Digital Commons Network^™

2018 October 22 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Design, Synthesis, And Evaluation Of Amphiphilic Cyclic And Linear Peptides Composed Of Hydrophobic And Positively-Charged Amino Acids As Antibacterial Agents, Neda Riahifard, Saghar Mozaffari, Taibah Aldakhil, Francisco Nunez, Qamar Alshammari, Saud Alshammari, Jason Yamaki, Keykavous Parang, Rakesh Kumar Tiwari

Pharmacy Faculty Articles and Research

Antimicrobial peptides (AMPs) contain amphipathic structures and are derived from natural resources. AMPs have been found to be effective in treating the infections caused by antibiotic-resistant bacteria (ARB), and thus, are potential lead compounds against ARB. AMPs’ physicochemical properties, such as cationic nature, amphiphilicity, and their size, will provide the opportunity to interact with membrane bilayers leading to damage and death of microorganisms. Herein, AMP analogs of [R₄W₄] were designed and synthesized by changing the hydrophobicity and cationic nature of the lead compound with other amino acids to provide insights into a structure-activity relationship against selected …

Week Of October 22, 2018, New York Medical College

InTouch

• College Supporters Gather for a Festive Evening at the Founder's Dinner
• NYMC Welcomes Bess J. Chazhur, M.S., as Chief Development Officer and Executive Director of Alumni Relations
• Center for Long-Term Care Hosts Colloquium on Aging

Anastomosis In Intestinal Tuberculosis: A Systematic Review, Agi S. Putranto, Stefanny Muchtar

The New Ropanasuri Journal of Surgery

Introduction. The heterogeneity of manifestations in intestinal tuberculosis requires different approach. One step or two steps surgical procedure referred to the method of choice to reduce morbidity and mortality. The review aimed to find out the indication to perform primary anastomosis in intestinal tuberculosis. Method. A systematic review was conducted in accordance with PRISMA guideline in June 2018. Literature searches were performed through online databases sites (PubMed, EBSCO, and Ovid) using keywords “intestinal tuberculosis” AND “surgery” AND “anastomosis”. Intestinal pathology, surgical procedures, anastomosis leaks, enterocutaneous fistula, and mortality were the variables of outcome have been analyzed. Results. Twelve articles of …

Gene Gangs Of The Chloroviruses: Conserved Clusters Of Collinear Monocistronic Genes, Phillip Seitzer, Adrien Jeanniard, Fangrui Ma, James L. Van Etten, Marc T. Facciotti, David D. Dunigan

Nebraska Center for Virology: Faculty Publications

Chloroviruses (family Phycodnaviridae) are dsDNA viruses found throughout the world’s inland waters. The open reading frames in the genomes of 41 sequenced chloroviruses (330 + 40 kbp each) representing three virus types were analyzed for evidence of evolutionarily conserved local genomic “contexts”, the organization of biological information into units of a scale larger than a gene. Despite a general loss of synteny between virus types, we informatically detected a highly conserved genomic context defined by groups of three or more genes that we have termed “gene gangs”. Unlike previously described local genomic contexts, the definition of gene gangs requires only …

Spatial And Temporal Clustering Analysis Of Tuberculosis In The Mainland Of China At The Prefecture Level, 2005-2015, Meng-Yang Liu, Qi-Huan Li, Ying-Jie Zhang, Yuan Ma, Yue Liu, Wei Feng, Cheng-Bei Hou, Endawoke Amsalu, Xia Li, Wei Wang, Wei-Min Li, Xiu-Hua Guo

Research outputs 2014 to 2021

BACKGROUND: Tuberculosis (TB) is still one of the most serious infectious diseases in the mainland of China. So it was urgent for the formulation of more effective measures to prevent and control it.

METHODS: The data of reported TB cases in 340 prefectures from the mainland of China were extracted from the China Information System for Disease Control and Prevention (CISDCP) during January 2005 to December 2015. The Kulldorff's retrospective space-time scan statistics was used to identify the temporal, spatial and spatio-temporal clusters of reported TB in the mainland of China by using the discrete Poisson probability model. Spatio-temporal clusters …

Prospectus, October 18, 2018, Parkland College, Savannah Weishaar, Ashley House, Paul Benson, Ayla Mcdonald, Emma Fleming

Prospectus 2018

Studying Around the World; Parkland College Outstanding Students Nominated for Illinois' Highest Honor; Parkland to go Solar with Renewable Energy; Wind Ensemble & Orchestra Hold Fall Concert

Curriculum And Standards Committee Report #2018-19-2 (Courses), University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

Board Of Trustees Meeting Minutes, October 18-19, 2018

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on October 18-19, 2018.

Neither Cruel Nor Unusual: An Hour And A Half Delay In Treatment Can Now Amount To Deliberate Indifference, Monica J. Raven

Seventh Circuit Review

The Eighth Amendment of the U.S. Constitution proscribes cruel and unusual punishment. To state a cognizable claim, a plaintiff must allege that a prison official or medical professional was deliberately indifferent to his or her objectively serious medical need. In Lewis v. McLean, the Seventh Circuit analyzed whether a nurse and prison official’s hour and a half delay in treatment created a triable issue as to whether they acted with deliberate indifference. The plaintiff alleged that the defendants showed deliberate indifference to his severe back pain by delaying his access to medical care. The defendants, on the other hand, …

Findings Determine A New Treatment Regimen For The Most Common Curable Sti, Staff

Browse All News

No abstract provided.

Role Of The Fractalkine Receptor In Cns Autoimmune Inflammation: New Approach Utilizing A Mouse Model Expressing The Human Cx3cr1I249/M280 Variant, Sandra M. Cardona, Sangwon V. Kim, Kaira A. Church, Vanessa O. Torres, Ian A. Cleary, Andrew S. Mendiola, Stephen P. Saville, Stephanie S. Watowich, Jan Parker-Thornburg, Alejandro Soto-Ospina, Richard M. Ransohoff, Astrid E. Cardona

Peer Reviewed Articles

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered the primary pathology of MS, but progressive axonal loss is the major cause of neurological disability. In an effort to understand microglia function during CNS inflammation, our laboratory focuses on the fractalkine/CX3CR1 signaling as a regulator of microglia neurotoxicity in various models of neurodegeneration. Fractalkine (FKN) is a transmembrane chemokine expressed in the CNS by neurons and signals through its unique receptor CX3CR1 present in microglia. During …

Role Of The Fractalkine Receptor In Cns Autoimmune Inflammation: New Approach Utilizing A Mouse Model Expressing The Human Cx3cr1, Sandra M. Cardona, Sangwon V. Kim, Kaira A. Church, Vanessa O. Torres, Ian A. Cleary, Andrew S. Mendiola, Stephen P. Saville, Stephanie S. Watowich, Jan Parker-Thornburg, Alejandro Soto-Ospina, Pedronel Araque, Richard M. Ransohoff, Astrid E. Cardona

Department of Microbiology and Immunology Faculty Papers

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered the primary pathology of MS, but progressive axonal loss is the major cause of neurological disability. In an effort to understand microglia function during CNS inflammation, our laboratory focuses on the fractalkine/CX3CR1 signaling as a regulator of microglia neurotoxicity in various models of neurodegeneration. Fractalkine (FKN) is a transmembrane chemokine expressed in the CNS by neurons and signals through its unique receptor CX3CR1 present in microglia. During …

Use Of Uv Treated Milk Powder To Increase Vaccine Efficacy In The Elderly, Sara Schaefer, Kasper Arthur Hettinga, James Cullor, J. Bruce German, University Of Nebraska - Lincoln

Department of Food Science and Technology: Faculty Publications

Aging populations experience a decline in adaptive immune system function also known as immunosenesence. Protein nutrition has been shown to stimulate and strengthen the immune system, and such approaches are needed for this growing segment of the population. A controlled, randomized, double blind pilot study was conducted to compare two different protein sources (soy and dairy) as nutritional supplementation to enhance vaccine response. Our objective was to examine the immune stimulating effects of dairy protein subjected to ultraviolet radiation (UV-C) radiation treatment process instead of pasteurization. Participants were 21 healthy individuals over 60 years of age who consumed 6 g …

Librarians: An Essential Part Of The Public Health Workforce, Laura Zeigen

Pacific Northwest Chapter of MLA Annual Meeting

Public health campaigns suffer when the general public refuses to believe credible health information, such as around issues of vaccination or fluoridation. Public health marketing and media experts work to craft excellent messaging in ways that can be best heard by these audiences. However, the best messages will go unheard if individuals have already not developed critical thinking and information literacy skills over time. Librarians from all sectors (school libraries, public libraries, university libraries, and health sciences libraries) are key to helping people develop these information literacy skills. As such, impacts on library infrastructure and funding ultimately impact public health. …

Characteristics Of Adolescents Living With Hiv Receiving Care And Treatment Services In Antiretroviral Therapy Clinics In Cambodia: Descriptive Findings From A Cross-Sectional Study., Siyan Yi, Sovannary Tuot, Khuondyla Pal, Vohith Khol, Say Sok, Pheak Chhoun, Laura Ferguson, Gitau Mburu

BACKGROUND: Adolescents living with HIV experience worse HIV care outcomes compared to adults, especially during transition from pediatric to adult care. However, data regarding adolescents are limited. This paper describes and compares characteristics of male and female adolescents living with HIV preparing for transition from pediatric to adult care in Cambodia.

METHODS: This cross-sectional study was conducted in August 2016 among 328 adolescents aged 15-17, randomly selected from 11 antiretroviral therapy (ART) clinics. Data were collected using a structured questionnaire, and descriptive analyses were conducted to compare characteristics of male and female adolescents.

RESULTS: Of total, 55.2% were male, and …

Infectious Disease Consultation Significantly Reduces Mortality Of Patients With Bloodstream Yeast Infections, Staff

Browse All News

No abstract provided.

A Simple, Sensitive And Reliable Lc-Ms/Ms Method For The Determination Of 7-Bromo-5-Chloroquinolin-8-Ol (Clbq14), A Potent And Selective Inhibitor Of Methionine Aminopeptidases: Application To Pharmacokinetic Studies, Oscar Ekpenyong, Candace Cooper, Jing Ma, Dong Liang, Omonike Olaleye, Huan Xie

Faculty Publications

CLBQ14 is an 8-hydroxyquinoline analogue that inhibits methionine aminopeptidase (MetAP), an enzyme responsible for the post-translational modification of several proteins and polypeptides. MetAP has been validated as druggable target for some infectious diseases, and its inhibitors have been investigated as potential therapeutic agents. In this study, we developed and validated a liquid chromatography tandem-mass spectrometry (LC-MS/MS) method for the quantification of CLBQ14 in solution, and in rat plasma and urine. This method was applied to the pharmacokinetic evaluation of CLBQ14 in adult male Sprague Dawley (SD) rats. Chromatographic separation was achieved using an ultra-high-performance liquid chromatography (UHPLC) system equipped with …

Leukemia Inhibitory Factor Modulates The Peripheral Immune Response In A Rat Model Of Emergent Large Vessel Occlusion, Stephanie M. Davis, Lisa A. Collier, Edric D. Winford, Christopher C. Leonardo, Craig T. Ajmo Jr., Elspeth A. Foran, Timothy J. Kopper, John C. Gensel, Keith R. Pennypacker

Neurology Faculty Publications

Background: The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation of antioxidant enzymes, promotes an anti-inflammatory phenotype in several types of immune cells. The goal of this study was to determine whether LIF treatment modulates the peripheral immune response after stroke.

Methods: Young male (3 month) Sprague-Dawley rats underwent sham surgery or permanent middle cerebral artery occlusion (MCAO). Animals were administered LIF (125 μg/kg) or …

Custom-Edited Dna: Legal Limits On The Patentability Of Crispr-Cas9'S Therapeutic Applications, Noah C. Chauvin

William & Mary Law Review

No abstract provided.

Efficiency Of Health Care In The Eu28 Countries With The Innovation Factor Taken Into Account, Mariola Zalewska

European Management Studies

The article presents an attempt to analyse the efficiency of health care systems in sub-regions of Poland in comparison to sub-regions of EU countries, using the indicator of average life expectancy and an innovation indicator developed on the basis of the European Innovation Scoreboard. The basic source of data presented in the article is commonly available data from databases of countries or international organisations: the Polish Central Statistical Office (GUS), Eurostat, WHO. Comparative methods were applied to the following indicators: the expenditure on health care, life expectancy and innovation at the country level. Life expectancy depends mainly on health expenditure, …

A Cloud Of Witnesses: External Mediation In Frodo’S Journey To Rivendell And Beyond, Carl P. Olson

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Applies Rene Girard’s mimetic theory to a study of Frodo’s motivations and role models in the early phases of The Lord of the Rings. Tolkien’s incorporation of extensive background material deepens our understanding of his main characters, most of all his central hero, Frodo. Commonly described as “role-models,” external mediators work to pacify relations in a community, and act to endow individuals with meaning, purpose, and direction they otherwise would not have. By the imitation of role-models, Frodo, Sam, Pippin, and Merry become real to Tolkien’s readers by comparison and contrast to Bilbo Baggins, Gildor and his high elves, …

Tick-Borne Pathogens In Ticks And Blood Samples Collected From Camels In Riyadh Province, Saudi Arabia, Abdullah Daria Alanazi, Swaid Abdullah, Chris Helps, Richard Wall, Robert Puschendorf, Samir Abdelkreem Alharbi, Sobhy Abdel-Shafy, Raafat Mohamed Shaapan

School of Biological and Marine Sciences

No abstract provided.

Variation Among Populations In The Immune Protein Composition Of Mother's Milk Reflects Subsistence Pattern, Laura D. Klein, Jincui Huang, Elizabeth A. Quinn, Melanie A. Martin, Alicia A. Breakey, Michael Gurven, Hillard Kaplan, Claudia Valeggia, Grazyna Jasienska, Brooke Scelza, Carlito B. Lebrilla, Katie Hinde

ESI Publications

Lay Summary: Adaptive immune proteins in mothers’ milk are more variable than innate immune proteins across populations and subsistence strategies. These results suggest that the immune defenses in milk are shaped by a mother’s environment throughout her life.

Background and objectives: Mother’s milk contains immune proteins that play critical roles in protecting the infant from infection and priming the infant’s developing immune system during early life. The composition of these molecules in milk, particularly the acquired immune proteins, is thought to reflect a mother’s immunological exposures throughout her life. In this study, we examine the composition of innate …

Effects Of Evolution On Laboratory Sublines Of Myxococcus Xanthus Dk1622, Mackenzie Ryan, Francesca Scribano, Kimberly Murphy

Celebration of Learning

Microbes have served as effective models for studying evolution because of their ability to be easily replicated, stored, and manipulated. Myxococcus xanthus is a soil bacterium that has served as a model organism in many laboratories. The unique social and motile behaviors exhibited by this bacterium make it ideal for phenotypic assays. A wild-type strain of M. xanthus, DK1622, has been distributed to laboratories across the United States and therefore we now have DK1622 sublines. The genomes of a number of these sublines have been sequenced and their social and motile phenotypes have been analyzed. When nine of these sublines …

Seroprevalence And Participatory Epidemiology Of Camelpox In Afar Region Of Ethiopia, Weldegebrial G. Aregawi, Getahun E. Agga, Jemal Gishe, Reta D. Abdi

Public Health, Health Administration, and Health Sciences Faculty Research

Camelpox is endemic in most camel rearing regions of the world, causing significant economic losses. However, its epidemiology is not extensively investigated. We conducted a cross sectional seroprevalence study of camelpox in Amibara and Awash Fentale districts in Afar region of Ethiopia from November 2014 to May 2015. In addition, participatory epidemiology (PE) was conducted to identify seasonal occurrence of the disease in the study districts. Blood samples were collected from 384 dromedary camels from 31 herds distributed in five pastoral associations (PAs) in the two districts. Serum samples were separated from the blood samples and tested for the presence …

Qualitative Case Study Of Needle Exchange Programs In The Central Appalachian Region Of The United States, Stephen M. Davis, Danielle Davidov, Alfgeir L. Kristjansson, Keith Zullig, Adam Baus, Melanie Fisher

Clinical and Translational Science Institute

Background

The Central Appalachian region of the United States is in the midst of a hepatitis C virus epidemic driven by injection of opioids, particularly heroin, with contaminated syringes. In response to this epidemic, several needle exchange programs (NEP) have opened to provide clean needles and other supplies and services to people who inject drugs (PWID). However, no studies have investigated the barriers and facilitators to implementing, operating, and expanding NEPs in less populous areas of the United States.

Methods

This qualitative case study consisted of interviews with program directors, police chiefs, law enforcement members, and PWID affiliated with two …

The Examination Of Esat-6, Cfp-10, Mpt-64 Antigens Of Mycobacterium Tuberculosis In Urine Of Pediatric Tuberculosis Patient With Immunochromatography To Support The Diagnosis, Anita Budiarti, Jusak Nugraha, Agung Dwi Wahyu Widodo

Folia Medica Indonesiana

Tuberculosis in children is often a systemic complication because of their imperfect cellular immune system. ESAT-6, CFP-10, and MPT-64 are small molecular dominant antigens secreted by Mtb into the blood and filtered by the kidneys into urine. The high proportion of children with TB cases according to the Ministry of Health of the Republic of Indonesia in 2013 was 7.9%-12%. Diagnis is difficult to establish with sputum and blood samples. Therefore, it is necessary to support the diagnosis using urine samples with ICT rapid test. The purpose of this study was to determine the examination of Mtb ESAT-6, CFP-10, and …

Analysis Of Prophylactic Antibiotics Usage In Caesarean Section Delivery, Binti Muzayyanah, Yulistiani Yulistiani, Didik Hasmono, Nuraida Wisudani

Folia Medica Indonesiana

Caesarean section is the delivery through a surgical incision in the abdomen and uterus with various risks, such as Surgical Site Infection (SSI) which either occurs rapidly (24-48 hours postoperatively) or delayed. To reduce the risk of various post-cesarean section infections, prophylactic antibiotics are given. The administration of prophylactic antibiotics with recommended regimens, such as in developed countries as in the United States and Europe, with first generation of cephalosporins has not been applied in Dr. Iskak Hospital, Tulungagung. This hospital still used other types of antibiotics, such as cefotaxime or ceftriaxone. In addition, for several reasons, prophylactic antibiotics were …

Impact Of The Use Of Local Fidaxomicin Treatment Algorithms For Managing Clostridium Difficile Infection In Hospitalized Patients In Southeastern United States, Jonathan C. Cho, Sandy J. Estrada, Jamie J. Kisgen, Angelina Davis, Laura Puzniak

Pharmacy Faculty Publications and Presentations

Background: Clostridium difficile-associated diarrhea (CDAD) is a major public health threat that results in increased length of stay, hospital readmissions, deaths, and economic burden. CDAD treatment is often guided by severity of disease. Although various tools exist to determine CDAD severity, real-world data evaluating the use of such tools in treatment algorithms are sparse. Methods: A local CDAD treatment pathway was developed independently to guide fidaxomicin prescribing at wellStar Health System (WellStar) and at Lee Health (LH) and Sarasota Memorial Hospital (SMH). Each algorithm was designed locally by the stewardship pharmacist and was utilized to identify patients at high risk …