Digital Commons Network^™

Ethical Implications Of Treatment For Gender Dysphoria In Youth, Kelsey Hayes

Journal of Health Ethics

This manuscript explores ethical implications on treatment for youth with diagnosed gender dysphoria. The ethical considerations outlined and analyzed in this essay involve illuminating an understanding of whether the administration of pubertal suppression with GnRH agonists, and cross-sex hormones to children with gender dysphoria is morally justified as treatment to manage their psychological distress, or if safer more understood alternatives exist. This essay emphasizes that as health care professionals we must ensure youth with gender dysphoria receive adequate medical treatment and care however, this essay concludes through extensive literature review, that the use of inconclusive and under researched methods to …

Archarios, 2018 Fall / 2019 Spring, Office Of Student Life

Archarios Literary Art Magazine

Archarios 27. Editor: Rob Sperduto. Faculty Advisor: Jeff Case. Cited as 27th edition. Printed by Sheriar Press.

Temperature Forecasting: A Comparison Between Parametric And Non-Parametric Models, Alaa Sheta, Ajay Katangur, Abdelkarim Baareh

Applied Mathematics & Information Sciences

The development of accurate temperature prediction models is essential for not only human life but also for agricultural, animal life, tourism, and many others. Power consumption and achieving energy efficiency in buildings also depends on temperature. Although modeling-based regression is one of the most popular approaches, it still suffers from many difficulties related to the number of available measurements, the order of the model and the non-linearity of the data. In this paper, we provide a comparison between parametric and non-parametric models for temperature forecasting. We propose three-model structures to estimate the temperature in Mumbai, the business capital of India. …

Optimal Control And Cost-Effectiveness Analysis For Dysentery Epidemic Model, Hailay Weldegiorgis Berhe, Oluwole Daniel Makinde, David Mwangi Theuri

Applied Mathematics & Information Sciences

In this paper, optimal control theory is applied to a system of ordinary differential equations representing a dysentery diarrhea epidemic. Optimal control strategies are proposed to reduce the number of infected humans and the cost of interventions. The Pontryagin’s maximum principle is employed to find the necessary conditions for the existence of the optimal controls. Runge- Kutta forward-backward sweep numerical approximation method is used to solve the optimal control system. The incremental costeffectiveness analysis technique is used to determine the most cost-effective strategy.We observe that the control measure implementing sanitation and education campaign is the most efficient and cost-effective.

Graphene Quantum Dots Potently Block Copper-Mediated Oxidative Dna Damage: Implications For Cancer Intervention, Rachel E. Li, Y R. Li, Hong Zhu, Zhenquan Jia

Osteopathic Medicine, Jerry M. Wallace School of

Our early work suggested that graphene quantum dots (GQDs) block Cu(II)/Cu(I) redox cycle in biological systems. Here we report that GQDs could also potently protect against copper redox-mediated oxidative DNA damage. Using Cu(II)/hydrogen peroxide, Cu(II)/hydroquinone, and Cu(II)/ascorbic acid as three biologically relevant systems for inducing oxidative DNA damage, we demonstrated that GQDs protected against the above system-induced DNA strand breaks in ϕx-174 plasmid DNA in a concentration-dependent manner. Notably, a significant protection was observed with GQDs at 1 μg/ml, and a nearly complete protection was shown with 10 and 100 μg/ml of GQDs. Using electron paramagnetic resonance (EPR) spectrometry in …

Preliminary Results From A First-In-Human Phase 1 Study Of The Cd40 Agonist Monoclonal Antibody (Mab) Cdx-1140, Rachel Sanborn, Michael S. Gordon, Mark O'Hara, Nina Bhardwaj, Yi He, Tracey Rawls, Tibor Keler, Michael Yellin

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Agonist CD40 mAbs can mediate antitumor immunity through multiple mechanisms, including enhancing tumor antigen presentation, activation of tumoricidal macrophages, and direct growth inhibition/killing of CD40- expressing tumor cells. To fully exploit these mechanisms may require the mAb to be dosed at levels that provide significant tumor and tissue penetration, without dose-limiting-toxicities (DLT) from systemic CD40 activation. Our agonist CD40 mAb, CDX-1140, was selected based on its unique and linear dose-dependent in vitro and in vivo activity and is postulated will achieve maximum agonist activity at dose levels associated with good systemic exposure. CDX-1140 is a fully human IgG2 agonist …

Nktr-214 (Cd122-Biased Agonist) And Nktr-262 (Tlr7/8 Agonist) Combination Treatment Pairs Local Innate Immune Activation With Systemic Cd8+ T Cell Expansion To Enhance Anti-Tumor Immunity, Annah S. Rolig, Daniel Rose, Saul Kivimäe, Deborah Charych, Werner Rubas, Jonathan Zalevsky, William L. Redmond

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Radiation therapy (RT) remains the standard of care for many human cancers. Combining NKTR-214, a CD122-biased cytokine agonist conjugated with releasable polyethylene-glycol (PEG) chains, with local RT significantly enhanced therapeutic efficacy in preclinical models. Mechanistically, NKTR-214 provides sustained signaling through the IL-2 receptor pathway (IL-2Rβγ) to preferentially activate and expand effector CD8+ T and NK cells and RT modulates the tumor microenvironment (TME) to induce antigen-release. Together, NKTR-214/RT treatment resulted in improved therapeutic responses compared to either treatment alone. However, abscopal responses in murine tumors were modest, leading us to explore alternative approaches with the potential to elicit more …

Combined Anti-Pd-1 And Anti-Lag-3 Checkpoint Blockade Enhances Cd8+ Til Effector Function While Reducing Tregs Leading To Reduced Immune Suppression And Improved Overall Survival, Elizabeth Sturgill, Courtney Mick, David Jenkins, Johanna Kaufmann, William L. Redmond

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Checkpoint inhibition is a potent strategy to reinvigorate T cells. However, aCTLA-4 or aPD-1 monotherapy has not been effective for the majority of patients, resulting in the exploration of combinatorial approaches to improve treatment efficacy. One such target is LAG-3, which is upregulated on T cells that have experienced repeated antigen exposure, such as in the tumor microenvironment (TME), and is associated with reduced T cell effector function. In addition, high LAG-3 expression on regulatory T cells (Tregs) has been reported for patients with varying cancer types, providing an additional rationale for targeting LAG-3 with the aim of reducing …

Vocational And Life Skills Monthly Data Update: November 2018, Uno Nebraska Center For Justice Research, Katelynn Towne, Michael Campagna

Reports

Grantees use an online data management system to submit data on participants served under their Vocational and Life Skills programming. This data is due monthly and reflects all services provided during the previous month to participants. Evaluators at the Nebraska Center for Justice Research work with grantees directly to manage data entry errors on an ongoing basis during monthly update calls and regular site visits.

The current data derives from an active database, with live data being entered and updated daily. Data values, including previously submitted information, may fluctuate depending on changes made from data entry oversight. One common example …

Beyond Section 230: Liability, Free Speech, And Ethics On Global Social Networks, Brett G. Johnson

The Business, Entrepreneurship & Tax Law Review

No abstract provided.

A Slanted View On The Morality Bars: Matal V. Tam, In Re Brunetti, And The Future Of Section 2(A) Of The Lanham Act, John Langworthy

The Business, Entrepreneurship & Tax Law Review

Section 2(a) of the Lanham Act contained two “morality bars” to the registration of trademarks: the Disparagement Clause and the Immoral and Scandalous Clause. Two recent cases, the Supreme Court decision in Matal v. Tam and the subsequent decision from the Federal Circuit, In re Brunetti, both held that the morality bars violate the First Amendment. Given the inconsistent application of the Disparagement Clause and the potential for viewpoint discrimination, theTam Court was correct in finding it unconstitutional. For similar reasons, the court in Brunetti properly extended this holding to the Immoral and Scandalous Clause. However, both decisions ignored the …

Lost In Translation: Persons With Limited English Proficiency And Police Interaction In The United States, Anastasia Coppersmith

Northern Illinois Law Review Supplement

This article explores United States jurisprudence of the constitutionality of language rights as it correlates to communications between law enforcement officials and non-English speaking persons in emergency situations. The judicial and legislative bodies provide protections to limited English speaking minorities in the realms of education, healthcare, and when navigating through the United States court system. However, these protections are not extended to include interactions between language-minority citizens and initial police interactions during emergency situations.

Nasp Report Of Graduate Education In School Psychology: 2016–2017, Daniel L. Gadke, Sarah Valley-Gray, Eric Rossen

Faculty Articles

Each year the Graduate Education Committee of the National Association of School Psychologists (NASP) administers the National School Psychology Program Database Survey. Data regarding the status of graduate education in school psychology have been collected annually for both specialist and doctoral programs since 2010. This report for the 2016–2017 academic year summarizes data collected from the directors of all known school psychology programs and provides estimates regarding selected outcomes for those programs. During the 2016–2017 academic year, an estimated 10,209 students (including interns) were enrolled in school psychology programs. Further, an estimated 3,118 first-year students were enrolled, and an estimated …

Minimizing And Addressing Microaggressions In The Workplace: Be Proactive, Part Two, Shamika Dalton

Scholarly Works

No abstract provided.

Development Of A Postburn Pruritus Relief Protocol, Phoebe (Yeon) S. Kim

Nursing Faculty Publications

Background Postburn pruritus is a syndrome of stressful symptoms that is pervasive and occurs in over 90% of burn patients and continues for years after the burn has healed. Postburn pruritus is experienced by burn survivors that may require medical management and effective interventions.

Purpose This article shows how to effectively relieve postburn pruritus by developing a postburn pruritus relief protocol.

Design A descriptive literature review was conducted, and relevant empirical articles written during the years 2000–2014 were appraised to create a postburn pruritus relief protocol. Twenty-six of 79 articles were selected using preestablished inclusion criteria: any age group experiencing …

When Failure Is Not An Option, Lindsey Ago, Caitlin Digirolamo, Dylan Gagner

Dental Hygiene Student Research Posters

This research poster addresses the question, “What treatment modalities are most effective at treating peri-implantitis (PI)?” Dental implants are one of the most innovative ways to support dental prosthetics. They can support heavy physical loads. However, infection causes inflammation and bone loss around implants. Studies indicate that there are many factors that can increase the risk for PI. These factors include: Smoking; pre-existing periodontal disease; oral hygiene, quality of prosthetic reconstruction; some systemic conditions and medications.

There are a significant amount of treatment options for PI that range from surgical, nonsurgical, antibiotics, and even lasers. While reviewing studies related to …

Breastfeeding: The Best Formula For The Oral Microbiome, Eliza Lopes, Alexandra Cabana

Dental Hygiene Student Research Posters

This research poster addresses the question “What differences are seen between formula and breastfed babies in the development of the oral microbiome?” The bacteria that make up the oral microbiome begins accumulating from birth through interactions with the environment and caregivers. When it comes to the oral cavity, bacteria such a Streptococcus mutans and Lactobacilli, can be transferred through saliva or feeding. Breastfeeding provides important nutritional and immunological benefits to the development of infants but it also plays a vital role in the development of the oral microbiome that may be superior to that of formula-feeding. Studies show that the …

Faculty Senate Meeting Minutes – November 2018, Faculty Senators

Minutes 2018-2019

This is the archived record of the November 14, 2018 faculty senate meeting minutes. Contact the Faculty Senate president or JagWorks Repository Coordinator to request access to this document.

Education Systems In Juvenile Detention Centers, Karen Sullivan

Brigham Young University Education and Law Journal

No abstract provided.

Family Members Of Will Marion Cook: Biographical Materials For Immediate Family Members, Peter M. Lefferts

Glenn Korff School of Music: Faculty Publications

This document is a supplement to "Chronology and Itinerary of the Career of Will Marion Cook," a 2017 document which is mounted on-line at http://digitalcommons.unl.edu/musicfacpub/66/. It presupposes some familiarity with the "Chronology and Itinerary," and puts into some kind of order a number of additional research notes, principally drawing upon newspaper and genealogy databases, that amplify the earlier work in certain respects regarding the public lives of his immediate family members. This is not a finished, polished effort; it represents work in progress, complete with repetitions, missing data, and the occasional typographical error. I invite queries, amplifications, and corrections, …

Spartan Daily, November 1, 2018, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2018

Volume 151, Issue 32

Ada Code Of Ethics (November 2018), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.

Vol.46 N.15 November 1st 2018, Voice Media Ventures

Black Voice News

No abstract provided.

Women's Tennis Media Guide 2018-19, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

Characterization And Effect Of Metal Ions On The Formation Of The Thermus Thermophilus Sco Mixed Disulfide Intermediate, Liezelle C. Lopez, Nikita Mukhitov, Lindsey D. Handley, Cristina S. Hamme, Cristina R. Hofman, Lindsay Euers, Jennifer R. Mckinney, Amani D. Piers, Ellen Wadler, Laura M. Hunsicker-Wang

Chemistry Faculty Research

The Sco protein from Thermus thermophilus has previously been shown to perform a disulfide bond reduction in the Cu_A protein from T. thermophilus, which is a soluble protein engineered from subunit II of cytochrome ba ₃ oxidase that lacks the transmembrane helix. The native cysteines on TtSco and TtCu_A were mutated to serine residues to probe the reactivities of the individual cysteines. Conjugation of TNB to the remaining cysteine in TtCu_A and subsequent release upon incubation with the complementary TtSco protein demonstrated the formation of the mixed disulfide intermediate. The cysteine of …

Ethical Hot Potatoes: New Perspectives, Dr. Sheila Davis

Journal of Health Ethics

Editor's introduction to Volume 14, Issue 2 of the Online Journal of Health Ethics.

Obesity: The Elephant In The Room We Can No Longer Afford To Ignore, Joanie Sompayrac, Katharine Linehart Trundle

Journal of Health Ethics

Everyone pays the price for the obesity-related illnesses of our fellow citizens – through increased premiums on our group health insurance policies, through reduced productivity of our co-workers, through taxpayer support of hospitals that provide indigent care and through soaring Medicare costs, to name a few. The fact that our entire society often ends up paying many of the costs for the obesity-related illnesses of not only ourselves but also our family members, our friends, our co-workers and even strangers raises questions: Why doesn’t insurance pay to help overweight and obese people to make lifestyle changes that could save us …

Euthanasia, Assisted-Suicide, And Palliative Sedation: A Brief Clarification And Reinforcement Of The Moral Logic, Peter A. Depergola Ii

Journal of Health Ethics

A persistent misunderstanding of the moral distinctions between the practices of euthanasia, assisted suicide, and palliative sedation suggests a critical need to revisit the relationship each shares with licit medical practice in the context of palliative care. To that end, this essay grounds its arguments in two, straightforward premises: (i) the licitness of medical practice is largely determined by the balance between (a) good ends, (b) proportionate means, (c) appropriate circumstances, and (d) benevolent intentions; and (ii) whereas palliative sedation employs criteria A-D (above), both euthanasia and assisted suicide fail to secure criteria A-C. Drawing from this syllogism, the aim …

Nicotine Vaccines For Smoking Prevention And Treatment From Utilitarian And Deontological Ethical Perspectives, Enam A. Alsrayheen, Khaldoun Aldiabat

Journal of Health Ethics

Nicotine vaccines are a new prevention and treatment method for smoking addiction. They are promoted as a method to cease smoking among those who smoke and possibly prevent this behaviour from taking place among those who do not smoke. However, offering these vaccines to adults, adolescents, and children will undoubtedly raise an ethical debate among policy-makers, health professionals, and the public. This paper discusses the possibility of using nicotine vaccines treat and prevent smoking among adults/children/adolescents through the lenses of two ethical theories: utilitarianism and deontology (Kantianism). From an utilitarian perspective, nicotine vaccines are good for society because they provide …

Tremblings, November 2018, Western Aspen Alliance

Tremblings

Aspen seedlings follow Brian Head Fire

Karen Mock

Larissa Yocom

Over the past decade, views on the importance and frequency of aspen seeding events in the Intermountain West have begun to change. Once thought to be so rare as to be ecologically and operationally negligible, there is increasing evidence that aspen seedling establishment may actually be common under certain conditions. These conditions include seed production, soil moisture sufficient for germination and establishment, low herbivory pressure, and reduced competition for soil access, light, and water. Post-fire landscapes often provide just this “window of opportunity,” and in fact most observations of aspen …