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2017

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Species Distributions Models In Wildlife Planning: Agricultural Policy And Wildlife Management In The Great Plains, Joseph J. Fontaine, Christopher F. Jorgensen, Erica F. Stuber, Lutz F. Gruber, Andrew A. Bishop, Jeffrey J. Lusk, Eric S. Zach, Karie L. Decker Jan 2017

Species Distributions Models In Wildlife Planning: Agricultural Policy And Wildlife Management In The Great Plains, Joseph J. Fontaine, Christopher F. Jorgensen, Erica F. Stuber, Lutz F. Gruber, Andrew A. Bishop, Jeffrey J. Lusk, Eric S. Zach, Karie L. Decker

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

We know economic and social policy has implications for ecosystems at large, but the consequences for a given geographic area or specific wildlife population are more difficult to conceptualize and communicate. Species distribution models, which extrapolate species-habitat relationships across ecological scales, are capable of predicting population changes in distribution and abundance in response to management and policy, and thus, are an ideal means for facilitating proactive management within a larger policy framework. To illustrate the capabilities of species distribution modeling in scenario planning for wildlife populations, we projected an existing distribution model for ring-necked pheasants (Phasianus colchicus) onto …


Protected Areas As Social-Ecological Systems: Perspectives From Resilience And Social-Ecological Systems Theory, Graeme S. Cumming, Craig R. Allen Jan 2017

Protected Areas As Social-Ecological Systems: Perspectives From Resilience And Social-Ecological Systems Theory, Graeme S. Cumming, Craig R. Allen

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Conservation biology and applied ecology increasingly recognize that natural resource management is both an outcome and a driver of social, economic, and ecological dynamics. Protected areas offer a fundamental approach to conserving ecosystems, but they are also social-ecological systems whose ecological management and sustainability are heavily influenced by people. This editorial, and the papers in the invited feature that it introduces, discuss three emerging themes in social-ecological systems approaches to understanding protected areas: (1) the resilience and sustainability of protected areas, including analyses of their internal dynamics, their effectiveness, and the resilience of the landscapes within which they occur; (2) …


A Bayesian Method For Assessing Multi-Scale Species-Habitat Relationships, Erica F. Stuber, Lutz F. Gruber, Joseph J. Fontaine Jan 2017

A Bayesian Method For Assessing Multi-Scale Species-Habitat Relationships, Erica F. Stuber, Lutz F. Gruber, Joseph J. Fontaine

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Context Scientists face several theoretical and methodological challenges in appropriately describing fundamental wildlife-habitat relationships in models. The spatial scales of habitat relationships are often unknown, and are expected to follow a multi-scale hierarchy. Typical frequentist or information theoretic approaches often suffer under collinearity in multiscale studies, fail to converge when models are complex or represent an intractable computational burden when candidate model sets are large.

Objectives Our objective was to implement an automated, Bayesian method for inference on the spatial scales of habitat variables that best predict animal abundance.

Methods We introduce Bayesian latent indicator scale selection (BLISS), a Bayesian …


Reframing Communication About Zika And Mosquitoes To Increase Disease Prevention Behavior, Amanda E. Sorensen, Rebecca C. Jordan, Shannon Ladeau Jan 2017

Reframing Communication About Zika And Mosquitoes To Increase Disease Prevention Behavior, Amanda E. Sorensen, Rebecca C. Jordan, Shannon Ladeau

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Emergence of invasive vector species and the diseases they carry present a clear danger to the public as well as a challenge for scientists and experts to control effectively. Given the urgent need to address this phenomenon, we suggest that desired public action toward these invasive vectors can be motivated through intentional framing in science communication. In this paper, we sought to evaluate the effect of framing about ZIKV (Zika virus) on reported willingness to comply with mosquito prevention action. Post framing intervention, we found a significant increase (N = 26, p < 0.001) in individuals willing to take preventative action against mosquitoes. By methodically investigating best communication practices, this study and others can help practitioners mobilize communities to address large-scale ecological problems. Additionally, the principles outlined here may be transferrable to other communication efforts about ecological issues outside of ZIKV and mosquitoes.


What Do Undergraduate Students Know About Scholarly Communication? A Mixed Methods Study, Catherine Fraser Riehle, Merinda Kaye Hensley Jan 2017

What Do Undergraduate Students Know About Scholarly Communication? A Mixed Methods Study, Catherine Fraser Riehle, Merinda Kaye Hensley

University of Nebraska-Lincoln Libraries: Faculty Publications

Amid movements that recognize undergraduate students as knowledge creators, transformative work is being done at the intersection of information literacy and scholarly communication. Absent from the literature so far is research related to students’ perception and understanding of scholarly communication. This paper reports a mixed methods study at two major research universities in the United States, where undergraduate student researchers were surveyed and interviewed about their scholarly communication practices and perceptions. This work informs development of programming at the intersection of scholarly communication and information literacy in general, and for those involved with undergraduate research experiences in particular.


List Of Contributors Jan 2017

List Of Contributors

Textile Terminologies from the Orient to the Mediterranean and Europe, 1000 BC to 1000 AD

The 42 contributors include Salvatore Gaspa, Cécile Michel, Marie-Louise Nosch, Elena Soriga, Louise Quillien, Luigi Malatacca, Nahum Ben-Yehuda, Christina Katsikadeli, Orit Shamir, Agnes Korn, Georg Warning, Birgit Anette Olsen, Stella Spantidaki, Peder Flemestad, Peter Herz, Ines Bogensperger, Herbert Graßl, Mary Harlow, Berit Hildebrandt, Magdalena Öhrman, Roland Schuhmann, Kerstin Droß-Krüpe, John Peter Wild, Maria Mossakowska-Gaubert, Julia Galliker, Anne Regourd, Fiona J. L. Handley, Götz König, Miguel Ángel Andrés-Toledo, Stefan Niederreiter, Oswald Panagl, Giovanni Fanfani, Le Wang, Feng Zhao, Mari Omura, Naoko Kizawa, Maciej Szymaszek, Francesco Meo, Felicitas Maeder, Kalliope Sarri, Susanne Lervad, and Tove Engelhardt Mathiassen.


Developing An Innovative Entity Extraction Method For Unstructured Data, Waleed A. Zaghloul, Silvana Trimi Jan 2017

Developing An Innovative Entity Extraction Method For Unstructured Data, Waleed A. Zaghloul, Silvana Trimi

Department of Management: Faculty Publications

The main goal of this study is to build high-precision extractors for entities such as Person and Organization as a good initial seed that can be used for training and learning in machine-learning systems, for the same categories, other categories, and across domains, languages, and applications. The improvement of entities extraction precision also increases the relationships extraction precision, which is particularly important in certain domains (such as intelligence systems, social networking, genetic studies, healthcare, etc.). These increases in precision improve the end users’ experience quality in using the extraction system because it lowers the time that users spend for training …


Nebraska Game And Parks Commission 2017 Annual Report Jan 2017

Nebraska Game And Parks Commission 2017 Annual Report

Nebraska Game and Parks Commission: Publications

No abstract provided.


Strengthening Links Between Waterfowl Research And Management, Anthony Roberts, John M. Eadie, David W. Howerter, Fred A. Johnson, James D. Nichols, Michael C. Runge, Mark P. Vrtiska, Byron K. Williams Jan 2017

Strengthening Links Between Waterfowl Research And Management, Anthony Roberts, John M. Eadie, David W. Howerter, Fred A. Johnson, James D. Nichols, Michael C. Runge, Mark P. Vrtiska, Byron K. Williams

Nebraska Game and Parks Commission: Staff Research Publications

Waterfowl monitoring, research, regulation, and adaptive planning are leading the way in supporting science-informed wildlife management. However, increasing societal demands on natural resources have created a greater need for adaptable and successful linkages between waterfowl science and management. We presented a special session at the 2016 North American Duck Symposium, Annapolis, Maryland, USA on the successes and challenges of linking research and management in waterfowl conservation, and we summarize those thoughts in this commentary. North American waterfowl management includes a diversity of actions including management of harvest and habitat. Decisions for waterfowl management are structured using decision analysis by incorporating …


Implementing The 2012 North American Waterfowl Management Plan Revision: Populations, Habitat, And People, Dale D. Humburg, Michael G. Anderson, Michael G. Brasher, Michael F. Carter, John M. Eadie, David C. Fulton, Fred A. Johnson, Michael C. Runge, Mark P. Vrtiska Jan 2017

Implementing The 2012 North American Waterfowl Management Plan Revision: Populations, Habitat, And People, Dale D. Humburg, Michael G. Anderson, Michael G. Brasher, Michael F. Carter, John M. Eadie, David C. Fulton, Fred A. Johnson, Michael C. Runge, Mark P. Vrtiska

Nebraska Game and Parks Commission: Staff Research Publications

The North American Waterfowl Management Plan (NAWMP) has established a model for wildlife conservation planning over the last 3 decades. Management at a continental scale, leveraged funding, regional partnerships, and a strong science basis have been notable features. Periodic updates to the NAWMP occurred since implementation in 1986; however, a fundamental revision was accomplished in 2012 after extensive stakeholder engagement. An explicit fundamental goal for waterfowl conservation supporters was added in 2012, complementing existing goals for sustainable populations and sufficient habitat found in previous updates. We present a synopsis of progress toward implementation of the 2012 NAWMP and challenge the …


The Nebraska Stream Fishery Surveys: Being A Comparison Of The First Statewide Collections Of Raymond Johnson (1939-1941) With A Recent Resurvey (2003-2005), Steven C. Schainost, Edward J. Peters Jan 2017

The Nebraska Stream Fishery Surveys: Being A Comparison Of The First Statewide Collections Of Raymond Johnson (1939-1941) With A Recent Resurvey (2003-2005), Steven C. Schainost, Edward J. Peters

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The first statewide survey of Nebraska fishes was done between 1939 and 1941. This survey was repeated between 2003 and 2005. This document compares and contrasts the results of those two surveys to illustrate what has changed and what hasn't changed over that 60 year period. It is hoped that this document can serve as a resource for future researchers to track changes in Nebraska's fish communities.


Five Species Of Fossil Equids Preserved In-Situ At Ashfall Fossil Beds, Rick E. Otto Jan 2017

Five Species Of Fossil Equids Preserved In-Situ At Ashfall Fossil Beds, Rick E. Otto

University of Nebraska State Museum: Programs Information

Fully articulated, three-dimensionally preserved skeletons from five species of fossil Equids are now represented, and preserved in-situat the Ashfall Fossil Beds in northcentral Nebraska. The site is well known for dozens of barrel-bodied rhino (Teleoceras major) skeletons. A diversity of horse species that inhabited Nebraska during the late Miocene Epoch have been exposed in the fossil bed. Genera include Cormohipparion, Neohipparon, Pliohippus, Protohippus, and Pseudhipparion. An exceptionally well-preserved skeleton of the small-sized, three-toed species Pseudhipparion gratumwas recently exposed, and is on display only a few feet from where visitors stand.


Climate Science Special Report: Fourth National Climate Assessment (Nca4), Volume I Jan 2017

Climate Science Special Report: Fourth National Climate Assessment (Nca4), Volume I

National Oceanographic and Atmospheric Administration: Technical Reports and Related Materials

This report is an authoritative assessment of the science of climate change, with a focus on the United States. It represents the first of two volumes of the Fourth National Climate Assessment, mandated by the Global Change Research Act of 1990.

Credits

Jump to:

Writing Team

Coordinating Lead Authors

  • Donald J. Wuebbles National Science Foundation and U.S. Global Change Research Program – University of Illinois
  • David W. Fahey NOAA Earth System Research Lab
  • Kathy A. Hibbard NASA Headquarters

Lead Authors …


Decision Tree And Random Forest Methodology For Clustered And Longitudinal Binary Outcomes, Jaime Lynn Speiser Jan 2017

Decision Tree And Random Forest Methodology For Clustered And Longitudinal Binary Outcomes, Jaime Lynn Speiser

MUSC Theses and Dissertations

Clustered binary outcomes are frequently encountered in medical research (e.g. longitudinal studies). Generalized linear mixed models (GLMMs) typically employed for clustered endpoints have challenges for some scenarios (e.g. high dimensional data). In the first dissertation aim, we develop an alternative, data-driven method called Binary Mixed Model (BiMM) tree, which combines decision tree and GLMM. We propose a procedure akin to the expectation maximization algorithm, which iterates between developing a classification and regression tree using all predictors and developing a GLMM which includes indicator variables for terminal nodes from the tree as predictors along with a random effect for the clustering …


Assessing Soil Structural Quality Under Brazilian Sugarcane Expansion Areas Using Visual Evaluation Of Soil Structure (Vess), Maurício R. Cherubin, André L.C. Franco, Rachel M.L. Guimarães, Cássio A. Tormena, Carlos E. P. Cerri, Douglas Karlen, Carlos C. Cerri Jan 2017

Assessing Soil Structural Quality Under Brazilian Sugarcane Expansion Areas Using Visual Evaluation Of Soil Structure (Vess), Maurício R. Cherubin, André L.C. Franco, Rachel M.L. Guimarães, Cássio A. Tormena, Carlos E. P. Cerri, Douglas Karlen, Carlos C. Cerri

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Increasing global demand for biofuel has accelerated land-use change (LUC) in Brazil, primarily through the planting of sugarcane (Saccharum officinarum) to replace degraded pastures. The intensive mechanization associated with this LUC has increased concerns regarding structural quality of Brazilian tropical soils. Through decades of research focusing on identifying sensitive indicators of soil degradation due to land use and management, the Visual Evaluation of Soil Structure (VESS) method has emerged as a simple, fast, reliable and accurate semi-quantitative approach for assessing soil structure changes. VESS integrates soil properties related to size, strength and porosity of aggregates, and root characteristics …


Recent Advances In Understanding, Diagnosing, And Treating Ovarian Cancer [Version 1; Referees: 3 Approved], Kathryn Mills, Katherine Fuh Jan 2017

Recent Advances In Understanding, Diagnosing, And Treating Ovarian Cancer [Version 1; Referees: 3 Approved], Kathryn Mills, Katherine Fuh

Open Access Publications

No abstract provided.


Photoaffinity Labeling With Cholesterol Analogues Precisely Maps A Cholesterol-Binding Site In Voltage-Dependent Anion Channel-1, Melissa M. Budelier, Wayland W. L. Cheng, Lucie Bergdoll, Zi-Wei Chen, James W. Janetka, Jeff Abramson, Kathiresan Krishnan, Laurel Mydock-Mcgrane, Douglas F. Covey, Julian P. Whitelegge, Alex S. Evers Jan 2017

Photoaffinity Labeling With Cholesterol Analogues Precisely Maps A Cholesterol-Binding Site In Voltage-Dependent Anion Channel-1, Melissa M. Budelier, Wayland W. L. Cheng, Lucie Bergdoll, Zi-Wei Chen, James W. Janetka, Jeff Abramson, Kathiresan Krishnan, Laurel Mydock-Mcgrane, Douglas F. Covey, Julian P. Whitelegge, Alex S. Evers

Open Access Publications

No abstract provided.


In A Randomized Trial In Prostate Cancer Patients, Dietary Protein Restriction Modifies Markers Of Leptin And Insulin Signaling In Plasma Extracellular Vesicles, Erez Eitan, Valeria Tosti, Caitlin N. Suire, Edda Cava, Sean Berkowitz, Beatrice Bertozzi, Sophia M. Raefsky, Nicola Veronese, Ryan Spangler, Francesco Spelta, Maja Mustapic, Dimitrios Kapogiannis, Mark P. Mattson, Luigi Fontana Jan 2017

In A Randomized Trial In Prostate Cancer Patients, Dietary Protein Restriction Modifies Markers Of Leptin And Insulin Signaling In Plasma Extracellular Vesicles, Erez Eitan, Valeria Tosti, Caitlin N. Suire, Edda Cava, Sean Berkowitz, Beatrice Bertozzi, Sophia M. Raefsky, Nicola Veronese, Ryan Spangler, Francesco Spelta, Maja Mustapic, Dimitrios Kapogiannis, Mark P. Mattson, Luigi Fontana

Open Access Publications

No abstract provided.


Postnatal Development Of The Murine Notochord Remnants Quantified By High-Resolution Contrast-Enhanced Microct, Sameer Bhalla, Kevin H. Lin, Simon Y. Tang Jan 2017

Postnatal Development Of The Murine Notochord Remnants Quantified By High-Resolution Contrast-Enhanced Microct, Sameer Bhalla, Kevin H. Lin, Simon Y. Tang

Open Access Publications

No abstract provided.


Circulating Resistin Levels And Risk Of Multiple Myeloma In Three Prospective Cohorts, Loredana Santo, Lauren R. Teras, Graham G. Giles, Stephanie J. Weinstein, Demetrius Albanes, Ye Wang, Ruth M. Pfeiffer, Qing Lan, Nathaniel Rothman, Brenda M. Birmann, Graham A. Colditz, Michael N. Pollak, Mark P. Purdue, Jonathan N. Hofmann Jan 2017

Circulating Resistin Levels And Risk Of Multiple Myeloma In Three Prospective Cohorts, Loredana Santo, Lauren R. Teras, Graham G. Giles, Stephanie J. Weinstein, Demetrius Albanes, Ye Wang, Ruth M. Pfeiffer, Qing Lan, Nathaniel Rothman, Brenda M. Birmann, Graham A. Colditz, Michael N. Pollak, Mark P. Purdue, Jonathan N. Hofmann

Open Access Publications

No abstract provided.


A Phase 2 Study Incorporating Sorafenib Into The Chemotherapy For Older Adults With Flt3-Mutated Acute Myeloid Leukemia: Calgb 11001, Geoffrey L. Uy, Peter Westervelt Jan 2017

A Phase 2 Study Incorporating Sorafenib Into The Chemotherapy For Older Adults With Flt3-Mutated Acute Myeloid Leukemia: Calgb 11001, Geoffrey L. Uy, Peter Westervelt

Open Access Publications

No abstract provided.


Genome Sequence Of Christensenella Minuta Dsm 22607t, Bruce A. Rosa, Kymberlie Hallsworth-Pepin, John Martin, Aye Wollam, Makedonka Mitreva Jan 2017

Genome Sequence Of Christensenella Minuta Dsm 22607t, Bruce A. Rosa, Kymberlie Hallsworth-Pepin, John Martin, Aye Wollam, Makedonka Mitreva

Open Access Publications

No abstract provided.


Weight Of Evidence Evaluation Of A Network Of Adverse Outcome Pathways Linking Activation Of The Nicotinic Acetylcholine Receptor In Honey Bees To Colony Death, Carlie A. Lalone, Daniel L. Villeneuve, Judy Wu-Smart, Rebecca Y. Milsk, Keith Sappington, Kristina V. Garber, Justin Housenger, Gerald T. Ankley Jan 2017

Weight Of Evidence Evaluation Of A Network Of Adverse Outcome Pathways Linking Activation Of The Nicotinic Acetylcholine Receptor In Honey Bees To Colony Death, Carlie A. Lalone, Daniel L. Villeneuve, Judy Wu-Smart, Rebecca Y. Milsk, Keith Sappington, Kristina V. Garber, Justin Housenger, Gerald T. Ankley

United States Environmental Protection Agency: Publications

Ongoing honey bee (Apis mellifera) colony losses are of significant international concern because of the essential role these insects play in pollinating crops. Both chemical and non-chemical stressors have been implicated as possible contributors to colony failure; however, the potential role(s) of commonly-used neonicotinoid insecticides has emerged as particularly concerning. Neonicotinoids act on the nicotinic acetylcholine receptors (nAChRs) in the central nervous system to eliminate pest insects. However, mounting evidence indicates that neonicotinoids also may adversely affect beneficial pollinators, such as the honey bee, via impairments on learning and memory, and ultimately foraging success. The specificmechanisms linking activation …


Atp Binding Cassette Sub-Family Member 2 (Abcg2) And Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation, Mitchell B. Rosen, Susan C. Jeffay, Harriette P. Nichols, Maria R. Hoopes, E. Sidney Hunter Iii Jan 2017

Atp Binding Cassette Sub-Family Member 2 (Abcg2) And Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation, Mitchell B. Rosen, Susan C. Jeffay, Harriette P. Nichols, Maria R. Hoopes, E. Sidney Hunter Iii

United States Environmental Protection Agency: Publications

Background: ATP binding cassette sub-family member 2 (ABCG2) is a welldefined efflux transporter found in a variety of tissues. The role of ABCG2 during early embryonic development, however, is not established. Previous work which compared data from the ToxCast screening program with that from in-house studies suggested an association exists between exposure to xenobiotics that regulate Abcg2 transcription and differentiation of mouse embryonic stem cells (mESC), a relationship potentially related to redox homeostasis.

Methods: mESC were grown for up to 9 days. Pharmacological inhibitors were used to assess transporter function with and without xenobiotic exposure. Proliferation and differentiation were …


Cannabinoid Disposition In Oral Fluid After Controlled Smoked, Vaporized, And Oral Cannabis Administration, Madeleine J. Swortwood, Matthew N. Newmeyer, Maria Andersson, Osama A. Abulseoud, Karl B. Scheidweiler, Marilyn A. Huestis Jan 2017

Cannabinoid Disposition In Oral Fluid After Controlled Smoked, Vaporized, And Oral Cannabis Administration, Madeleine J. Swortwood, Matthew N. Newmeyer, Maria Andersson, Osama A. Abulseoud, Karl B. Scheidweiler, Marilyn A. Huestis

United States Food and Drug Administration: Publications

Oral fluid (OF) is an important matrix for monitoring drugs. Smoking cannabis is common, but vaporization and edible consumption also are popular. OF pharmacokinetics are available for controlled smoked cannabis, but few data exist for vaporized and oral routes. Frequent and occasional cannabis smokers were recruited as participants for four dosing sessions including one active (6.9% Δ9-tetrahydrocannabinol, THC) or placebo cannabis-containing brownie, followed by one active or placebo cigarette, or one active or placebo vaporized cannabis dose. Only one active dose was administered per session. OF was collected before and up to 54 (occasional) or 72 (frequent) h …


Certain Dyes As Pharmacologically Active Substances In Fish Farming And Other Aquaculture Products, Eric Verdon, Wendy C. Andersen Jan 2017

Certain Dyes As Pharmacologically Active Substances In Fish Farming And Other Aquaculture Products, Eric Verdon, Wendy C. Andersen

United States Food and Drug Administration: Publications

The last 40 years have brought enormous changes to the aquaculture industry. The farming of fish and of seafood products has been continuously increasing from 3.9% by weight in 1970 to 36% in 2006 according to theWorld Health Organization (WHO) and Food and Agriculture Organization (FAO) of the United Nations.1 The global trend of aquaculture development gaining importance in total fish supply has remained uninterrupted. Farmed food fish contributed a record 42.2% of the total 158 million tonnes of fish produced by capture fisheries and aquaculture in 2012 (Figure 9.1). This compares with just 13.4% in 1990 and 25.7% …


An Overview Of The Role Of Mathematical Models In Implementation Of Quality By Design Paradigm For Drug Development And Manufacture, Sharmista Chatterjee, Christine M.V. Moore, Moheb M. Nasr Jan 2017

An Overview Of The Role Of Mathematical Models In Implementation Of Quality By Design Paradigm For Drug Development And Manufacture, Sharmista Chatterjee, Christine M.V. Moore, Moheb M. Nasr

United States Food and Drug Administration: Publications

A model is a representation of an underlying physical–chemical phenomenon. In the pharmaceutical industry, mathematical‐based models can be applied at all stages of development, starting with formulation design, continuing through process development and scale‐up, and extending into process monitoring and control of the commercial process. Implementation of models offers many benefits. These include, but are not limited to, (i) enhanced process understanding, (ii) reduction of experimentation cost, and (iii) improvement of productivity and product quality.

Models can be broadly categorized as either qualitative or quantitative. The focus of this chapter is quantitative models. These can be classified into three broad …


The Mechanism Of Cirp In Inhibition Of Keratinocytes Growth Arrest And Apoptosis Following Low Dose Uvb Radiation, Yi Liao, Jianguo Feng, Yi Zhang, Liling Tang, Shiyong Wu Jan 2017

The Mechanism Of Cirp In Inhibition Of Keratinocytes Growth Arrest And Apoptosis Following Low Dose Uvb Radiation, Yi Liao, Jianguo Feng, Yi Zhang, Liling Tang, Shiyong Wu

United States Food and Drug Administration: Publications

UV induces CIRP expression and subsequent Stat3 activation, but the biological function and mechanism of CIRP and Stat3 in mediating UVB-induced skin carcinogenesis have not been fully elucidated. In this study, we demonstrate that CIRP is elevated in all tested melanoma and non-melanoma skin cancer cell lines; and the expression of CIRP is upregulated in keratinocytes after being irradiated with relatively low dose (<5 mJ/cm2), but not high dose (50 mJ/cm2), UVB acutely and chronically. The increased expression of CIRP, either induced by UVB or through overexpression, leads to resistance of keratinocytes to UVB-induced growth arrest and …


Investigations At The Crossroads Of Down Syndrome And Alzheimer’S Disease, Eric Daniel Hamlett Jan 2017

Investigations At The Crossroads Of Down Syndrome And Alzheimer’S Disease, Eric Daniel Hamlett

MUSC Theses and Dissertations

People with Down syndrome (DS) have elevated neuroinflammation early in life and develop neuropathology by the age of twenty. Most individuals with DS go on to develop abnormal dementia and Alzheimer’s disease (AD). This dissertation is focused on biological pathways involved in DS-AD and includes studies in humans with DS and DS mouse models. Locus coeruleus (LC) noradrenergic (NE) neurons decline before other transmitter systems on the path to DS-AD, which leads to increased neuropathology and accelerated memory loss. To investigate the specific roles of LC-NE in DS-AD, designer receptors exclusively activated by designer drugs (DREADDs) were utilized in the …


Sexually Dimorphic Aggression Indicates Male Gray Wolves Specialize In Pack Defense Against Conspecific Groups, Kira A. Cassidy, L. David Mech, Daniel R. Macnulty, Daniel R. Stahler, Douglas W. Smith Jan 2017

Sexually Dimorphic Aggression Indicates Male Gray Wolves Specialize In Pack Defense Against Conspecific Groups, Kira A. Cassidy, L. David Mech, Daniel R. Macnulty, Daniel R. Stahler, Douglas W. Smith

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

Aggression directed at conspecific groups is common among gregarious, territorial species, and for some species such as gray wolves (Canis lupus) intraspecific strife is the leading cause of natural mortality. Each individual in a group likely has different measures of the costs and benefits associated with a group task, such as an aggressive attack on another group, which can alter motivation and behavior. We observed 292 inter-pack aggressive interactions in Yellowstone National Park between 1 April 1995 and 1 April 2011 (>5300 days of observation) in order to determine the role of both sexes, and the influence of pack, …