Digital Commons Network^™

The Missing Electrostatic Interactions Between Dna Substrate And Sulfolobus Solfataricus Dna Photolyase: What Is The Role Of Charged Amino Acids In Thermophilic Dna Binding Proteins?, Yvonne Gindt, Ban H. Edani, Antonia Olejnikova, Ariana N. Roberts, Sudipto Munshi, Robert J. Stanley

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

DNA photolyase can be used to study how a protein with its required cofactor has adapted over a large temperature range. The enzymatic activity and thermodynamics of substrate binding for protein from Sulfolobus solfataricus were directly compared to protein from Escherichia coli. Turnover numbers and catalytic activity were virtually identical, but organic cosolvents may be necessary to maintain activity of the thermophilic protein at higher temperatures. UV-damaged DNA binding to the thermophilic protein is less favorable by ∼2 kJ/mol. The enthalpy of binding is ∼10 kJ/mol less exothermic for the thermophile, but the amount and type of surface area buried …

Teaching And Research In Scil 101: Science And Decision-Making For A Complex World, Jenny Dauer

Discipline-Based Education Research Group Speaker Series

SCIL 101 “Science and decision-making for a complex world” is the new introductory core class for all of the students in CASNR. The learning objectives are targeted toward developing students’ science literacy skills. The course will be described, as well as findings from on-going science literacy research that investigates indicators of formal and informal decision-making in the course.

Contesting Liberalism, Refusing Death: A Biopolitical Critique Of Navajo History, Melanie K. Yazzie

American Studies ETDs

This dissertation considers the pivotal role that liberalism, particularly as it is expressed and enforced through post-livestock reduction era logics of tribal economic development, plays in advancing a relentless and violent form of U.S. settler colonialism bent on the elimination of Navajo life. I use Michel Foucault’s framework of biopolitics as a theory of history to unlock, identify, and interpret what brought Navajo life into the realm of explicit calculation in Navajo political formations. I use the terms ‘experimental liberalism’ and ‘extractive liberalism’ to frame the two primary biopolitical formations I see at work in this period of Navajo history. …

In-Vivo Imaging Of Magnetic Fields Induced By Transcranial Direct Current Stimulation (Tdcs) In Human Brain Using Mri, Mayank V. Jog, Robert X. Smith, Kay Jann, Walter Dunn, Belen Lafon, Dennis Truong, Allan Wu, Lucas C. Parra, Marom Bikson, Danny J. J. Wang

Publications and Research

Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation technique that applies mA currents at the scalp to modulate cortical excitability. Here, we present a novel magnetic resonance imaging (MRI) technique, which detects magnetic fields induced by tDCS currents. This technique is based on Ampere’s law and exploits the linear relationship between direct current and induced magnetic fields. Following validation on a phantom with a known path of electric current and induced magnetic field, the proposed MRI technique was applied to a human limb (to demonstrate invivo feasibility using simple biological tissue) and human heads (to demonstrate feasibility in …

Deoxyribonucleic Acid (2016), Dennis Kelly

Season 2016-2017

No abstract provided.

Daily Eastern News: October 06, 2016, Eastern Illinois University

October

No abstract provided.

Chanticleer | October 6, 2016, Jacksonville State University

Chanticleer

No abstract provided.

Cotinine Antagonizes The Behavioral Effects Of Nicotine Exposure In The Planarian Girardia Tigrina, Daniel J. Bach, Matthew Tenaglia, Debra L. Baker, Sean Deats, Erica Montgomery, Oné R. Pagán

Biology Faculty Publications

Nicotine is one of the most addictive drugs abused by humans. Our laboratory and others have demonstrated that nicotine decreases motility and induces seizure-like behavior in planarians (pSLM, which are vigorous writhing and bending of the body) in a concentration-dependent manner. Nicotine also induces withdrawal-like behaviors in these worms. Cotinine is the major nicotine metabolite in humans, although it is not the final product of nicotine metabolism. Cotinine is mostly inactive in vertebrate nervous systems and is currently being explored as a molecule which possess most of nicotine’s beneficial effects and few of its undesirable ones. It is not known …

Nsf Data Management Requirements 101, Jeffrey M. Mortimore

University Libraries: Faculty Presentations

As federal funding requirements continue to evolve and more publishers are requiring open data sharing as a condition of publication, academic libraries have an important role to play supporting campus researchers’ data management needs. During this session, we will explore in detail the National Science Foundation’s current data management requirements, giving special attention to data planning as part of the NSF’s grant application process. In so doing, we will discuss basic tools and levels of service for supporting campus researchers throughout the data life cycle.

Wsu Board Of Trustees Meeting Minutes, October 6-7, 2016

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on October 6-7, 2016.

What’S In The Gift? Towards A Molecular Dissection Of Nuptial Feeding In A Cricket, Yannick Pauchet, Natalie Wielsch, Paul A. Wilkinson, Aleš Svatoš, Scott K. Sakaluk, Richard H. Ffrench-Constant, David G. Heckel, John Hunt

Faculty Publications – Biological Sciences

Nuptial gifts produced by males and transferred to females during copulation are common in insects. Yet, their precise composition and subsequent physiological effects on the female recipient remain unresolved. Male decorated crickets Gryllodes sigillatus transfer a spermatophore to the female during copulation that is composed of an edible gift, the spermatophylax, and the ampulla that contains the ejaculate. After transfer of the spermatophore, the female detaches the spermatophylax and starts to eat it while sperm from the ampulla are evacuated into the female reproductive tract. When the female has finished consuming the spermatophylax, she detaches the ampulla and terminates sperm …

The George-Anne, Georgia Southern University

The George-Anne

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Functional Value Of Elytra Under Various Stresses In The Red Flour Beetle, Tribolium Castaneum, David M. Linz, Alan W. Hu, Michael I. Sitvarin, Yoshinori Tomoyasu

Entomology Faculty Publications

Coleoptera (beetles) is a massively successful order of insects, distinguished by their evolutionarily modified forewings called elytra. These structures are often presumed to have been a major driving force for the successful radiation of this taxon, by providing beetles with protection against a variety of harsh environmental factors. However, few studies have directly demonstrated the functional significance of the elytra against diverse environmental challenges. Here, we sought to empirically test the function of the elytra using Tribolium castaneum (the red flour beetle) as a model. We tested four categories of stress on the beetles: physical damage to hindwings, predation, desiccation, …

Glycoside Hydrolases Family 20 (Gh20) Represent Putative Virulence Factors That Are Shared By Animal Pathogenic Oomycetes, But Are Absent In Phytopathogens, Isabel Olivera, Katrina Fins, Sara Rodriguez, Sumayyah K. Abiff, Jaime Tartar, Aurelien Tartar

Biology Faculty Articles

Background

Although interest in animal pathogenic oomycetes is increasing, the molecular basis mediating oomycete-animal relationships remains virtually unknown. Crinkler (CRN) genes, which have been traditionally associated with the cytotoxic activity displayed by plant pathogenic oomycetes, were recently detected in transcriptome sequences from the entomopathogenic oomycete Lagenidium giganteum, suggesting that these genes may represent virulence factors conserved in both animal and plant pathogenic oomycetes. In order to further characterize the L. giganteum pathogenome, an on-going genomic survey was mined to reveal novel putative virulence factors, including canonical oomycete effectors Crinkler 13 (CRN13) orthologs. These novel sequences provided a basis to …

Interplay Between Evanescence And Disorder In Deep Subwavelength Photonic Structures, Hanan Herzig Sheinfux, Ido Kaminer, Azriel Z. Genack, Mordechai Segev

Publications and Research

Deep subwavelength features are expected to have minimal impact on wave transport. Here we show that in contrast to this common understanding, disorder can have a dramatic effect in a one-dimensional disordered optical system with spatial features a thousand times smaller than the wavelength. We examine a unique regime of Anderson localization where the localization length is shown to scale linearly with the wavelength instead of diverging, because of the role of evanescent waves. In addition, we demonstrate an unusual order of magnitude enhancement of transmission induced due to localization. These results are described for electromagnetic waves, but are directly …

The Bg News October 06, 2016, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. October 6, 2016. Volume 96-Issue 15.

Biallelic Mutations In Tbcd, Encoding The Tubulin Folding Cofactor D, Perturb Microtubule Dynamics And Cause Early-Onset Encephalopathy., Elisabetta Flex, Marcello Niceta, Serena Cecchetti, Isabelle Thiffault, Margaret G. Au, Alessandro Capuano, Emanuela Piermarini, Anna A. Ivanova, Joshua W. Francis, Giovanni Chillemi, Balasubramanian Chandramouli, Giovanna Carpentieri, Charlotte A. Haaxma, Andrea Ciolfi, Simone Pizzi, Ganka V. Douglas, Kara Levine, Antonella Sferra, Maria Lisa Dentici, Rolph R. Pfundt, Jean-Baptist Lepichon, Emily G. Farrow, Frank Baas, Fiorella Piemonte, Bruno Dallapiccola, John M. Graham, Carol J. Saunders, Enrico Bertini, Richard A. Kahn, David A. Koolen, Marco Tartaglia

Manuscripts, Articles, Book Chapters and Other Papers

Microtubules are dynamic cytoskeletal elements coordinating and supporting a variety of neuronal processes, including cell division, migration, polarity, intracellular trafficking, and signal transduction. Mutations in genes encoding tubulins and microtubule-associated proteins are known to cause neurodevelopmental and neurodegenerative disorders. Growing evidence suggests that altered microtubule dynamics may also underlie or contribute to neurodevelopmental disorders and neurodegeneration. We report that biallelic mutations in TBCD, encoding one of the five co-chaperones required for assembly and disassembly of the αβ-tubulin heterodimer, the structural unit of microtubules, cause a disease with neurodevelopmental and neurodegenerative features characterized by early-onset cortical atrophy, secondary hypomyelination, microcephaly, thin …

Pattern Phase Transitions Of Self-Propelled Particles: Gases, Crystals, Liquids, And Mills, Zhao Cheng, Zhiyong Chen, Tamás Vicsek, Duxin Chen

Dartmouth Scholarship

To understand the collective behaviors of biological swarms, flocks, and colonies, we investigated the non-equilibrium dynamic patterns of self-propelled particle systems using statistical mechanics methods and H-stability analysis of Hamiltonian systems. By varying the individual vision range, we observed phase transitions between four phases, i.e., gas, crystal, liquid, and mill-liquid coexistence patterns. In addition, by varying the inter-particle force, we detected three distinct milling sub-phases, i.e., ring, annulus, and disk. Based on the coherent analysis for collective motions, one may predict the stability and adjust the morphology of the phases of self-propelled particles, which has promising potential applications in …

Plants Having Increased Bomass And Methods For Making The Same, Aleel K. Grennan, Donald R. Ort, Stephen Patrick Moose, Damla D. Bilgin, Thomas Clemente, Fredy Altpeter, Stephen P. Long

Department of Agronomy and Horticulture: Faculty Publications

The impact of plastid size change in both monocot and dicot plants has been examined. In both, when plastid size is increased there is an increase in biomass relative to the parental lines. Thus, provided herein are methods for increasing the biomass of a plant, comprising decreasing the expression of at least one plastid division protein in a plant. Optionally, the level of chlorophyll in the plant is also reduced.

Peripersonal Space And Margin Of Safety Around The Body: Learning Visuo-Tactile Associations In A Humanoid Robot With Artificial Skin, A Roncone, M Hoffmann, U Pattacini, L Fadiga, G Metta

School of Engineering, Computing and Mathematics

This paper investigates a biologically motivated model of peripersonal space through its implementation on a humanoid robot. Guided by the present understanding of the neurophysiology of the fronto-parietal system, we developed a computational model inspired by the receptive fields of polymodal neurons identified, for example, in brain areas F4 and VIP. The experiments on the iCub humanoid robot show that the peripersonal space representation i) can be learned efficiently and in real-time via a simple interaction with the robot, ii) can lead to the generation of behaviors like avoidance and reaching, and iii) can contribute to the understanding the biological …

Throat Swabs And Sputum Culture As Predictors Of P. Aeruginosa Or S. Aureus Lung Colonization In Adult Cystic Fibrosis Patients, Darius Seidler, Mary Griffin, Amanda Nymon, Katja Koeppen, Alix Ashare

Dartmouth Scholarship

Background:

Due to frequent infections in cystic fibrosis (CF) patients, repeated respiratory cultures are obtained to inform treatment. When patients are unable to expectorate sputum, clinicians obtain throat swabs as a surrogate for lower respiratory cultures. There is no clear data in adult subjects demonstrating the adequacy of throat swabs as a surrogate for sputum or BAL. Our study was designed to determine the utility of throat swabs in identifying lung colonization with common organisms in adults with CF.

Methods:

Adult CF subjects (n = 20) underwent bronchoscopy with BAL. Prior to bronchoscopy, a throat swab was obtained. A sputum …

October 2016 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.

University Physics Volume 2, Samual J. Ling, Jeff Sanny, William Moebs, Gerald Friedman, Stphen D. Druger, Alice Kolakowska, David Anderson, Daniel Bowman, Dedra Demaree, Edw. S. Ginsberg, Lev Gasparov, Lee Larue, Mark Lattery, Richard Ludlow, Patrick Motl, Tao Pan, Kenneth Podolak, Takashi Sato, David Smith, Joseph Trout, Kevin Wheelock

Open Access Textbooks

University Physics is a three-volume collection that meets the scope and sequence requirements for two- and three-semester calculus-based physics courses. Volume 1 covers mechanics, sound, oscillations, and waves. Volume 2 covers thermodynamics, electricity and magnetism, and Volume 3 covers optics and modern physics. This textbook emphasizes connections between theory and application, making physics concepts interesting and accessible to students while maintaining the mathematical rigor inherent in the subject. Frequent, strong examples focus on how to approach a problem, how to work with the equations, and how to check and generalize the result.

October 6, 2016, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Conflict Or Congruence? Maternal And Infant-Centric Factors Associated With Shorter Exclusive Breastfeeding Durations Among The Tsimane, Melanie A. Martin, Geni Garcia, Hillard Kaplan, Michael Gurven

ESI Publications

No abstract provided.

Identification Of Snps Located On Bta 6 And Bta 20 Significantly Associated With Bovine Respiratory Disease In Crossbred Cattle, S. L. Miller, S. Mizell, R. Walker, T. Page, Matthew D. Garcia

Animal, Dairy, and Veterinary Science Faculty Publications

The objective of the present study was to evaluate single nucleotide polymorphisms (SNPs) located in two quantitative trait locus (QTL) regions (BTA 6 and BTA 20) that are associated with bovine respiratory disease (BRD). A population of 323 crossbred steers sired by five purebred sire breeds during 2010-2013 (Angus, Braford, Braunvieh, Charolais, and Simmental) were evaluated for BRD susceptibility during the finishing process at a commercial feedlot. A total of 21 animals representing all sire breeds were affected with BRD at some time during the finishing process over the 4-year period. Although multiple sire breeds were evaluated in the present …

Integrating Environmental Justice Into Public Health: Approaches For Understanding Cumulative Impacts, Gina Solomon, John Faust, Rachel Morello-Frosch, Lauren Zeise

Frontiers in Public Health Services and Systems Research

Communities located near multiple sources of pollution, including current and former industrial sites, major roadways, and agricultural operations, are often predominantly low-income, with a large percentage of minorities and non-English speakers. These communities face additional challenges that can affect the health of their residents, including limited access to health care, a shortage of grocery stores, poor housing quality, and a lack of parks and open spaces. Research is now showing that environmental exposures can interact with social stressors, thereby worsening health outcomes. Age, nutrition, genetic characteristics, and preexisting health conditions also increase the risk of adverse health effects from exposure …

Probabilistic Analysis Of Polyovulation Frequencies, Tiffany N. Kolba, Kaylyn Banaszak, Anna Kaniewski

Spora: A Journal of Biomathematics

Polyovulation is the production of more than one ovum, or egg, during a single menstrual cycle. This paper examines the probability of the human ovarian system ovulating $k$ eggs during a single cycle, for $k\geq0$. In order to obtain precise estimates for the probability of polyovulation, we use U.S. birth data from the 1950's (before the introduction of artificial reproductive technologies). However, to utilize birth data, we model the various processes that eggs undergo in order to result in a live birth, including fertilization, possible division, implantation, and potential miscarriage. Our model produces novel estimates for the probability that a …

Insects: Still Looking Like Zombies, Christopher S. Hill

Animal Sentience

In arguing that insect brains are capable of sentience, Klein & Barron rely heavily on Bjorn Merker’s claim that activity in the human mid-brain is sufficient for conscious experience. I criticize Merker’s claim by pointing out that the behaviors supported by midbrain activity are much more primitive than the ones that appear to depend on consciousness. I raise a similar objection to Klein & Barron’s contention that insect behaviors are similar to behaviors that manifest consciousness in human beings. The similarity is weak. I also respond to the related view that integrative activity in mid-brain structures is sufficient to explain …

Moments And Momentum In Jefferson County African American History, John Cuthbert, Stewart Plein, James Green Jr., James A. Tolbert Sr., George C. Rutherford

ASA Annual Conference

Moderator.