Digital Commons Network^™

The Surgical Infection Society Revised Guidelines On The Management Of Intra-Abdominal Infection, John E. Mazuski, Jeffrey M. Tessier, Addison K. May, Robert G. Sawyer, Evan P. Nadler, Matthew R. Rosengart, Phillip K. Chang, Patrick J. O'Neill, Kevin P. Mollen, Jared M. Huston, Jose J. Diaz Jr, Jose M. Prince

Open Access Publications

No abstract provided.

Evaluation Of Correlation Between Pretest Probability For Clostridium Difficile Infection And Clostridium Difficile Enzyme Immunoassay Results, Jennie H. Kwon, Kimberly A. Reske, Tiffany Hink, Carey-Ann D. Burnham, Erik R. Dubberke

Open Access Publications

No abstract provided.

Animal Models Of Zika Virus Infection, Pathogenesis, And Immunity, Thomas E. Morrison, Michael S. Diamond

Open Access Publications

No abstract provided.

Exacerbated Leishmaniasis Caused By A Viral Endosymbiont Can Be Prevented By Immunization With Its Viral Capsid, Patrick Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzxchneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Nicolas Fasel, Catherine Ronet

Open Access Publications

No abstract provided.

The Brief Case: Central Nervous System Sparganosis In A 53-Year-Old Thai Man, Abigail L. Carlson, Nattapol Pruetpongpun, Aubonphan Buppajarntham, Pansachee Damronglerd, Neil W. Anderson, Anucha Apisarnthanarak

Open Access Publications

No abstract provided.

Vaccination Status And Factors For Non- Vaccination In Children At A Tertiary Care Hospital, Shiyam Sunder Tikmani, Tufail Soomro, Sumera Aziz Ali

Community Health Sciences

Immunization is a very effective strategy to prevent against common infectious disease. The objectives of the study were to determine the immunization status and reasons for non-vaccination of children coming to Civil Hospital Sukkur. This cross-sectional study was conducted pediatric OPD at Civil Hospital Sukkur from January 1, 2013, to June 30, 2013. Parents of children under five years of age brought their child to Outpatient Department of Civil Hospital Sukkur for any illness were asked to participate in the study. Parents who gave informed consent were included in the study. Data were collected using a small questionnaire by the …

An Immunoinformatics-Derived Dna Vaccine Encoding Human Class Ii T Cell Epitopes Of Ebola Virus, Sudan Virus, And Venezuelan Equine Encephalitis Virus Is Immunogenic In Hla Transgenic Mice, Callie E. Bounds, Frances E. Terry, Leonard Moise, Drew Hannaman, William D. Martin, Anne S. De Groot, John J. Suschak, Lesley C. Dupuy, Connie S. Schmaljohn

Cell and Molecular Biology Faculty Publications

Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of Venezuelan equine encephalitis virus (VEEV). Selected epitopes were tested for binding to soluble HLA molecules representing 5 class II alleles (DRB1*0101, DRB1*0301, DRB1*0401, DRB1*0701, and DRB1*1501). All but one of the 25 tested peptides bound to at least one of the DRB1 alleles, and 4 of the peptides bound at least moderately or weakly to all 5 DRB1 alleles. Additional algorithms were used to design …

Green Building Business Is Booming, Richard Snow, Mary Snow

Publications

Shelter is one of life’s basic necessities. However, according to the U.S. Department of Energy, residential and commercial buildings account for nearly 40% of the total carbon dioxide (CO2) released in the United States annually [1]. The percentage is even higher in China, which leads the world in CO2 emissions from buildings. Most of this CO2 comes from burning fossil fuels to provide the energy necessary to cool, heat, and light homes, office buildings, and retail space. CO2 emissions from residential and commercials buildings are forecast to increase more than emissions from any other sector over the next 25 years. …

Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth

All ETDs from UAB

A. fumigatus is one of the most common fungal isolates with clinical disorders ranging from mild to severe. The development of Aspergillus-induced allergic and invasive fungal infections is a major health concern in several patient populations. IL-1 family members have been shown to play critical roles in host defense against A. fumigatus. IL-33, an IL-1 family member widely study in allergic and inflammatory diseases, was induced upon acute exposure to A. fumigatus. IL-33 receptor knockout mice, (Il1rl1-/-), demonstrated lower lung fungal burden in the presence of enhanced IL-1α, IL-1β, IL-6, IL-17A, IL-22, and PGE2 production. Administration of IL-33 to normal …

Bioactive Materials: Ion Release, Flexural Strength, Secondary Caries Depth And Elemental Analysis Of Surrounding Tooth Structure, Prajakta Shreeram Kulkarni

All ETDs from UAB

ABSTRACT Objectives: Bioactive materials release calcium, phosphate, and fluoride which may increase tooth remineralization. But limited data is available demonstrating the superiority of bioactive or ion releasing materials compared to fluoride or no ion releasing materials. The aims of the present study are to measure and compare the calcium, fluoride, and phosphate ion release at different pH, flexural strength and caries protecting ability of the materials including the ion uptake of surrounding tooth structure. Methods: Activa, Cention N, Fuji LC II and Filtek Supreme Ultra were the restorative materials tested. Firstly, the fluoride and calcium release of these materials was …

Aga Khan University, Report 2017, Aga Khan University

The Aga Khan University Reports Archives

• Chancellor’s Message
• Chairman’s Message
• President’s Message
• Timeline of Highlights /By the Numbers
• Ready for the Rise of Non-communicable Diseases
• Building Better Education Systems
• Talking About Their Generation
• Setting the Agenda in Maternal and Child Health and Development
• Alumni Survey Demonstrates Impact
• Giving Nature a Voice
• Pluralism in Action
• Leading the Way in East African Nursing and Midwifery
• Virtual Reality, Real-World Results
• A New Hospital for Uganda
• Supporters & Partners
• Board of Trustees and Executive Team
• Financial Highlights
• The World of AKU

Uncovering The Role Of Common Gamma-Chain Cytokines In Aspergillus Fumigatus Associated Diseases, Kristen Marie Reeder

All ETDs from UAB

Fungal pathogens contribute to a wide range of diseases that are largely dependent on the host’s immune state. In the case of immune suppression, Aspergillus fumigatus is the causative agent of invasive aspergillosis. Furthermore, asthmatics sensitized to fungi such as Aspergillus fumigatus are reported to have more severe asthma. We have previously described a role for IL-22 in mouse models of invasive aspergillosis and fungal asthma. IL-22 was found to play a protective role in invasive aspergillosis, while it was found to play an immunopathogenic role in asthma. Here we describe the cell sources of IL-22 in both models. We …

Evaluation Of Peripheral And Mucosal T Cell Phenotypes Of Chlamydia-Infected Women, Brian Makori Omwena Ogendi

All ETDs from UAB

Chlamydia trachomatis (CT) infection is the most prevalent bacterial sexually transmitted infection worldwide and women are disproportionately affected due to its reproductive complications. T cell phenotypes present during CT infection have been well characterized in the murine model, but remain to be elucidated in humans. Therefore, studies aimed at increasing our understanding of T cell phenotypes in CT-infected humans were the focus of this dissertation. The first chapter of this dissertation reviews various aspects of chlamydial infection while in the second chapter aims to address the influence of CT infection on T cell phenotypes. We first compared differences in peripheral …

The Dragon’S Flight To The Tropics: China’S Involvement In The Caribbean, Kellie O'Boyle

Honors College Theses

In 2008, the United States experienced an economic crisis that ultimately caused it to take a step back from its involvement in the Caribbean, in particular. This vacuum left by the United States was swiftly filled by China, which shifted the balance of power in the region and provided China a strategic foothold. This event allowed China to expand its influence, as well as challenge US interests through the use of soft power such as trade and investments in infrastructure. While this symbiotic relationship benefits both parties, there is usually a trade inequality in China’s favor. China’s traditional use of …

Erratum To: Scaling Up Strategies Of The Chronic Respiratory Disease Programme Of The European Innovation Partnership On Active And Healthy Ageing (Action Plan B3: Area 5)., J Bousquet, J Farrell, G Crooks, P Hellings, E H. Bel, M Bewick, N H. Chavannes, J Correia De Sousa, A A. Cruz, T Haahtela, G Joos, N Khaltaev, J Malva, A Muraro, M Nogues, S Palkonen, S Pedersen, C Robalo-Cordeiro, B Samolinski, T Strandberg, A Valiulis, A Yorgancioglu, T Zuberbier, A Bedbrook, W Aberer, M Adachi, A Agusti, C A Akdis, M Akdis, J Ankri, A Alonso, I Annesi-Maesano, I J. Ansotegui, J M. Anto, S Arnavielhe, H Arshad, C Bai, I Baiardini, C Bachert, A K. Baigenzhin, C Barbara, E D. Bateman, B Beghé, A Ben Kheder, K S. Bennoor, M Benson, K C. Bergmann, T Bieber, C Bindslev-Jensen, L Bjermer, H Blain, F Blasi, A L. Boner, M Bonini, S Bonini, S Bosnic-Anticevitch, L P. Boulet, R Bourret, P J. Bousquet, F Braido, A H. Briggs, C E. Brightling, J Brozek, R Buhl, P G. Burney, A Bush, F Caballero-Fonseca, D Caimmi, M A. Calderon, P M. Calverley, P A M Camargos, G W. Canonica, T Camuzat, K H. Carlsen, W Carr, A Carriazo, T Casale, A M. Cepeda Sarabia, L Chatzi, Y Z. Chen, R Chiron, E Chkhartishvili, A G. Chuchalin, K F. Chung, G Ciprandi, I Cirule, L Cox, D J. Costa, A Custovic, R Dahl, S E. Dahlen, U Darsow, G De Carlo, F De Blay, T Dedeu, D Deleanu, E De Manuel Keenoy, P Demoly, J A. Denburg, P Devillier, A Didier, A T. Dinh-Xuan, R Djukanovic, D Dokic, H Douagui, G Dray, R Dubakiene, S R. Durham, M S. Dykewicz, Y El-Gamal, R Emuzyte, L M. Fabbri, M Fletcher, A Fiocchi, A Fink Wagner, J Fonseca, W J. Fokkens, F Forastiere, P Frith, M Gaga, A Gamkrelidze, J Garces, J Garcia-Aymerich, B Gemicioğlu, J E. Gereda, S González Diaz, M Gotua, I Grisle, L Grouse, Z Gutter, M A. Guzmán, L G. Heaney, B Hellquist-Dahl, D Henderson, A Hendry, J Heinrich, D Heve, F Horak, J O' B Hourihane, P Howarth, M Humbert, M E. Hyland, M Illario, J C. Ivancevich, J R. Jardim, E J. Jares, C Jeandel, C Jenkins, S L. Johnston, O Jonquet, K Julge, K S. Jung, J Just, I Kaidashev, M R. Khaitov, O Kalayci, A F. Kalyoncu, T Keil, P K. Keith, L Klimek, B Koffi N'Goran, V Kolek, G H. Koppelman, M L. Kowalski, I Kull, P Kuna, V Kvedariene, B Lambrecht, S Lau, D Larenas-Linnemann, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K Lodrup Carlsen, R Louis, W Macnee, Y Magard, A Magnan, B Mahboub, A Mair, I Majer, M J. Makela, P Manning, S Mara, G D. Marshall, M R. Masjedi, P Matignon, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O. Meltzer, A Menzies-Gow, H Merk, J P. Michel, N Miculinic, F Mihaltan, B Milenkovic, G M Y Mohammad, M Molimard, I Momas, A Montilla-Santana, M Morais-Almeida, M Morgan, R Mösges, J Mullol, S Nafti, L Namazova-Baranova, R Naclerio, A Neou, H Neffen, K Nekam, B Niggemann, G Ninot, T D. Nyembue, R E. O'Hehir, K Ohta, Y Okamoto, K Okubo, S Ouedraogo, P Paggiaro, I Pali-Schöll, P Panzner, N Papadopoulos, A Papi, H S. Park, G Passalacqua, I Pavord, R Pawankar, R Pengelly, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, D Poethig, W Pohl, T A. Popov, F Portejoie, P Potter, D Postma, D Price, K F. Rabe, F Raciborski, F Radier Pontal, S Repka-Ramirez, S Reitamo, S Rennard, F Rodenas, J Roberts, J Roca, L Rodriguez Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, L Rosenwasser, M Rottem, D Ryan, M Sanchez-Borges, G K. Scadding, H J. Schunemann, E Serrano, P Schmid-Grendelmeier, H Schulz, A Sheikh, M Shields, N Siafakas, Y Sibille, T Similowski, F E R Simons, J C. Sisul, I Skrindo, H A. Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J. Sterk, J Sunyer, C Thijs, T To, A Todo-Bom, M Triggiani, R Valenta, A L. Valero, E Valia, E Valovirta, E Van Ganse, M Van Hage, O Vandenplas, T Vasankari, B Vellas, J Vestbo, G Vezzani, P Vichyanond, G Viegi, C Vogelmeier, T Vontetsianos, M Wagenmann, B Wallaert, S Walker, D Y. Wang, U Wahn, M Wickman, D M. Williams, S Williams, J Wright, B P. Yawn, P K. Yiallouros, O M. Yusuf, A Zaidi, H J. Zar, M E. Zernotti, L Zhang, N Zhong, M Zidarn, J Mercier

Manuscripts, Articles, Book Chapters and Other Papers

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Lessons Learned: The Pea Ridge School District's Discrimination Against Students With Hiv/Aids Has Rekindled Difficult Issues, Nicole Oelrich Tupman, Barbara C. Gartin, Nikki L. Murdick

South Dakota Law Review

No abstract provided.

Body Piercing And Health Complications Among College Students In Puerto Rico, Elsie Goicochea

Walden Dissertations and Doctoral Studies

The incidence and prevalence of body piercing health complications among students is a public health matter that has not been researched in Puerto Rico. College students are the most consistent participants in body piercing activities and have reported health complications resulting in visits to medical offices and emergency rooms. Based on the health belief model, which is used to explain and predict health attitudes, the purpose of this quantitative nonexperimental study was to analyze the health risks and possible complications occurring after body piercing and to investigate the association between sex and age and medical complications. Data were collected from …

Compliance Of Caregivers With Polio Vaccine Dosages And Timelines In Lagos State Nigeria, Grace Olubunmi Salako Smith

Walden Dissertations and Doctoral Studies

Caregivers' compliance with polio vaccine regimens and timely receipt of the recommended 4 doses of polio vaccine are pivotal to eliminating polio. This cross sectional study, conducted in Lagos State, Nigeria, examined polio vaccine compliance and demographic attributes of caregivers' for statistically significant associations. Using an adapted health belief model theoretical framework, 1,200 participants were recruited from well-baby clinics in 8 local government areas in Lagos State. Participants completed a brief demographic survey providing data on caregivers' age, gender, residence (rural or urban), and their level of education as well as records from their children's immunization cards. Data obtained were …

A Behavioral And Neuroimmune System Model Of The Effects Of Chronic Low-Level Lead Exposure In Young Male C57bl/6j Mice, Mayra Gisel Flores-Montoya

Open Access Theses & Dissertations

Chronic low-level lead exposure reduces memory in children however the brain mechanisms mediating these effects are not known. In previous studies we showed that early lead exposure reduced olfactory memory and exploratory behavior in young mice, and reduced microglia cell density in hippocampus/dentate gyrus. The present studies aimed to identify additional behavioral tests that were sensitive to early low-level lead exposure in young mice; and to examine whether microglia upregulated factors known to promote cell migration. Seventy-two C57BL/6J male mice were exposed to 0 ppm (controls), 30 ppm (low-dose), or 430 ppm (high-dose) of lead acetate via dams' milk from …

Evaluation Of Pertussis Knowledge Within The Child Daycare Staff And Management In The El Paso, Texas, Diana Jaqueline Gomez

Open Access Theses & Dissertations

BACKGROUND: Child daycare centers have an enormous influence on the children's health, which is important to maintain daycare staff and management informed on how to prevent communicable diseases, such as pertussis. Bordetella pertussis (Bp), the causative agent of whooping cough, is a small gram-negative bacterium that infects the nasopharynx of humans, which are the only reservoir. Bp is a highly contagious respiratory disease, which continues to be a severe disease in infants. The disease affects all ages and is easily transmitted from person to person, through respiratory droplets. Even though there is a vaccine available for all ages there are …

Identification And Characterization Of Tumor-Associated Antigens (Taas) And Anti-Taas Autoantibodies As Biomarkers In Immunodiagnosis Of Human Osteosarcoma By Serological Proteome Analysis (Serpa), Jitian Li

Open Access Theses & Dissertations

Osteosarcoma (OS) is the most common highly malignant primary solid bone-tumor. Despite its relatively low incidence rate among overall cancers, it remains one of the most harmful primary malignant tumors in childhood and adolescence. Although some tumor markers like mutant p53 can be potentially used as biomarker to detect OS, its extensive association with the clinical outcome is poorly understood. The establishment of a methodology to identify patient with early stage of OS remains to be investigated. It is now evident that serum autoantibodies against tumor-associated antigens (TAAs) could be used as serological cancer biomarkers in types of cancers, which …

Developing Dual Diagnosis Care Curriculum For Nurses In Acute Psychiatric Inpatient Settings, Kofi Ahumkah Bonnie

Yale School of Nursing Digital Theses

Patients with co-existing substance use and mental disorder (dual diagnosis) have complex and challenging care needs especially in acute psychiatric inpatient settings. Acute psychiatric care plays a vital role in mental health service delivery and there is evidence that nurses working in these settings often have unmet learning needs regarding dual diagnosis care, posing a challenge to nursing practice. The purpose of this project was to develop an educational module which will equip nurses with the skills and knowledge required to deliver evidence-based dual diagnosis care in acute psychiatric settings. A survey of 74 acute psychiatric nurses was initially completed …

Why Some Religious Accommodations For Mandatory Vaccinations Violate The Establishment Clause, Hillel Y. Levin

Scholarly Works

All states require parents to inoculate their children against deadly diseases prior to enrolling them in public schools, but the vast majority of states also allow parents to opt out on religious grounds. This religious accommodation imposes potentially grave costs on the children of non-vaccinating parents and on those who cannot be immunized. The Establishment Clause prohibits religious accommodations that impose such costs on third parties in some cases, but not in all. This presents a difficult line-drawing problem. The Supreme Court has offered little guidance, and scholars are divided.

This Article addresses the problem of religious accommodations that impose …

Erratum To: Scaling Up Strategies Of The Chronic Respiratory Disease Programme Of The European Innovation Partnership On Active And Healthy Ageing (Action Plan B3: Area 5), J Bousquet, J. Farrell, G. Crooks, P. Hellings, E. H. Bel, M. Bewick, N. H. Chavannes, Sousa Jc De, A. A. Cruz, T. Haahtela, G. Joos, N. Khaltaev, J. Malva, A. Muraro, M. Nogues, S. Palkonen, S. Pedersen, C. Robalo-Cordeiro, B. Samolinski, T. Strandberg, A. Valiulis, A. Yorgancioglu, T. Zuberbier, A. Bedbrook, W. Aberer, M. Adachi, A. Agusti, Ca Akdis, M Akdis, J. Ankri

School of Psychology

No abstract provided.

Quantification Of Rotavirus Diarrheal Risk Due To Hydroclimatic Extremes Over South Asia: Prospects Of Satellite‐Based Observations In Detecting Outbreaks, M. Alfi Hasan, Colleen B. Mouw, Antarpreet Jutla, Ali S. Akanda

Graduate School of Oceanography Faculty Publications

Rotavirus is the most common cause of diarrheal disease among children under 5. Especially in South Asia, rotavirus remains the leading cause of mortality in children due to diarrhea. As climatic extremes and safe water availability significantly influence diarrheal disease impacts in human populations, hydroclimatic information can be a potential tool for disease preparedness. In this study, we conducted a multivariate temporal and spatial assessment of 34 climate indices calculated from ground and satellite Earth observations to examine the role of temperature and rainfall extremes on the seasonality of rotavirus transmission in Bangladesh. We extracted rainfall data from the Global …

Analysis Of Infectious Diseases Screening Systems For Transatlantic Air Passengers, Lukas Gold

Open Access Theses & Dissertations

Since transportation systems, especially air transportation, have the potential to spread infectious diseases (e.g. Ebola, SARS) quickly across large geographical area through its users, passenger health screening systems installed at the airports can help to slow down the international spread.

This Thesis identifies and tests health screening system designs using discrete event simulation. The three objectives are: (1) to provide the necessary background regarding the diseases and screening technologies, (2) to create models of an air transportation network in a simulation software, and (3) to conduct simulation experiments, analyze and interpret the results including the formulation of recommendations for decision …

The Contribution Of Alternative Splicing Toward The Global Control Of Sumo1 Sumoylation, Myriah Lorraine Acuna

Open Access Theses & Dissertations

SUMOylation, the attachment of the Small Ubiquitin-like Modifier (SUMO) to a target protein, is a post-translational modification similar to that of Ubiquitination in terms of the cascade of events required to produce the final modified target. However, instead of targeting proteins for degradation, as Ubiquitination usually does, SUMOylation appears to regulate many vital cellular processes including nucleocytoplasmic transport, transcription, apoptosis, protein stability, response to stress, and progression through the cell cycle (Hay, R.T, 2005). This versatility exhibited by the SUMOylation system makes it an optimal target for viral manipulation, as our laboratory has previously described for Influenza A virus (Pal, …

Utilizing Historical Mosquito Surveillance Data To Investigate The Efficacy Of Municipal Fogging In Controlling Mosquito Population Density, Andrea Betina Carzoli

Open Access Theses & Dissertations

Background: Mosquito borne diseases are the cause of many different disease syndromes and deaths in animals, both wild and domesticated, and humans of all ages and ethnicities. Though El Paso, TX is located in an arid region, mosquito populations are still rapidly growing in urban and agricultural communities and so are the mosquito borne illnesses. The most common vectors associated with mosquito borne illnesses in El Paso County are Culex quinquefasciatus, Culex tarsalis, and Aedes aegypti. Vector management is often the primary option to prevent and control outbreaks of mosquito borne illnesses and very often utilize fogging as the primary …

Novel Possibilities For The Treatment And Prevention Of Cutaneous Leishmaniasis, Eva A. Iniguez

Open Access Theses & Dissertations

Protozoan parasites from the genus Leishmania cause broad clinical manifestations known as leishmaniasis, which affect millions of people worldwide. Cutaneous leishmaniasis (CL) is mainly caused by either Leishmania major or L. tropica parasites, which produce localized cutaneous ulcers, often leading to scarring and social stigma. Currently, the disease has reached hyperendemicity levels in the Middle East due to conflict and human displacement and is one the most common forms of the disease in the Old World. Furthermore, the first choice of treatment in that region continues to be pentavalent antimonials, which are costly and highly toxic, and current vector control …

Cardiovascular Disease Risk Factor Assessment And Lifestyle Adjustments In African Americans, Biruk Nigatu Nigatu

Walden Dissertations and Doctoral Studies

Multiple studies have indicated a higher burden of overweight/obesity and exposure to environmental toxins, such as alcohol and tobacco smoke, in association with higher prevalence of cardiovascular disease (CVD) in the African American population. Thus, the purpose of this research was to determine if there was a significant difference in the use of lifestyle adjustments such as moderating alcohol consumption, weight loss, and smoking cessation on the prevalence of CVD in the African American population. The theoretical foundation was social cognitive theory and the social ecological model that posits the interplay of individual, social, and environmental factors. This cross-sectional quantitative …