Digital Commons Network^™

Family Based Treatment For Adults With Anorexia Nervosa Using Insights From Neurobiology, The Center For Balanced Living

Learning Showcase 2016: A Celebration of Discovery, Transformation and Success

Anorexia Nervosa (AN) is a biologically-based brain disorder, which has the highest death rate of all mental illnesses. No effective treatments exist for adults with severe and enduring AN (5-7+ years). Brain imaging studies at University of California San Diego on AN temperament, cognition and eating show common traits related to neural function. The temperaments are characterized by increased trait anxiety and state anxiety related to food and eating, high incidence of co-morbid anxiety disorders, high punishment sensitivity and low reward reactivity, elevated intolerance of uncertainty and exaggerated harm avoidance (HA). HA is a multifaceted temperament trait that contains elements …

Scene & Herd, October 7, 2016, University Of South Florida St. Petersburg. Division Of University Relations

Points of Pride, Scene & Herd, and E-News

The October 7, 2916, issue of Scene & Herd, a newsletter for faculty and staff at the University of South Florida St. Petersburg.

Evaluation Of A School Nurse-Led Obesity Program For Severely Obese New York City Public School Students, Krista Schroeder, Haomiao Jia, Y. Claire Wang, Arlene Smaldone

Sigma Foundation for Nursing Research Grant Reports

The purpose of this mixed-methods study was to evaluate the Healthy Options and Physical Activity Program (HOP), a school nurse-led childhood obesity initiative for severely obese New York City Public School students. Aims 1, 2, and 3 employed a retrospective cohort design and examined program implementation and the effect of HOP on health behavior change and change in BMI percentile; Aim 4 employed a qualitative design to provide context and inform recommendations to more fully deploy HOP within the New York City school system. The formal aims of the study are as follows:

Aim 1) Examine demographic and medical characteristics …

The Structure Of The Antibiotic Deactivating, N-Hydroxylating Rifampicin Monooxygenase, Li Kai Liu, Heba Abdelwahab, Julia S. Martin Del Campo, Ritcha Mehra-Chaudhary, Pablo Sobrado, John J. Tanner

Chemistry Faculty Research & Creative Works

Rifampicin monooxygenase (RIFMO) catalyzes the N-hydroxylation of the natural product antibiotic rifampicin (RIF) to 2′-N-hydroxy-4-oxo-rifampicin, a metabolite with much lower antimicrobial activity. RIFMO shares moderate sequence similarity with well characterized flavoprotein monooxygenases, but the protein has not been isolated and characterized at the molecular level. Herein, we report crystal structures of RIFMO from Nocardia farcinica, the determination of the oligomeric state in solution with small angle x-ray scattering, and the spectrophotometric characterization of substrate binding. The structure identifies RIFMO as a class A flavoprotein monooxygenase and is similar in fold and quaternary structure to MtmOIV and OxyS, which are enzymes …

Circnet: A Database Of Circular Rnas Derived From Transcriptome Sequencing Data, Yu-Chen Liu, Jian-Rong Li, Chuan-Hu Sun, Erik Andrews, Rou-Fang Chao, Feng-Mao Lin, Shun-Long Weng, Sheng-Da Hsu, Chieh-Chen Huang, Chao Cheng, Chun-Chi Liu, Hsien-Da Huang

Dartmouth Scholarship

Circular RNAs (circRNAs) represent a new type of regulatory noncoding RNA that only recently has been identified and cataloged. Emerging evidence indicates that circRNAs exert a new layer of post-transcriptional regulation of gene expression. In this study, we utilized transcriptome sequencing datasets to systematically identify the expression of circRNAs (including known and newly identified ones by our pipeline) in 464 RNA-seq samples, and then constructed the CircNet database (http://circnet.mbc.nctu.edu.tw/) that provides the following resources: (i) novel circRNAs, (ii) integrated miRNA-target networks, (iii) expression profiles of circRNA isoforms, (iv) genomic annotations of circRNA isoforms (e.g. 282 948 exon positions), …

Seasonal Fecundity Is Not Related To Geographic Position Across A Species’ Global Range Despite A Central Peak In Abundance, Katharine J. Ruskin, Matthew A. Etterson, Thomas P. Hodgman, Alyssa C. Borowske, Jonathan B. Cohen, Chris S. Elphick, Christopher R. Field, Rebecca A. Kern, Erin King, Alison R. Kocek, Adrienne I. Kovach, Kathleen M. O’Brien, Nancy Pau, W. Gregory Shriver, Jennifer Walsh, Brian J. Olsen

United States Environmental Protection Agency: Publications

The range of a species is determined by the balance of its demographic rates across space. Population growth rates are widely hypothesized to be greatest at the geographic center of the species range, but indirect empirical support for this pattern using abundance as a proxy has been mixed, and demographic rates are rarely quantified on a large spatial scale. Therefore, the texture of how demographic rates of a species vary over its range remains an open question. We quantified seasonal fecundity of populations spanning the majority of the global range of a single species, the saltmarsh sparrow (Ammodramus caudacutus …

The Value Of Crowdsourcing For Complex Problems: Comparative Evidence From Software Developed By The Crowd And Professionals, Abhishek Tripathi, Deepak Khazanchi

Information Systems and Quantitative Analysis Faculty Publications

Crowdsourcing is a problem solving model. In the context of complex problems, conventional theory suggests that solving complex problems is a province of professionals, that is, people with sufficient knowledge about the domain. Prior literature has indicated that the crowd, in addition to professionals, is also a great source for solving problems such as product innovation and idea generation. However, this assumption has yet to be tested. Adopting a quasi-experimental approach, this study uses a two-phase process to investigate this question. In the first phase we compare the development of a software by the crowd and professionals. In the second …

Two Students Recognized As Rising Stars In New Hampshire, Kassidy Taylor

UNH Today Archive

No abstract provided.

Large-Scale Off-Target Identification Using Fast And Accurate Dual Regularized One- Class Collaborative Filtering And Its Application To Drug Repurposing, Hansaim Lim, Aleksandar Poleksic, Yuan Yao, Hanghang Tong, Di He, Luke Zhuang, Patrick Meng, Lei Xie

Publications and Research

Target-based screening is one of the major approaches in drug discovery. Besides the intended target, unexpected drug off-target interactions often occur, and many of them have not been recognized and characterized. The off-target interactions can be responsible for either therapeutic or side effects. Thus, identifying the genome-wide off-targets of lead compounds or existing drugs will be critical for designing effective and safe drugs, and providing new opportunities for drug repurposing. Although many computational methods have been developed to predict drug-target interactions, they are either less accurate than the one that we are proposing here or computationally too intensive, thereby limiting …

A Novel Genetic Variant In Long Non-Coding Rna Gene Nexn-As1 Is Associated With Risk Of Lung Cancer, Hua Yuan, Hongliang Liu, Zhensheng Liu, Kouros Owzar

Dartmouth Scholarship

Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wideassociation studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortiumin populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10−7) were further validated in two additional independent lung cancer GWAS datasets from Harvard University anddeCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant(odds ratio = 1.17; 95% confidence interval = 1.11–1.24; P = 8.31 × 10−9). In further in silico analysis,rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.

Allosteric Modulation Of The Cannabinoid Receptor One: Evaluation Of Analogs Of Indole-2-Carboxamide And Pyrimidinyl Biphenylurea, Leepakshi Khurana

Doctoral Dissertations

Archival abstract submitted

Decreasing Blood Pressure Readings Using A Patient-Centered Interprofessional Team Approach, Elaine Diane Briggs

DNP and Student Works

Hypertension is one of the most modifiable risk factors for the prevention of heart disease. Current practice involves medical management of hypertension by the primary care provider. Provision of medical management alone is not improving blood pressures of patients with hypertension. Therefore, a patient-centered interprofessional team was developed to address the lack of a coordinated approach to the management of hypertensive patients.

Differential Functional Connectivity Of Rostral Anterior Cingulate Cortex During Emotional Interference, Akos Szekely, Rebecca L. Silton, Wendy Heller, Gregory A. Miller, Aprajita Mohanty

Psychology: Faculty Publications and Other Works

The rostral-ventral subdivision of the anterior cingulate cortex (rACC) plays a key role in the regulation of emotional processing. Although rACC has strong anatomical connections with anterior insular cortex (AIC), amygdala, prefrontal cortex and striatal brain regions, it is unclear whether the functional connectivity of rACC with these regions changes when regulating emotional processing. Furthermore, it is not known whether this connectivity changes with deficits in emotion regulation seen in different kinds of anxiety and depression. To address these questions regarding rACC functional connectivity, non-patients high in self-reported anxious apprehension (AP), anxious arousal (AR), anhedonic depression (AD) or none (CON) …

Effect Of Cover Crops And Nitrogen Application Timing On Nutrient Loading And Concentration Through Subsurface Tile Drainage, Michael Douglas Ruffatti

Theses and Dissertations

It has been estimated that nitrate (NO3-N) leaching from artificially drained agricultural fields in the Upper Mississippi River Basin accounts for approximately 65% of nitrogen (N) delivered annually to the Gulf of Mexico. Therefore, the objectives of this study were to investigate the impact fertilizer application timing and cover crops (CC) adoption on the load and concentration of nutrients in subsurface drainage leachate. This experiment was conducted at the Illinois State University Nitrogen Management Field Station, in Lexington, IL. Treatments include a zero control (no N fertilizer and no cover crop), fall dominated N application (70% fall, 30% spring) with …

Pregnancy, Drug Use, And The Unborn Child: When A Baby's Lifeline Leads To Neonatal Drug Withdrawal, Kristie M. Pierce

Liberty University Law Review

No abstract provided.

Packaging Film Impact On Food Organoleptic Properties: An Experimental Study, Stefano Tamarindo, Carine Pastore

Journal of Applied Packaging Research

Most packaged food products deteriorate in quality due to mass transfer phenomena such as moisture absorption, oxygen invasion, flavor loss, undesirable odor absorption and packaging material migration. An approach to increase the shelf life of the packaged food, while exploiting the advantages of flexible packaging, is to use flexible multi-layer polyethylene (PE)-based films including a barrier layer. This paper reviews different oxygen barrier layers used in Doy Pack flexible pouches for fruit puree and presents the impact of storage conditions on the organoleptic properties. In this study, the performances of five types of PE film pouched filled with fruit puree …

Share Cropping Blackness: White Supremacy And The Hyper-Consumption Of Black Popular Culture, Nyambura Njee

McNair Scholars Research Journal

This qualitative study will explore the impact of the way that “Blackness” is constructed and commodified for consumption within a White supremacist culture, and examine the effects of this construct on the Black community. According to Leonard and King (2012), in their book Commodified and Criminalized: New Racism and African Americans in Contemporary Sports, “The process of commodification is not simply about selling an essentialized Black culture, but rather a particular construction of Blackness that has proven beneficial to White[s]” (p. 10). This paper will discuss some of the twenty-first century consequences of this phenomenon. The methodology will be …

Review Of Native Fragile Sites In Saccharomyces Cerevisiae: A Comparison To Human Fragile Sites, Tayler M. Murphy

McNair Scholars Research Journal

Saccharomyces cerevisiae (S. cerevisiae) was the first eukaryote to have its full genome sequenced, which makes it one of the longest studied genomes. The scientific community has established that S. cerevisiae is a useful model in the study of human diseases due to the homology that exists in numerous human and yeast genes. Yeast artificial chromosomes (YACs) have been developed that contain inserts of human DNA. These YACs can be used to study the mechanisms that cause DNA fragility in humans by placing a known human fragile site within a YAC. Though it is useful to study human …

The Intersection Of American Indians/Alaskan Natives And The Child Welfare System: A Review Of The Literature, Rebecca J. Luth

McNair Scholars Research Journal

American Indians/Alaskan Natives (AI/AN) have historically been forcefully integrated into the child welfare system. Their relationship began before a formal child welfare system was established in the United States and continues to the present. It is critical to examine AI/AN history and the child welfare system in the United States to fully understand their difficult and often damaging interactions. This paper will review the literature on this topic in an effort to highlight the intersectionality of AI/ AN children and families, and the policies and practices of the American child welfare system.

Accuracy Of Dna Repair During Replication In Saccharomyces Cerevisiae, Mikael K. Dunn

McNair Scholars Research Journal

DNA repair is a crucial part of organismal survival. The repair process is carried out by DNA polymerases and mismatch repair proteins. Things don’t always go as planned in DNA repair, and sometimes DNA repair is inaccurate. Inaccurate DNA repair can potentially lead to the loss of the genes important for cell division and replication. There has been much research into the efficiency of these DNA polymerases, yet there has been no thorough research into how the accuracy of repair is distributed among all of the different types of homologous recombination. The goal of this article is to review the …

Learning Is Not Child's Play: Assessing The No Child Left Behind Act, Gwendolyn J. Dean

McNair Scholars Research Journal

This research examines the implementation and impact of the 2001 No Child Left Behind Act (NCLB) on education quality. More specifically, it outlines how states defined NCLB provisions, including trajectory selection, reporting techniques, confidence interval use, and methods used to inform the public of outcomes. It also discusses NCLB’s impact on education outcomes by assessing changes in fourth grade reading scores under NCLB. This qualitative study includes several demographic variables that will allow the study to control for the impact that NCLB’s implementations has caused and its effect on school districts that have taken on this process.

Development Of Biosensors For Small Environmental Target Molecules Using Ce-Selex, Mariah C. Brito

McNair Scholars Research Journal

Microcystin is a naturally occurring liver cyanotoxin that can be found in water bodies around the world. Cyanobacterial blooms occur worldwide and can potentially contaminate municipal drinking water supplies with various toxins. These events are hazardous, naturally occurring processes that can be worsened by anthropogenic activities. The past 50 years have shown notable changes in global climate, likely due to environmentally detrimental human activities. Our environmental impacts have increased the frequency and severity of these events in the past decade. Developments in water quality control and maintenance have greatly reduced exposure to contaminated water, but current methods to detect microcystin …

Unlocking Young Minds: An Examination Of Minority Mental Health In The Juvenile Justice System, Brandie Bentley

McNair Scholars Research Journal

A substantial number of minority youth in the juvenile justice system have mental health issues, and many do not have access to necessary mental health services and support. This paper is an extended review of literature that examines present racial disparities in the juvenile justice system and further, explores the disproportionate racial and ethnic differences in mental health service utilization prior to, during, and after involvement in the corrections system. Additionally, this paper will discuss contributing factors that influence minority youth interaction with mental health services, including federal policy, community resources, and socioeconomic status. Based on the findings of this …

Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for October 6-12, 2016. Vol. 104, No. 2.

Electro-Chemotactic Fields Induce Cooperative Movement Of Cns Cells, Shawn Mishra, Stephen Redenti, Maribel Vazquez

Publications and Research

Vision loss in adults with Age Related Macular Degeneration (AMD) is attributed to damage of retinal photoreceptor cells that initiate vision by absorbing light. Mouse models have suggested that transplantation of precursor cells may be a novel approach to restore vision. This project uses a combination of electrotactic and chemotactic stimuli to promote and guide CNS cell migration within a microdevice model.

The Setonian, October 6, 2016, Seton Hall University

2016

No abstract provided.

October 6, 2016, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The East Texan, 2016-10-06, Texas A&M University-Commerce

All Issues

A color copy of The East Texan, a student newspaper published at Texas A&M University-Commerce.

Bd Medical Tour | Biological Engineering, Usu College Of Engineering

College of Engineering News

On October 6, 2016, 19 students, mostly from the Biological Engineering Department, traveled to Sandy, UT to tour BD Medical. Students were able to experience a medical manufacturing company first hand. They were able to see the various steps that go into the research, development, production, and quality control when producing and streamlining a product. The tour featured questions and answers about what BD Medical does, career and internship opportunities, and a walk-through of the manufacturing facility.

Genome-Wide Association Study Identifies Candidate Loci Underlying Agronomic Traits In A Middle American Diversity Panel Of Common Bean, Samira Mafi Moghaddam, Sujan Mamidi, Juan M. Osorno, Rian Lee, Mark A. Brick, James Kelly, Phillip N. Miklas, Carlos A. Urrea, Qijian Song, Perry B. Cregan, Jane Grimwood, Jeremy Schmutz, Phillip E. Mcclean

Panhandle Research and Extension Center

Common bean (Phaseolus vulgaris L.) breeding programs aim to improve both agronomic and seed characteristics traits. However, the genetic architecture of the many traits that affect common bean production are not completely understood. Genome-wide association studies (GWAS) provide an experimental approach to identify genomic regions where important candidate genes are located. A panel of 280 modern bean genotypes from race Mesoamerica, referred to as the Middle American Diversity Panel (MDP), were grown in four US locations, and a GWAS using >150,000 single-nucleotide polymorphisms (SNPs) (minor allele frequency [MAF] ≥ 5%) was conducted for six agronomic traits. The degree of …