Digital Commons Network^™

Investigating The Antiproliferative Activity Of Synthetic Troponoids, Eric R. Falcone

Doctoral Dissertations

Troponoid (more commonly, tropone/tropolone) refers to a family of naturally occurring compounds with a unique seven-membered aromatic ring. As with many secondary metabolites, many of the tropolones display a wide range of biological activity. This activity includes: antibacterial/antifungal, insecticidal, phytotoxic, antimitotic, anti-inflammatory, enzyme inhibition, anticancer and reactive oxygenated species (ROS) scavenging. Most of this broad-range activity is attributed to the tropolone moiety while side chains attribute to selectivity. Therefore, tropolone may offer a unique scaffold to develop antiproliferatives since it can chelate metal ions, is relatively small and most likely promiscuous, likely resulting in several mechanisms of action to diminish …

The Lumberjack, October 5, 2016, The Lumberjack Staff

2016

The student newspaper of Humboldt State University

The Anchor, Volume 130.06: October 5, 2016, Hope College

The Anchor: 2016

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Vacht Overexpression Increases Acetylcholine At The Synaptic Cleft And Accelerates Aging Of Neuromuscular Junctions, Satoshi Sugita, Leland L. Fleming, Caleb Wood, Sydney K. Vaughan, Matheus P. S. M. Gomes, Wallace Camargo, Ligia A. Naves, Vania F. Prado, Marco A. M. Prado, Cristina Guatimosim, Gregorio Valdez

Anatomy and Cell Biology Publications

Background: Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to age-and disease-related degeneration of the motor system. Here we investigated the effect of moderately increasing levels of synaptic acetylcholine (ACh) on the neuromuscular junction (NMJ), muscle fibers, and motor neurons during development and aging and in a mouse model for amyotrophic lateral sclerosis (ALS). Methods: Chat-ChR2-EYFP (VAChTHyp) mice containing multiple copies of the vesicular acetylcholine transporter (VAChT), mutant superoxide dismutase 1 (SOD1G93A), and Chat-IRES-Cre and tdTomato transgenic mice were used in this …

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

Volume 54, Number 8: October 05, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Farm Of The Future, Michelle Morrissey

UNH Today Archive

No abstract provided.

The Collegian: October 05, 2016, The Collegian Staff

The Collegian, 2016-2017

Volume 132
Issue 7

Synthesis And Characterization Of Polycyclic Aromatic Hydrocarbon ( Pah )-Porphyrin Hybrids, Ruixiao Gao

Theses and Dissertations

Carbaporphyrins are porphyrin analogs where one or more pyrrole units are replaced with a carbocyclic ring. Benziporphyrins are porphyrin analogues with a 1,3-phenylene unit replacing one of the pyrrole subunits. Because of cross-conjugation, benziporphyrins are not aromatic species. However, protonation of benziporphyrins can afford some aromatic characteristics. Although the synthesis of many examples of monocarbaporphyrins have been successfully executed, no examples of porphyrinoids with pyrene subunits have been prepared. Pyrene-containing porphyrinoids, which have been named as pyreniporphyrins, are theoretically significant molecules that provide insights into the aromaticity and reactivity of porphyrinoid systems.

In this thesis, two projects were conducted to …

Author Returns To Oxford For School Reunion, Book Signing, Sydney Slotkin Dupriest

University of Mississippi News

Robert Magarian learned to think like a detective for his latest thriller

Hazcom 2012, Cheri Marcham

Publications

This presentation reviews changes to the OSHA Standard called HazCom 2012. Old and new definitions for "health hazards" are discussed as well as labeling requirements.

Rna-Seq Of Borrelia Burgdorferi In Multiple Phases Of Growth Reveals Insights Into The Dynamics Of Gene Expression, Transcriptome Architecture, And Noncoding Rnas, William K. Arnold, Christina R. Savage, Catherine A. Brissette, Janakiram Seshu, Jonathan Livny, Brian Stevenson

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Borrelia burgdorferi, the agent of Lyme disease, differentially expresses numerous genes and proteins as it cycles between mammalian hosts and tick vectors. Insights on regulatory mechanisms have been provided by earlier studies that examined B. burgdorferi gene expression patterns during cultivation. However, prior studies examined bacteria at only a single time point of cultivation, providing only a snapshot of what is likely a dynamic transcriptional program driving B. burgdorferi adaptations to changes during culture growth phases. To address that concern, we performed RNA sequencing (RNA-Seq) analysis of B. burgdorferi cultures at early-exponential, mid-exponential, and early-stationary phases …

The Guardian, October 5, 2016, Wright State University Student Body

The Guardian Student Newspaper

Eight page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

Takeover On The Tallgrass Prairie: How Lespedeza Cuneata Establishes Dominance, Morgan Rae Walder

Theses and Dissertations

Invasion ecology aims to study mechanisms by which invasive species are able to enter, establish, and spread within an ecosystem. This study analyzed Darwin’s naturalization and the biotic resistance hypotheses as the most likely explanations for invasion by an exotic legume, Lespedeza cuneata, into a tallgrass prairie. Darwin’s naturalization hypothesis posits that exotic species are less able to establish in communities that have related species, because similarity in morphology and function promotes intense competition for resources. The biotic resistance hypothesis states that competitors, herbivores, and pathogens already present in the community limit the colonization, naturalization, and persistence of invaders, therefore …

Semi-Supervised Deep Neural Network For Network Intrusion Detection, Mutahir Nadeem, Ochaun Marshall, Sarbjit Singh, Xing Fang, Xiaohong Yuan

KSU Proceedings on Cybersecurity Education, Research and Practice

Network security is of vital importance for corporations and institutions. In order to protect valuable computer systems, network data needs to be analyzed so that possible network intrusions can be detected. Supervised machine learning methods achieve high accuracy at classifying network data as normal or malicious, but they require the availability of fully labeled data. The recently developed ladder network, which combines neural networks with unsupervised learning, shows promise in achieving a high accuracy while only requiring a small number of labeled examples. We applied the ladder network to classifying network data using the Third International Knowledge Discovery and Data …

Brain Betrayal: A Neuropsychological Categorization Of Insider Attacks, Rachel L. Whitman

KSU Proceedings on Cybersecurity Education, Research and Practice

Thanks to an abundance of highly publicized data breaches, Information Security (InfoSec) is taking a larger place in organizational priorities. Despite the increased attention, the threat posed to employers by their own employees remains a frightening prospect studied mostly in a technical light. This paper presents a categorization of insider deviant behavior and misbehavior based off of the neuropsychological foundations of three main types of insiders posing a threat to an organization: accidental attackers; neurologically “hot” malcontents, and neurologically “cold” opportunists.

Ionic Basis Of Ventricular Action Potentials, Ariel L. Escobar

Science Seminar Series

Dr. Escobar will talk about his cutting-edge approach to understanding molecular mechanisms underlying electrical activity in the heart.

Intensive, Regular Sampling And Removal Of Modest Numbers Of Fishes Shows No Measurable Impact On Fish Populations In Three Streams Of North Georgia, Steven L. Powers

Southeastern Fishes Council Proceedings

Recent publications and restrictions on collecting by state fish and game managers indicate a growing concern regarding the impact of field sampling on native fish populations. To evaluate the validity of these concerns, data from five life-history studies conducted in Cherokee County, Georgia were examined to test the hypothesis that regular sampling has a negative impact on fish populations. Number of individuals collected was divided by time collecting to calculate catch per unit effort (CPUE) as an indicator of relative abundance for each species. The collecting sequence (i.e. the number of times a species had previously been sampled) was regressed …

Recruitment Sources Of Channel And Blue Catfishes Inhabiting The Middle Mississippi River, Troy W. Laughlin, Gregory Whitledge, Devon C. Oliver, Neil P. Rude

Publications

Insight into environments that contribute recruits to adult fish stocks in riverine systems is vital for effective population management and conservation. Catfish are an important recreational species in the Mississippi River and are commercially harvested. However, contributions of main channel and tributary habitats to catfish recruitment in large rivers are unknown. Stable isotope and trace elemental signatures in otoliths are useful for determining environmental history of fishes in a variety of aquatic systems, including the Mississippi River. The objectives of this study were to identify the principal natal environments of channel catfish Ictalurus punctatus and blue catfish I. furcatus in …

Jami Hodgins Selected As Inaugural Recipient Of The Roddey, Johnson, Gladden, Meriwether Scholarship, Winthrop University

Winthrop News 2016

• Jami Hodgins, an English major from Florence, was selected as the inaugural recipient of the Roddey, Johnson, Gladden, Meriwether Scholarship.
• The scholarship is named for Cynthia Plair Roddey ’67, Delores Johnson Hurt ’68, Arnetta Gladden Mackey ’67 and Sue Frances Meriwether Steed ’67, who became the first African-American students to enroll at Winthrop.
• In total, 10 corporations and foundations, four Winthrop student organizations and 176 individuals made generous contributions to the scholarship.

Performance-Constrained Binary Classification Using Ensemble Learning: An Application To Cost-Efficient Targeted Prep Strategies, Wenjing Zheng, Laura Balzer, Maya L. Petersen, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Binary classifications problems are ubiquitous in health and social science applications. In many cases, one wishes to balance two conflicting criteria for an optimal binary classifier. For instance, in resource-limited settings, an HIV prevention program based on offering Pre-Exposure Prophylaxis (PrEP) to select high-risk individuals must balance the sensitivity of the binary classifier in detecting future seroconverters (and hence offering them PrEP regimens) with the total number of PrEP regimens that is financially and logistically feasible for the program to deliver. In this article, we consider a general class of performance-constrained binary classification problems wherein the objective function and the …

Sulfatase 2 Facilitates Lymphangiogenesis In Breast Cancer By Regulating Vegf-D., Chenfang Zhu, Xiaoliang Qi, Xin Zhou, Xin Nie, Yan Gu

Surgery Faculty Publications

In our previous studies, sulfatase 2 (Sulf2) was found to upregulate vascular endothelial growth factor-D (VEGF-D) expression in breast cancer. As VEGF-D plays an important role in lymphangiogenesis, we hypothesized that Sulf2 facilitates lymphangiogenesis in breast cancer by regulating VEGF-D. To evaluate the functions of Sulf2 on lymphangiogenesis in breast cancer, proliferation, apoptosis, cell cycle, cell mobility and tube-formation of lymphatic endothelial cells (LECs) were measured in vitro. Lymphangiogenesis in nude mouse ears and breast cancer xenografts were examined in vivo. Furthermore, the expression levels of related signaling pathway genes were screened and verified in LECs. We found that Sulf2 …

Ecological Crisis And The Re-Enchantment Of Nature In Jaime Huenún’S Reducciones., Ida Day

Modern Languages Faculty Research

Chilean poet Jaime Huenún’s Reducciones (Reductions; 2012) explores the social and environmental consequences of European colonization since the second half of the nineteenth century, when southern Chile received thousands of German immigrants as part of a state-sponsored colonization plan. Confronted with large stretches of impenetrable native forests, the colonists began a deforestation process in order to prepare the land for agriculture and livestock farming, which left a profound impact on the society, economy, and geography of the region. In less than a century, the region spanning La Araucanía to Chiloé lost at least three million hectares of native forests. The …

Tumor Vessel Normalization After Aerobic Exercise Enhances Chemotherapeutic Efficacy., Keri L Schadler, Nicholas J Thomas, Peter Galie, Dong Ha Bhang, Kerry C Roby, Prince Addai, Jacob E Till, Kathleen Sturgeon, Alexander Zaslavsky, Christopher S Chen, Sandra Ryeom

Henry M. Rowan College of Engineering Departmental Research

Targeted therapies aimed at tumor vasculature are utilized in combination with chemotherapy to improve drug delivery and efficacy after tumor vascular normalization. Tumor vessels are highly disorganized with disrupted blood flow impeding drug delivery to cancer cells. Although pharmacologic anti-angiogenic therapy can remodel and normalize tumor vessels, there is a limited window of efficacy and these drugs are associated with severe side effects necessitating alternatives for vascular normalization. Recently, moderate aerobic exercise has been shown to induce vascular normalization in mouse models. Here, we provide a mechanistic explanation for the tumor vascular normalization induced by exercise. Shear stress, the mechanical …

Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy, Jiang Liu, Jiang Tian, Muhammad Chaudhry, Nader G. Abraham, Joseph Shapiro

NYMC Faculty Publications

We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the induction of uremic …

Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy, Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, Yanling Yan, Xiaoliang Wang, Preeya T. Shah, Asad A. Khawaja, Rebecca Martin, Tylor J. Robinette, Adee El-Hamdani, Michael W. Dodrill, Komal Sodhi, Christopher A. Drummond, Steven T. Haller, David J. Keenedy, Nader G. Abraham, Zijian Xie, Joseph I. Shapiro Md

Biochemistry and Microbiology

We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the induction of uremic …

Jefferson Digital Commons Quarterly Report: July-September 2016, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

Highlights in this quarterly report include:

• Class Day programs from 1964-2015
• Commencement programs from the Medical College from 1870 to the present.
• Commencement programs from College of Graduate Studies
• Readership download map for the quarter
• Top 10 government and education domains accessing content in the JDC
• What people are saying about the Jefferson Digital Commons

Defining And Targeting Health Disparities In Chronic Obstructive Pulmonary Disease, Roy A. Pleasants, Isaretta L. Riley, David M. Mannino

Preventive Medicine and Environmental Health Faculty Publications

The global burden of chronic obstructive pulmonary disease (COPD) continues to grow in part due to better outcomes in other major diseases and in part because a substantial portion of the worldwide population continues to be exposed to inhalant toxins. However, a disproportionate burden of COPD occurs in people of low socioeconomic status (SES) due to differences in health behaviors, sociopolitical factors, and social and structural environmental exposures. Tobacco use, occupations with exposure to inhalant toxins, and indoor biomass fuel (BF) exposure are more common in low SES populations. Not only does SES affect the risk of developing COPD and …

Core Curriculum Operating Manual, Butler University

Policy Documents

This document serves as the companion to the Original Core Document (June 2005); it contains updated information about the mission of each area, the constitution and duties of advisory committees and provides implementation information for both curriculum development and assessment. Information of special importance to advisors, including policies regarding exemptions, variances and transfer credits are also included. The manual will be updated annually; substantive changes must be approved by the Core Curriculum Committee; minor changes (such as typographical errors, broken links, or changes to maintain conformity) shall not require the approval of the Core Curriculum Committee, rather only an annual …

Mitochondrial Dna Sequence And Lack Of Response To Anoxia In The Annual Killifish Austrofundulus Limnaeus, Josiah Tad Wagner, Florisela Herrejon Chavez, Jason E. Podrabsky

Center for Life in Extreme Environments Publications

The annual killifish Austrofundulus limnaeus inhabits ephemeral ponds in regions of Venezuela, South America. Permanent populations of A. limnaeus are maintained by production of stress-tolerant embryos that are able to persist in the desiccated sediment. Previous work has demonstrated that A. limnaeus have a remarkable ability to tolerate extended periods of anoxia and desiccating conditions. After considering temperature, A. limnaeus embryos have the highest known tolerance to anoxia when compared to any other vertebrate yet studied. Oxygen is completely essential for the process of oxidative phosphorylation by mitochondria, the intracellular organelle responsible for the majority of adenosine triphosphate production. Thus, …