Digital Commons Network^™

Increased Ca2+ Signaling Through Cav1.2 Promotes Bone Formation And Prevents Estrogen Deficiency-Induced Bone Loss, Chike Cao, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, Amy L. Mcnulty, Farshid Guilak, Courtney M. Karner, Matthew J. Hilton, Geoffrey S. Pitt

Open Access Publications

While the prevalence of osteoporosis is growing rapidly with population aging, therapeutic options remain limited. Here, we identify potentially novel roles for CaV1.2 L-type voltage-gated Ca2+ channels in osteogenesis and exploit a transgenic gain-of-function mutant CaV1.2 to stem bone loss in ovariectomized female mice. We show that endogenous CaV1.2 is expressed in developing bone within proliferating chondrocytes and osteoblasts. Using primary BM stromal cell (BMSC) cultures, we found that Ca2+ influx through CaV1.2 activates osteogenic transcriptional programs and promotes mineralization. We used Prx1-, Col2a1-, or Col1a1-Cre drivers to express an inactivation-deficient CaV1.2 mutant in chondrogenic and/or osteogenic precursors in vivo …

The Synthesis Of A Novel Bibenzopyran Relied On Electrooxydation Of Malloapelta B By Cyclic Voltammetry, Binh Phan Thi, Ninh Bui Hai, Minh Chau Van, Nam Nguyen Hoai, Huong Le Mai, Kiem Phan Van

ASEAN Journal on Science and Technology for Development

A novel bibenzopyran named bimalloapelta (1) was synthesized relying on electrooxydation of malloapelta B by cyclic voltammetry in acetonitril adding LiClO4 0.1 M as supporting electrolyte. Its structure determination based on extensive NMR studies and ESI mass spectral measurements. The new compound showed significant cytotoxicity againsts two cancer cell lines as human hepatocellular carcinoma (Hep-2; IC50: 0.46 µg/m) and rhabdosarcoma (RD; IC50: 0.33 µg/m). These results were the same that of malloapelta B (Hep-2, IC50: 0.49 µg/ml and KB, IC50: 0.54 µg/ml).

Chanticleer | November 16, 2017, Jacksonville State University

Chanticleer

No abstract provided.

Hawks' Herald -- Nov. 16, 2017, Roger Williams University

Hawk's Herald

No abstract provided.

@Potus: Rethinking Presidential Immunity In The Time Of Twitter, Douglas B. Mckechnie

University of Miami Law Review

President Donald Trump’s use of Twitter portends a turning point in presidential communication. His Tweets animate his base and enrage his opponents. Tweets, however, like any form of communication, can ruin reputations. In Nixon v. Fitzgerald, the Supreme Court determined that a president retains absolute immunity for all actions that fall within the “outer perimeter” of his official duties. This Article explores the “outer perimeter” of presidential immunity. It suggests the First, Fifth, and Fourteenth Amendments inform the demarcation of the “outer perimeter,” and that when a president engages in malicious defamation, his speech falls outside this perimeter and …

Patterns In Abundance Of Louisiana’S Avifauna Revealed By The Louisiana Bird Atlas Project, Matthew L. Brady

LSU Master's Theses

The Louisiana Bird Atlas Project is a multi-year citizen science effort designed to quantify bird distribution and abundance for all species regularly occurring in the state of Louisiana during two time periods: summer and winter. Data were collected by volunteers in a citizen science framework across eight years, from 2007 to 2014. A total of 351 species was recorded (254 during the Summer Bird Atlas and 315 during the Winter Bird Atlas). Maps showing distribution and relative abundance for each species were generated within a Geographical Information System, and were accompanied by short descriptions of status, distribution, abundance, and other …

High-Throughput Droplet Barcoding And Automated Image Analysis In Microfluidic Droplet Trapping Array, Manibarathi Vaithiyanathan

LSU Master's Theses

Molecularly-targeted therapeutics and personalized medicine have dramatically increased the median survival rate of patients suffering from cancer. However, cellular heterogeneity and the personalized nature of cancer have resulted in the limited success of single drug treatments which has led to the use of multiple therapeutic combinations. This has required the development of new analytical methods capable of multiplexed high-throughput screening (HTS) technologies necessary to identify is single or multi-agent therapies are effective in ex vivo samples like liquid biopsies. Droplet microfluidic devices have garnered significant interest to facilitate high-throughput, single cell analysis of heterogeneous populations. However, these devices are still …

A Study Of The Urban Red Fox (Vulpes Vulpes) Population In Baton Rouge, Louisiana Using Social Media, Ahsennur Soysal

LSU Master's Theses

Foxes are timid yet resourceful animals that are integrated into many urban environments. Because they are elusive, collecting information about the number of urban foxes, their diet and spatial distribution, their interactions with the ecological community in their urban habitat, as well as residents’ response to them, is difficult. Involving stakeholders to participate in the data collection on wildlife via citizen science on social media is one way to overcome this complication, while simultaneously engaging residents in the ecology happening around them. Therefore, we used social media as the platform to engage the public to document and map the foxes …

Protein Tyrosine Signaling And Its Potential Therapeutic Implications In Carcinogenesis, Mihwa Kim, Minwoo Baek, Dae Joon Kim

School of Medicine Publications

Protein tyrosine phosphorylation is a crucial signaling mechanism that plays a role in epithelial carcinogenesis. Protein tyrosine kinases (PTKs) control various cellular processes including growth, differentiation, metabolism, and motility by activating major signaling pathways including STAT3, AKT, and MAPK. Genetic mutation of PTKs and/or prolonged activation of PTKs and their downstream pathways can lead to the development of epithelial cancer. Therefore, PTKs became an attractive target for cancer prevention. PTK inhibitors are continuously being developed, and they are currently used for the treatment of cancers that show a high expression of PTKs. Protein tyrosine phosphatases (PTPs), the homeostatic counterpart of …

Managing Cities As Urban Ecosystems: Fundamentals And A Framework For Los Angeles, California, Isaac T. Brown

Cities and the Environment (CATE)

Ecosystem-based frameworks offer a robust platform for managing complex ecological challenges associated with land management. Actionable frameworks for urban ecosystems are just emerging, and the purpose of this essay is to support advancing application in city management contexts. Comprehensive urban ecosystem frameworks have the potential to synergize interrelated, yet often siloed, urban environmental management themes including urban biodiversity and natural features, pollution management, ecosystem services enhancement, and natural hazards; particularly as urban sustainability, resiliency, and infrastructure initiatives increasingly reshape cities and elevate consideration of these topics. This essay begins with a review of fundamentals of urban ecosystems across multiple relevant …

Climate Change Adaptation In Mediterranean Cities: An Introduction To The Special Issue, W. Bowman Cutter, Barbara Norman, Eric G. Strauss

Cities and the Environment (CATE)

Given the highly developed nature of Mediterranean regions and their importance in global trade and migration, it is crucial to develop comprehensive solutions for climate change. The widespread societal impacts of climate change add urgency towards transdisciplinary and transnational solutions for climate change adaptation.

We represent the Mediterranean Climate Change Consortium (MC-4), an international network of scholars, policy makers, and practitioners working towards climate change adaptation in cities with Mediterranean climates. Our proposition is that areas with similar, Mediterranean, climates will have more climate adaptation lessons to share with each other than areas with distinctly different climates. As a step …

Quaternary Sea-Level History And The Origin Of The Northernmost Coastal Aeolianites In The Americas: Channel Islands National Park, California, Usa, Daniel R. Muhs, Jeffrey S. Pigati, R. Randall Schumann, Gary L. Skipp, Naomi Porat, Stephen B. Devogel

United States Geological Survey: Staff Publications

Along most of the Pacific Coast of North America, sand dunes are dominantly silicate-rich. On the California Channel Islands, however, dunes are carbonate-rich, due to high productivity offshore and a lack of dilution by silicate minerals. Older sands on the Channel Islands contain enough carbonate to be cemented into aeolianite. Several generations of carbonate aeolianites are present on the California Channel Islands and represent the northernmost Quaternary coastal aeolianites on the Pacific Coast of North America. The oldest aeolianites on the islands may date to the early Pleistocene and thus far have only been found on Santa Cruz Island. Aeolianites …

Multiple Species Of Cuckoos Are Superior Predictors Of Bird Species Richness In Asia, Anders Pape Møller, Federico Morelli, Yanina Benedetti, Timothy Mousseau, Tongping Su, Bo Zhou, Piotr Tryjanowski, Wei Liang

Faculty Publications

The abundance and the presence of common cuckoos Cuculus canorus have been shown to predict species richness of birds across Europe, while there are no such analyses available for other continents where species richness of parasitic cuckoos is larger. Here, we tested whether species richness of birds increased with the number of cuckoo species in two study areas in China and one in Japan. We also tested whether species richness of birds can be predicted by the number of cuckoo individuals. Furthermore, we compared the strength of association between overall bird species richness and species richness of cuckoos, Paridae, Corvidae, …

State V. Taylor Appellant's Brief Dckt. 45217

Not Reported

No abstract provided.

Growth And Development Of Two Broiler Strains With Low Protein And Crystalline Amino Acid Supplemented Diets, Chaoyang Li

LSU Master's Theses

The objective of this research was to compare the growth performance of broilers from two commercial breeds with control, low protein and low protein supplemented with crystalline amino acids diets. This was a randomized block design, and identical experiments were conducted on successively in two years. In each experiment, day-old chicks, Ross 708 broilers and Cobb 405 broilers, were randomly assigned into three dietary treatments: 1) positive control, 2) low crude protein (LP), and 3) LP + crystalline amino acids (CAA). A three phase feeding program was used. Feed and water were provided ad-libitum. On d 12, 19, 26, 33, …

Spartan Daily, November 16, 2017, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2017

Volume 149, Issue 37

Evaluation Of A Microsphere-Based Immunoassay (Mia) In Measuring Diagnostic And Prognostic Markers Of Dengue Virus Infection, Jason H. Ambrose

USF Tampa Graduate Theses and Dissertations

Infections with dengue viruses (DENV) constitute both a global problem as well as locally in Florida. DENV comprise four distinct serotypes of single-stranded RNA viruses and belong to the family Flaviviridae. DENV are among the most medically important arboviruses in the world and cases may currently exceed 400 million per annum. Additionally, dengue established its first recorded endemic transmission cycle in the state of Florida in over a half century, first within the Florida Keys during 2009-10 followed by an unrelated outbreak in Martin County in 2013. The clinical profile of DENV infections ranges from a mild febrile illness …

Ecological Epigenetics Of Avian Range Expansions, Holly J. Kilvitis

USF Tampa Graduate Theses and Dissertations

In light of human-mediated environmental change, a fundamental goal for biologists is to determine which phenotypic characteristics enable some individuals, populations or species to be more adept at coping with such change, while rendering others more vulnerable. Studying ongoing range expansions provide a unique opportunity to address this question by allowing documentation of how novel environments shape phenotypic variation on ecological timescales. At range-edges, individuals are exposed to strong selective pressures and population genetic challenges (e.g. bottlenecks and/or founder effects), which make genetic adaptation difficult. Nevertheless, certain species, such as the house sparrow (Passer domesticus), seem to thrive in their …

Design, Synthesis, Applications Of Polymers And Dendrimers, Alekhya Nimmagadda

USF Tampa Graduate Theses and Dissertations

WHO has reported that antibiotic resistance is the third major cause of human death all over the globe. Recent study, has focused on the development of new antibacterial resistance drugs. Herein, we tried to synthesis a series of polymers that can mimic the HDPs. HDPs can target the bacterial cell membrane and they have less chances to develop bacterial resistance. We synthesized the amphiphilic polycarbonates that are highly selective to Gram-positive bacteria, including multidrug resistant pathogens. The membrane disruption activity of these polymers was proved by fluorescence and TEM studies and the drug resistance study showed that the polymers don’t …

Ambient Ozone And Cadmium As Risk Factors For Congenital Diaphragmatic Hernia, Rema Ramakrishnan

USF Tampa Graduate Theses and Dissertations

Congenital diaphragmatic hernia (CDH) results from a defect in the diaphragm through which abdominal contents enter the thorax displacing the heart and the lungs. This causes lung hypoplasia and varying degrees of pulmonary hypertension resulting in high rates of morbidity and mortality. Though CDH has a prevalence rate of 2.61 per 10,000 live births it is an expensive birth defect with an estimated annual cost of nearly $250 million for all CDH survivors. Maternal exposure to air pollutants have not been studied as risk factors for CDH in humans. Ambient ozone has been found to be risk factors for certain …

Contributions Of Appetitive And Aversive Motivational Systems To Decision-Making, Heather E. Soder

USF Tampa Graduate Theses and Dissertations

Optimal decision-making entails outcome evaluation, comparing received costs and benefits with predicted costs and benefits. The anterior cingulate cortex (ACC), a brain area with major connections to the appetitive and aversive motivation systems, may provide the neural substrate of this evaluation process. One way to measure the relative contribution of these systems on decision-making is to measure individual differences in risk-taking behaviors. For individuals who make risky choices, this evaluation step may be biased: some show a preference for immediate, short-term rewards (increased appetitive system), while devaluing the long-term consequences of their choices (decreased aversive system). However, most studies supporting …

Design And Synthesis Of Cpg-Lytic Peptide Conjugate, Brachytherapy Beads And A Combinatorial Library Of Primary Amines Used As Potential Therapeutics In The Treatment Of Cancers, Josanne-Dee Woodroffe

USF Tampa Graduate Theses and Dissertations

Cancer remains one of the most feared diseases affecting the modern world. Second to heart disease, it is the largest cause of deaths, affecting one in three persons. Cancer cells are formed when normal, healthy cells become damage, losing their normal regulatory mechanism that control cell growth. There are many different types and progression of these cancer cells that determine the type of treatment a patient receives. The primary focus of this dissertation is to propose three studies of anticancer agents. In Chapter one, a CpG-lytic peptide conjugate was designed to target receptors on the cell membrane to concentrate the …

Optical Studies Of Penicillin Group In Relation To Their Medical Activity, Kumar R. Jeevan, Prasad G.V.R., Shoaib S.Md., Devadanam G. Paul, Fakruddin K.

ASEAN Journal on Science and Technology for Development

The study of Medical activity of antibiotics is gaining momentum now a days owing to the importance of their curative values. The Medical Activity correlated to molecular interactions,can be studied by various physical techniques, at present optical methods like Refractometry and Polarization are used to study the activity of a few antibiotics like Penicillin. The Refractive Indices Mean Molecular Polarizability Diamagnetic Susceptibilities and Electron Ionisation Cross Section are interpreted in terms of dosages and the toxic effects if any due to over dosages are discussed critically.

November 16, 2017, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Role Of Genetic, Dietary And Lifestyle Factors In Pediatric Metabolic Syndrome: A Review Of The Literature From Prenatal To Adolescence, Teresa Arora, Sahar Agouba, Ahmad Sharara, Shahrad Taheri

All Works

The metabolic syndrome (MetS) is described as a cluster of health conditions that are associated with an increased risk of cardiovascular disease. The clinical diagnosis of MetS in pediatrics is challenging due to differing criteria, although the estimated prevalence continues to rise. The increased prevalence of childhood obesity and insulin resistance, in both developed and developing countries, is believed to be a major contributor to MetS diagnosis in children. We review the current literature surrounding genetic predisposition, maternal influence, epigenetics, environmental and lifestyle factors pertaining to pediatric MetS with a specific emphasis on obesity and insulin resistance. We highlight and …

Linking Taxonomic Diversity And Trophic Function: A Graph-Based Theoretical Approach, Marcella M. Jurotich, Kaitlyn Dougherty, Barbara Hayford, Sally Clark

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The purpose of this study is to develop a novel, visual method in analyzing complex functional trait data in freshwater ecology. We focus on macroinvertebrates in stream ecosystems under a gradient of habitat degradation and employ a combination of taxonomic and functional trait diversity analyses. Then we use graph theory to link changes in functional trait diversity to taxonomic richness and habitat degradation. We test the hypotheses that: 1) taxonomic diversity and trophic functional trait diversity both decrease with increased habitat degradation; 2) loss of taxa leads to a decrease in trophic function as visualized using a bipartite graph; and …

Please Expect Turbulence: Liability For Communicable Disease Transmission During Air Travel, Kathryn Brown

DePaul Law Review

No abstract provided.

Silent Protest: A Catholic Justice Dissents In Buck V. Bell, Phillip Thompson

The Catholic Lawyer

No abstract provided.

About Logan Weihe And Beloved Microcosm, Logan M. Weihe

Steeplechase: An ORCA Student Journal

No abstract provided.

Pam-1 Localizations In The Regulation Of Autophagy During Caenorhabditis Elegans Oogenesis, Ashley N. Munie

Steeplechase: An ORCA Student Journal

Autophagy, the cell's recycling system, is a highly-conserved survival mechanism of the cell. Autophagy has been implicated in the mediation of the removal of cytotoxic aggregates, such as those linked to neurodegenerative disorders like Huntington and Alzheimer disease. Studies in several model organisms have identified numerous genes involved in mediating autophagy, including the Puromycin sensitive aminopeptidase (Psa). The Caenorhabditis elegans orthologue of Psa, pam-1, also governs fertility. Along with apoptosis, a form of regulated cell death, autophagy has been found to be required for efficient C. elegans oogenesis. When autophagy is suppressed through RNAi in worms harboring …