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Paul Piccone’S Providential Moment: Phenomenology, Subjectivity, And 20th Century Marxism In Telos, Jacob A. Ulmschneider

Theses and Dissertations

This thesis explores the intellectual history of editor, writer, and philosopher, Paul Piccone and Telos, an independent journal of contemporary critical theory, which he founded in 1968. Born in Italy, Piccone lived most of his life in the United States, earning his Ph.D. in philosophy at SUNY-Buffalo in 1970. Piccone served as Telos’ editor and a major contributor from 1968 to 2004. This thesis follows the trajectory of his thought by contextualizing his writing within the broader world of Marxist, and eventually post-Marxist, political philosophy. Telos also concerned itself with modern interpretations of historical dialectics and early 20^th-century …

The Role Of Ceramide In Neutrophil Elastase Induced Inflammation In The Lungs, Sophia Karandashova

Theses and Dissertations

Alterations to sphingolipid metabolism are associated with increased pulmonary inflammation, but the impact of inflammatory mediators, such as neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. NE is a protease associated CF lung disease progression, and can be found in up to micromolar concentrations in patient airways. While sphingolipids have been investigated in the context of CF, the focus has been on loss of cystic fibrosis transmembrane conductance regulator (CFTR) function. Here, we present a novel observation: oropharyngeal aspiration of NE increases airway ceramides in mice. Using a previously characterized mouse model of NE-induced inflammation, we demonstrate that NE …

Skin Cancer Detection Using Svm-Based Classification And Pso For Segmentation, Osamah A. Almasiri

Theses and Dissertations

Various techniques are developed for detecting skin cancer. However, the type of maligned skin cancer is still an open problem. The objective of this study is to diagnose melanoma through design and implementation of a computerized image analysis system. The dataset which is used with the proposed system is Hospital Pedro Hispano (PH²).

The proposed system begins with preprocessing of images of skin cancer. Then, particle swarm optimization (PSO) is used for detecting the region of interest (ROI). After that, features extraction (geometric, color, and texture) is taken from (ROI). Lastly, features selection and classification are done using a support …

Exogenous Fniii 12-14 Regulates Tgf-Β1-Induced Markers, Hilmi M. Humeid

Theses and Dissertations

The extracellular matrix protein Fibronectin (FN) plays an important role in cell contractility, differentiation, growth, adhesion, and migration. The 12th -14th Type III repeats of FN (FNIII 12-14), also referred to as the Heparin-II domain, comprise a highly promiscuous growth factor (GF) binding region. This binding domain aids in cellular signaling initiated from the ECM. Additionally, FN has the ability to assemble into fibrils under certain conditions, mostly observed during cell contractile processes such as those that initiate due to upregulation of Transforming Growth Factor Beta 1 (TGF-β1) [1], [2]. Previous work from our lab has shown that self-assembly of …

Molecular Brain Adaptations To Ethanol: Role Of Glycogen Synthase Kinase-3 Beta In The Transition To Excessive Consumption, Andrew D. Van Der Vaart

Theses and Dissertations

Alcoholism is a complex neuropsychiatric disease that is characterized by compulsive alcohol use and intensifying cravings and withdrawals, often culminating in physiologic dependency. Fundamental alterations in brain chemistry underlie the transition from initial ethanol exposure to repetitive excessive use. Key mediators of this adaptation include changes in gene expression and signal transduction. Here we investigated gene expression pathways in prefrontal cortex and nucleus accumbens following acute or chronic ethanol treatment, to identify genes with potentially conserved involvement in the long-term response of the corticolimbic system to repeated ethanol exposure. We investigated Gsk3b, which encodes glycogen synthase kinase 3-beta, as a …

Resolution Of Proximal Oxidative Base Damage And 3′-Phosphate Termini For Nonhomologous End Joining Of Free Radical-Mediated Dna Double-Strand Breaks, Sri Lakshmi Chalasani

Theses and Dissertations

Clustered damage to DNA is a signature mark of radiation-induced damage, which involves damage to the nucleobases and/or DNA backbone. Double-strand breaks created by damaging agents are detrimental to cell survival leading to chromosomal translocations. Normal cells employ Non-homologous end-joining because of its faster kinetics, to suppress chromosomal translocations. However, the presence of complex DNA ends constitutes a significant challenge to NHEJ. Location of Thymine glycol (Tg) at DSB ends was a potential hindrance to end joining. The substrate with Tg at the third position (Tg3) from the DSB joined better than when present at the fifth position (Tg5). However, …

Using A Custom Landscape Classification To Understand The Factors Driving Site Occupancy By A Rapidly Declining Migratory Songbird, Elizabeth K. Schold

Theses and Dissertations

Land cover classifications are useful in a broad range of ecological applications, yet publicly available classifications are not always useful for the needs of specific projects. Custom classifications are always a possibility, however, they can be financially or computationally out of reach for many researchers. Here we present a custom 1m resolution land cover classification created using freely available imagery and a random forest classification approach. This classification detected shrub cover more accurately and at a finer resolution than previous classifications. With the creation of this map, we were then able to examine landscape factors influencing occupancy dynamics of the …

Assessment Of A Predicted Diguanylate Cyclase In Treponema Denticola, Dhara T. Patel

Theses and Dissertations

Periodontal disease is a progressive inflammatory condition that is characterized by the reabsorption of alveolar bone, the destruction of connective tissue, and edentulism. It is caused by a dysbiosis in the oral microbiome as a result of a shift from a Gram-positive aerobic bacterial population, to one that becomes more Gram-negative and anaerobic. Treponema denticola is thought to drive this diseased state based on its role as a keystone periopathogen. A major component of T.denticola’s invasiveness is its motility, which allows the spirochete to penetrate and disseminate through tissues. This motility, which has been seen to be crucial to …

Zebrafish Model Of Mll-Rearranged Acute Myeloid Leukemia, Alex J. Belt

Theses and Dissertations

Acute myeloid leukemia (AML) is the second most common type of leukemia and accounts for 80% of adult acute leukemia cases and is characterized by the accumulation of poorly or undifferentiated myeloid blast cells. Standard treatment includes chemotherapy, which if unsuccessful, is followed by more rigorous chemotherapy as well as stem cell transplantation. Considering most patients are over the age of 45, these more rigorous therapies are not always possible, and as such, new therapies must be developed. Furthermore, AML patients harboring a chromosomal rearrangement involving Multiple Lineage Leukemia (MLL) that results in the expression of an MLL fusion protein …

The Pros And Cons Of Inclusion For Students With Autism Spectrum Disorder (Asd) In The Mainstream Classroom, Benjamin Kwofie

All Electronic Theses and Dissertations

General education placement are believed to offer innumerable benefits for students with Autism Spectrum Disorder (ASD), however, decisions about including students with ASD remain controversial. This thesis highlights the benefits and challenges of including students with ASD in the mainstream setting. Inclusion represents the belief or philosophy that students with disabilities should be integrated into the regular education classroom with the relevant support to enable them to succeed. ASD is a very complicated disability; there are various levels of ability a student with ASD may have and there are also many types of this disorder. There are several effective strategies …

Satellite Sensor Requirements For Monitoring Essential Biodiversity Variables Of Coastal Ecosystems, Frank E. Muller-Karger

Marine Science Faculty Publications

The biodiversity and high productivity of coastal terrestrial and aquatic habitats are the foundation for important benefits to human societies around the world. These globally distributed habitats need frequent and broad systematic assessments, but field surveys only cover a small fraction of these areas. Satellite-based sensors can repeatedly record the visible and near-infrared reflectance spectra that contain the absorption, scattering, and fluorescence signatures of functional phytoplankton groups, colored dissolved matter, and particulate matter near the surface ocean, and of biologically structured habitats (floating and emergent vegetation, benthic habitats like coral, seagrass, and algae). These measures can be incorporated into Essential …

Unprecedented Diversity Of Ssdna Phages From The Family Microviridae Detected Within The Gut Of A Protochordate Model Organism (Ciona Robusta), Alexandria Creasy, Karyna Rosario, Brittany A. Leigh

Marine Science Faculty Publications

Phages (viruses that infect bacteria) play important roles in the gut ecosystem through infection of bacterial hosts, yet the gut virome remains poorly characterized. Mammalian gut viromes are dominated by double-stranded DNA (dsDNA) phages belonging to the order Caudovirales and single-stranded DNA (ssDNA) phages belonging to the family Microviridae. Since the relative proportion of each of these phage groups appears to correlate with age and health status in humans, it is critical to understand both ssDNA and dsDNA phages in the gut. Building upon prior research describing dsDNA viruses in the gut of Ciona robusta, a marine invertebrate model system …

Taxonomy And Secondary Metabolites Of Selected Endophytic Actinomycete Strains, Nattakorn Kuncharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

A total of 50 endophytic actinomycetes isolated from fourteen plant species collected from six provinces of Thailand including Bangkok, Chachoengsao, Chiang Mai, Nakhon Pathom, Prachinburi and Suphan Buri were taxonomically studied relied on their phenotypic and chemotaxonomic characteristics, and the 16S rRNA gene sequence analysis. The isolates were identified as members of the family Streptomycetaceae involving Streptomyces (22 isolates), and the family Micromonosporaceae including Micromonospora (25 isolates), Plantactinospora (1 isolate) and Polymorphospora (1 isolate). Based on phenotypic characteristics, whole genome sequence analysis and DNA-DNA hybridization, 5 novel actinomycete species were proposed consisting of Micromonospora globbae (strain WPS1-2T), Micromonospora azadirachtae (strain …

Taxonomy And Secondary Metabolites Of Selected Endophytic Actinomycete Strains, Nattakorn Kuncharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

A total of 50 endophytic actinomycetes isolated from fourteen plant species collected from six provinces of Thailand including Bangkok, Chachoengsao, Chiang Mai, Nakhon Pathom, Prachinburi and Suphan Buri were taxonomically studied relied on their phenotypic and chemotaxonomic characteristics, and the 16S rRNA gene sequence analysis. The isolates were identified as members of the family Streptomycetaceae involving Streptomyces (22 isolates), and the family Micromonosporaceae including Micromonospora (25 isolates), Plantactinospora (1 isolate) and Polymorphospora (1 isolate). Based on phenotypic characteristics, whole genome sequence analysis and DNA-DNA hybridization, 5 novel actinomycete species were proposed consisting of Micromonospora globbae (strain WPS1-2T), Micromonospora azadirachtae (strain …

Fighting The Heat: Geoengineering Strategies And Potential Global Effects, Rachael Branscomb

The Synapse: Intercollegiate science magazine

No abstract provided.

The Synapse 18

The Synapse: Intercollegiate science magazine

No abstract provided.

Perspectives Volume 6: Number 1, Winter-Spring 2018, College Of Health Care Sciences

Perspectives

No abstract provided.

The Drug Repurposing Ecosystem: Intellectual Property Incentives, Market Exclusivity, And The Future Of "New" Medicines, Sam F. Halabi

Faculty Publications

The pharmaceutical industry is in a state of fundamental transition. New drug approvals have slowed, patents on blockbuster drugs are expiring, and costs associated with developing new drugs are escalating and yielding fewer viable drug candidates. As a result, pharmaceutical firms have turned to a number of alternative strategies for growth. One of these strategies is "drug repurposing"-finding new ways to deploy approved drugs or abandoned clinical candidates in new disease areas. Despite the efficiency advantages of repurposing drugs, there is broad agreement that there is insufficient repurposing activity because of numerous intellectual property protection and market failures. This Article …

Paulo Freire And Liberation Theology: The Christian Consciousness Of Critical Pedagogy, Peter Mclaren, Petar Jandrić

Education Faculty Articles and Research

"In this article we expand our work towards intersections and relationships between liberation theology and Paulo Freire. While Freire addressed liberation theology in his writings fairly sporadically (e.g. »The Politics of Education« [1985]), there is no doubt that he »lived a liberating Christian faith« and »significantly contributed to the thinking of liberation theology« (Kyrilo 2011, p. 167). Now that Paulo Freire is no longer with us, arguably the best way to reinvent his works for the present moment is through dialogue with Peter McLaren: Freire’s close friend, »intellectual relative« (Freire 1995, p. x), and one of the key contemporary thinkers …

Response And Resistance To Paradox-Breaking Braf Inhibitor In Melanomas, Edward J. Hartsough, Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison F. Goldberg, Michael A. Davies, Matthew J. Schiewer, Karen E. Knudsen, Gideon Bollag, Andrew E. Aplin

Department of Cancer Biology Faculty Papers

FDA-approved BRAF inhibitors produce high response rates and improve overall survival in patients with BRAF V600E/K-mutant melanoma, but are linked to pathologies associated with paradoxical ERK1/2 activation in wild-type BRAF cells. To overcome this limitation, a next-generation paradox-breaking RAF inhibitor (PLX8394) has been designed. Here, we show that by using a quantitative reporter assay, PLX8394 rapidly suppressed ERK1/2 reporter activity and growth of mutant BRAF melanoma xenografts. Ex vivo treatment of xenografts and use of a patient-derived explant system (PDeX) revealed that PLX8394 suppressed ERK1/2 signaling and elicited apoptosis more effectively than the FDA-approved BRAF inhibitor, vemurafenib. Furthermore, PLX8394 was …

Annual Report Of The Town Officers For The Year Ending December 31, 2017., Easton Town Representatives

Easton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Trimethyltin-Induced Cerebellar Damage On Adult Male Wistar Rats. Trimetil Estaño Induce Daño Cerebral En Ratas Machos Adultas Wistar., M. S. Ajao, A. Okesina, Martin C. Nwadiugwu

Interdisciplinary Informatics Faculty Publications

Abstract: This research work was done to investigate the acute toxicological effect of trimethyltin chloride on the cerebellum of Wistar rat. Ten adult male Wistar rats were used for the study. The animals were grouped into two: Group A and B, with five adult male Wistar rats in each group. Group A serves as the trimethyltin (TMT) group, while group B serves as the normal saline (NS) group. 3mg/kg of trimethyltin chloride was administered to animals in the TMT group, while 1.0mls of normal saline was administered to the animals in the NS group via intraperitoneal route for 3 …

Women Photographers In History, Sally A. Struthers

Art and Art History Faculty Publications

A presentation on women photographers in history.

In Re R.R.N.: Redefining "Caretaker" For North Carolina Child Protective Services, Jordan M. Spanner

Campbell Law Review

In 2015, the North Carolina Supreme Court interpreted for the first time the definition of "caretaker" as provided in the State's Juvenile Code. The court narrowed the definition, providing that the statutory language "an adult relative entrusted with the juvenile's care" means an adult relative who has "a significant degree of parental-type responsibility for the child. " The court's interpretation has made caretaker equivalent to in loco parentis, which results in a heightened standard that likely was not intended by the legislature. This Comment discusses the far-reaching effects of the court's decision on North Carolina's child welfare services, law enforcement, …

The Trademark Disclaimer Provision Of The Lanham Act: Is Uspto Flexibility Worth Litigant Ambiguity?, 17 J. Marshall Rev. Intell. Prop. L. 305 (2018), Scott Locke

UIC Review of Intellectual Property Law

Most trademark applicants and the attorneys who counsel them are familiar with the requirement that they disclaim terms within their trademarks because those terms are descriptive or generic. The United States Patent and Trademark Office’s authority to direct applicants to disclaim terms is codified in the Trademark Disclaimer Provision of the Lanham Act, which provides examiners with a great deal of discretion. The same provision has been interpreted as providing applicants with the options of: taking conflicting positions, e.g., that the term is neither descriptive nor generic in the context of their marks, when asserting common law rights; and pursuing …

Knowledge/Skill Standards Of A "Person Skilled In Art": A Concern Less Visited, 17 Marshall Rev. Intell. Prop. L. 588 (2018), Naina Khanna, Jasmeet Gulati

UIC Review of Intellectual Property Law

The law is differential across jurisdictions when it comes to the skill standard required for the PSITA/PHOSITA in Patent Law. This article will analyze the various levels of skill addressed throughout European, Indian, and U.S. Patent Law. Whether the level of skill be ‘ordinary’, ‘extraordinary’ or otherwise, discrepencies exist throughout the court systems, manuals of examination and the like. Much hinges on the determination of patentability when the expertise or level of skill of the PSITA/PHOSITA is often vague and indeterminative. It is submitted that since the advancement in technology is taking place at a very rapid scale and every …

The Slants Decision Understates The Value Of Trademark Registration In Promoting Speech - Correctly Decided With A Conclusory Analysis, 17 J. Marshall Rev. Intell. Prop. L. 380 (2018), David Brezina

UIC Review of Intellectual Property Law

The highly anticipated case of Matal v. Tam resulted in the band, The Slants, eventually being able to register their band name as a trademark, with a goal in mind to reclaim Asian stereotypes. Despite this decision, it is not immediately clear how having a registration enhances the registrant’s right to use the mark as a part of free speech, when the Court observes that Tam could call his band The Slants even without registration. This article touches on the Tam case, by analyzing both the positive and negative rights that federal trademark registration yields. By expanding on a variety …

She Is Right To Behave Thus: Implications Of Illicit Rendezvous In Medieval Narrative, Catherine Albers

Electronic Theses and Dissertations

While preconceptions of the Middle Ages often rely on assumptions about Christianity and the kind of society that the Catholic Church promoted, the reality is that the historical and literary medieval world is much more complicated. When discussing the issues of sexuality, women, and sexual normativity, these assumptions hinder our ability to accurately analyze the content and reception of medieval literature. This project addresses this gap by positioning itself among the criticism set forth by scholars of four different cultures (Irish, Norse, English, and Italian) to examine the connections between the reception of women who act outside of the boundaries …

Impact Of Human Disturbance On The Behavior And Physiology Of The Endangered Ringed Sawback Turtle (Graptemys Oculifera), Jessica Mary Heppard

Electronic Theses and Dissertations

Turtles are one of the most threatened taxa worldwide. In addition to direct anthropogenic impacts such as hunting and pollution, unintentional indirect human disturbance affects poikilothermic turtles by disrupting thermoregulatory basking behavior. In this thesis I assess the behavioral and physiologic impacts of high boat traffic, reductions of basking structures, and environmental factors on basking behavior, rates of disturbance, thermoregulation, parasite load, shell condition, and population recruitment in two populations of the endangered ringed sawback (Graptemys oculifera), also known at the ringed map turtle, on the Pearl River outside Jackson, MS. Basking behavior was influenced by availability of basking structures, …

Effects Of Clove Oil (Eugenol) On Proprioceptive Neurons, Heart Rate, And Behavior In Model Crustaceans, Samuel Wycoff, Kristin Weineck, Shannon Conlin, Chinni Suryadevara, Elizabeth Grau, Alec Bradley, Danielle Cantrell, Samantha Eversole, Carolyn Grachen, Kaylee Hall, Danielle Hawthorne, Claire Kinmon, Paula Ortiz Guerrero, Bhavik Patel, Kaitlyn Samuels, Gia Valdes, Andrew J. Ray, Leo J. Fleckenstein, Elena Piana, Robin L. Cooper

Biology Faculty Publications

Clove oil contains eugenol as an active ingredient and is used as a topical anesthetic in mammals to remedy pain and to anesthetize fish and other seafood for short periods; however, the exact mechanism of action of eugenol is not fully understood. We examined use of eugenol as a reversible anesthetic in crustaceans by examining its effect on sensory and motor neurons in the Red Swamp crayfish (Procambarus clarkii), Blue crab (Callinectes sapidus) and Whiteleg shrimp (Litopenaeus vannamei) with electrophysiological recordings. The neurogenic heart rate in the three species was also monitored along with …