Digital Commons Network^™

Technology And Grieving: A Relationship, James Nichols

Biology

No abstract provided.

Keynoter, November/December 2018, Boise State University Association Of Office Professionals

Boise State University Association of Office Professionals - Keynoter

President’s Message

AOP Purpose

Focus on Members

Holiday Auction Donations

Holiday Auction Registration

Budget/Website Reports

How Not to Plan...

Browser Tips & Tricks

Bosses Breakfast Recap

PSP Certification Infographic

Albertsons Library and AOP

IAEOP/NAEOP Date Info

IAEOP Annual Conference

NAEOP Conference Sampling

Membership and Events

Voting Information

Membership List

PSP Standards

Calendar of Events

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

My Total Health, Lehigh Valley Health Network

My Total Health

No abstract provided.

Is It Time To Drive A Stake Through Key Performance Indicators?, Singapore Management University

Perspectives@SMU

The metrics may be of little use and specific targets give rise to manipulation

Protecting Science At Federal Agencies: How Congress Can Help, Jacobs Institute Of Women’S Health, The George Washington University, Climate Science Legal Defense Fund, Democracy Forward, Environmental Integrity Project, Environmental Protection Network, Government Accountability Project, Greenpeace, National Federation Of Federal Employees, National Partnership For Women & Families, Power To Decide, Project On Government Oversight, Union Of Concerned Scientists

Jacobs Institute of Women's Health

No abstract provided.

Iba Newsletter [November 2018], Communications & Public Affairs Department

IBA News

No abstract provided.

The Impact Of Participation In Extracurricular Activities On Elementary School Students, Amy Meadows

Education Undergraduate Research

The purpose of this study was to investigate the relationship between participation in extracurricular activities and academic achievement. Surveys were administered to 23 4^th-8^th – grade students to gather information on their extracurricular participation, and data was collected on these students’ most recent standardized test scores and first-quarter grades. The quantitative data collected was then statistically analyzed using the SPSS program. The results of this analysis suggest a statistically significant positive correlation between hours spent participating in extracurricular activities and cumulative GPA. Students’ GPAs did not appear to be impacted by the total number nor types of …

Stem Cell Generated Β-Cells: A Possible Solution To The Growing Problem Of Type 1 Diabetes, Danielle Rae Steffen

Biology: Student Scholarship & Creative Works

Type 1 diabetes is a growing problem throughout the world. At this time, there is no functional cure, only various treatment options. However, in recent years there has been a significant increase in both the quantity and quality of research into potential cures for type 1 diabetes. This has led to a variety of new possibilities, the most promising of which are β-cells generated from the patient’s own stem cells.

The Pin-Up Boy Of The Symphony: St. Louis And The Rise Of Leonard Bernstein, Kenneth H. Winn

The Confluence (2009-2020)

Much has been written about Leonard Bernstein to commemorate the 100th anniversary of his birth. St. Louis and the St. Louis Symphony Orchestra played a key role in Bernstein’s early career—including performing the first work by Bernstein to be recorded.

Trunk Control And Gross Motor Outcomes After Body-Weight Supported Treadmill Training In Young Children With Severe Cerebral Palsy: A Case Series, Megan Flores, Carolyn Da Silva

Physical Therapy Collection

BACKGROUND AND PURPOSE: Children with cerebral palsy (CP) in Gross Motor Function Classification System (GMFCS) levels IV and V present with decreased gross motor function and trunk control that impacts their functional activities and participation in family activities. Research indicates body-weight supported treadmill training (BWSTT) may improve motor control for children with neuromotor disabilities. The toddler years present a window of opportunity for developmental changes. The purpose of this case series was to explore the impact of a 6-week BWSTT intervention on postural control and gross motor function in 3 young children with cerebral palsy in GMFCS levels IV and …

Caregiver Perspectives On Body-Weight Supported Treadmill Training As An Intervention For Young Children With Cerebral Palsy, Megan Flores, Carolyn Da Silva

Physical Therapy Collection

PURPOSE/HYPOTHESIS: Children with cerebral palsy (CP) in Gross Motor Function Classification System (GMFCS) levels IV and V present with challenges that impact their functional activities and participation in family activities. The purpose of this study was to examine caregivers’ perspectives on body-weight supported treadmill training (BWSTT) as an intervention for their young children with CP.

NUMBER OF SUBJECTS: Participants included 4 caregivers of children with CP in GMFCS levels IV (n = 2) and V (n = 2) who previously participated in 6 weeks of BWSTT.

MATERIALS/METHODS: Three children diagnosed with CP in GMFCS levels IV and V between the …

Mortality And Associated Morbidities Following Traumatic Brain Injury In Older Medicare Statin Users, Bilal Khokhar, Linda Simoni-Wastila, Julia F. Slejko, Eleanor Perfetto, Min Zhan, Gordon S. Smith

Clinical and Translational Science Institute

Objective: To assess the relationship between posttraumatic brain injury statin use and (1) mortality and (2) the incidence of associated morbidities, including stroke, depression, and Alzheimer’s disease and related dementias following injury. Setting and Participants: Nested cohort of all Medicare beneficiaries 65 years of age and older who survived a traumatic brain injury (TBI) hospitalization during 2006 through 2010. The final sample comprised 100 515 beneficiaries. Design: Retrospective cohort study of older Medicare beneficiaries. Relative risks (RR) and 95% confidence interval (CI) were obtained using discrete time analysis and generalized estimating equations. Measures: The exposure of interest included monthly atorvastatin, …

A Group Randomized Trial To Reduce Obesity Among Appalachian Church Members: The Walk By Faith Study, Electra D. Paskett, Ryan D. Baltic, Greg S. Young, Mira L. Katz, Samuel M. Lesko, Kelly H. Webber, Karen A. Roberto, Eugene J. Lengerich, Nancy E. Schoenberg, Stephenie K. Kennedy, Scherezade Mama, Courtney C. Midkiff, Mark B. Dignan

Clinical and Translational Science Institute

Background: Appalachia is a rural, socioeconomically disadvantaged region with high rates of cancer and obesity. Using community-based participatory research principles, the Appalachia Community Cancer Network tested an initiative to reduce weight among overweight and obese participants by partnering with churches, an important community-based institution in Appalachia. Methods: A group randomized trial was conducted with counties or groups of counties in five Appalachian states. These groups were randomly assigned to receive either monthly diet and exercise education sessions (“Walk by Faith”; WbF) or an educational program focused on cancer screening and education (“Ribbons of Faith”; RoF) to examine effects on weight …

Feasibility Of Dose Escalation Using Intraoperative Radiotherapy Following Resection Of Large Brain Metastases Compared To Post-Operative Stereotactic Radiosurgery, John A. Vargo, Kristie M. Sparks, Rahul Singh, Geraldine M. Jacobson, Joshua D. Hack, Christopher P. Cifarelli

Clinical and Translational Science Institute

Background and purpose Post-operative SRS (stereotactic radiosurgery) for large brain metastases is challenged by risks of radiation necrosis that limit SRS dose. Intraoperative radiotherapy (IORT) is a potential alternative, however standard dose recommendations are lacking. Methods and materials Twenty consecutive brain metastases treated with post-operative SRS were retrospectively compared to IORT plans generated for 10–30 Gy in 1 fraction to 0–5 mm by estimating the applicator size and distance from critical organs using pre-operative and post-operative MRI. Additionally, 7 consecutive patients treated with IORT 30 Gy to surface were compared to retrospectively generated SRS plans using the post-operative MRI to …

Mesenchymal Cox2-Pg Secretome Engages Nr4a-Wnt Signalling Axis In Haematopoietic Progenitors To Suppress Anti-Leukaemia Immunity, Limei Wu, Surya Amarachintha, Jian Xu, Frank Oley Jr., Wei Du

Clinical and Translational Science Institute

The bone marrow (BM) microenvironment (niche) plays important roles in supporting normal/abnormal haematopoiesis. We investigated the interaction between leukaemic mesenchymal niche and haematopoietic stem and progenitor cells (HSPCs) using the model of Fanconi anaemia (FA), a genetic disorder characterized by BM failure and leukaemia. Healthy donor HSPCs co‐cultured on mesenchymal stromal cells (MSCs) derived from FA patients with acute myeloid leukaemia (AML) exhibited higher human engraftment and myeloid expansion in Non‐obese diabetic severe combined immunodeficiency IL‐2γ−/−/SGM3 recipients. Untargeted metabolomics analysis revealed the progressively elevated prostaglandins (PGs) in the MSCs of FA patients with myelodysplastic syndromes (MDS) and AML. Reduced secretion …

Out Of The Basement And Into The Classroom: Pathways For Expanding The Role Of Radiation Oncologists In Medical Student Education, Malcolm D. Mattes, William Small Jr., Neha Vapiwala

Clinical and Translational Science Institute

Purpose To characterize radiation oncologist involvement in undergraduate medical education at US academic medical centers and to incorporate these findings into practical pathways for greater and broader integration of radiation oncology (RO) into medical curricula. Methods Chairpersons and residency program directors at RO departments directly affiliated with a medical school were asked to describe all the ways in which radiation oncologists in their department are involved in medical student education, excluding their elective clerkship. Results Of 75 eligible departments, 49 responded (response rate 65.3%). Twenty departments (40.8%) reported that at least one faculty member participates in a curricular educational session …

Repeat Lactate Level Predicts Mortality Better Than Rate Of Clearance, Zachary D. W. Dezman, Angela C. Comer, Gordon S. Smith, Peter F. Hu, Colin F. Mackenzie, Thomas M. Scalea, Jon Mark Hirshon

Clinical and Translational Science Institute

Background Lactate clearance has been developed into a marker of resuscitation in trauma, but no study has compared the predictive power of the various clearance calculations. Our objective was to determine which method of calculating lactate clearance best predicted 24-hour and in-hospital mortality after injury. Study design Retrospective chart review of patients admitted to a Level-1 trauma center directly from the scene of injury from 2010 to 2013 who survived >15 min, had an elevated lactate at admission (≥3 mmol/L), followed by another measurement within 24 h of admission. Lactate clearance was calculated using five models: actual value of the …

Comparative Study Of Clinical Outcome Of Endovascular Aortic Aneurysms Repair In Large Diameter Aortic Necks (>31 Mm) Versus Smaller Necks, Ali F. Aburahma, Trevor Derderian, Zachary T. Aburahma, Stephen M. Hass, Michael Yacoub, L. Scott Dean, Shadi Abu-Halimah, Albeir Y. Mousa

Clinical and Translational Science Institute

Background This study compares short-term (30 days) and intermediate term (3 years) clinical outcomes in patients with large (≥31 mm) versus small aortic neck diameters (≤28 and ≤31 mm). Methods Prospectively collected data from 741 patients who underwent endovascular aortic aneurysm repair were analyzed. Some surgeons have reported the threshold for a large aortic neck for endovascular aortic aneurysm repair to be 28 mm, whereas for others it is 31 mm. Therefore, we classified aortic neck diameter into less than or equal to 28 versus greater than 28 mm; and less than or equal to 31 versus greater than 31 …

Graduate News, Graduate School, Old Dominion University

Graduate News

November 2018 issue of Graduate News from the ODU Graduate School.

Illuminator, Volume 2, Issue 3, Batten College Of Engineering & Technology, Old Dominion University

College of Engineering & Technology Newsletter

November 2018 issue of Illuminator, a monthly publication of ODU's Batten College of Engineering and Technology.

Sjsu Erfa News, Winter 2018, San Jose State University, Emeritus And Retired Faculty Association

Emeritus and Retired Faculty Association (ERFA) Newsletter

Volume 32, Number 2

Mertk Is A Therapeutic Target In Combination With Radiation To Promote Adaptive Immune Tumor Responses, Garth Tormoen, Jason R Baird, Gwen Kramer, Shelly Bambina, Marka R Crittenden, Michael J. Gough

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Mertk is a member of the Tyro3-Axl-Mertk (TAM) family of receptors and regulates phagocytosis of dying cells by macrophages. Cancer cells killed by radiation therapy direct repolarization of macrophages into immune suppressive phenotypes. Mertk-/- mice grafted with immunogenic tumors have enhanced tumor control following ionizing radiation compared to Mertkwt mice. Gas6 is the endogenous ligand for Mertk and its ability to signal through Mertk requires a post-translational vitamin k-dependent modification that is inhibited by warfarin.

Methods: Mertk-/- and WT mice were injected subcutaneously in the flank with 5E4 CT26 cells (BALB/c) or 5E6 Panc02-SIY cells (C57BL/6) and allowed to …

Mv-626, A Potent And Selective Inhibitor Of Enpp1 Enhances Sting Activation And Augments T-Cell Mediated Anti-Tumor Activity In Vivo, Jason Baird, Gregory Dietsch, Vincent Florio, Michael Gallatin, Clayton Knox, Joshua Odingo, Marka Crittenden, Michael J. Gough

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: STING is an endogenous sensor of cGAMP, which is synthesized by cGAS following detection of cytoplasmic DNA. STING activation leads to interferon production and activation of inflammatory pathways that facilitate cytolytic T cell priming. STING agonists administered intratumorally show potent anti-tumor efficacy in a range of preclinical models; several agonists are in clinical development. Radiation therapy also increases cytoplasmic DNA levels in cancer cells, resulting in STING activation and secretion of inflammatory cytokines. Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the phosphodiesterase that negatively regulates STING by hydrolyzing cGAMP. MV-626, a highly potent and selective ENPP1 inhibitor with 100% oral bioavailability …

Preliminary Evaluation Of A Novel Whole Slide Multispectral Assessment Of Seven Markers: Potential To Minimize Bias In The Characterization Of The Tumor Immune Environment, Carmen Ballesteros Merino, Shawn Jensen, Carla Coltharp, Kristin Roman, Chichung Wang, Nikhil Lonberg, Sebastian Marwitz, Tarsem Moudgil, William Miller, William Redmond, Yoshinobu Koguchi, Carlo Bifulco, Clifford Hoyt, Bernard A. Fox

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: PD-L1 expression and tumor-mutational burden enrich for patients that respond to checkpoint blockade, but these evaluations are only a component of the entire story. Recently, our lab reported that evaluation of specific cell-cell relationships provided a powerful biomarker for overall survival in patients with HPV- head and neck cancer (HNSCC). However, the areas selected for analysis were operator selected “hot spots”. This approach introduces the potential for unconscious bias in the selection process. To address this, we have sought to perform whole slide evaluations of sections to compare with hot spot analysis. This study is a preliminary report applying …

Pegzilarginase In Combination With Agonist Anti-Ox40 Therapy Enhances T Cell Priming And Effector Function Leading To Improved Tumor Regression And Survival, Melissa Kasiewicz, Annah Rolig, Elizabeth Sturgill, Mark Badeaux, Scott Rowlinson, William L. Redmond

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Tumor cells defective in enzymes required for arginine biosynthesis are dependent upon arginine uptake from the environment. Extracellular depletion of arginine directly affects tumor cells, inducing autophagy and apoptosis. Pegzilarginase (AEB1102) is a bioengineered, pegylated, human arginase 1 (Aeglea Biotherapeutics) currently in phase I clinical trials. This arginine-depleting agent has been shown to both inhibit arginine auxotrophic tumor growth and to enhance the efficacy of PD-L1 blockade in preclinical models. In the current study, we investigated the therapeutic efficacy and mechanism of action of combined pegzilarginase/anti-OX40 (aOX40) immunotherapy. We hypothesized that pegzilarginase/aOX40 treatment would synergize to enhance T cell …

Integrative Spatially-Resolved, High-Plex Digital Profiling Enables Characterization Of Complex Immune Biology In The Tumor Microenvironment Of Mesothelioma, Carmen Ballesteros-Merino, Moritz Widmaier, Sarah Church, Thomas Herz, Alexei Budco, Das Medrikova, Ivan Kanchev, Andrew White, Douglas Hinerfeld, Shawn Jensen, John Handy, Rachel Sanborn, Carlo Bifulco, Sarah Warren, Joseph Beechem, Bernard .. Fox

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Malignant mesothelioma is an aggressive cancer with poor prognosis and few effective therapies. Since mesothelioma is derived from the mesothelium of the lung, we hypothesize that immune cells in the tumor microenvironment (TME) may behave differently than other solid tumors. In our previous studies, utilizing multi-plexed immunofluorescence, we did not find immune phenotypes associated with improved patient survival. Here we describe a novel combination of two technologies to spatially characterize the interface between mesothelioma cells, stroma and immune cells in the TME in a high-plex capacity.

Methods: Ten FFPE mesothelioma tumors were characterized by Definiens’ Immune-Oncology Profiling (IOP) and …

Ethical Implications Of Treatment For Gender Dysphoria In Youth, Kelsey Hayes

Journal of Health Ethics

This manuscript explores ethical implications on treatment for youth with diagnosed gender dysphoria. The ethical considerations outlined and analyzed in this essay involve illuminating an understanding of whether the administration of pubertal suppression with GnRH agonists, and cross-sex hormones to children with gender dysphoria is morally justified as treatment to manage their psychological distress, or if safer more understood alternatives exist. This essay emphasizes that as health care professionals we must ensure youth with gender dysphoria receive adequate medical treatment and care however, this essay concludes through extensive literature review, that the use of inconclusive and under researched methods to …

Archarios, 2018 Fall / 2019 Spring, Office Of Student Life

Archarios Literary Art Magazine

Archarios 27. Editor: Rob Sperduto. Faculty Advisor: Jeff Case. Cited as 27th edition. Printed by Sheriar Press.

Temperature Forecasting: A Comparison Between Parametric And Non-Parametric Models, Alaa Sheta, Ajay Katangur, Abdelkarim Baareh

Applied Mathematics & Information Sciences

The development of accurate temperature prediction models is essential for not only human life but also for agricultural, animal life, tourism, and many others. Power consumption and achieving energy efficiency in buildings also depends on temperature. Although modeling-based regression is one of the most popular approaches, it still suffers from many difficulties related to the number of available measurements, the order of the model and the non-linearity of the data. In this paper, we provide a comparison between parametric and non-parametric models for temperature forecasting. We propose three-model structures to estimate the temperature in Mumbai, the business capital of India. …