurate model of DNA and protein reactivity was constructed, which predicts …

Tunable Electronic And Optical Properties Of Low-Dimensional Materials, Shiyuan Gao

Arts & Sciences Graduate Student Theses and Dissertations

Two-dimensional (2D) materials with single or a few atomic layers, such as graphene, hexagonal boron nitride (h-BN) and transition metal dichalcogenides (TMDCs), and the heterostructures or one-dimensional (1D) nanostructures they form, have attracted much attention recently as unique platforms for studying many condensed-matter phenomena and holds great potentials for nanoelectronics and optoelectronic applications. Apart from their unique intrinsic properties which has been intensively studied for over a decade by now, they also allow external control of many degrees of freedom, such as electrical gating, doping and layer stacking. In this thesis, I present a theoretical study of the electronic and …

Radiolabeled Nanohydroxyapatite As A Platform For The Development Of New Pet Imaging Agents, Stacy Lee Queern

Arts & Sciences Graduate Student Theses and Dissertations

Positron emission tomography (PET) imaging utilizes drugs labeled with positron emitters to target and evaluate different biological processes occurring in the body. Tailoring medicine to the individual allows for higher quality of care with better diagnosis and treatment and is a key purpose for advancing research into developing new platforms for PET imaging agents. A PET nuclide of high interest for the development of these agents is 89Zr. This can be attributed to the long half-life of 3.27 days and low positron energy of 89Zr.In this work, we developed a production method for 89Zr using Y sputtered coins that is …

Linking Structure And Dynamics In Metallic Liquids: A Combined Experimental And Molecular Dynamics Approach, Robert Ashcraft

Arts & Sciences Graduate Student Theses and Dissertations

A major outstanding problem in condensed matter physics is the nature of the glass transition, in which a rapidly cooled liquid can bypass the transition into a crystalline state and the liquid structure is "frozen-in" due to kinetic arrest. To characterize the fundamental features behind this transition the liquid, both in the high temperature (equilibrium) and supercooled state, needs to be better understood. By examining the relationship between structure and dynamics a better characterization of the liquid state and a determination of the mechanisms that are ultimately important for the formation of the glass can be gained. In this dissertation, …

Nanopower Analog Frontends For Cyber-Physical Systems, Kenji Aono

McKelvey School of Engineering Graduate Student Theses & Dissertations

In a world that is increasingly dominated by advances made in digital systems, this work will explore the exploiting of naturally occurring physical phenomena to pave the way towards a self-powered sensor for Cyber-Physical Systems (CPS). In general, a sensor frontend can be broken up into a handful of basic stages: transduction, filtering, energy conversion, measurement, and interfacing. One analog artifact that was investigated for filtering was the physical phenomenon of hysteresis induced in current-mode biquads driven near or at their saturation limit. Known as jump resonance, this analog construct facilitates a higher quality factor to be brought about without …

Photophysical Characterization And Wavelength Tuning Of Natural And Synthetic Oxobacteriochlorins And Biohybrids, Don Hood

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATIONPhotophysical Characterization and Wavelength Tuning of Natural and Synthetic Oxobacteriochlorins and BiohybridsByDonald L. HoodDoctor of Philosophy in ChemistryWashington University in St. Louis, 2018Dr. Dewey Holten, ChairpersonHerein is discussed the theoretical and practical unpinnings of photophysical behaviors and kinetic constants for tetrapyrrole macrocycles, to wit, porphyrins, chlorins, and bacteriochlorins. Understanding the characteristic photophysical response of tetrapyrroles to changes in environment or substituents is important to designing synthetic chromophores with tunable absorption wavelengths and for preparing useful biohybrids of natural photosynthetic light antennas combined with unnatural chromophores attached to the light antenna oligomers. Synthetic oxobacteriochlorins provide simpler synthetic pathway …

Mechanisms Of Calcium Phosphate Mineralization On Biological Interfaces And Their Engineering Applications, Doyoon Kim

McKelvey School of Engineering Graduate Student Theses & Dissertations

All living organisms utilize phosphorus (P) as an essential component of their cell membranes, DNA and RNA, and adenosine triphosphate. Bones, in addition to bearing loads, play an important role in balancing P levels in our bodies. In bones, a network of collagen templates and calcium phosphate (CaP) nanocrystals builds hierarchical levels, from nano- to macroscale. Within this architecture, the thermodynamic properties of CaP minerals are influential. Despite the importance of nucleation, growth, and crystallization in collagen structures for tissue development, little kinetic study of these processes has been conducted due to the limited in situ techniques for monitoring these …

Decoding Complexity In Metabolic Networks Using Integrated Mechanistic And Machine Learning Approaches, Tolutola Timothy Oyetunde

McKelvey School of Engineering Graduate Student Theses & Dissertations

How can we get living cells to do what we want? What do they actually ‘want’? What ‘rules’ do they observe? How can we better understand and manipulate them? Answers to fundamental research questions like these are critical to overcoming bottlenecks in metabolic engineering and optimizing heterologous pathways for synthetic biology applications. Unfortunately, biological systems are too complex to be completely described by physicochemical modeling alone.

In this research, I developed and applied integrated mechanistic and data-driven frameworks to help uncover the mysteries of cellular regulation and control. These tools provide a computational framework for seeking answers to pertinent biological …

Anodic Cyclization Reaction: Manipulation Of Reaction Pathway And Efforts To Radical Cation And Radical Intermediate, Ruozhu Feng

Arts & Sciences Graduate Student Theses and Dissertations

In recent years, synthetic chemists have been expressing significant interest in electro-organic synthetic methods. This interest is being fueled by the existence of an increasing number of successful methods in the literature and the availability of new electrochemical equipment that removes the barrier to attempting an electrolysis reaction for the first time. Yet while these developments have fueled growth in some areas of electro-organic synthesis (the recycling of chemical catalysts for example), other areas remain underdeveloped. One such area is the exploration of reactions that can be triggered directly as an electrode surface without the use of any chemical reagent. …

Optimal Placement Of Distributed Energy Storage Systems In Distribution Networks Using Artificial Bee Colony Algorithm, Choton K. Das, Octavian Bass, Ganesh Kothapalli, Thair S. Mahmoud, Daryoush Habibi

Research outputs 2014 to 2021

The deployment of utility-scale energy storage systems (ESSs) can be a significant avenue for improving the performance of distribution networks. An optimally placed ESS can reduce power losses and line loading, mitigate peak network demand, improve voltage profile, and in some cases contribute to the network fault level diagnosis. This paper proposes a strategy for optimal placement of distributed ESSs in distribution networks to minimize voltage deviation, line loading, and power losses. The optimal placement of distributed ESSs is investigated in a medium voltage IEEE-33 bus distribution system, which is influenced by a high penetration of renewable (solar and wind) …

Working Paper No. 29, Lina Khan, New Technologies, And Institutional Reform, Lillian Garcia

Working Papers in Economics

This inquiry seeks to establish that Lina Khan’s work brings to light the importance of reforming institutions in order to address the challenges of internet technology. As the dominance of a small number of technology giants has increased to unforeseen proportions, legal mind Lina Khan has emerged as a leading voice in the call for an updated legal framework, as well as a revision of current economic understanding, to address the new forms of monopoly power these firms practice. The first part of this inquiry examines Chicago School dominance over economic thought and its effect on antitrust enforcement over the …

New Chamber Music With Guitar: The Aleph Gitarrenquartett, Gubaidulina, And Plucking, Nathan Cornelius

Soundboard Scholar

Reviews of the following recordings:

• Aleph Guitar Quartet, Aleph Gitarrenquartett, vol. 2 (NEOS 11710, 2017)
• Bernard Lang, The Cold Trip, with Sarah Maria Sun, Juliet Fraser, Mark Knoop, and the Aleph Guitar Quartet (Kairos 0015018, 2017)
• Sofia Gubaidulina, Complete Guitar Works, with David Tanenbaum et al. (Naxos 8.573379, 2015)
• Tom Johnson, Plucking, with Just Strings (MicroFest Records MF9, 2017)

Multiple Regression Models To Analyze Length Of Hospitalization Due To Nosocomial Infections In U.S. Hospitals, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Nosocomial diseases are a serious concern and detriment to hospitals’ abilities to provide appropriate patient care. Bearing this in mind, an effort must be made to determine whether infection surveillance and control programs have reduced the rates of nosocomial infection at U.S. hospitals. The data that were studied were obtained as part of the Study on the Efficacy of Nosocomial Infection Control (SENIC) and used to develop a model of what variables most contribute to a patient’s length of stay at the Cleveland Clinic (Quade et al, 1980).

Inequality, Rubber, And Thermodynamics In Indonesia, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Intersectionality has led the charge in ensuring that workplace justice is assured to all people, irrespective of their identities. While intersectionality is a useful theory for explaining inequality, what must not be understated is the contributions that postcolonialism and the blue-collar working identity can have on harsh working conditions. Particularly, miners in Indonesia have had to work in very hostile environments where they are at-risk for sulfur poisoning as they mine for materials to vulcanize rubber. This article serves two purposes. The first is to call attention to how place can help explain the differential experiences of miners in the …

The Chemical Causes And Social Effects Of Acid Rain, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

While global warming tends to dominate the collective conscious for environmentalism of academics and the public alike, many other physical phenomena bear serious implications for humanity's future. One such phenomenon, acid rain, has been under-reported considering how damaging it is to the ecosystem and how much politicking is involved when determining how to address it. This article serves two purposes. The first is to inform readers of the basic chemical processes underlying acid rain and why it is damaging to organisms. The second is to inform readers of how acid rain has been portrayed by other publications, like the National …

A Newcomer's Guide To Kabbalah, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Kabbalah is a mystical and highly spiritual form of Judaism. Popularized by its endorsement by high-profile celebrities like Madonna, the average layperson knows enough about Kabbalah to recognize it as a vaguely familiar term, but not much else. This article strives to serve as an entry-point for both an intellectual and a popular audience to help familiarize readers with core components of Kabbalah and to help to begin fostering an appreciation for this very sophisticated faith. Matters of history, philosophy, science, doctrine, and more pertaining to Kabbalah will be discussed in this article

The Theory Of Relativity And Applications: A Simple Introduction, Ellen Rea

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper will provide a brief overview of the theory of relativity by looking at its two parts: special relativity and general relativity. It will omit most of the complex mathematics involved in order to focus on providing a more conceptual understanding. However, some simplified equations will be introduced to illustrate various aspects of the theory. Some of the experiments and scientific observations that support the theory as well as some of the scientific advances that emerged from the theory will also be discussed. Following the overview of the theory of relativity will be some of its applications in past …

An Examination Of The Death Penalty, Alexandra N. Kremer

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

The death penalty, or capital punishment, is the use of execution through hanging, beheading, drowning, gas chambers, lethal injection, and electrocution among others in response to a crime. This has spurred much debate on whether it should be used for reasons such as ethics, revenge, economics, effectiveness as a deterrent, and constitutionality. Capital punishment has roots that date back to the 18^th century B.C., but, as of 2016, has been abolished in law or practice by more than two thirds of the world’s countries and several states within the United States. Here, the arguments for and against the death …

Disciplines Derived From The Discovery Of Historical Archives, Yongsheng Chen, Huanning Su

Proceedings from the Document Academy

This paper reviews four famous areas of study in China that emerged from the discovery of historical archives to become their own disciplines. Through a literature review, this paper analyzes the importance of historical archives for forming disciplines by introducing the origin, development, research objectives and research contents of these four disciplines. Based on that, this paper finally suggests that people’s attention to archives is the biggest reason for forming disciplines. By discussing the reasons for accelerating the combination of studies and historical archives, this paper gives suggestions for archives management.

The Architext Of Biblion: Digital Echoes Of Paul Otlet, Arthur Perret

Proceedings from the Document Academy

Paul Otlet's 1934 Traité de documentation is a landmark publication, but its considerable scope, complex structure and sheer volume make it a particularly challenging resource to use. This paper reports on an experiment in which visual methods and lexicometry are used to understand how the Traité is organized and what it is about. We describe the underlying logic of the experiment using the concepts of biblion and architext, then process the table of contents and full text of the book with several visualization methods, discussing their output. This allows us to confirm and expand on previous qualitative appraisal of the …

Infusing Infographics Into The Business Curriculum: A Study Of Infographic Interpretations In China, New Zealand, And The United States, Stephanie Kelly, Stephen Croucher, Todd L. Sandel, Fei Yu

Global Advances in Business Communication

The present study sought to identify whether infographics should be infused into business curriculum as a tool for improving the efficiency of cross-cultural business communication. Students from the United States, New Zealand, and China were presented with a series of 10 infographics with all text in French, a language not spoken by any of the student participants. Of the infographics, eight were designed with traditional visual relationships, one was designed based upon metaphor, and one relied upon visual relationships and incorporated metaphor. The majority of students in both samples were able to successfully interpret the information in each infographic except …

Fall Commencement Program, December 14, 2018, Coastal Carolina University

Commencement Programs

Program of Commencement Exercises at Coastal Carolina University.

Limit Properties Of Order Statistics, А. Madraximov, S. Kukieva

Scientific journal of the Fergana State University

The paper studies the question of estimating the concentration function for the sums of minima of positive random variables.

Substantiation The Parameters Of The Cotton Cleaners’ Polyhedral Vibrating Fire-Bars, A. Djuraev, R.Kh. Maksudov, Sh. Shukhratov

Scientific journal of the Fergana State University

The article describes the principle of operation of the recommended multifaceted grate on elastic supports, as well as the results of the analysis of the grate oscillations, and the parameters are justified. The results of comparative production tests.

Mathematical Models For The Numerical Solution Of Boundary Value Problems Nonstationary Three-Phase Filtering, А. Abdukodirov, G. Аkramova

Scientific journal of the Fergana State University

The construction of an explicit / implicit scheme for the numerical solution of regional problems of non-stationary three-phase filtration is considered in the article.

Recommendations For Developing Modern Electronic Educational Resources, S. Abdurakhmonov, I. Bilolov

Scientific journal of the Fergana State University

The article discusses the use of AutoPlay Media Studio in creating e-learning resources, and also studies the technology of creating electronic resources. Based on the examples, recommendations for use in the education system are developed and provided,

The Value Of Commodity Products Based On Furfural In The National Economy (Review), M. Аkhмаdaliev, I. Аskarov

Scientific journal of the Fergana State University

The article describes the methods of obtaining furfuralis by recycling of vaste and importance of goods production’s on the base of furfuralis for economy

The Value Of Checking An Infrared Spectrophotometer According To The Program Of Metrological Certification For The Correct Classification Of Motor Oils By Their Chemical Composition, М. Imomova, B. Аbduganiev

Scientific journal of the Fergana State University

In this article the questions of determining the chemical composition of the motor oils after the metrological certification of infrared spectrophotometer are elucidated

Water Soluble Polysaccharides Of The Plant Aconitum Leucostomum, Sh. Turgunboev, R. Rakhmonberdieva

Scientific journal of the Fergana State University

Polysaccharides are polymers with a wide spectrum of biological activity. They contribute to detoxification of the body, remove toxic substances, cholesterol, heavy metals, radionuclide from the body, and also repair damaged cells, do not allow the formation of free radicals, restores the immune system. In medicine, based on polysaccharides, biological active additives such as rheopolyglucin, polyglucin, heparin, mucaltin and others have been created.