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Presence And Potential Sources Of Pharmaceutical And Personal Care Product Chemicals In Messalonskee Lake, Alyssa T. Kullberg

Honors Theses

Pharmaceuticals and personal care product chemicals (PPCPs) represent a large group of contaminants that are mostly not regulated in surface or drinking water and whose presence and environmental and health impacts are poorly understood. We investigated the presence and potential sources of 18 PPCPs in Messalonskee Lake. We collected samples four times over the summer of 2017 at 13 sites around the lake. Samples were tested for PPCPs using liquid chromatography-tandem mass spectrometry. We detected five out of the 18 PPCPs we tested for at the ng/L level: caffeine, 1,7-dimethylxanthine, acetaminophen, sulfachloropyridazine, and amphetamine. PPCPs showed a significant positive correlation …

Compositional Craft And Theory Across Tonal Languages, Liam Butchart

Honors Theses

This paper accompanies Liam Butchart's senior honors voice recital and his composition for the Colby Symphony Orchestra, Genevan Overture. The essay examines how form and cadence, two integral components of compositional craft, have been utilized by composers who either were included in the voice recital or were major influences on the composition. Specifically, the paper analyzes how different composers end their musical sentences similarly and differently through the lens of structurally-relevant cadences.

Haloferax Volcanii For Carotenoid Production, Erika Smith

Honors Theses

Carotenoids are used as natural colorants and have been shown to have numerous health benefits, making these molecules highly desirable in the aquaculture, pharmaceutical, and nutraceutical markets. There is increasing consumer demand for the natural synthesis of carotenoids, but current methods are limited by the cost and difficulty of extraction from organisms. The halophilic archaeon Haloferax volcanii is amenable to extraction and has an endogenous carotenoid biosynthetic pathway that culminates in the accumulation of the carotenoid bacterioruberin; however, H. volcanii also synthesizes important precursors that can be converted into more highly-desired carotenoids, such as β-carotene and astaxanthin, in the presence …

From Forced To Voluntary Participation: The History Of Biomedical Human Experimentation In The United States After The Second World War, Haley L. Andonian

Honors Theses

For as long as medicine and medical practices have been around, so has the need for testing treatments in or procedures on the human body. Over the course of history, however, the nature, structure, and prominence of human biomedical experimentation has changed drastically both on an international and national level. My thesis focuses on revealing the driving forces behind these changes in administrative, legal and social factors related to human experimentation in an effort to connect the dots from the manipulative, forceful and unethical experimentation of early medical practitioners to the safe, voluntary and highly regulated experimentation characteristic of clinical …

The Identification And Application Of Generalizable Spatial Patterns Of Human-Wildlife Conflict, Vivian F. Hawkinson

Honors Theses

Many human-wildlife conflict studies focus on one location or one individual species or taxonomic group; fewer comparative studies analyze patterns of conflict across species and regions. As a result, numerous studies report similar conclusions across diverse cases of human-wildlife conflict. I found 133 scholarly articles published between 1975 and 2017 referencing distance from a protected area boundary as a variable associated with human-wildlife conflict. I identified three generalizable patterns of human-wildlife conflict that appear across taxonomic groups and geographic locations. The family Felidae had the highest maximum average conflict distance and furthest distance from a protected area that conflict was …

Disc1 Knockout Rats Reveal Sexually Dimorphic Patterns Of Impairment Across Development, Stephanie S. Desrochers

Honors Theses

Schizophrenia is a chronic disorder characterized by three symptom categories: positive (hallucinations, delusions), negative (anhedonia, anxiety), and cognitive (sensory processing and memory deficits). We worked with a biallelic deletion of the Disrupted-in-schizophrenia-1 (DISC1) gene in Sprague-Dawley rats to facilitate our understanding of the biological bases of schizophrenia. Mutations of DISC1 are associated with a higher prevalence of schizophrenia. Adult DISC1 knockout, compared to wildtype, rats display features of schizophrenia-like outcomes in rodent models. The present study investigated the progression of the cognitive symptom deficits in prepulse inhibition (PPI), assessing animals at postnatal days 17 (pre-weaning), 26 (post-weaning), 39 (adolescent), and …

Synthesis And Cytotoxicity Of Mansonone G Derivatives, Nhung Ngo Thi Tuyet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mansonone G (N01), a naturally occurring o-naphthoquinone was isolated from the heartwoods of Mansonia gagei Drumm. as the major component. Seventeen ether derivatives N02-N18 were successfully synthesized by the reaction of mansonone G with corresponding alkyl halide. All derivatives were characterized by 1H, 13C NMR and HRMS. Eleven of them were confirmed to be new compounds. The cytotoxic evaluation was performed against A549 and HT-29 cancer cell lines. Interestingly, all candidates displayed more potent cytotoxicity than mansonone G. The hydrophobicity was found as an important contributor to the activity. N08 displayed the most potent cytotoxicity toward the interested cells with …

Variation In Secondary Metabolites Contents Of Spinoso Sardo Artichoke (Cynara Cardunculus L.) Under Different Day Lengths, Angela Fadda, Adriana Virdis, Antonio Barberis, Sara Melito

Turkish Journal of Agriculture and Forestry

Globe artichoke (Cynara cardunculus L. var. scolymus Fiori) is an economically important crop in the Mediterranean basin and particularly in Italy, which is a leading producer. In this research, we studied the effect of extended photoperiod (15 and 17 h) on polyphenolic, flavonoids, lignin concentrations, and antioxidant activity in edible and inedible organs of artichoke. The influence of day length on morphological traits and biomass accumulation was also assessed. The total phenolic content of whole plants grown under natural day length conditions exceeds that of photoperiod extended for 15 and 17 h by 31% and 32.4%, respectively. The decrease of …

Effect Of Chemical Cleaning Regimes On Ageing Of Microfiltration (Mf) And Ultrafiltration (Uf) Hollow-Fiber Membranes, Mariny Chheang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Membrane fouling is a major obstacle in microfiltration (MF) and ultrafiltration (UF) in wastewater treatment and water reuse. Fouling and membrane cleaning have been extensively studied in batch experiments at a short filtration time, but long-term membrane property changes (e.g. ageing) are not fully explored. Thus, this dissertation focused on changes in physical and chemical properties of the PVDF membranes, and membrane ageing. Impacts of feed water composition (tannic acid and tannic acid+Fe2O3) and chemical cleaning regimes (NaOH, citric acid) on the membrane performance and property changes were investigated. UF and MF membranes rejected iron oxide particles perfectly. Whilst both …

Comparison Of The Stem Cell Characteristics Among Periodontium-Derived Human Mesenchymal Stem Cells, Manutsanun Choosiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To investigate and compare the characteristics of human mesenchymal stem cells (MSCs) among 3 different stem cell sources in periodontium; periodontal ligament (PDL) tissue, marginal gingival tissue (MG), and supra-crestal gingival connective tissue (SG). Materials and Methods: PDL-MSCs, MG-MSCs, and SG-MSCs were obtained from 4 subjects with healthy periodontal condition. The characteristics of 3 types of MSCs were compared in terms of an expression of MSCs markers, colony-forming ability (CFA), cell proliferation, alkaline phosphatase (ALP) activity, osteogenic and adipogenic potential. Results: Flow cytometry revealed a similar pattern of MSCs marker expression among 3 cells types with positive expression of …

Preparaton Of Selenium Nanoparticles Stabilized By Pullulan And Derivatives, Punnida Nonsuwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The inorganic/organic selenium nanoparticles (SeNPs)/pullulan derivative hybrid material was obtained using a simple and green strategy. The chemical structure of pullulan, folic acid decorated cationic pullulan (FA-CP) was designed for stabilizing SeNPs. The SeNPs stabilized by FA-CP were observed after the addition of a cysteine hydrochloride solution into the solution mixture of Na2SeO3 and FA-CP. The results suggested that the concentrations of cysteine and stabilizer were the key factors to control the shape and morphology of SeNPs. The spherical SeNP/FA-CP was found in ratio of Na2SeO3 to cysteine was 1:1. It exhibited low toxicity against normal cells while higher toxicity …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

The Effect Of Using Rosemary (Rosmarinus Officinalis) In Broiler Nutrition On Production Parameters, Slaughter Characteristics, And Gut Microbiological Population, Veselin Petricevic, Milos Lukic, Zdenka Skrbic, Simeon Rakonjac, Vladimir Doskoviç, Maja Petricevic, Aleksandar Stanojkovic

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the effects of the supplementation of different concentrations of rosemary in broiler diets from day 1 to 42 on growth performance, carcass quality, and cecal microbiological composition of chickens. The research was carried out with 1200 Ross 308 chickens, divided into 4 groups with 6 repetitions per group. The treatment groups were: control group (C) without rosemary, 0.2% rosemary group (0.2R), 0.4% rosemary group (0.4R), and 0.6% rosemary group (0.6R). Production parameters and the European Production Efficiency Factor (EPEF) were determined. At the end of the trial 12 chicks per group were …

The Biopolitical Elements In Yan Lianke's Fiction Worlds, Xiaoyu Gao

Masters Theses

No abstract provided.

The Development Of Serial Killers: A Grounded Theory Study, Meher Sharma

Masters Theses

The worldview that portrays a serial killer as being a white male, an evil monster with unusual appearance, having dysfunctional relationships (Yaksic, 2015), engaging in animal torture or being sexually or physical abused in childhood, and therefore, sadistically killing for sexual gratification should be challenged (Beasley, 2004). Leyton (1996) and Skrapec (2001) suggested researchers should approach with open minds while searching for knowledge relating to this phenomenon without preconceived assumptions or hypotheses. Furthermore, every serial killers' drive to kill multiple victims may be unique, dependent on his/her history and experiences, and is therefore difficult to quantify (Yaksic, 2015). The current …

Examining Gender Differences In Play Choice In Kindergarten, Danielle Bily

Masters Theses

This study explored the gender differences in play choice in a kindergarten classroom in rural Illinois. Kindergarten expectations support free choice time to enhance classroom behavior, interactions with peers, and conflict resolution. Participants were 12 male students and 11 female students in one general education classroom. Students were given an individual survey to label various pictures of toys as being for males, females, or both males and females. Parent questionnaires were sent home to measure what children play with outside of school hours. Results suggested that (a) it may be important to display images that include both males and females …

Biotransformation Of Oxo-Bile Acids Derivatives By Human Gut Bacteria, Laina Sallam

Masters Theses

Bile acids are one group of steroids that can be metabolically transformed by human gut anaerobes. One of these transformations is the conversion of primary bile acids to secondary bile acids by 7α-dehydroxylating gut bacteria such as Clostridium scindens, Clostridium hylemonae, and Clostridium hiranonis. These anaerobes metabolize bile acid derivatives via 3α- and 7α-hydroxysteroid dehydrogenases (HSDH). Studies to date have not reported if these organisms are capable of converting 12-oxolithocholic acid (12-oxoLCA) to deoxycholic acid (DCA). The emphasis of this study was to determine the ability of C. scindens ATCC 35704, C. hiranonis DSM 13275, and C. …

The Role Of Prrx1 And Snai2 As Master Regulators Of Fibroblast Identity, Huda A. Alzahrani

Masters Theses

Mammalian development involves a complex system of regulatory signals and reactions, leading to the creation of distinct tissues with specific structures and functions controlled by various gene expression profiles. Tissue-specific gene expression is by controlled specific combinations of transcription factors and cofactors that dictate cell differentiation via activation and repression of genes in mammalian cells.

Whole genome microarray analyses of fibroblasts have revealed candidate genes that may serve as master regulators of fibroblast identity, such as Prrx1 and Snai2, that activate downstream genes such as Bmp3, Twist, Shox2, Cfos, Slug, Sema3A, Spp1, and Col1a1. A previous study showed that Prrx1 …

Spice And Herb Use Among Cancer Patients, Mallory H. Krueger

Masters Theses

Purpose: The purpose of this study was to examine cancer patients' use of, perceived benefits, and beliefs about herbs and spices after their cancer diagnosis.

Methods: An online questionnaire was used to explore types of herbs and spices used by cancer patients and assess cancer patients' experiences with, and perceived benefits of, and beliefs about spice and herb use. The online questionnaire included three sections: herb and spice use, herb and spice attitudes, and cancer characteristics and demographics. Participants were recruited through online cancer groups and registered dietitian nutritionists.

Results: The study included 135 cancer patients. Participants (71.9%) were likely …

A Review Of Expanding Literate Landscapes: Persons, Practices, And Sociohistoric Perspectives Of Disciplinary Development By Kevin Roozen And Joe Erickson, Brian Hendrickson

Arts & Sciences Faculty Publications

No abstract provided.

Comparing Primary And Lntermediate Elementary Trade Books’ Historical Representation Of George Washington, Maria Anita Penn

Masters Theses

As teachers learn to adjust to the Common Core State Standards, they are left with little to no time for subjects like science and social studies. History is slowly falling by the wayside in elementary classrooms across the country, including the studies of the people who helped shape our nation. This study analyzes a data sample of 32 primary and intermediate level trade books about George Washington, our first president, in search of patterns and misrepresentations. Within the findings, patterns of omission and spiraling were seen across the board. This study allows teachers to see the importance of teaching history …

Effects Of Main-Stem Impoundments On Hydrology And Larval Fish Communities In Major Tributaries Of Two Large Midwestern Rivers, Jordan Pesik

Masters Theses

Anthropogenic modifications, like impoundments, have altered natural environmental conditions in most lotic systems and impacted fish ecology in many ways. We examined the effect of large river impoundments on fish reproductive behavior by studying the larval fish communities in tributaries of the impounded Illinois and unimpounded Wabash Rivers. We hypothesized that larval fish communities would be similar between the geographically proximal systems, but temporal structuring would depend largely on flow regimes. Biweekly larval densities were greatest among all taxa in the Wabash system, though overall communities were similar between systems. Of the six tributaries, the four smallest rivers were most …

Co-Product Potential Of Algae Biocake, Elizabeth J. Nixon

Masters Theses

Society needs to find replacements for fossil fuels, which are finite resources that may be fully depleted within a few generations. While solar and wind have great potential as alternative energy sources, they are unlikely to completely replace all of the current fuel sources, particularly liquid fuels. Plant biomass has great potential for this market, and is already used in many forms for heat energy (e.g. direct combustion). However, the bulk density of important bioenergy crops, particularly grasses, is often low, which necessitates the use of binders in densification strategies. In the present study, waste algae biocake from a proprietary …

Reproductive Health And Morphometric Comparison Of Catostomid Species In Two Midwestern Rivers, Bethany Ellen Hoster

Masters Theses

Wastewater treatment effluent, agricultural runoff, and impoundments can alter the water quality and flow regime of rivers. Fishes around the world are increasingly exposed to estrogenic compounds due to the discharge of wastewater into rivers. Estrogenic compounds, such as those found in birth control pills and soybean byproducts, are endocrine disruptors in vertebrates. The Sanitary District of Decatur serves the municipal and industrial entities of Macon County, IL, and discharges its effluent into the Sangamon River, which includes byproducts of industrial soybean processing. I assessed impacts of treated wastewater on the health of fishes in the Sangamon River. Abnormal caudal …

Distiphallus Morphology And Its Role In Copulation Dynamics In Anastrepha Suspensa (Loew), Taylor J. Inboden

Masters Theses

Anastrepha suspensa (Diptera; Tephritidae) is an agricultural pest species causing severe economic damage and is controlled, in part, by applying knowledge of this species' reproduction (e.g., disrupting fertile copulations by SIT). During copulation, males transfer sperm as well as protein rich fluids through an aedeagus and distiphallus, which females then store in three spermathecae and one ventral receptacle. Within the female reproductive tract, the ventral receptacle and the three spermathecae are strategically separated from each other. I hypothesized males' ability to direct sperm transfer within the female reproductive tract is through the structures found in the distiphallus. Utilizing scanning electron …

Only In It For The News: Satire Television Pilot Critiquing The Structure Of Television News, Dakota Pruemer

Masters Theses

Televisual satire news is currently a way for the creators of the programming to critique what is being said in broadcast news media. I think that satire should go a step further and also critique how broadcast news media works. In order to do this, I created a television pilot that breaks the paradigm in which television news operates. Only in it for the News is a creative thesis that incorporates communication and media theory with production techniques to create a television pilot that critiques television news and provides an alternative approach to how television satire is typically presented. The …

Ruina, Jacob Nolt

School of Art Graduate Exhibitions, Portfolios, and Theses

No abstract provided.

Dwine, Michael A. Lake

School of Art Graduate Exhibitions, Portfolios, and Theses

No abstract provided.

Tides, Isa N. Gagarin

Theses and Dissertations

My artistic practice creates relationships between the abstract and the personal. I define the abstract in the context of my studio work as a material exploration of color and form. The personal encompasses autobiography in relation to my sense of time and place. In this text, I use my concept of oceanic tides (considered as a temporal and spatial shift between states) to chart my activities as an artist. These activities include making objects that change in character over time, and durational work including performance and video. Interwoven throughout Tides are narrative passages based on my personal experiences, including witnessing …

Lorcaserin As A Potential Opioid-Sparing Adjunct, Kumiko M. Lippold

Theses and Dissertations

Opioids, such as oxycodone, morphine, and fentanyl, are commonly used medications in the treatment of moderate to severe pain. In spite of their efficacious analgesic properties, their increased prescribing rates by physicians and inherent abuse-related effects have led to the ongoing opioid epidemic. Their clinical utility is limited by the risk of adverse dose-dependent side effects, such as constipation and respiratory depression, and the development of tolerance and dependence. Opioid-sparing adjunctive therapies are sought to address these issues by reducing the dose of opioid needed to achieve analgesia through alternative non-opioidergic mechanisms and as a result, reduce the incidence of …