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Week Of January 16, 2018, New York Medical College

InTouch

• BioInc@NYMC Names New Director
• Bridge Funding Grants Are Announced
• La Casita de la Salud Continues to Bridge the Gap in Health Disparities
• First Patient Arrives at Touro Dental Health

Netprophet 2.0: Mapping Transcription Factor Networks By Exploiting Scalable Data Resources, Yiming Kang, Hien-Haw Liow, Ezekiel J Maier, Michael R Brent

2010-2019 OA Pubs

MOTIVATION: Cells process information, in part, through transcription factor (TF) networks, which control the rates at which individual genes produce their products. A TF network map is a graph that indicates which TFs bind and directly regulate each gene. Previous work has described network mapping algorithms that rely exclusively on gene expression data and 'integrative' algorithms that exploit a wide range of data sources including chromatin immunoprecipitation sequencing (ChIP-seq) of many TFs, genome-wide chromatin marks, and binding specificities for many TFs determined in vitro. However, such resources are available only for a few major model systems and cannot be easily …

Factors Associated With Perceived Accuracy Of The Undetectable = Untransmittable Slogan Among Men Who Have Sex With Men: Implications For Messaging Scale-Up And Implementation, H Jonathon Rendina, J T. Parsons

Publications and Research

Introduction: Recent research has shown high efficacy of HIV treatment for reducing the risk of HIV transmission to sexual partners. As the efficacy of treatment as prevention (TasP) has proliferated, a new messaging campaign, Undetectable = Untransmittable, has been gaining popularity. The purpose of this paper was to assess factors associated with the perceived accuracy of this TasP messaging strategy among a large and diverse sample of gay, bisexual, and other men who have sex with men (GBMSM) in order to inform subsequent efforts at large-scale and implementation of the HIV prevention message.

Methods: We conducted a nationwide survey of …

Vaccine Licensure In The Public Interest: Lessons From The Development Of The U.S. Army Zika Vaccine, Ana Santos Rutschman

All Faculty Scholarship

Vaccines developed by the public sector are key to preventing future outbreaks of infectious diseases. However, the licensure of these vaccines to private-sector companies under terms that do not ensure both their availability and affordability compromises their development. This Essay analyzes the recent attempted licensing deal for a Zika vaccine between the U.S. Army and Sanofi, a French pharmaceutical company. The proposed grant of an exclusive license to Sanofi triggered widespread concern because none of its substantive terms were disclosed. While § 209 of the Patent Act imposes limitations on exclusive licensure, the Army released no information supporting its finding …

Landscape Genomics: Natural Selection Drives The Evolution Of Mitogenome In Penguins, Barbara Ramos, Daniel González-Acuña, David Loyola, Warren Johnson, Patricia Parker, Melanie Massaro, Gisele Dantas, Marcelo Miranda, Juliana Vianna

Biology Department Faculty Works

BackgroundMitochondria play a key role in the balance of energy and heat production, and therefore the mitochondrial genome is under natural selection by environmental temperature and food availability, since starvation can generate more efficient coupling of energy production. However, selection over mitochondrial DNA (mtDNA) genes has usually been evaluated at the population level. We sequenced by NGS 12 mitogenomes and with four published genomes, assessed genetic variation in ten penguin species distributed from the equator to Antarctica. Signatures of selection of 13 mitochondrial protein-coding genes were evaluated by comparing among species within and among genera (Spheniscus, Pygoscelis, Eudyptula, Eudyptes and …

Novel Role Of Histone Deacetylase 11 (Hdac11) In Regulating Normal And Malignant Hematopoiesis, Jie Chen

USF Tampa Graduate Theses and Dissertations

During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual hematopoietic lineages. In normal myelopoiesis, the immature myeloid cells (IMCs) differentiate into macrophages, neutrophils or dendritic cells. However, under tumor burden, these IMCs differentiate into myeloid derived suppressor cells (MDSCs) result in an up-regulation of immune suppressive factors and pro-tumor effect. The development of normal or malignant is tightly controlled by endogenous signals such as transcription factors and epigenetic regulations. HDAC11 is the newest identified members of the histone deacetylase (HDAC) family. Previous study in our group had identified HDAC11 as a negative regulator of interleukin 10 (IL-10) …

Rapid Increase In Seasonal Flu Cases Taxes Area Hospitals, Tyler Greer

Browse All News

No abstract provided.

Assessing The Links Among Environmental Contaminants, Endocrinology, And Parasites To Understand Amphibian Declines In Montane Regions Of Costa Rica, Christopher Leary, Hannah Ralicki, David Laurencio, Sarah Crocker‐Buta, John H. Malone

Faculty and Student Publications (Open Access)

No abstract provided.

State Of Tennessee Advisory Council On Workers' Compensation, 2017 Summary Of Significant Tennessee Supreme Court Workers' Compensation Decisions, Tennessee. Department Of Treasury.

Worker's Compensation Reports

No abstract provided.

Strains Of Bacterial Species Induce A Greatly Varied Acute Adaptive Immune Response: The Contribution Of The Accessory Genome, Uri Sela, Chad W. Euler, Joel Correa Da Rosa, Vincent A. Fischetti

Publications and Research

A fundamental question in human susceptibility to bacterial infections is to what extent variability is a function of differences in the pathogen species or in individual humans. To focus on the pathogen species, we compared in the same individual the human adaptive T and B cell immune response to multiple strains of two major human pathogens, Staphylococcus aureus and Streptococcus pyogenes. We found wide variability in the acute adaptive immune response induced by various strains of a species, with a unique combination of activation within the two arms of the adaptive response. Further, this was also accompanied by a dramatic …

Independent Association Of Resting Energy Expenditure With Blood Pressure: Confirmation In Populations Of The African Diaspora, Chloe Creber, Richard S. Cooper, Jacob Plange-Rhule, Pascal Bovet, Estelle V. Lambert, Terrence E. Forrester, Dale Schoeller, Walter Riesen, Wolfgang Korte, Guichan Cao, Amy Luke, Lara R. Dugas

Faculty Publications

Background: Obesity is a major risk factor for hypertension, however, the physiologic mechanisms linking increased adiposity to elevations in blood pressure are not well described. An increase in resting energy expenditure (REE) is an obligatory consequence of obesity. Previous survey research has demonstrated that REE is an independent predictor of blood pressure, and eliminates the co-linear association of body mass index. This observation has received little attention and there have been no attempts to provide a causal explanation. Methods: At baseline in an international comparative study on obesity, 289 participants aged 25-44 were recruited from communities in the US, the …

Volume 55, Number 21: January 10, 2018, University Of North Dakota

University Letter Archive

No abstract provided.

Positioning Animal Welfare In The One Health Concept Through Evaluation Of An Animal Welfare Center In Skopje, Macedonia, Miroslav Radeski

Department of Biological Sciences Publications

The Animal Welfare Center (AWC) in Macedonia was established in 2009. The objectives of the center are animal welfare (AW) education, research, raising public awareness of AW, and increasing cooperation between the stakeholders. One Health (OH) was not the major focus of the AWC work initially, but, rather, a focus that evolved recently. The objective of this study was to evaluate the AWC from the OH perspective as an example case for positioning the AW within the overall OH concept. Three types of evaluation were performed: (1) assessment of OH-ness, by quantitative measurement of the operational and infrastructural aspects of …

Production Of Genetically Engineered Golden Syrian Hamsters By Pronuclear Injection Of The Crispr/Cas9 Complex, Rong Li, Jinxin Miao, Seokhwan Song, Il-Keun Kong, Yaohe Wang, Zhongde Wang

Animal, Dairy, and Veterinary Science Faculty Publications

The pronuclear (PN) injection technique was first established in mice to introduce foreign genetic materials into the pronuclei of one-cell stage embryos. The introduced genetic material may integrate into the embryonic genome and generate transgenic animals with foreign genetic information following transfer of the injected embryos to foster mothers. Following the success in mice, PN injection has been applied successfully in many other animal species. Recently, PN injection has been successfully employed to introduce reagents with gene-modifying activities, such as the CRISPR/Cas9 system, to achieve site-specific genetic modifications in several laboratory and farm animal species. In addition to mastering the …

Model Prediksi Pengendalian Komplikasi Penyakit Penyerta Pada Pengguna Narkotika Di Palembang, Rico Januar Sitorus, Feranita Utama, Imelda G. Purba, Bina Melvina

Media Kesehatan Masyarakat Indonesia

Penyalahgunaan narkotika dapat mengakibatkan komplikasi fisik, psikologis dan beban ekonomi keluarga. Semakin lama menggunakan narkotika dan tidak menjalani rehabilitasi akan membuat kecanduan yang berat. Pengguna narkotika dengan adiksi berat akan berdampak juga terhadap beratnya penyakit yang dialami dan lamanya menjalani rehabilitasi. Beban penyakit yang diakibatkan ketergantungan narkotika akan berdampak terhadap kondisi sosial ekonomi sendiri dan keluarga. Penelitian ini bertujuan untuk menghasilkan suatu model prediksi terhadap pengendalian komplikasi penyakit penyerta pengguna narkotika. Desain penelitian ini adalah cross sectional study dengan populasi penelitian adalah semua pengguna narkotika baik pengguna narkotika suntik dan narkotika bukan suntik. Sampel dalam penelitian ini adalah pecandu narkotika …

"Lessons From The Other America" Turning A Public Health Lens On Fighting Racismand Poverty, Dayna Bowen Matthew

University of Memphis Law Review

No abstract provided.

Label-Free Sensors Based On Graphene Field-Effect Transistors For The Detection Of Human Chorionic Gonadotropin Cancer Risk Biomarker, Shakil A. Awan

School of Engineering, Computing and Mathematics

No abstract provided.

Medical School Watercooler Newsletter - January 7, 2018, Lindsey Lyle

Watercooler Newsletter

This is the January 7, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Researchers Develop Experimental Model to Further Understand Antibiotic-Resistant Bacteria
• Art Gallery on Display in Mast in Building
• Pediatrics Hosting Grand Rounds Jan. 19

Nextgen Voices: Research Resolutions, Felicia Olmeta-Schult, Lauren Massa Segal, Sam Tyner, Twila Alexandra Moon, Ryan Dz Wei Chow, Prosanta Chakrabarty, Martin Pacesa, Anna Igorevna Podgornaia, Jennifer Chen, Bipin Singh, Bo Cao, Rishi Raj Singh Sidhu, Bryce W.Q. Tan, Prashant Sood, Stuart Parker, Matthew A. Scult, Desiree Van Haute, Nikos Konstantinides, Beat A. Schwendimann, Sudhakar Srivastava, Raffaele Fiorenza, Ken Dutton-Regester, Rachel Hale, Emre Ozan Polat, Edward Lau, Audrey L. Mayer, Easton R. White

Faculty Publications

No abstract provided.

The Microbe Directory: An Annotated, Searchable Inventory Of Microbes’ Characteristics, Heba Shaaban, David A. Westfall, Rawhi Mohammad, David Danko, Daniela Bezdan, Ebrahim Afshinnekoo, Nicola Segata, Christopher E. Mason

Publications and Research

The Microbe Directory is a collective research effort to profile and annotate more than 7,500 unique microbial species from the MetaPhlAn2 database that includes bacteria, archaea, viruses, fungi, and protozoa. By collecting and summarizing data on various microbes’ characteristics, the project comprises a database that can be used downstream of large-scale metagenomic taxonomic analyses, allowing one to interpret and explore their taxonomic classifications to have a deeper understanding of the microbial ecosystem they are studying. Such characteristics include, but are not limited to: optimal pH, optimal temperature, Gram stain, biofilm-formation, spore-formation, antimicrobial resistance, and COGEM class risk rating. The database …

2018-January-04-Graduate Research Award, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Exosomes Serve As Novel Modes Of Tick-Borne Flavivirus Transmission From Arthropod To Human Cells And Facilitates Dissemination Of Viral Rna And Proteins To The Vertebrate Neuronal Cells, Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B. Sherman, Kyung H. Choi, Girish Neelakanta, Hameeda Sultana

Faculty Publications

Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Our study shows that tick-borne Langat virus (LGTV), a model pathogen closely related to tick-borne encephalitis virus (TBEV), profusely uses arthropod exosomes for transmission of viral RNA and proteins to the human- skin keratinocytes and blood endothelial cells. Cryo-electron microscopy showed the presence of purified arthropod/neuronal exosomes …

Sooty Mangabey Genome Sequence Provides Insight Into Aids Resistance In A Natural Siv Host, David Palesch, Steven E. Bosinger, Gregory K. Tharp, Thomas H. Vanderford, Mirko Paiardini, Ann Chahroudi, Zachary P. Johnson, Frank Kirchhoff, Beatrice H. Hahn, Robert B. Norgren, Nirav B. Patel, Donald L. Sodora, Reem A. Dawoud, Caro-Beth Stewart, Sara M. Seepo, R. Alan Harris, Yue Liu, Muthuswamy Raveendran, Yi Han, Adam English, Gregg W.C. Thomas, Matthew W. Hahn, Lenore Pipes, Christopher E. Mason, Donna M. Muzny, Richard A. Gibbs, Daniel Sauter, Kim Worley, Jeffrey Rogers, Guido Silvestri

Journal Articles: Genetics, Cell Biology & Anatomy

In contrast to infections with human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys (Cercocebus atys), is non-pathogenic despite high viraemia. Here we sequenced and assembled the genome of a captive sooty mangabey. We conducted genome-wide comparative analyses of transcript assemblies from C. atys and AIDS-susceptible species, such as humans and macaques, to identify candidates for host genetic factors that influence susceptibility. We identified several immune-related genes in the genome of C. atys that show substantial sequence divergence from macaques or humans. One of these sequence divergences, a …

Using Photovoice As A Tool For Community Engagement To Assess The Environment And Explore Environmental Health Disparities, Heather M. Brandt, Venice E. Haynes, Lashanta J. Rice, Dayna Campbell, Edith Williams, *Sacoby Wilson, Saundra H. Glover

Journal of Health Disparities Research and Practice

Photovoice was used as a participatory research method to document perceived local environmental hazards, pollution sources, and potential impact on health among community members to address environmental health disparities. A convenience sample of 16 adults in Orangeburg, South Carolina participated in Photovoice. Photos depicted positive and negative implications of the environment across seven themes: recreation and leisure; food access; hazards and pollution; health, human, and social services; economic issues; beautification; and accommodation and accessibility. Positive and negative photos demonstrated a high level of interest among community members in considering how the environment influences health and health disparities.

Impact Of Environmental Pollutions And Waste Management, A. Kaveri, S. Dhanasekaran Ph.D.

International Review of Business and Economics

This paper will discuss the problem of environmental pollution and waste management. Everything that surrounds us is directly or indirectly connected to the environment. Not only the man, but also other living beings as well as the nature (volcanic eruptions, earthquakes) have effects on environmental pollution. Environmental pollution is present from the very beginning of life, but today it is a serious problem that threatens the survival of mankind. During the preparation of scientific research, we noticed a problem: “What is the influence of the waste management on the environment?” Today, every person living on planet Earth is worried about …

Environmental Hazards And Its Impact On Human Health, G. Geetha Ph.D., S. Dhanasekaran Ph.D.

International Review of Business and Economics

This paper provides the insight view about the environmental hazards and its impact on human health. Environmental hazards means every type of disorder that occur in the environment .Hazards can present themselves to us in various media e.g. air, water. The influence they can exert on our health is very complex and may be modulated by our genetic makeup, psychological factors and by our perceptions of the risks that they present. Every year thousands of deaths are reported because of environmental hazards. Environmental hazards can affect a particular organ or body system, directly damaging it or leading to further complications. …

Impact Of Water Pollution In Tamil Nadu, J. Jacob Stanley Inbaraj Ph.D., A. Kannappan

International Review of Business and Economics

Water resource is one of the important natural resources it essential for the survival of living organisms. The adequate safe water is essential to human lives and it is required in day to day life. Water pollution may take place due to natural causes such as silt carried by run-off, organic wastes of plants and animals, minerals leaching through soils, thermal pollution and algal blooms. In most of the developing countries are being polluted beyond their capacity because of high population growth. Increasing the urbanization and industrialization has reason for create a very large point of water pollution. Agro – …

Biology In Your World Antibiotics Modern Medicine, Feb 24, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Career Week | Environmental Plant Biology Alumni Panel, Feb 1, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Climate And Environmental Changes: Restrospect And Prospect, Pradeep Prajapati

International Review of Business and Economics

Discussion on problems of climate and environmental changes i.e. global warming has inundated in recent years. Every major newspaper publishes multiple editorials or op- ed pieces on the topic, the broadcast media and researchers regularly discuss the issue, and thousands of Web pages and blogs provide definitions and information and suggest causes and consequences of action and inaction. Under the situation why are we adding to congestion on the subject? Because the analysis of past has much to contribute, especially in understanding prospects of adapting to climate change, which has received relatively little study and comment relative to the standing …