Digital Commons Network^™

Phylogeography And Population Dynamics Of North American Wolverines (Gulo Gulo Luscus) In Alaska And Western Canada, Dianna M. Krejsa

Biology ETDs

The circumboreal wolverine (Gulo gulo sp.) is ideal for studying responses to environmental perturbation in the North due to a history of persistence in glacial refugia and subsequent glacial recolonization. Wolverines are also excellent indicators of human influence on the environment due to their close association with remote areas and cold, snowy climes. Through the use of genetic tools (i.e., nuclear microsatellite loci and mitochondrial sequences), I examined population structure of wolverines in Alaska and western Canada to identify signatures of glacial refugia, bottlenecks, and distinctive populations, sex-biased dispersal, gene flow, and source and sink population dynamics. I identified genetic …

Ectoparasitic Mites Of The Genus Gigantolaelaps (Acari: Mesostigmata: Laelapidae) Associated With Small Mammals Of The Genus Nephelomys (Rodentia: Sigmodontinae), Including Two New Species From Peru, Donald D. Gettinger, Scott Lyell Gardner

Scott L. Gardner Publications

An extensive survey of small mammals and ectoparasites along an altitudinal transect in the Manu Biodiversity Reserve in Peru found the sigmodontine rodent genus Nephelomys infested by mites of the genus Gigantolaelaps Fonseca, 1939. Two distinct species co-occurred exclusively in the pelage of Nephelomys keaysi, G. inca Fonseca and G. minima n. sp. Nephelomys levipes, which replaces N. keaysi at higher elevations, was infested exclusively with a single new species, G. nebulosa n. sp. In this paper, we formally describe these new mite species, and provide more information on the morphology of G. inca.

Discovering Antibacterial And Anti-Resistance Agents Targeting Multi-Drug Resistant Eskape Pathogens, Renee Fleeman

USF Tampa Graduate Theses and Dissertations

Antibiotic resistance has been a developing problem for mankind in recent decades and multi-drug resistant bacteria are now encountered that are resistant to all treatment options available. In 2014, the World Health Organization announced that this problem is driving us towards a “post-antibiotic era” that will change the face of modern medicine as we know it. If lack of novel antibiotic development and FDA approval continues, by the year 2050, 10 million people will die each year to an antimicrobial resistant bacterial infection. With lack of pharmaceutical industry involvement in developing novel antibiotics, the responsibility now lies within the academic …

Prevalence Of Cytotoxin Associated Gene-A Positive Strains In Children With Symptomatic H. Pylori Infection, Patricia Mumbi Muriithi

Master of Medicine in Paediatrics and Child Health

Introduction: Helicobacter pylori is a common bacterial infection in humans with early acquisition in childhood. It is adapted to the gastric environment and has been associated with chronic active gastritis, peptic ulcers, atrophic gastritis, gastric adenocarcinoma and mucosa associated lymphoid tissue (MALT) lymphoma. H. pylori strains bearing the Cytotoxin Associated Gene-A (CagA) gene have enhanced pathogenicity and have been strongly linked with increased risk for gastric carcinoma in adulthood. Objectives: The primary objective was to determine the prevalence of CagA positive strains in children with H. pylori infection. The secondary objectives were to compare CagA status and endoscopy findings and …

Odelay: A Large-Scale Method For Multi-Parameter Quantification Of Yeast Growth., Thurston Herricks, Fred D Mast, Song Li, John D Aitchison

Articles, Abstracts, and Reports

Growth phenotypes of microorganisms are a strong indicator of their underlying genetic fitness and can be segregated into 3 growth regimes: lag-phase, log-phase, and stationary-phase. Each growth phase can reveal different aspects of fitness that are related to various environmental and genetic conditions. High-resolution and quantitative measurements of all 3 phases of growth are generally difficult to obtain. Here we present a detailed method to characterize all 3 growth phases on solid media using an assay called One-cell Doubling Evaluation of Living Arrays of Yeast (ODELAY). ODELAY quantifies growth phenotypes of individual cells growing into colonies on solid media using …

Crisis Leadership And Decision-Making: Hospital Administration And Nurse Leaders' Concerns For Disaster Response, Tener Goodwin Veenema, Katherine Deruggiero, Sarah Lynn Losinski, Daniel Barnett

International Nursing Research Congress (INRC)

Purpose: The purpose of this study was to characterize and explore the essential elements of effective hospital and nursing leadership during disasters and MCIs and to identify those events of greatest concern for response. Disaster and mass casualty incidents (MCIs) impose a huge burden on health care leaders. These events create a sudden, unanticipated demand for care referred to as ‘patient surge" that has the potential to quickly overwhelm a hospital"s capacity to function properly. The demand for health care services exceeds capacity to respond and the institution"s normally acceptable patterns of operations and logistics are disrupted. Strong crisis leadership …

Personalized Pediatric Pain Management: Myth Or Reality?, Cheryl Mele

International Nursing Research Congress (INRC)

For a child undergoing a surgical procedure or issues with chronic pain, an essential goal is to obtain optimal pain management without significant adverse effects. Regretfully, safe and operative analgesia is an indefinable medical objective. Pain management within the pediatric realm reports that 50% pediatric perioperative pain experience will be efficient and acquire minimal side effects from opioids (Sadhasivam et al., 2014), It is well known that poor pain control can harvest physical difficulties, prolonged post-op recovery, and long-term behavioral complications. Still there is an extensive range of reactions to opioids secondary to variability in patient"s gender, ethnicity, development, co-morbidities …

Two-Year Antibody Persistence In Children Vaccinated At 12-15 Months With A Measles-Mumps-Rubella Virus Vaccine Without Human Serum Albumin., Andrea A. Berry, Remon Abu-Elyazeed, Clemente Diaz-Perez, Maurice A. Mufson, Christopher J. Harrison, Michael Leonardi, Jerry D. Twiggs, Christopher Peltier, Stanley Grogg, Antonio Carbayo, Steven Shapiro, Michael Povey, Carmen Baccarini, Bruce L. Innis, Ouzama Henry

Manuscripts, Articles, Book Chapters and Other Papers

One combined measles-mumps-rubella (MMR) vaccine without Human Serum Albumin (HSA) is currently licensed in the USA (M-M-R II; Merck, USA) and another has been developed (Priorix™ [MMR-RIT, GSK, Belgium]). In this follow-up study, children from USA or Puerto Rico, who had received one dose of M-M-R II or MMR-RIT at 12-15 months of age in the primary study (NCT00861744), were followed-up for 2 y post-vaccination. Anti-measles and anti-rubella antibodies were measured using Enzyme-Linked Immunosorbent Assay (ELISA), and anti-mumps antibodies using ELISA and plaque reduction neutralization (PRN) assays. Serious adverse events (SAEs) were recorded during the entire follow-up. The according-to-protocol (ATP) …

Identifying Nodes Of Transmission In Disease Diffusion Through Social Media, David Sebastian Lamb

USF Tampa Graduate Theses and Dissertations

The spread of infectious diseases can be described in terms of three interrelated components: interaction, movement, and scale. Transmission between individuals requires some form of interaction, which is dependent on the pathogen, to occur. Diseases spread through the movement of their hosts; they spread across many spatial scales from local neighborhoods to countries, or temporal scales from days to years, or periodic intervals. Prior research into the spread of disease have examined diffusion processes retrospectively at regional or country levels, or developed differential equation or simulation models of the dynamics of disease transmission. While some of the more recent models …

Constructing The 'Addict': A Discourse Analysis Of National Newspapers Concerning North America's First Supervised Injection Site, Katie Sills

Social Justice and Community Engagement

Safe injection sites provide injection drug users with a safe space to inject drugs with clean supplies under the supervision of medical professionals. This study centres on a discursive analysis of newspaper representations of Insite, North America’s first supervised injection site, located in the Downtown Eastside of Vancouver, British Columbia, Canada. Insite opened in 2003 under an exemption from the Controlled Drugs and Substances Act and has provided benefits to its clients through a reduction in public injections, decreased spread of infectious disease, and by providing clients with referrals to other community and social services. Despite these accomplishments the Canadian …

Healthy You, Lehigh Valley Health Network

Healthy You

No abstract provided.

Better Medicine, Lehigh Valley Health Network

Better Medicine

No abstract provided.

The Greenbook, Faculty Handbook, 2017-2018, Marshall University Academic Affairs

The Greenbook

This book has been published for the faculty of Marshall University for the specified period of time. This book was created by what is now known as Academic Affairs and is for the period of 2017-2018.

Oncology Section Edge Task Force On Urogenital Cancer Outcomes: Clinical Measures Of Lymphedema—A Systematic Review, Joy C. Cohn, Hannah Geyer, Jeannette Lee, Mary Insana Fisher

Physical Therapy Faculty Publications

Background: Valid and reliable tools to assess lymphedema are necessary to accurately evaluate status and to objectively document and measure the results of interventions. Understanding the advantages and disadvantages of each measure can inform the clinician's choice of the appropriate tool to be used in the clinic or research setting.

Purpose: To identify reliable and valid measurement techniques that are sensitive to change for assessing edema volume or soft tissue change in the lower extremities or genital region of patients with lymphedema.

Methods: A systematic review of the literature was conducted to assess the published psychometric properties and clinical feasibility …

Practical Pearl: C. Difficile Infection (Cdi) - July 2017, Donna Fisher Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Parasite Microbiome Project: Systematic Investigation Of Microbiome Dynamics Within And Across Parasite-Host Interactions., Nolwenn M Dheilly, Daniel Bolnick, Seth Bordenstein, Paul J Brindley, Cédric Figuères, Edward C Holmes, Joaquín Martínez Martínez, Anna J Phillips, Robert Poulin, Karyna Rosario

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Understanding how microbiomes affect host resistance, parasite virulence, and parasite-associated diseases requires a collaborative effort between parasitologists, microbial ecologists, virologists, and immunologists. We hereby propose the Parasite Microbiome Project to bring together researchers with complementary expertise and to study the role of microbes in host-parasite interactions. Data from the Parasite Microbiome Project will help identify the mechanisms driving microbiome variation in parasites and infected hosts and how that variation is associated with the ecology and evolution of parasites and their disease outcomes. This is a call to arms to prevent fragmented research endeavors, encourage best practices in experimental approaches, and …

Helminth Infection-Induced Malignancy., Paul J Brindley, Alex Loukas

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Infectious diseases cause more than 20% of cancers in the developing world [1]. About a dozen pathogens including Epstein-Barr virus and human T cell lymphocytotropic virus 1 are among the well-known examples. In addition, infection with several trematodes, which are eukaryotes, can cause malignancy. The International Agency for Research on Cancer categorizes infection with the fish-borne trematodes Opisthorchis viverrini and Clonorchis sinensis and the blood fluke Schistosoma haematobium as Group 1 biological carcinogens [2]. In addition to parasitism directly damaging development, health, and prosperity of infected populations, infection with these helminths leads to cholangiocarcinoma (CCA) (bile duct cancer) and squamous …

Climate Change And Health: Risk Awareness Can Improve Patient Care, Julia Sanabria, Leslie A. Duram

Publications

No abstract provided.

Penile Anaerobic Dysbiosis As A Risk Factor For Hiv Infection, Cindy Liu, Jessica Prodger, Aaron Tobian, Alison Abraham, Godfrey Kigozi, Lance B. Price, +Several Additional Authors

Environmental and Occupational Health Faculty Publications

Sexual transmission of HIV requires exposure to the virus and infection of activated mucosal immune cells, specifically CD4⁺ T cells or dendritic cells. The foreskin is a major site of viral entry in heterosexual transmission of HIV. Although the probability of acquiring HIV from a sexual encounter is low, the risk varies even after adjusting for known HIV risk factors. The genital microbiome may account for some of the variability in risk by interacting with the host immune system to trigger inflammatory responses that mediate the infection of mucosal immune cells. We conducted a case-control study of uncircumcised participants …

Syphilis In Men That Have Sex With Men, Nathaniel Helser

Nursing Student Class Projects (Formerly MSN)

Syphilis rates in the United States hit their nadir in the 1960’s and 1970’s with almost complete disappearance during the 1980’s in conjunction with the onset of the human immunodeficiency virus outbreak (Read et al, 2015). This dramatic fall was a direct consequence of the introduction of penicillin in the 1940’s, but since this decline a widely documented reemergence in endemic levels has been seen across the country (Petrosky et al, 2016). Recent rates in men have jumped from 3 per 100,000 to 9.8 per 100,000 (Petrosky et al, 2016) in a two year span, an alarming increase, which has …

Kingella Kingae: Emerging Outbreaks In Daycare Facilities, Kimberly Iracki

Nursing Student Class Projects (Formerly MSN)

In today’s Western countries, families are more likely than those of past decades to include two full-time working parents. This has led to an increase in he number of children attending daycare or some form of childcare outside the home. It is known that close quarters or semi-confined setting increase the risk of certain infections. Out of these infections, an emerging pediatric pathogen, that has also shown some prevalence in adults, is Kingella kingae.

Mathematical Modelling Of An Avian Influenza: Optimal Control Study For Intervention Strategies, Chairat Modnak

Applied Mathematics & Information Sciences

Avian influenza, caused by influenza A viruses, has drawn attention from scientists worldwide to study its epidemic dynamics. In this paper, we study the spread of bird flu or avian influenza and optimal control theory for intervention strategies from SIR-based model. In addition, we divide human population into five states; Susceptible (S), Vaccinated (V), Exposed (E), Infective (I) and Recovered (R). Equilibrium analysis to investigate the dynamics of the model is carefully derived. We further study the optimal control to seek cost effective for control and treatment strategies. Numerical results show that strategically deployed vaccination and medical treatment can significantly …

Dynamics Of Diseased Prey Predator Model With Nonlinear Feedback Control, V. Madhusudanan, B. R.Tapas Bapu

Applied Mathematics & Information Sciences

In this paper we investigate the dynamics of diseased prey- predator system with nonlinear feedback. A nonlinear feedback mathematical model is proposed and analyzed to study the predator interaction with infected prey. We showed that the continuous time diseased prey-predator system can be asymptotically stabilized using nonlinear feedback control. By constructing Lyapunov function, global asymptotic stability is established. Also we obtained necessary control law for asymptotic stability of this system. Finally, a numerical simulation supports our analytical findings

Syncing The Unsyncable: Legal And Policy Implications Of Paperless Clinical Trials, Kimberly Rhodes

UC Law Science and Technology Journal

No abstract provided.

College Of Pharmacy And Allied Health Professions, South Dakota State University

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 2 Thomas Gajewski : University of Chicago immunology researcher shares treatment’s progress in the fight against cancer at Francis Miller Lecture. [Page] 4 Endowed positions: The college will soon have three endowed posts on its faculty. Two are in the area of cancer. The other is in community pharmacy. All are considered transformational.
[Page] 6 White Coat: A familiar face, Dave Helgeland, one of the class’s professors, delivered a message on expectations to this year’s group of P1 students.
[Page] 8 Spring convocation: The 2015 Independent Pharmacist of Year visits to teach about enhanced value to payers.
[Page] 10 …

Csusb Magazine (Summer 2017), Csusb

CSUSB Magazine

Features

President's Agenda......Page 2
President Tomas Morales regularly engages with the local community, university partners, legislative representatives and educational leaders worldwide to champion CSUSB and its mission.

Enriched Sense of Community......Page 12
CSUSB enhances residential life and shifts perception as a commuter campus.

Albert K. Karnig......Page 18
Al Karnig led CSUSB for 15 years molding the university to meet the educational needs of the region's growing population, its diversity and demand for higher education.

The Obershaws: Nearly Three Decades of Generous Support......Page 22
Philanthropists Charles and Shelby Obershaw continue to make positive impacts on the CSUSB …

Unm Pathology Pathfinder Summer 2017, Unm Department Of Pathology

Newsletters

No abstract provided.

Joint Force Quarterly 86 (3rd Quarter, July 2017), National Defense University Press

Joint Force Quarterly ARCHIVES

No abstract provided.

The Internationalization Of Climate Damages Litigation, Michael Byers, Kelsey Franks, Andrew Gage

Washington Journal of Environmental Law & Policy

The annual global costs of climate change in 2010 were estimated at nearly $700 billion. As the costs continue to escalate, discussion is necessarily shifting to who should pay for mitigation and adaption. Many scholars argue that policy considerations and principles of tort law support holding greenhouse gas producers responsible for the costs of climate change. However, legal claims against greenhouse gas producers in the United States have thus far proven unsuccessful. This Article explores two previously overlooked potentialities that could significantly and rapidly alter the landscape for climate change litigation: (1) the emergence of transnational climate change litigation coupled …

Mutations In The Transmembrane Domain And Cytoplasmic Tail Of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly, Nicolás P. Cifuentes-Muñoz, Weina Sun, Greeshma Ray, Phuong Tieu Schmitt, Stacy Webb, Kathleen Gibson, Rebecca Ellis Dutch, Anthony P. Schmitt

Molecular and Cellular Biochemistry Faculty Publications

Hendra virus (HeV) is a zoonotic paramyxovirus that causes deadly illness in horses and humans. An intriguing feature of HeV is the utilization of endosomal protease for activation of the viral fusion protein (F). Here we investigated how endosomal F trafficking affects HeV assembly. We found that the HeV matrix (M) and F proteins each induced particle release when they were expressed alone but that their coexpression led to coordinated assembly of virus-like particles (VLPs) that were morphologically and physically distinct from M-only or F-only VLPs. Mutations to the F protein transmembrane domain or cytoplasmic tail that disrupted endocytic trafficking …