Digital Commons Network^™

Target Intestinal Microbiota To Alleviate Disease Progression In Amyotrophic Lateral Sclerosis, Yong-Guo Zhang, Shaoping Wu, Jianxun Yi, Yinglin Xia, Dapeng Jin, Jingsong Zhou, Jun Sun

Faculty and Staff Publications

Purpose: Emerging evidence has demonstrated that gut microbiome plays essential roles in the pathogenesis of human diseases in distal organs. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. Treatment with the only drug approved by the US Food and Drug Administration for use in ALS, riluzole, extends a patient׳s life span by only a few months. Thus, there is an urgent need to develop novel interventions that for alleviate disease progression and improve quality of life in patients with ALS. Here we present evidence that intestinal dysfunction and dysbiosis may actively …

Induced Pluripotent Stem Cells Derived From Mouse Germ Cells, Nora Khan

Theses and Dissertations

While embryonic stem cells are well known to give rise to tissues comprising all three germ layers, only recently was it found that embryonic-like stem cells could be derived from the postnatal mice testis in culture. Embryonic-like stem cells from postnatal testes have shown that they can undertake most if not all, the functions of embryonic stem cells. Most recent reports have demonstrated that somatic cells can be induced to pluripotent stem cells, mostly with the addition of genes. However, the aim of this work is to explore the potential of testicular cells to become pluripotent, including expression of pluripotency-associated …

The Five Hundred And Thirty-Seventh Report Of The Curricular Affairs Committee: Program Changes., University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

An Historical Analysis Of Lab Techniques As Applies To Current Glial Cell Research, Nathan Ostermann

JCCC Honors Journal

The primary focus of neurology, since the beginning, has been the neuron. This is understandable, neuronal networks and nerves being the main communication mechanism between the brain and the rest of the body. However, this focus on neurons has overshadowed and delayed research on the other cells in the brain. Glial cells, or neuroglia, are defined as all cells in the brain that are not electrically excitable neurons or vascular cells. This definition of glial cells introduced by Rudolf Ludwig Karl Virchow in 1858. Until relatively recently, the idea that glial cells are simply passive elements of the brain that …

Central Washington University 2017-2018 Graduate Catalog, Central Washington University

Course Catalogs

No abstract provided.

Diabetes Mellitus: Concerns, Treatment Options, And The Future, Ryan Curry

Biology: Student Scholarship & Creative Works

Diabetes is a serious disease that is becoming very serious worldwide. This review will discuss some of the treatment options that are available for type two diabetes with a comparison to insulin management. It will discuss the history, genetics, economics, and also the future of diabetes management.

Eagle Families Newsletter Winter 2017, Bridgewater College

Eagle Families Newsletter

No abstract provided.

Lyric Repertory Company, Lyric Repertory Company

All Music Department Programs

Welcome to the 49th season of the Lyric Repertory Company! As we approach our golden anniversary we are thrilled to present what we feel will be one of our best seasons yet. This summer we present two show that have never been seen on the Caine Lyric Theatre stage. Baskerville is a farcical take on Sir Arthur Conan Doyle's classic thriller, The Hound of the Baskervilles, and Singin' in the Rain is based on one of the most popular movie musicals of all time. These Lyric Rep firsts are joined by two classics. Watch a different actor each night …

Ergonomics Within The Workplace: An Occupation Based Injury Prevention Program For Computer Users, Jessica T. Maxwell

Occupational Therapy Doctorate Capstone Projects

An ergonomic intervention increased computer workers’ knowledge of ergonomics, and improved their work station, thereby reducing risk for injury. Occupational therapy’s ability to implement ergonomic training programs for computer workers is an effective way to improve worker safety.

Employing The Enzyme Cofactor Function Of Ascorbic Acid To Affect Oncogenic Pathways In Human Melanoma: Modulating Hypoxia Inducible Factor-1Α And Dna Demethylation To Reduce Malignant Potential, Adam Patrick Fischer

Theses, Dissertations and Capstones

Dioxygenase enzymes such as the HIF hydroxylases (PHD1-3, FIH) and the Ten-eleven translocation (TET1-3) enzymes regulate the activity of the hypoxia inducible factor-1_a (HIF1_a) transcription factor and the DNA methylation status of cells, respectively. Aberrant accumulation and activation of HIF-1_a can allow malignant cells to acquire attributes that promote progression, chemotherapy resistance, and survival, while aberrant hypermethylation of gene promoters can silence the expression of tumor suppressor genes essential to preventing tumorigenesis. Inadequate levels of intracellular ascorbic acid (AA), a necessary cofactor for optimal dioxygenase enzyme function, could potentiate these tumorigenic conditions. In fact, plasma levels …

Shinrin-Yoku (Forest Bathing) And Nature Therapy: A State-Of-The-Art Review, Dr. Margaret M. Hansen, Reo Jones, Kirsten Tocchini

Nursing and Health Professions Faculty Research and Publications

Background: Current literature supports the comprehensive health benefits of exposure to nature and green environments on human systems. The aim of this state-of-the-art review is to elucidate empirical research conducted on the physiological and psychological effects of Shinrin-Yoku (or Forest Bathing) in transcontinental Japan and China. Furthermore, we aim to encourage healthcare professionals to conduct longitudinal research in Western cultures regarding the clinically therapeutic effects of Shinrin-Yoku and, for healthcare providers/students to consider practicing Shinrin-Yoku to decrease undue stress and potential burnout. Methods: A thorough review was conducted to identify research published with an initial open date range and then …

Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms Of Eye Fatigue, Jonathan B. Lin, Blair W. Gerratt, Carl J. Bassi, Rajendra S. Apte

Educator Preparation & Leadership Faculty Works

Purpose: The purpose of this study was to determine whether subjects who wear short wavelength–blocking eyeglasses during computer tasks exhibit less visual fatigue and report fewer symptoms of visual discomfort than subjects wearing eyeglasses with clear lenses.

Methods: A total of 36 healthy subjects (20 male; 16 female) was randomized to wearing no-block, low-blocking, or high-blocking eyeglasses while performing a 2-hour computer task. A masked grader measured critical flicker fusion frequency (CFF) as a metric of eye fatigue and evaluated symptoms of eye strain with a 15-item questionnaire before and after computer use.

Results: We found that the change in …

Physician Assistant Orlando 2017, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Semantic Inference On Clinical Documents: Combining Machine Learning Algorithms With An Inference Engine For Effective Clinical Diagnosis And Treatment, Shuo Yang, Ran Wei, Jingzhi Guo, Lida Xu

Information Technology & Decision Sciences Faculty Publications

Clinical practice calls for reliable diagnosis and optimized treatment. However, human errors in health care remain a severe issue even in industrialized countries. The application of clinical decision support systems (CDSS) casts light on this problem. However, given the great improvement in CDSS over the past several years, challenges to their wide-scale application are still present, including: 1) decision making of CDSS is complicated by the complexity of the data regarding human physiology and pathology, which could render the whole process more time-consuming by loading big data related to patients; and 2) information incompatibility among different health information systems (HIS) …

An Exploration Of Job Satisfaction Levels, Pathways Into Education, And Recruiting Behaviors Of Teachers In Indiana, Tricia Johnson

All-Inclusive List of Electronic Theses and Dissertations

Teacher retention and recruitment has been studied from many different perspectives, but there is limited research on the issue from the perspectives of current teachers. The purpose of this quantitative study was to gather data to fill a gap in the research concerning teacher recruiting behaviors by asking teachers if they were likely to encourage different categories of people (friend or relative, community member, current student, other students, recent high school graduate, and their own child) to enter the field of Education as a profession. Analysis of the data from 2,083 current Indiana teachers found multiple statistically significant differences in …

Uab Magazine - Fall 2017, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Gonzaga University Factbook 2017-18, Institutional Research, Gonzaga University

Institutional Research

The Gonzaga University Factbook contains information on student enrollments, demographic profiles, admissions statistics, majors, retention and graduation rates, degree completions, faculty information, and more. It is updated annually with the most current and commonly-needed information about Gonzaga University.

A New Model For Phd Elective Course, H R. Ahmad, Satwat Hashmi, M H. Mahmood

Department of Biological & Biomedical Sciences

No abstract provided.

Lived Experiences Of African American Males With Fibromyalgia, Ethel Denise Perry

Walden Dissertations and Doctoral Studies

Fibromyalgia (FM) is a musculoskeletal and neurological disorder that causes constant pain, cognitive problems with short term memory, and sleep disorders. There are more females diagnosed with FM than males, and research has therefore primarily been conducted with females. Because little is known about African American males with FM, biopsychosocial theory was used in this phenomenological study to examine how African American males with FM are affected biologically, psychologically, and socially. Eight African American males diagnosed with FM were recruited from Houston, Texas and were interviewed about their lived experiences with FM, including experiences with the healthcare system, and how …

Eastern Magazine, Fall 2017, Eastern Michigan University

Alumni News: Eastern Magazine

No abstract provided.

A Comprehensive Molecular Phylogeny Of Holocephalans And Identification Of Sex-Specific Genetic Markers In Chondrichthyan Fishes, Jenny Marie Kemper

MUSC Theses and Dissertations

Holocephalan fishes occupy an important phylogenetic position as members of the basal clade of jawed vertebrates, as well as the sister group to bony vertebrates. Thus, they can be used to provide an important reference for comparative studies aimed at understanding early gnathostome genome evolution. However, despite this importance, holocephalans have been understudied, and no comprehensive phylogeny for their inter-relationships has been estimated. A phylogeny will provide information about ancestor-descendant relationships, forming a framework that can be used to test future hypotheses by mapping characters, identifying patterns, and estimating ancestral states. A cross-species hybridization capture method was used to sequence …

Low Cost, Multi-Purpose Genotyping Panels For Dairy And Beef Cattle, Michelle Judge

Theses

rhe selection of animals based on DNA has revolutionised animal breeding, but the associated high cost of obtaining genotypes has limited its uptake. The objective of this thesis was to develop a low-cost, low-density, multi-purpose genotyping panel for the procurement of reliable genotype information, and to quantify the long-term consequences of using such low-density genotype panels in breeding programs. The objectives were achieved through a combination of real-life cattle genotype data and simulations to mimic a cattle population. The in-silico development of genotype panels was based on actual genotypes from up to 58,705 beef cattle. Alternative novel strategies were used …

Development & Validation Of An Improved Biomechanical Model For Motion Analysis, Darren Dawson

Theses

Three dimensional motion analysis systems are utilised across a number of different disciplines, including clinical gait analysis, sports performance studies and analysis of tasks of daily living. These systems utilise biomechanical models which define body segment coordinate systems and calculate kinematic and kinetic relationships about the joints between adjacent coordinate systems. In this study, a biomechanical model for general use in motion analysis was developed and validated. It was designed to improve upon the accuracy and capability of currently available models. The newly developed model utilises state of the art techniques to accurately define body segment coordinate systems. Accurate predictive …

Self Reported Knowledge Of Concussion Symptoms And Management By Middle And High School Club Lacrosse Coaches, Logan Ellis

Graduate Student Theses, Dissertations, & Professional Papers

TITLE: Self-reported knowledge of concussion symptoms and management by middle and high school club lacrosse coaches

AUTHORS: Logan Ellis

BACKGROUND: With an increase in sport participation across all levels, concussion prevalence has increased as well as reliance on coaches to recognize a concussed player. Little research has been done investigating how effective our current educational materials are with Lacrosse coaches of grades 6-12.

STUDY DESIGN: Cross- Sectional

LEVEL of EVIDENCE: Level 4

METHODS: Self-administered, online survey that included closed ended questions regarding recognition of signs and symptoms, consequences of inappropriate care, perception of own knowledge, …

Using Nursing Simulation To Improve Early Recognition Of Emergent Situations, Carlene Blais

Walden Dissertations and Doctoral Studies

Nurses' ability to recognize and respond to postoperative patients who require emergent medical care and need immediate assistance during a code blue in the first 10 minutes is essential to improve patient outcomes. This is particularly important for the project site, a 44-bed inpatient surgical specialty hospital located in the Northeast, providing care for patients with head and neck cancer, as the hospital does not have an internal code blue response team. An adjacent facility responds to all code blue emergencies and takes approximately 10 minutes for the team to respond. The purpose of this DNP project was to develop …

Evaluating Student Use Patterns Of Streaming Video Lecture Capture In A Large Undergraduate Classroom, Nathan E. Whitley-Grassi

Walden Dissertations and Doctoral Studies

Large classes that allow smaller amounts of instructor-student interaction have become more common in today's colleges. The best way to provide needed opportunities for students to overcome this lack of interaction with instructors remains unidentified. This research evaluated the use of video lecture capture (VLC) as a supplemental method for teacher-student interaction and what, if any, impact it and attendance have on student performance in large lecture courses. This ex post facto study conducted at a Northeastern research university utilized cognitive and andragogical frameworks to examine the relationships between the independent variables frequency of video viewing, quantity of videos viewed, …

Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms Of Eye Fatigue, Carl Bassi, Jonathan Lin, Blair Gerratt, Rajendra Apte

College of Optometry Faculty Works

Purpose: The purpose of this study was to determine whether subjects who wear short wavelength–blocking eyeglasses during computer tasks exhibit less visual fatigue and report fewer symptoms of visual discomfort than subjects wearing eyeglasses with clear lenses.Methods: A total of 36 healthy subjects (20 male; 16 female) was randomized to wearing no-block, low-blocking, or high-blocking eyeglasses while performing a 2-hour computer task. A masked grader measured critical flicker fusion frequency (CFF) as a metric of eye fatigue and evaluated symptoms of eye strain with a 15-item questionnaire before and after computer use.Results: We found that the change in CFF after …

Nitrosative Stress Sensing In Porphyromonas Gingivalis: Structure And Function Of The Heme Binding Transcriptional Regulator Hcpr, Benjamin R. Belvin

Theses and Dissertations

Porphyromonas gingivalis, a Gram negative anaerobe implicated in the progression of periodontal disease, is capable of surviving and causing infection despite high levels of reactive nitrogen species found in the oral cavity due to its efficient nitrosative stress response. HcpR is an important sensor-regulator that plays a vital step in the initiation of the nitrosative stress response in many Gram negative anaerobic bacteria. We employ a combination of X-ray crystallography, SAXS, resonance Raman spectroscopy, UV-Vis spectroscopy, and molecular biology techniques to better understand this key regulator. Knockout of the hcpR gene in W83 P. gingivalis results in the inability of …

The Role Of N-Myc Downstream Regulated Gene 1 In Breast Cancer Lipid Metabolism, Christopher James Sevinsky

Legacy Theses & Dissertations (2009 - 2024)

Altered carbohydrate and lipid metabolism are increasingly well characterized hallmarks of aggressive breast cancers. While aerobic glycolysis, or “the Warburg effect”, is a well-established metabolic adaptation exploited by tumor cells, the understanding of unique aspects of cancer lipid metabolism lags behind. This is especially true regarding the coordination of complex lipid synthesis and trafficking pathways, which remains poorly understood. N-Myc Downstream Regulated Gene1 (NDRG1) is overexpressed in many solid tumors, but its function is unclear. The importance of NDRG1 is best exemplified by the effect of null mutations on human physiology: inactivating mutations give rise to the severe autosomal recessive …

Fundamental Principles Of Tremor Propagation In The Upper Limb, Andrew D. Davidson, Steven Knight Charles

Faculty Publications

Although tremor is the most common movement disorder, there exist few effective tremor-suppressing devices, in part because the characteristics of tremor throughout the upper limb are unknown. To clarify, optimally suppressing tremor requires a knowledge of the mechanical origin, propagation, and distribution of tremor throughout the upper limb. Here we present the first systematic investigation of how tremor propagates between the shoulder, elbow, forearm, and wrist. We simulated tremor propagation using a linear, time-invariant, lumped-parameter model relating joint torques and the resulting joint displacements. The model focused on the seven main degrees of freedom from the shoulder to the wrist …