Digital Commons Network^™

Vitamin D Status In Healthy Black African Adults At A Tertiary Hospital In Nairobi, Kenya: A Cross Sectional Study, Elizabeth Kagotho, Geoffrey Omuse, Nancy Okinda, Peter Ojwang

Pathology, East Africa

Background: Vitamin D has been known since the twentieth Century for its benefits in bone health. Recent observational studies have demonstrated its benefits in infectious diseases such as tuberculosis and non-communicable diseases such as diabetes mellitus, cardiovascular diseases and cancer. This has led to a dramatic increase in testing among adults. The cut-offs for vitamin D deficiency have been debated for decades and the current cut off is derived from a Caucasian population. Studies done among black African adults in Africa are few with vitamin D deficiency ranging from 5 to 91%. A few cut- offs have correlated vitamin D …

Two Subspecies Of Bent-Winged Bats (Miniopterus Orianae Bassanii And Oceanensis) In Southern Australia Have Diverse Fungal Skin Flora But Not Pseudogymnoascus Destructans, Peter H. Holz, Linda F. Lumsden, Mark S. Marenda

KIP Articles

Fungi are increasingly being documented as causing disease in a wide range of faunal species, including Pseudogymnoascus destructans, the fungus responsible for white nose syndrome which is having a devastating impact on bats in North America. The population size of the Australian southern bent-winged bat (Miniopterus orianae bassanii), a critically endangered subspecies, has declined over the past 50 years. As part of a larger study to determine whether disease could be a contributing factor to this decline, southern bent-winged bats were tested for the presence of arange of potentially pathogenic fungi: P. destructans, dermatophytes and Histoplasma capsulatum (a potential human …

A Novel Cancer Syndrome Caused By Kcnq1-Deficiency In The Golden Syrian Hamster, Rong Li, Jinxin Miao, Alexandru-Flaviu Tabaran, M. Gerard O'Sullivan, Kyle J. Anderson, Patricia M. Scott, Zhongde Wang, Robert T. Cormier

Animal, Dairy, and Veterinary Science Faculty Publications

BACKGROUND: The golden Syrian hamster is an emerging model organism. To optimize its use, our group has made the first genetically engineered hamsters. One of the first genes that we investigated is KCNQ1 which encodes for the KCNQ1 potassium channel and also has been implicated as a tumor suppressor gene.

MATERIALS AND METHODS: We generated KCNQ1 knockout (KO) hamsters by CRISPR/Cas9­-mediated gene targeting and investigated the effects of KCNQ1­-deficiency on tumorigenesis.

RESULTS: By 70 days of age seven of the eight homozygous KCNQ1 KOs used in this study began showing signs of distress, and on necropsy six of the seven …

The Current Volume 29 : Issue 9, Nova Southeastern University

Student Newspapers

No abstract provided.

Marrazzo Named To National Infectious Disease Organization Board, Staff

Browse All News

No abstract provided.

Vancomycin Delays Clindamycin-Induced Fatality In The Hamster Model Of Clostridioides [Clostridium] Difficile Infection, Amelia E. Fox-King, Chrisabelle Mefferd, Jacqueline R. Phan, Nancy O. Nou, Ernesto Abel-Santos, Brian P. Hedlund

LSAMP Poster Presentations

Antibiotics can leave the host gut microbiome susceptible to Clostridioides [Clostridium] difficile colonization and lethal toxin production. For instance, clindamycin-induced susceptibility to C. difficile infection (CDI) results in rapid fatality in hamster models, yet vancomycin has been shown to offer increased survival in hamsters challenged with C. difficile. We aim to develop an antibiotic treatment that will facilitate CDI susceptibility without prompt fatality in hamster models. An antibiotic regimen starting with a continuous vancomycin treatment along with a single clindamycin dosage is thought to reduce the major disruption in the indigenous gut microbiome and prevent clindamycin-induced death. …

Week Of October 8, 2018, New York Medical College

InTouch

• NYMC Appoints Jerry L. Nadler, M.D., FACP, FAHA, FACE, Dean of the School of Medicine
• HSL to Host Special Presentation: The Art of Observation

Perceptions Of Needs, Assets, And Priorities Among Black Men Who Have Sex With Men With Hiv: Community-Driven Actions And Impacts Of A Participatory Photovoice Process, Christina J. Sun, Jennifer L. Nall, Scott D. Rhodes

OHSU-PSU School of Public Health Faculty Publications and Presentations

Black men who have sex with men (MSM) with HIV experience significant health inequities and poorer health outcomes compared with other persons with HIV. The primary aims of this study were to describe the needs, assets, and priorities of Black MSM with HIV who live in the Southern United States and identify actions to improve their health using photovoice. Photovoice, a participatory, collaborative research methodology that combines documentary photography with group discussion, was conducted with six Black MSM with HIV. From the photographs and discussions, primary themes of discrimination and rejection, lack of mental health services, coping strategies to reduce …

Pulse Vaccination Of An Sirs Epidemic Model With Nonlinear Incidence Rate, Meruyert Yeleussinova

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

The Effect Of Demographic Variability, Environmental Variability, And Periodic Fluctuations On Stochastic Epidemic Models, Kaniz Fatema Nipa, Linda J. Allen

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Mathematical Model Of The Inflammatory Response To Pathogen Challenge, Lester Caudill, Fiona Lynch

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling The Transmission Of Wolbachia In Mosquitoes For Controlling Mosquito-Borne Diseases, Zhuolin Qu

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Biomathematics And Social Justice: Reinventing Models Of Disease Spread To Study Efficacy Of Bystander Violence Prevention, Hannah Callender Highlander

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Simulating Antibiotic Resistance In The Computer Lab And Biology Lab: Ideas For Undergraduate Projects, Anne E. Yust

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

With-In Host Dynamics Of L. Monocytogenes And Thresholds For Distinct Infection Scenarios, Ashrafur Rahman, Daniel Munther, Aamir Fazil, Ben Smith, Jianhong Wu

Mathematics and Statistics Faculty Publications

The case fatality and illness rates associated with L. monocytogenes continue to pose a serious public health burden despite the significant efforts and control protocol administered by private and public sectors. Due to the advance in surveillance and improvement in detection methodology, the knowledge of sources, transmission routes, growth potential in food process units and storage, effect of pH and temperature are well understood. However, the with-in host growth and transmission mechanisms of L. monocytogenes, particularly within the human host, remain unclear, largely due to the limited access to scientific experimentation on the human population. In order to provide insight …

Understanding The Impact Of Social Factors On The Transmission Dynamics Of Infectious Diseases, Victor Moreno

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Immuno-Epidemiological Modeling Of Infectious Diseases: A Careful Attempt At A Review, Maia Martcheva

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Proposed Interventions For The Containment Of Influenza In Boarding Schools And Small Colleges, Alexis Vittengl

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Vaccination Strategies And Herd Immunity Thresholds In Small World Models, Emily Mcclung, Sam Rivas, Emma Soriano

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling The Role Of Edge Effects On The Spread Of A Zoonotic Disease, Dustin Padilla

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Bone Protection By Inhibition Of Microrna-182, Eugenia G. Giannopoulou, Kazuki Inoue, Zhonghao Deng, Yufan Chen, Ren Xu, Shiaoching Gong, Matthew B. Greenblatt, Lingegowda S. Mangala, Gabriel Lopez-Berestein, David G. Kirsch, Anil K. Sood, Liang Zhao, Baohong Zhao

Publications and Research

Targeting microRNAs recently shows significant therapeutic promise; however, such progress is underdeveloped in treatment of skeletal diseases with osteolysis, such as osteoporosis and rheumatoid arthritis (RA). Here, we identified miR-182 as a key osteoclastogenic regulator in bone homeostasis and diseases. Myeloid-specific deletion of miR-182 protects mice against excessive osteoclastogenesis and bone resorption in disease models of ovariectomy-induced osteoporosis and inflammatory arthritis. Pharmacological treatment of these diseases with miR-182 inhibitors completely suppresses pathologic bone erosion. Mechanistically, we identify protein kinase double-stranded RNA-dependent (PKR) as a new and essential miR-182 target that is a novel inhibitor of osteoclastogenesis via regulation of the …

October 4, 2018, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Applications Of Electronic-Nose Technologies For Noninvasive Early Detection Of Plant, Animal And Human Diseases, Alphus Dan Wilson

KIP Articles

The development of electronic-nose (e-nose) technologies for disease diagnostics was initiated in the biomedical field for detection of biotic (microbial) causes of human diseases during the mid-1980s. The use of e-nose devices for disease-diagnostic applications subsequently was extended to plant and animal hosts through the invention of new gas-sensing instrument types and disease-detection methods with sensor arrays developed and adapted for additional host types and chemical classes of volatile organic compounds (VOCs) closely associated with individual diseases. Considerable progress in animal disease detection using e-noses in combination with metabolomics has been accomplished in the field of veterinary medicine with new …

Whitley Receives Prestigious Lifetime Achievement Award, Staff

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No abstract provided.

Children As Agents Of Change: Parent Perceptions Of Child-Driven Environmental Health Communication In The Apsáalooke (Crow Indian) Community, Jessica Milakovich, Vanessa W. Simonds, Frances L. Kim, Deborah Laveaux, Velma Pickett, Suzanne Held, Christine Martin, Jason Cummins, Lynn Kelting-Gibson

Journal of Health Disparities Research and Practice

While previous research suggests children have successfully acted as health change agents, no studies have examined the role of children in promoting environmental health knowledge and awareness. This study describes parent perceptions of the impact of a five-day water-focused environmental health summer camp on elementary school children in an American Indian community. We interviewed parents about their perception of changes in their child's environmental health knowledge, attitudes, and behaviors. Parents in this study confirmed that their child had shared information related to the camp activities. In addition, parents perceived that their children had increased knowledge and positive changes in attitudes …

Nocardia Brasiliensis Infection After Hurricane Irma: Two Case Reports, Sarah Al-Obaydi Md, James Demaio, Nemer Dabage Md

Infectious Disease

Background: Although an increase in skin and soft tissue infections has been well documented after natural disasters, cases of Nocardia brasiliensis infection have not been included in prior reports. We present two cases of N. brasiliensis lymphadenitis that occurred in Manatee County, Florida after Hurricane Irma.

Methods: Case 1-A 75 year old immune competent male may have injured his arm while retrieving a golf ball approximately four weeks after Hurricane Irma. Ten days later he presented to the hospital with an abscess on his left forearm and a lymphadenitis extending nearly to the axilla. Despite treatment with vancomycin, the lymph …

New Clinic To Expand Sexually Transmitted Infections, Sexual Health Research, Alicia Rohan

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No abstract provided.

The Impact Of Multiplex Pcr Panel In The Diagnosis Of Meningitis In Children, Jeanette Taveras Do, Tibisay Villalobos Md, Faap

Department of Pediatrics

No abstract provided.

Exposure To Community Violence And Substance Use Among Black Men Who Have Sex With Men: Examining The Role Of Psychological Distress And Criminal Justice Involvement, Dexter R. Voisin

Faculty Scholarship

Young Black MSM (YBMSM) are disproportionately affected by violence, criminal justice involvement, and other structural factors that also increase vulnerability to HIV. This study examined associations between exposure to community violence (ECV) and substance use, psychological distress, and criminal justice involvement (CJI) among YBMSM in Chicago, IL. Respondent driven sampling was used to recruit a sample of 618 YBMSM (aged 16–29) from the South Side of Chicago between June 2013 and July 2014. Weighted logistic regression assessed the direct effects of ECV, CJI, and psychological distress on substance use outcomes. Indirect effects were assessed via path analysis with mean and …

An Essential Staphylococcus Aureus Cell Division Protein Directly Regulates Ftsz Dynamics, Prahathees J. Eswara, Robert S. Brzozowski, Marissa G. Viola, Gianni Graham, Catherine Spanoudis, Catherine Trebino, Jyoti Jha, Joseph I. Aubee, Karl M. Thompson, Jodi L. Camberg, Kumaran S. Ramamurthi

Cell and Molecular Biology Faculty Publications

Binary fission has been well studied in rod-shaped bacteria, but the mechanisms underlying cell division in spherical bacteria are poorly understood. Rod-shaped bacteria harbor regulatory proteins that place and remodel the division machinery during cytokinesis. In the spherical human pathogen Staphylococcus aureus, we found that the essential protein GpsB localizes to mid-cell during cell division and co-constricts with the division machinery. Depletion of GpsB arrested cell division and led to cell lysis, whereas overproduction of GpsB inhibited cell division and led to the formation of enlarged cells. We report that S. aureus GpsB, unlike other Firmicutes GpsB orthologs, directly …