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Planaria: An Animal Model That Integrates Development, Regeneration And Pharmacology, Oné R. Pagán

Biology Faculty Publications

Although planarians are established model organisms in developmental biology and regeneration studies, in the last forty years or so, they have caught the attention of pharmacologists, especially to study the pharmacology of drugs of abuse. This review covers the following topics: some fundamentals of the history of animal models and planarians in biomedical research; an abbreviated story of systematic pharmacology research using planarians as a model organism; an example of how planarians are contributing to the search for compounds against acute cocaine toxicity; an analysis of the number of papers on planarians and pharmacological topics from 1900- 2016; some perspectives …

Open Educational Resource 2017 Textbook List, Zachariah Claybaugh, Chelsea Stone

Librarian Publications

This is an updated, discipline specific OER textbook list for departments at Sacred Heart University, compiled by Zach Claybaugh and Chelsea Stone.

Kss 5260 : Cardiopulmonary Exercise Physiology, Kinesiology & Sports Studies

Approved Course Proposals

No abstract provided.

Kss 4340 : Exercise Physiology, Kinesiology & Sports Studies

Approved Course Proposals

No abstract provided.

Altitude- And Sex-Specific Variation In Roosting Ecology And Thermoregulation Of Myotis Lucifugus In Yellowstone National Park, Alexandra C. Slusher

Theses and Dissertations--Forestry and Natural Resources

Fifty-nine female and six male little brown myotis (Myotis lucifugus) were radio-tagged during the summers of 2012, 2013, 2014, and 2015 in Yellowstone National Park. The grand models for daily maximum skin temperature (F_98,154 = 1.55, P = 0.007), daily minimum skin temperature (F_98,154 = 1.33, P = 0.05), and daily variation in skin temperature (F_98,154 = 1.56, P = 0.006) were significant across roost type and reproductive condition class for adult females. Roosts were classified into Types A (warmest roosts), B (roosts with largest daily temperature variance), and C (stable and cool roosts) depending …

Structural Characteristics And Corrosion Behavior Of Bio-Degradable Zn-Li Alloys In Stent Application, Shan Zhao

Dissertations, Master's Theses and Master's Reports

Zinc has begun to be studied as a bio-degradable material in recent years due to its excellent corrosion rate and optimal biocompatibility. Unfortunately, pure Zn’s intrinsic ultimate tensile strength (UTS; below 120 MPa) is lower than the benchmark (about 300 MPa) for cardiovascular stent materials, raising concerns about sufficient strength to support the blood vessel. Thus, modifying pure Zn to improve its mechanical properties is an important research topic.

In this dissertation project, a new Zn-Li alloy has been developed to retain the outstanding corrosion behavior from Zn while improving the mechanical characteristics and uniform biodegradation once it is implanted …

The Role Of Hur In Astrocytes In Spinal Cord Injury, Thaddaeus Kwan

All ETDs from UAB

Neuroinflammation is a defining event during the acute phase of spinal cord injury (SCI). The inflammatory cascade is initiated by activated glial cells such as astrocytes and microglia in the milieu of the injured tissue through release of pro-inflammatory cytokines, matrix metalloproteinases, and reactive oxygen species. These soluble factors produce cytotoxicity to neurons and other cells either directly or indirectly by promoting permeabilization of the blood-spinal cord barrier, edema and subsequent ischemia. These factors also serve to recruit and activate additional glia and peripheral immune cells. The mRNAs of many of these soluble factors such as TNFα, IL-1β, CXCL1, and …

How Can The Use Of Human Enhancement (He) Technologies In The Military Be Ethically Assessed?, Philip Andrew Taraska

Electronic Theses and Dissertations

War is a terrible price to pay for the prospect of peace. Yet every nation has a moral obligation to protect its citizenry from unjust aggression and threats to security. To be sure, war is always a failure. It is a failure of mankind to come together in mutual respect for the inherent dignity of the human person. The issue of the use of HE in the military is relevant today because the Global War on Terror (GWOT) and the rapid rise of emerging technologies have led to a never-before-seen type of asymmetrical warfare. The rise of these technologies can …

Single Low-Dose Lipopolysaccharide Preconditioning: Neuroprotective Against Axonal Injury And Modulates Glial Cells, Ryan C. Turner, Zachary J. Naser, Brandon P. Lucke-Wold, Aric F. Logsdon, Reyna L. Vangilder, Rae Reiko Matsumoto, Jason D. Huber

Faculty Publications & Research of the TUC College of Pharmacy

AIM: Over 7 million traumatic brain injuries (TBI) are reported each year in the United States. However, treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly understood. Lipopolysaccharide (LPS) administration before controlled cortical impact can contribute to neuroprotection. However, the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains unclear.

METHODS: The authors hypothesized that preconditioning with a low dose of LPS (0.2 mg/kg) would regulate glial reactivity and protect against diffuse axonal injury induced by weight drop. LPS was administered 7 days prior to TBI. LPS administration reduced locomotion, which recovered completely …

Unsung, Unprecedented, Unwavering: 2016-17 Report Of The President, Office Of The President, Gonzaga University

Office of the President Publications

Each year, Gonzaga University's Office of the President produces an annual Report of the President. This publication that highlights just a few of the many accomplishments over the previous academic year, and is intended to convey gratitude to our Trustees and Regents, benefactors, and many supporters.

Synthesis And Biological Evaluation Of Cannabinoid Receptor Ligands, Mariah Leigh Cole

Honors Theses

The cannabinoid receptors, members of the G-protein coupled receptor (GPCR) superfamily, have been implicated in numerous human physiological functions and diseases. These receptors, cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2), are most concentrated in the central nervous system and immune cells, respectively, and have each become a target of therapeutic interest. Dual CB1/CB2 agonists such as delta-9-tetrahydrocannbinol (THC) have demonstrated efficacy in the treatment of nausea, pain, and glaucoma, but suffer from psychotropic effects mediated by CB1, motivating the search for CB2 selective therapeutic agents. Selective modulation of the CB2 receptor has therapeutic potential in human health disorders …

Issues Related To Implementing High-Fidelity Simulation In A Nursing Program, Sherry Rene Ray

Walden Dissertations and Doctoral Studies

Due to the shortage of clinical sites, nursing educators, deans, and directors are compelled to implement alternative clinical solutions such as high-fidelity simulation (HFS). The problem is that nursing educators are often not prepared to implement HFS as a teaching strategy. Faculty readiness is imperative for a successful simulation program and student outcomes. Therefore, the purpose of this study was to investigate the perceptions and practices of faculty, deans, and directors on the implementation of HFS across the nursing curriculum. Kolb's experiential learning theory provided the theoretical support for both the teaching and learning required by faculty for a successful …

Valveless Pumping: The Reflected Pulse Wave Hypothesis, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

No abstract provided.

Mechanisms Of Hormonal Regulation Of Invasiveness And Metastasis Of Luminal Breast Cancer, Thomas Mcfall

Wayne State University Dissertations

ABSTRACT

MECHANISMS OF HORMONAL REGULATION OF INVASIVENESS AND METASTASIS OF LUMINAL BREAST CANCER

By

THOMAS MCFALL

December 2017

Advisor: Dr. Manohar Ratnam

Major: Cancer Biology

Degree: Doctor of Philosophy

Over 20% of breast cancer cases present with distal metastasis and they are predominantly of luminal subtypes. As luminal breast cancer is relatively indolent, it is believed that progression to metastasis must occur over many years, generally well into post-menopausal years. Unfortunately, very little is known about the mechanisms by which these hormone receptor positive tumors metastasize, likely in part due to their slow metastatic rates in animal model systems as …

Stable Isotope Analysis Of The Dietary Habits Of A Greek Community In Archaic Syracuse (Sicily): A Pilot Study, Davide Tanasi, Robert Tykot, Andrea Vianello, Stephan Hassam

History Faculty Publications

The study and reconstruction of ancient dietary habits has become a very significant topic in archaeological research. Most chemical analysis studies for diet at Greek sites are limited to prehistory, with very few examples of studies for the Classical period. This paper represents a pilot study of stable isotope analysis carried out on a group of 15 individuals selected among the population interred in the Archaic necropolis of Scala Greca at Syracuse (Sicily), a cemetery discovered in 2010-2011. Based on the funerary assemblages and certain features such as shape, dimensions, coverage system and architectural features, a preliminary distinction has been …

Hydrogen Sulfide Regulation Of Kir Channels, Junghoon Ha

Theses and Dissertations

Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain and other peripheral tissues. Phosphatidylinositol- 4,5-bisphosphate (PIP2) is a key direct activator of ion channels, including Kir channels. Gasotransmitters, such as carbon monoxide (CO), have been reported to regulate the activity of Kir channels by altering channel-PIP2 interactions. We tested, in a model system, the effects and mechanism of action of another important gasotransmitter, hydrogen sulfide (H2S) thought to play a key role in cellular responses under ischemic conditions. Direct administration of sodium hydrogen sulfide (NaHS), as an exogenous H2S source, …

Surface Enabled Lab-On-A-Chip (Loc) Device For Protein Detection And Separation, Zhichao Wang

Dissertations, Master's Theses and Master's Reports

Sensitive and selective chemical/biological detection/analysis for proteins is essential for applications such as disease diagnosis, species phenotype identification, product quality control, and sample examination. Lab-on-a-chip (LOC) device provides advantages of fast analysis, reduced amount of sample requirements, and low cost, to magnificently facilitate protein detection research. Isoelectric focusing (IEF) is a strong and reliable electrophoretic technique capable of discerning proteins from complex mixtures based on the isoelectric point (pI) differences. It has experienced plenty of fruitful developments during previous decades which has given it the capability of performing with highly robust and reproducible analysis. This progress has made IEF devices …

Neurosecurity For Brainware Devices, Brian Cusack, Kaushik Sundararajan, Reza Khaleghparast

Australian Information Security Management Conference

Brainware has a long history of development down into the present day where very simple and usable devices are available to train for the control of games and services. One of the big areas of application has been in the health sciences to provide compensatory control to humans who may lack the usual capabilities. Our concern has been the protection of information in brainware so that a human intention may have confidentiality, integrity, and accessibility to the required implementation mechanisms for services. The research question was: What are the consequences of security failure in brainware? Our research tested a brainware …

Error Aggregation In The Reengineering Process From 3d Scanning To Printing, Jennifer G. Michaeli, Matthew C. Degroff, Roman C. Roxas

Engineering Technology Faculty Publications

This work aims to study the aggregation of dimensional errors in the reengineering processes using 3D scanning and printing without initial design drawings. A 57-tooth spur gear is used as an example to facilitate the discussion. Two approaches are investigated. The first one builds the gear model based upon measurement taken from a caliper, and the second approach uses a 3D scanner to collect geometry data. Dimensional errors in each stage of these two approaches are investigated. Particular attention is paid to the geometry data flow in the reengineering process from data acquisition and editing to model construction. Recommendations are …

Systematic Review Of Countermeasures To Minimise Physiological Changes And Risk Of Injury To The Lumbopelvic Area Following Long-Term Microgravity, Andrew Winnard, Mona Nasser, Dorothee Debuse, Maria Stokes, Simon Evetts, Mick Wilkinson, Julie Hides, Nick Caplan

More Faculty of Health Research

No abstract provided.

A Mathematical Investigation On Tumor-Immune Dynamics: The Impact Of Vaccines On The Immune Response, Jonathan Quinonez, Neethi Dasu, Mahboob Qureshi

College of Osteopathic Medicine (TUN) Publications and Research

Mathematical models analyzing tumor-immune interactions provide a framework by which to address specific scenarios in regard to tumor-immune dynamics. Important aspects of tumor-immune surveillance to consider is the elimination of tumor cells from a host’s cell-mediated immunity as well as the implications of vaccines derived from synthetic antigen. In present studies, our mathematical model examined the role of synthetic antigen to the strength of the immune system. The constructed model takes into account accepted knowledge of immune function as well as prior work done by de Pillis et al. All equations describing tumor-immune growth, antigen presentation, immune response, and interaction …

Using The Medication Cabinet To Predict Fall Risk In Elderly Adults, Jessica Lopez

University of the Pacific Theses and Dissertations

Background: In the United States, 30-60% of older adults fall each year; 10-20% of these falls result in injury, hospitalization, or even death. Better prevention of falls in this population may be facilitated by broader identification of risk factors. The use of statins has emerged as a potential risk factor, but the data provide conflicted results.

Purpose: To examine the relationship between statin use and falls among community-dwelling older adults.

Methods: We evaluated the patient registry of a Level 1 trauma center. All patients aged > 50 years who were admitted for falls in 2015 were included (n=615). Many of these …

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

Computational Fluid Dynamics In A Terminal Alveolated Bronchiole Duct With Expanding Walls: Proof-Of-Concept In Openfoam, Jeremy Myers

Theses and Dissertations

Mathematical Biology has found recent success applying Computational Fluid Dynamics (CFD) to model airflow in the human lung. Detailed modeling of flow patterns in the alveoli, where the oxygen-carbon dioxide gas exchange occurs, has provided data that is useful in treating illnesses and designing drug-delivery systems. Unfortunately, many CFD software packages have high licensing fees that are out of reach for independent researchers. This thesis uses three open-source software packages, Gmsh, OpenFOAM, and ParaView, to design a mesh, create a simulation, and visualize the results of an idealized terminal alveolar sac model. This model successfully demonstrates that OpenFOAM can be …

Glutamine Transporters In Human Hepatocellular Carcinoma And In The Emt6 Mammary Tumor And Adjacent Stroma In The Syngeneic Balb/C Mouse Model, Clare Kron

Graduate Research Theses & Dissertations

Human hepatocellular carcinoma (HCC) is an increasing threat worldwide due to cirrhosis of the liver developing from viral hepatitis and non-alcoholic steatohepatitis (NASH). Breast cancer is the second leading cause of cancer death in American women, with the most intractable type classified as triple negative. Both cancers depend on glutamine as the major oxidizable substrate for tumor growth, therefore, identification of glutamine transporters and transporter activity is of vital importance in the development of treatment options. It is well documented that ASCT2 is the major glutamine transporter in both cancers but little is known regarding the relative amounts of additional …

Vmed 646: Animal Physiology Ii—A Peer Review Of Teaching Project Benchmark Portfolio, Renee M. Mcfee

UNL Faculty Course Portfolios

This Peer Review of Teaching Project portfolio focuses on the Animal Physiology II course which is required for first year veterinary medicine students. Weekly quizzes assess baseline knowledge and had been administered individually and in groups. I hypothesized the discontinuation of group quizzes would increase student effort when preparing for quizzes. Unit exams involve scenario-based questions and require students to apply information. I hypothesized the implementation of group exams would help under-performing students improve their ability to apply information they had learned. Exams were still taken individually prior to being taken in groups to encourage adequate preparation. Student impacts were …

Shinrin-Yoku (Forest Bathing) And Nature Therapy: A State-Of-The-Art Review, Margaret M. Hansen Edd, Msn, Rn, Reo Jones, Kirsten Tocchini

Nursing and Health Professions Faculty Research and Publications

Background: Current literature supports the comprehensive health benefits of exposure to nature and green environments on human systems. The aim of this state-of-the-art review is to elucidate empirical research conducted on the physiological and psychological effects of Shinrin-Yoku (or Forest Bathing) in transcontinental Japan and China. Furthermore, we aim to encourage healthcare professionals to conduct longitudinal research in Western cultures regarding the clinically therapeutic effects of Shinrin-Yoku and, for healthcare providers/students to consider practicing Shinrin-Yoku to decrease undue stress and potential burnout. Methods: A thorough review was conducted to identify research published with an initial open date range …

Development Of A 3d Microphysiologic Liver For Drug Toxicity Testing, Maryrose Kammer

All ETDs from UAB

Development of almost all novel effective drug compounds is immensely expensive and time consuming. The process is slowed by the ineffectiveness of current toxicity testing methods, with 80% of drugs undergoing late-stage failure in clinical trials or post-market withdrawal. The leading cause of these failures and withdrawals is due to drug-induced liver injury. Much of drug metabolism occurs in the liver, but there are incredible differences among the metabolic pathways in humans, animal models, and two-dimensional testing platforms. Thus, the current methods are limited to accurately predict in vivo metabolic response of a novel compound. Three dimensional (3D) in vitro …

The Child As Risk: Precocious Girls And Sexual Consent In Late Victorian Britain, Victoria Bates

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

The figure of the precocious girl pervaded Victorian culture, yet is poorly understood. This article focuses on concerns about sexual precocity and their influence on age-of-consent debates in the 1880s. It shows that even this single form of precocity (sexual) took multiple forms and was a malleable concept, often used selectively in parliamentary debates to suit particular agendas. These different uses of precocity did have in common, however, a tendency to be situated against the normal as 'ideal' rather than only statistically 'typical'. As precocity was generally measured against the ideal sexual development and behaviour of respectable North European girls, …

Mathematical Models For Treatment Time Of Pathogenic Infection In Blood After Antibiotics Administration, Panit Suavansri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective in this thesis is to create a mathematical model to predict the period of time needed to clear out the pathogens from the bloodstream after the patient receives certain antibiotics. The result will lead to the time where the drug administration can be terminated. This research is to compute the densities of bacteria and malaria in bloodstream at any given time and to compare this level with the actual results of the patient's blood sampling, which was sent to the laboratory for investigation. The laboratory process of the blood sampling will usually take more than 2-3 days to …