Digital Commons Network^™

Multiomics Analysis Of Skeletal Muscle Identifies Dysregulation Of Hypoxia-Induced Genes In Peripheral Artery Disease, Ahmed Ismaeel, Emma Fletcher, Evlampia Papoutsi, Nicholas T. Thomas, William T. Bohannon, Iraklis I. Pipinos, Yuan Wen, Dimitrios Miserlis, Panagiotis Koutakis

Physiology Faculty Publications

BACKGROUND: Epigenetic modifications such as DNA methylation play a critical role in hypoxic cell programs. However, no previous studies have investigated the epigenetic regulation of gene expression in peripheral artery disease (PAD), a condition characterized by intermittent ischemia. Our study aims to examine how PAD affects the DNA methylome in skeletal muscle of patients with PAD with intermittent claudication or critical limb ischemia compared with non-PAD controls. METHODS: This was a cross-sectional study evaluating differences in the DNA methylome and transcriptome using reduced representation bisulfite sequencing, and small and bulk RNA sequencing, in skeletal muscle from non-PAD controls, intermittent claudication, …

High-Order Adaptive Solutions For Coupled Fractional Riccati Equations Via Daubechies Redundant Frames, Mutaz Mohammad, Alexander Trounev

Mathematical Modelling and Numerical Simulation with Applications

Coupled fractional Riccati equations play a fundamental role in modeling complex systems with memory effects and anomalous diffusion, frequently arising in engineering, control theory, finance, and quantum mechanics. Their analytical and numerical treatment remains highly challenging due to the nonlocal nature of fractional-order derivatives and the presence of nonlinear coupling terms. This study introduces an adaptive numerical framework that combines the Caputo fractional derivative with redundant Daubechies wavelet frames. The method leverages multi-resolution analysis, compact support, and controlled redundancy to achieve accurate approximation of both localized and global solution features, particularly in scenarios characterized by singular behavior and long-range memory …

Stabilized Weak-Gradient Discontinuous Finite Elements With Optimal Error Estimates For Second-Order Elliptic Pdes, Aymen Laadhari

Mathematical Modelling and Numerical Simulation with Applications

This work introduces an accurate finite element approach employing a new stabilized discrete weak gradient, designed for second-order elliptic problems on arbitrary conforming meshes. We formulate the approach within a discontinuous Galerkin framework and derive a consistent and coercive bilinear form. Appropriate error analysis on a model problem confirms optimal convergence. Building on the core analysis, we extend the method to more challenging settings, including time-dependent heterogeneous scenarios and a biophysically realistic optimal-control model of photobleaching in the budding yeast cell. We further illustrate the versatility of the weak-gradient construction by applying it to an unsteady level-set equation relevant to …

Network Pharmacology And Molecular Docking Analysis Of Nephelium Lappaceum (Rambutan) Compounds As Potential Alternative Treatments For Lung Cancer, Dwi Utami, Muhammad Farid, Rachma Greta Perdana Putri

Makara Journal of Science

Introduction: Lung cancer is characterized by high mortality rates and poor prognosis, further requiring alternative therapies owing to the adverse effects of conventional chemotherapy. Rambutan (Nephelium lappaceum L.) has antimicrobial, antiproliferative, and antioxidant properties and can cure cancer. Method: Compounds from rambutan peel were identified through PubChem and analyzed for physicochemical properties using SwissADME. Target proteins were identified using SuperPred and compared with lung cancer–related proteins from GeneCards via Venny. Protein interactions were examined and visualized using STRING and Cytoscape, respectively. Protein activity was analyzed using WebGestalt, and docking simulations were performed using Autodock 4.2.6. Result: Physicochemical analysis of …

Global Stability And Bifurcation Analysis Of A Predator-Prey Model Involving Allee Effect And Monod-Haldane Functional Response, Resmawan Resmawan, Agus Suryanto, Isnani Darti, Hasan S. Panigoro

Mathematical Modelling and Numerical Simulation with Applications

In this paper, the complexity of the dynamic behavior of the interaction between prey and predator is studied. The predator-prey relationship involves Allee effects and Monod-Haldane functional response. The constructed model has been shown to have validity in several respects, including the existence and uniqueness of the solution, as well as its non-negativity and boundedness. Three equilibrium points, namely trivial, axial, and coexistence points, are found, including their global dynamics using the Lyapunov function together with the LaSalle's invariance principle. The effect of the predation conversion rate causes changes in the dynamic behavior of predators and prey, which is characterized …

Solution Of Fractional Order Diffusion Equations With Clique Neural Network, Merve Zeynep Kaya, Mesut Karabacak, Ercan Çelik

Mathematical Modelling and Numerical Simulation with Applications

In this paper, the clique artificial neural network method is used to solve the fractional diffusion equation, which is a subclass of partial differential equations. The clique neural network architecture is constructed using input, hidden, and output layers. Several degrees of clique polynomials were used as activation functions, and the output layer was obtained by multiplying them with weight coefficients. Subsequently, the optimization equation was derived, and the exact solution, numerical solution, and error function graphs were obtained using a specialized algorithm. Analysis of the results demonstrates that the clique artificial neural network method provides quicker and more accurate results …

Synergistic Modeling Of Hydrogel Gelation Via Time-Delay Dynamics And Machine Learning Algorithms, Mine Babaoglu, Dipesh ., Pankaj Kumar, Jagjit Singh Dhatterwal, Mansoor Alsulami

Mathematical Modelling and Numerical Simulation with Applications

This paper presents an integrated framework in which delay differential equation (DDE) modeling and machine learning (ML) approaches are coupled to study hydrogel formation kinetics, with emphasis on delayed crosslinker addition. Conventional mechanistic models disclose many physical and kinetic complexities of reacting mixtures; they seldom depict the nonlinear and time-evolving complexities inherent in developing polymer networks. To address this, a mathematical model is developed that examines how the insertion of crosslinkers affects system stability and equilibrium. Analytical and numerical results show that delays nearing critical levels cause bifurcation behavior with substantial implications on gelation kinetics. Sophisticated machine learning systems, including …

Dynamics And Optimal Intervention Strategies In A Shigellosis Transmission Model, Mehmet Gümüs, Shewafera Wondimagegnhu Teklu, Kemal Türk

Mathematical Modelling and Numerical Simulation with Applications

This research explores how water treatment contributes to limiting the transmission of Shigellosis, an infection caused by bacteria from the Shigella genus. A mathematical framework is formulated to evaluate the influence of protective strategies and water purification on the spread of the disease. To confirm the model's biological relevance, its well-posedness is investigated. The basic reproduction number $(\mathfrak{R}_0)$, a critical indicator of disease behavior, is derived using the matrix operator method. Findings indicate that if $\mathfrak{R}_01$, the infection persists, with the endemic equilibrium exhibiting local asymptotic stability. A comprehensive cost-effectiveness analysis reveals that combining environmental protection with water treatment represents …

Htlv-1 And Atll: Epidemiology, Oncogenesis, And Opportunities For Community-Informed Research In The United States, Adrian D. Altieri, Sean P. Reilly, Abu Mansalay, Alan Khoo, Nettie Johnson, Zafar K. Khan, Amy Leader, Pooja Jain, Pierluigi Porcu

Kimmel Cancer Center Faculty Papers

Human T-cell leukemia virus type 1 (HTLV-1), the first oncogenic human retrovirus, causes adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm of mature CD4+ T-cells that is incurable in most patients and is associated with a median survival of less than 1 year. HTLV-1 also causes inflammatory disorders, including HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and uveitis. The estimated lifetime risks of ATLL and HAM/TSP in HTLV-1 carriers are 3-5% and 0.25-1.8%, respectively. Although there is uncertainty about other health effects of HTLV-1, a recent meta-analysis showed an association between HTLV-1 and cardiovascular, cerebrovascular, and metabolic diseases and a 57% increased risk …

Ketorolac Use Following Operative Clavicle Fracture Fixation Is Not Associated With Increased Nonunion Or Surgical Complications: A Propensity-Matched Analysis, Tuckerman Jones, Tej Joshi, Akhil Katakam, Daniella Ogilvie, Sefy Paulose, Balazs Galdi

Wills Eye Hospital Papers

OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, are commonly used for postoperative pain management. Concerns about their potential impact on bone healing have been raised. This study investigated the relationship between ketorolac use and postoperative complications following clavicle surgery, including nonunion rates.

METHODS: This retrospective cohort study used the TriNetX Research Database to identify patients who underwent surgical fixation of clavicle fractures between 2002 and 2022. Two propensity-matched cohorts were created: patients who received postoperative ketorolac and those who did not. Primary outcomes included nonunion diagnosis and revision surgery; secondary outcomes included opioid use, wound disruption, surgical site infection, and …

Application Of Dematel Based On Bipolar Neutrosophic Sets For Sustainable Agriculture Practices, Lazim Abdullah, Nor Liyana Amalini Binti Mohd Kamal

Neutrosophic Systems with Applications

The development of natural capital is a fundamental objective within sustainable agricultural systems, where the optimization of both crop and livestock production is vital to addressing global food demands. Despite this imperative, major agricultural sectors such as paddy and rubber production, often fall short of satisfying consumption needs. This study aims to identify and prioritize the most influential criteria for sustainable agriculture using the Bipolar Neutrosophic Set-based Decision-Making Trial and Evaluation Laboratory (BNS-DEMATEL) method. Expert evaluations were elicited from five agricultural specialists using linguistic assessments to analyze the performance and interdependencies among sustainability criteria. Computational analyses were conducted using MATLAB …

The Lived Experiences Of Mothers Facing Phubbing From Their Adolescent Children, Mye Alexis

Walden Dissertations and Doctoral Studies

Widespread use of technology, particularly smartphones, introduced new challenges involving parent–adolescent attachment. Although existing literature primarily examines parental phubbing of adolescents, there is a significant gap in research exploring the experiences of mothers who are phubbed by their adolescent children. To address this gap, the central research question guiding this study was: What are the lived experiences of mothers who have been phubbed by their adolescent (ages 14-18) children? Grounded in Bowlby’s attachment theory, this phenomenological qualitative study aimed to deepen understanding of the emotional impacts of phubbing on mothers’ emotional wellbeing, emotional bonding, and mother–adolescent attachment. A homogeneous convenience …

Cookie-Pro: Covalent Inhibitor Binding Kinetics Profiling On The Proteome Scale, Hanfeng Lin, Bin Yang, Lang Ding, Yen-Yu Yang, Matthew V Holt, Sung Yun Jung, Bing Zhang, Meng C Wang, Jin Wang

Faculty, Staff and Students Publications

Covalent inhibitors are an emerging class of therapeutics, but methods to comprehensively profile their binding kinetics and selectivity across the proteome have been limited. Here we introduce COOKIE-Pro (COvalent Occupancy KInetic Enrichment via Proteomics), an unbiased method for quantifying irreversible covalent inhibitor binding kinetics on a proteome-wide scale. COOKIE-Pro uses a two-step incubation process with mass spectrometry-based proteomics to determine kinact and KI values for covalent inhibitors against both on-target and off-target proteins. We validated COOKIE-Pro using BTK inhibitors spebrutinib and ibrutinib, accurately reproducing known kinetic parameters and identifying both expected and unreported off-targets. The method revealed that …

Observational Activation Of Anterior Cingulate Cortical Neurons Coordinates Hippocampal Replay In Social Learning, Xiang Mou, Daoyun Ji

Faculty, Staff and Students Publications

Social learning enables a subject to make decisions by observing the actions of another. How neural circuits acquire relevant information during observation to guide subsequent behavior is unknown. Utilizing an observational spatial working memory task, we show that neurons in the rat anterior cingulate cortex (ACC) associated with spatial trajectories during self-running in a maze are reactivated when observing another rat running the same maze. The observation-induced ACC activities are reduced in error trials and are correlated with activities of hippocampal place cells representing the same trajectories. The ACC activities during observation also predict subsequent hippocampal place cell activities during …

Enhancing Stemm Education Through Advanced Technologies And Collaborative Programs, Zhongcheng Shi, Michael Nguyen, Yuan Yao, Debra D Murray, Rayne H Rouce, Veronica Ajewole, Huan Xie, Shixia Huang

Faculty and Staff Publications

Integrating advanced technologies into STEMM (Science, Technology, Engineering, Mathematics, and Medicine) education is essential for preparing a future-ready, diverse scientific workforce capable of addressing complex global challenges. This paper presents three interconnected programs-BRITE (Biotechnology Research Incubator for Teachers), ASPIRATION (AI-guided Scientist-Mentored Primary Literature Adaptation for STEMM Education), and C-REP (Cancer Research Education Program)-developed through collaborations with Advanced Technology Cores and multi-institutional participation, involving mentors ranging from core directors to graduate and medical students. While initially supported by internal funding, two of these initiatives have since secured NIH grant support. These initiatives provide immersive, hands-on training in genomics, proteomics, metabolomics, flow …

Cyp1b1 Mediates Cigarette Smoke-Induced Lipid Accumulation In Alveolar Type 2 Cells, Yin Zhu, Siddhika Gamare, Francesca Polverino, Caroline A Owen, Payaningal R Somanath, Xiaoyun Wang, Duo Zhang

Faculty, Staff and Students Publications

Alterations in lipid profiles have been shown in patients with chronic obstructive pulmonary disease (COPD), but the underlying molecular mechanisms remain unclear. In this study, we aimed to investigate the role of cytochrome P450 family-1 subfamily B member 1 (CYP1B1) in cigarette smoke (CS)-induced lipid accumulation in alveolar type II epithelial (AT2) cells. We observed a steady increase in CYP1B1 protein levels in AT2 cells from COPD patients. Additionally, CS exposure induced CYP1B1 expression in AT2 cells of murine lungs. In vitro, treatment with cigarette smoke extract (CSE) not only upregulated CYP1B1 expression but also triggered lipid accumulation in AT2-like …

Decorin Evokes A Pro-Lysosomal Pathway In Lymphatic Endothelial Cells, Gabriel J. Pascal, Dipon K. Mondal, Sadie Kim, Christopher Xie, Devanarayanan Siva Sankar, Jörn Dengjel, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The lymphatic system is critical to the body's immune and circulatory system, and lymphangiogenesis, the development of new lymphatic vessels from pre-existing ones, is a significant process capitalized upon by cancer during tumorigenesis. Decorin is a small leucine-rich proteoglycan which we have previously shown to be anti-tumorigenic and a suppressor of lymphangiogenesis. We have also shown that decorin exercises its anticancer properties through its ability to evoke autophagy. Through a comprehensive and unbiased proteomic analysis, we explored the implications of decorin exposure on protein expression within mouse lymphatic endothelial cells. We discovered that decorin enriches several protein pathways, notably proteasomal …

Review On Exploring The Potential Of Black Soldier Fly (Hermetia Illucens) As A Novel Feed Ingredient For Poultry, Muhammad Naeem Jan, Nasir Rajput, Muhammad Naeem, Sher Ali, Ghulam Shabir Barham, Tehseen Fatima Miano

Journal of Bioresource Management

Poultry provides both direct and indirect employment opportunities to individuals. Every farm owner desires a reduced investment with more earnings. Over 50 % of the overall cost of chicken rearing is allocated to feed stuff. Among all feed ingredients, protein sources are the most expensive, yet protein is essential for production and growth. This exorbitant price cannot be sustained by the small-scale farmers. Consequently, contemporary scientists are attempting to substitute the protein supply with black soldier fly in their formulations. This review study examines the advantageous effect of utilizing Black Soldier Fly powder, larvae or oil, as demonstrated in scientific …

Drawing On Uncertainty Methodologies Of Neutrosophic Hypersoft Sets In Cognitive Computing-Driven Healthcare Systems, Mona Mohamed, Nurhan Alaa

Neutrosophic Systems with Applications

A new paradigm called cognitive computing simulates human reasoning and decision-making through integrating advanced techniques such as artificial intelligence (AI) and natural language processing (NLP). Cognitive computing systems, in contrast to traditional systems, can handle both structured and unstructured data, adjust to new information, and offer context-sensitive insights. This study examines how cognitive computing improves decision-making, personalization, and human-machine collaboration in various fields. Cognitive computing in the healthcare sector processes clinical notes, imaging data, and electronic health records to help physicians with diagnosis, treatment planning, and patient engagement. This study examines key applications, including their role in diagnostic support, where …

Indoor Air Quality And Sick Building Syndrome In Selected Public Buildings In Shah Alam, Selangor, Ismaniza Ismail, Mohamad Solehin Zulkarnain, Ilyas Syafiq Darul Ridzuan, Yahya Thamrin, Nasrul Hamidin

Media Kesehatan Masyarakat Indonesia

Indoor Air Quality (IAQ) is always associated with Sick Building Syndromes (SBS) despite the age of the buildings, particularly in buildings where indoor air pollutants may affect occupants’ health and productivity. This study assessed IAQ parameters and SBS symptoms in five selected public buildings aged 10 and above in Shah Alam, Selangor. Physical, chemical and biological parameters were measured, while structured questionnaires were completed by 87 respondents occupying the buildings. Most IAQ parameters were within the ranges of the Industry Code of Practice on IAQ (ICOP IAQ 2010), except for air velocity, formaldehyde and Total Volatile Organic Compound (TVOC) in …

Understanding Cardiovascular Risk: Insights From Coastal Communities In Southeast Sulawesi, Syahrianti Syahrianti, Lilin Rosyanti, Reni Revianti Usman, Ismail Ismail, Agus Bintara Birawida, Sumarheni Sumarheni, Muhammad Fahmi Aziz

Media Kesehatan Masyarakat Indonesia

Cardiovascular Disease (CVD) remains the leading cause of death worldwide, with a greater impact on low- and middle-income countries, particularly coastal communities that depend on fragile ecosystems. This study explores the effects of sociodemographic, behavioral, and metabolic factors on CVD incidence among the coastal population of Soropia, Konawe, Southeast Sulawesi. This research employs a quantitative approach with a cross-sectional design and applies Structural Equation Modeling (SEM) using Smart PLS software. Data collection was conducted through standardized questionnaires and physical examinations. The findings reveal that age significantly reduces CVD risk (p = 0.043, Exp(B) = 0.378), while gender and occupation show …

Spartan Daily, September 30, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 16

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Engineered Exosomes With Krasg12d Specific Sirna In Pancreatic Cancer: A Phase I Study With Immunological Correlates, Valerie S Kalluri, Brandon G Smaglo, Krishnan K Mahadevan, Michelle L Kirtley, Kathleen M Mcandrews, Mayela Mendt, Sujuan Yang, Ana S Maldonado, Hikaru Sugimoto, Maria E Salvatierra, Luisa M Solis Soto, Cara Haymaker, Rick Finch, Mihai Gagea, Adam C Fluty, Steven J Ludtke, J Jack Lee, Abhinav K Jain, Gauri Varadhachary, Rachna T Shroff, Anirban Maitra, Elizabeth Shpall, Shubham Pant, Raghu Kalluri

Faculty, Staff and Students Publications

Oncogenic KRAS is amongst the key genetic drivers for initiation and maintenance of pancreatic ductal adenocarcinoma (PDAC). Here, we show that engineered exosomes with KrasG12D specific siRNA (iExoKrasG12D) reveal a biodistribution in pancreas with negligible toxicity in preclinical studies in mice and Rhesus macaques. Clinical testing of iExoKrasG12D in the iEXPLORE (iExoKrasG12D in Pancreatic Cancer) Phase I study employed a non-randomized single-arm classical 3 + 3 dose escalation design (Phase Ia), followed by an accelerated titration design (Phase Ib) (NCT03608631). The primary outcomes included safety, tolerability and target engagement, and the secondary outcomes aimed to assess disease control. …

The (4h) Strategy On Emotional Intelligence And Social Interaction And Its Relationship To The Performance Of Sending And Receiving Skills, Zahraa Jawad Ahmed, Luma Sameer Hamoodi Al-Shaikhly

Modern Sport

The research problem lies in the modern use of strategies, including the (4H) strategy and the weak performance of the skills of serving and receiving the serve in volleyball among third-year female students. The researchers have decided to conduct a study. They tried to know the role of each (4H) strategy, emotional intelligence, and social interaction in the performance of the two skills under study. The research aims to know the degree of each of (4H strategy - emotional intelligence- social interaction- serving- receiving the serve) in the research sample, as well as knowing its effect on each of (emotional …

Development Of A Leucine-Rich Repeat-Containing Protein 15-Targeted Radio-Immunotheranostic Approach To Deplete Pro-Tumorigenic Mechanisms And Immunotherapy Resistance, Claire M Storey, Abbie Hasson, Diane Abou, Daniel Thorek, Et Al.

2020-Current year OA Pubs

Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and treatment resistant tumor cells derived from mesenchymal stem cells, with minimal expression observed in non-neoplastic tissues. We have developed a humanized monoclonal antibody, DUNP19, that specifically binds with high affinity to a phylogenetically conserved LRRC15 epitope and is rapidly internalized upon LRRC15 binding. In multiple subcutaneous and orthotopic tumor xenograft mouse models, Lutetium-177 labeled DUNP19 ([

A Clinical Audit Of Women’S Records Of Care Providing Warm Compresses In The Second Stage Of Labour, Rebecca Glover

South West Clinical School Journal

#400WORDS: KNOWLEDGE + ACTION

Biodiversity Performance Of Living Wall Systems In Temperate Urban Environments: Plant Selection And Substrate Effects On Multi-Taxa Communities: Biodiversity Performance Of Living Wall Systems In Urban Environments, Paul Lunt, Thomas Murphy, James Buckley

School of Geography, Earth and Environmental Sciences

Urban densification threatens biodiversity, yet conventional greenspace expansion is con-strained by limited land availability. Living wall systems (LWS) offer potential biodiversity enhancement through vertical green infrastructure, though their ecological value re-mains underexplored. This study evaluated the biodiversity performance of three LWS in Plymouth, UK, using multi-taxa surveys to assess invertebrate communities, bird assemblages, and bat activity. A scoping review of 2,638 publications revealed limited research on LWS biodiversity, with only 27% of biodiversity-focused papers referencing specific species. Field surveys employed standardized protocols including flower-visiting pollinator observations, spider assessments, soil invertebrate extraction using Tullgren funnels, acoustic bird monitoring, and bat emergence …

Physical Functioning Of Patients Undergoing Neoadjuvant Treatment For Cancer Of The Oesophagus And The Subsequent Impact Of Exercise Prehabilitation—Results Of A Cohort Study Within The Prehiit Trial, Linda O’Neill, Emily Smyth, Neil Kearney, Grainne Sheill, Louise Brennan, Sarah Wade, Sophie Grehan, Sanela Begic, Ross T. Murphy, Myles Mckittrick, Suzanne L. Doyle, John V. Reynolds, Juliette Hussey, Emer Guinan

Research Outputs: 2025-Present

Background: Multimodality treatment {surgery + pre-operative chemoradiation [chemoradiotherapy for oesophageal cancer followed by surgery (CROSS)] or perioperative chemotherapy [fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT)]} is the standard of care for locally advanced oesophageal cancer. Whilst highly tolerated, clinically, patients may experience toxicities which negatively impact their functional status. Exercise prehabilitation aims to improve functional status in advance of oesophagectomy to minimise postoperative morbidities. The PRE-HIIT trial examined the ability of a high-intensity interval training (HIIT) exercise programme to improve cardiorespiratory fitness in advance of complex cancer surgery. This cohort study charts the physical functioning of a sub-cohort of participants recruited …

Contributing To Acari Knowledge: The First Report Of Trombidium Grandissimum From The Soils Of Cholistan Desert, Rahim Yar Khan, Punjab, Pakistan, Muhammad Adnan Bodlah, Alishbah Mohsin, Ayesha Younas, Aleena Kanwal, Imran Bodlah, Yasir Niaz, Shumaila Khan, Shabbir Hussain

Journal of Bioresource Management

Trombidium grandissimum is also known by names, red velvet mite, real velvet mite, giant red velvet mite and rain bug, belongs to the family Trombidiidae and subclass Acari. Red velvet mite has four life stages: egg, larva, nymph, and adult. Adult red velvet mites were collected from agricultural farm area of Khwaja Fareed University of Engineering & Information Technology. Important taxonomic features were revealed by morphological study, including a body length of around half of an inch, velvety, unridged skin with dense hairs, stalked eyes, and specialized organs on the anterior legs including sensilla and claws. Carotene-induced bright red coloring …