Digital Commons Network^™

An Environmental Study On Problems Faced By Healthcare Visitors Of Kanchipuram District, N. Palaniraj Ph.D., Prakash V.

International Review of Business and Economics

India as a developing economy is healthier nation because of proper and well-developed healthcare infrastructure. This leads to improvement in the life years and happiness of the population. The high life style increases the unhealthy practices of eating culture, fast food, no exercise and other. Even children’s are facing serious health issues in early ages. Due to this, every individual’s visiting the hospitals at least once in a month. Many get diseases while visiting hospitals where there is poor maintenance of various wastes, which leads to air pollution, waste water pollution, bio medical waste pollution, and soil pollution. Tamil nadu …

Perspective Study Of Environmental Effects On Public Health, M Mohan Raju Ph.D.

International Review of Business and Economics

In this paper it is critically review the economic literature on the effects of environmental changes on public health ,in both the developed and the developing wolrd. The first focus on the economic methodologies that are available for the evaluation of the effects of environmental changes on public health .Then it explain how the monetary valuations of these effects can feed back in the construction of economic policy for creating agent specific incentives for more efficient public management,which is also equitable and environmentally sustainable. Every minute, five children in developing countries die from malaria or diarrhoea. Every hour, 100 children …

Challenges Of Climate Change On Human Health, Sharon P.R., S. Seethalakshmi Ph.D.

International Review of Business and Economics

Climate change is the biggest global health threat of the 21st century. Climate change is adversely affecting the human health. Maximum impact of global warming and climate change will be seen on underdeveloped and developing countries like India. In Indian context the implications of climate change are broadly classified into rising sea levels, increasing CO2 levels, rising temperatures and extreme weather conditions. Climate change affects the human health in various ways. In developing countries like India, the health sector and the infrastructural facilities are very weak. The impact of the human activity on climate system is the most serious environmental …

In Vivo Inhibition Of Tryptophan Catabolism Reorganizes The Tuberculoma And Augments Immune-Mediated Control Of Mycobacterium Tuberculosis, Uma S. Gautam, Taylor W. Foreman, Allison N. Bucsan, Ashley V. Veatch, Xavier Alvarez, Toidi Adekambi, Nadia A. Golden, Kaylee M. Gentry, Lara A. Doyle-Meyers, Kasi E. Russell-Lodrigue, Peter J. Didier, James L. Blanchard, K. Gus Kousoulas, Andrew A. Lackner, Daniel Kalman, Jyothi Rengarajan, Shabaana A. Khader, Deepak Kaushal, Smriti Mehra

Faculty Publications

Mycobacterium tuberculosis continues to cause devastating levels of mortality due to tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the highly specialized strategies that M. tuberculosis utilizes to modulate host immunity and thereby persist in host lungs. Here, we show that M. tuberculosis induced the expression of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in tryptophan catabolism, in macrophages and in the lungs of animals (mice and macaque) with active disease. In a macaque model of inhalation TB, suppression of IDO activity reduced bacterial burden, pathology, and clinical signs of TB disease, leading to increased host …

Flp-1 Neuropeptides Modulate Sensory And Motor Circuits In The Nematode Caenorhabditis Elegans, Ingrid Buntschuh, Daniel A. Raps, Ivor Joseph, Christopher Reid, Alexander Chait, Raubern Totanes, Michelle Sawh, Chris Li

Publications and Research

Parasitic nematodes infect over one quarter of the population worldwide, causing morbidity in over one billion people. Current anthelmintic drugs are beginning to lose effectiveness due to the presence of resistant strains. We are interested in the role of neuropeptides, which regulate behaviors in all organisms, as another possible target for anthelmintic drugs. FMRFamide-related peptides (FaRPs) are a family of neuropeptides that are conserved throughout the animal kingdom. In particular, nematodes contain the largest family of FaRPs identified thus far and many of these FaRPs are identical among different nematode species; FaRPs in nematodes are collectively referred to as FLPs …

Hiv-Tb Coinfection Among 57 Million Pregnant Women, Obstetric Complications, Alcohol Use, Drug Abuse, And Depression, Dorian Fernandez, Imoleayo Salami, Janelle Davis, Florence Mbah, Aisha Kazeem, Abreah Ash, Justin Babino, Laquiesha Carter, Jason L. Salemi, Kiara K. Spooner, Omonike A. Olaleye, Hamisu M. Salihu

Faculty Publications

Objective. HIV and tuberculosis represent diseases of major public health importance worldwide. Very little is known about HIV-TB coinfection among pregnant women, especially from industrialized settings. In this study, we examined the association between TB, HIV, and HIV-TB coinfection among pregnant mothers and obstetric complications, alcohol use, drug abuse, and depression. Method. We examined inpatient hospital discharges in the United States from January 1, 2002, through December 31, 2014. We employed multivariable survey logistic regression to generate adjusted estimates for the association between infection status and study outcomes. Results. We analyzed approximately 57 million records of pregnant women and their …

Subperiosteal Abscess Of The Distal Radius In A 13-Year-Old Boy: A Case Report, Anastasiya K. Haponyuk, Deana M. Mercer

UNM Orthopaedic Research Journal

Children and adolescents have the tendency to develop osteomyelitis in metaphyseal sinusoids because turbulent blood flow increases the probability of bacterial growth. Osteomyelitis in children is frequently misdiagnosed owing to lack of symptoms and specific findings from laboratory tests. Without rapid antibiotic treatment of osteomyelitis, complications such as subperiosteal abscesses may occur. We describe a 13-year-old boy who underwent irrigation and debridement to treat a subperiosteal abscess of the right distal radius and ulna, caused by acute osteomyelitis. After debridement, the patient was placed on a continuous 6-week course of nafcillin infusion through a peripherally inserted central catheter (PICC). The …

A Community Outreach Project Assisting Evergreen Elementary School With Students’ Nutritional Needs, Robin C. Erickson, Nicole Roach, Megan Smith

All Electronic Theses and Dissertations

Nine months out of the year, students within the United States attend elementary school to be educated on English, mathematics, history, and other topics. The Anoka- Hennepin School District’s philosophy of an elementary education highlights many important factors for success in school but neglects to highlight nutrition as one of the factors. The purpose of our community outreach project is aimed at reducing the stress of hunger for the students at Evergreen Elementary School (EES) by implementing a food drive. Through the food drive, the project team members were able to collect various donations including food, clothing items, and hygiene …

Factors Influencing Provider Antibiotic Prescribing Behaviors: A Qualitative Study, Patrick Kevin Hayden, Emily Palmer

All Electronic Theses and Dissertations

The prevalence of antibiotic resistance has grown steadily over the past few decades. Hundreds of thousands of people are dying each year due to the unavailability of previously effective antibiotic regimens. A major influence in the continued progression of this resistance can be attributed to the overuse and inappropriate prescribing of antibiotics. This study explored the factors that influence medical providers to use or prescribe antibiotics in situations when they are not indicated. The study was conducted through a semi-structured interview to providers from Minnesota and Wisconsin who work or have previously worked in urgent cares or emergency rooms. Providers …

Attitudes Towards Vaccinations In The Minnesota Slavic Community, Maksim Kozak, Hannah Margaret Roy, Rachel Van Heest

All Electronic Theses and Dissertations

The incidence of vaccine preventable illnesses is increasing in the United States. Negative attitudes towards vaccinations, or vaccine hesitancy is fueling the decreasing vaccination rates. Ascertaining the level of vaccine hesitancy in susceptible populations is essential in combatting the rise of vaccine preventable illnesses in the United States. Very little research has previously been compiled on vaccine attitudes in Slavic immigrants. Slavic immigrants identify racially as “white” on surveys, masking differences in the Slavic population from the much larger Caucasian population in the United States. In order to better understand the level of vaccine hesitancy in the Minnesota Slavic immigrant …

Exploring Community Associated Clostridium Difficile, Patricia Dumonceaux Msn, Rn, Cic, Phn, Dana Schmidt Rn

Nursing Posters

Clostridium difficile (C. difficile) is a life threatening bacteria spread in spore form through diarrhea. C. difficile effects approximately 500,000 people annually (CDC, 2016). From 2009-2016, the incidence rate of C. difficile in Minnesota* has increased from 50 to 227/1000,000 persons, with 58% of cases considered community associated** (CA), 17% healthcare facility onset (HCFO), and 25% community onset-HCFO (MDH, 2016). MDH 2016 data indicates C. difficile is being transmitted within healthcare and community settings and among patients primarily greater than 65 years of age, with 54% of CA cases using antibiotics during the 12 weeks prior to positive specimen (2016).

Influence Of The Oral Microbiome On General Health, Zvi G. Loewy, Shoshana Galbut, Ephraim Loewy, David A. Felton

Touro College of Pharmacy (New York) Publications and Research

The prevalence of edentulism is common worldwide. While improvements in access to healthcare and dental care are reducing the prevalence rate of edentulism, the rapidly growing number of elderly as a percent of the global population will sustain a need for denture therapy for the foreseeable future. While denture use has positive impacts on the quality of life, their use is associated with some problems and risks. Denture stomatitis, a chronic infection-related inflammatory disorder of the oral mucosa, is extremely common and has been reported to occur in up to two-thirds of denture wearers. Importantly, epidemiology studies have shown edentulism …

Graduate Catalog, 2018-2019, Valparaiso University

Graduate Catalogs

No abstract provided.

Healthnet News V.33:No.3 May-June 2018, Wendy Urciuoli

Articles - Patient Care

Linking Connecticut Patients and Families to Reliable Health Information

Nonmodal Clinical Decision Support And Antimicrobial Restriction Effects On Rates Of Fluoroquinolone Use In Uncomplicated Infections, L R. Gunn, R Tunney, K E. Kelly

Pharmacy Practice

No abstract provided.

#Foamems: Engaging Paramedics With Free, Online Open-Access Education, Paige Mason, Alan M. Batt

Faculty & Staff Publications - Public Safety

Background and aim: Twitter use among paramedics and other prehospital care clinicians is on the rise and is increasingly being used as a platform for continuing education and international collaboration. In 2014, the hashtag #FOAMems was registered. It is used for the sharing of emergency medical services, paramedicine, and prehospital care-related content. It is a component of the 'free open-access meducation' (FOAM) movement. The aim of this study was to characterize and evaluate the content of #FOAMems tweets since registration.

Materials and methods: An analytical report for #FOAMems was generated on symplur.com from February 4, 2014, to April 30, 2017. …

An Overview Of Perinatal Health And Childhood Development In Honduras, Rose Margaret Carlson, Abigail D. Conrad, Alexandra Nicole Lothe, Caitlin M. O'Donnell, Cameron Svihla

All Electronic Theses and Dissertations

Honduras is a country with great healthcare needs. Within health care, the largest percentage of mortality is due to conditions occurring in the perinatal period, including prenatal and maternal health, delivery and postnatal care (PAHO, 2017a). Additionally, malnutrition continues to affect infants as they growth throughout their childhood (Gray, Cossman, & Powers, 2006). Education is shown to produce positive outcomes in low-income populations (Perkins, et al, 2011). The purpose of this project was to identify Honduran healthcare needs and provide effective and sustainable intervention. A needs assessment with a Honduran-Canadian health organization reiterated evidence found in the literature, illustrating the …

Contraceptive Utilization Among New Exotic Dancers: A Cross-Sectional Study, Mishka Terplan, Caitlin E. Martin, Jennifer Nail, Susan G. Sherman

Obstetrics and Gynecology Publications

Background
Female exotic dancers are a population at high risk of unintended pregnancy. The objective of this study is to describe the reproductive health needs and contraceptive utilization of exotic dancers.

Methods
New exotic dancers (< 6 months dancing) from 26 clubs in Baltimore City/County completed a one-time survey.

Results
Of 117 participants, 96 (82%) had current contraceptive need. The mean age was 24 years, and 55% were black. Sex work (45%), alcohol use disorder (73%), illicit (44%; e.g., heroin, crack, cocaine), and injection drug use (8%) were common. The majority (66%) reported contraception use in the prior 6 months. Condoms were reported by 46% whereas 45% reported non-barrier methods, most commonly hormonal …

Benchmark Evaluation Of True Single Molecular Sequencing To Determine Cystic Fibrosis Airway Microbiome Diversity, Andrea Hahn, Matthew L. Bendall, Keylie M. Gibson, Hollis Chaney, Iman Sami, Geovanny F. Perez, Anastassios C. Koumbourlis, Timothy A. Mccaffrey, Robert J. Freishtat, Keith A Crandall

Computational Biology Institute

Cystic fibrosis (CF) is an autosomal recessive disease associated with recurrent lung infections that can lead to morbidity and mortality. The impact of antibiotics for treatment of acute pulmonary exacerbations on the CF airway microbiome remains unclear with prior studies giving conflicting results and being limited by their use of 16S ribosomal RNA sequencing. Our primary objective was to validate the use of true single molecular sequencing (tSMS) and PathoScope in the analysis of the CF airway microbiome. Three control samples were created with differing amounts of Burkholderia cepacia, Pseudomonas aeruginosa, and Prevotella melaninogenica, three common bacteria found in cystic …

Synthesis Of Multivalent Glyco-Magnetic Nanoparticles For Rapid Point-Of-Care Diagnostic System, Surangi Jayawardena

Summer Community of Scholars (RCEU and HCR) Project Proposals

No abstract provided.

Quantification Of The Limit Of Detection Of Pathogenic Bacteria Using A Glyconanomaterial Based Rapid Point-Of-Care Diagnostic System, Surangi Jayawardena

Summer Community of Scholars (RCEU and HCR) Project Proposals

No abstract provided.

Functionalized Nanomaterial As A Tool For Rapid Point-Of-Care Diagnostics, Surangi Jayawardena

Summer Community of Scholars (RCEU and HCR) Project Proposals

No abstract provided.

Assessment And Optimization Of Respiratory Syncytial Virus Prophylaxis Regimens In Connecticut, 1995-2013, Ben Artin

Yale School of Medicine Physician Associate Program Theses

BACKGROUND - Respiratory syncytial virus (RSV) causes seasonal respiratory infection with potentially serious complications in children, and leads to hospitalization rates as high as 50% in high-risk infants. Safe and effective immunoprophylaxis (palivizumab) is available, but costly. The American Academy of Pediatrics (AAP) recommends palivizumab only for infants at high risk of complications, and only during the RSV season. Although the current AAP guidelines acknowledge the existence of spatial and temporal variation in RSV incidence, they do not recommend spatial or temporal adjustments to immunoprophylaxis regimen outside of Florida. In this study, we investigate the value of using spatial and …

Power Calculation For Cross-Sectional Stepped Wedge Cluster-Randomized Trials With Variable Cluster Sizes, Linda J. Harrison, Tom Chen, Rui Wang

Harvard University Biostatistics Working Paper Series

Standard sample size calculation formulas for Stepped Wedge Cluster Randomized Trials (SW-CRTs) assume that cluster sizes are equal. When cluster sizes vary substantially, ignoring this variation may lead to an under-powered study. We investigate the relative efficiency of a SW-CRT with varying cluster sizes to equal cluster sizes, and derive variance estimators for the intervention effect that account for this variation under the assumption of a mixed effects model; a commonly-used approach for analyzing data from cluster randomized trials. When cluster sizes vary, the power of a SW-CRT depends on the order in which clusters receive the intervention, which is …

Adult Onset Immunoglobulin A Vasculitis (Henoch-Schonlein Purpura) With Alveolar Hemorrhage, N. Niknam, L. Ha, P. Gautam-Goyal

Journal Articles

© 2018 The Authors S. pyogenes is the cause of many important human diseases, ranging from mild superficial skin infections to life-threatening systemic diseases. The post streptococcal syndromes are immune mediated phenomena including Immunoglobulin A Vasculitis (Henoch-Schönlein purpura). HSP is more common in children and usually self limited but it can cause skin, joint, renal, gastrointestinal and rarely respiratory involvement. We present a case with Streptococcus pyogenes pneumonia that presented with respiratory failure, pulmonary hemorrhage, extensive rash and renal failure.

Exome Chip Analyses Identify Genes Affecting Mortality After Hla-Matched Unrelated-Donor Blood And Marrow Transplantation, Q. Zhu, L. Yan, Q. Liu, C. Zhang, L. Wei, Q. Hu, L. Preus, A. I. Clay-Gilmour, K. Onel, L. E. Sucheston-Campbell, +10 Additional Authors

Journal Articles

© 2018 by The American Society of Hematology Although survival outcomes have significantly improved, up to 40% of patients die within 1 year of HLA-matched unrelated-donor blood and marrow transplantation (BMT). To identify non-HLA genetic contributors to mortality after BMT, we performed the first exome-wide association study in the DISCOVeRY-BMT cohorts using the Illumina HumanExome BeadChip. This study includes 2473 patients with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome and 2221 10/10 HLA-matched donors treated from 2000 to 2011. Single-variant and gene-level analyses were performed on overall survival (OS), transplantation-related mortality (TRM), and disease-related mortality (DRM). Genotype mismatches …

Microbiota-Sensitive Epigenetic Signature Predicts Inflammation In Crohn's Disease., D. Kelly, M. Kotliar, V. Woo, S. Jagannathan, J. Whitt, J. Moncivaiz, B. J. Aronow, M. C. Dubinsky, J. F. Markowitz, T. Alenghat, +12 Additional Authors

Journal Articles

Altered response to the intestinal microbiota strongly associates with inflammatory bowel disease (IBD); however, how commensal microbial cues are integrated by the host during the pathogenesis of IBD is not understood. Epigenetics represents a potential mechanism that could enable intestinal microbes to modulate transcriptional output during the development of IBD. Here, we reveal a histone methylation signature of intestinal epithelial cells isolated from the terminal ilea of newly diagnosed pediatric IBD patients. Genes characterized by significant alterations in histone H3-lysine 4 trimethylation (H3K4me3) showed differential enrichment in pathways involving immunoregulation, cell survival and signaling, and metabolism. Interestingly, a large subset …

Implementation Of An Emergency Medicine Research Associates Program: Sharing 20 Years Of Experience, B. Abar, V. Derienzo, J. Glick, N. Wood, M. N. Shah, S. Schneider, D. Adler

Journal Articles

© 2018 Abar et al. Introduction: The use of research associates (RA) programs to facilitate study enrollment in the emergency department was initiated during the mid-1990s. The University of Rochester Medical Center (URMC) was an early adopting site for this model, which has experienced considerable growth and development over the past 20 years. Methods: Our goal was to detail the Emergency Department Research Associates (EDRA) program processes developed at the URMC that has led to our program’s sustainability and productivity. These processes, and the lessons learned during their development, can assist institutions seeking to establish an RA program or refine …

Automated Real-Time Collection Of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology, L. Meyers, C. C. Ginocchio, A. N. Faucett, F. S. Nolte, P. H. Gesteland, A. Leber, D. Janowiak, V. Donovan, S. Juretschko, M. A. Poritz, +23 Additional Authors

Journal Articles

© Lindsay Meyers, Christine C Ginocchio, Aimie N Faucett, Frederick S Nolte, Per H Gesteland, Amy Leber, Diane Janowiak,. Background: Health care and public health professionals rely on accurate, real-time monitoring of infectious diseases for outbreak preparedness and response. Early detection of outbreaks is improved by systems that are comprehensive and specific with respect to the pathogen but are rapid in reporting the data. It has proven difficult to implement these requirements on a large scale while maintaining patient privacy. Objective: The aim of this study was to demonstrate the automated export, aggregation, and analysis of infectious disease diagnostic test …

Strongyloides Stercoralis−Associated Tip Variant Focal Segmental Glomerulosclerosis, M. Merzkani, N. N. Uppal, D. W. Ross, P. Gautam-Goyal, P. Malhotra, H. H. Shah, K. D. Jhaveri, V. D. D'Agati

Journal Articles

No abstract provided.