Digital Commons Network^™

Context-Dependent Regulation Of Six1 By Ets1 Within Emt-Associated Transcriptional Networks, İrem Yalim Camci

Turkish Journal of Biology

Background/aim: Epithelial-mesenchymal transition (EMT) is a fundamental process driving tumor plasticity, metastasis, and therapy resistance. Although E26 transformation-specific transcription factor 1 (ETS1) and Sine oculis homeobox homolog 1 (SIX1) are individually implicated in EMT-related transcriptional programs, the regulatory interplay and functional coordination of these proteins across tumor states remain unclear. Hence, this study aimed to investigate the mechanistic and clinical behavior of the ETS1–SIX1 axis, with a focus on hepatocellular carcinoma (HCC) and aggressive endothelial-like cancer phenotypes.

Materials and methods: ETS1–SIX1 expression patterns were analyzed using real‐time quantitative polymerase chain reaction in HCCderived cell lines and the endothelial-like SK-HEP-1 cell …

Retinoic Acid-Loaded Nanoparticles Enhance Macrophage-Mediated Control Of Leishmania Infantum, Zeynep İşlek, Merve Gündoğdu, Zeynep Di̇la Yüksel

Turkish Journal of Biology

Background/aim: Visceral leishmaniasis, primarily caused by Leishmania infantum, remains a major global health challenge due to limitations in current chemotherapeutic options, including toxicity and emerging drug resistance. Host-directed therapeutic approaches are increasingly recognized as promising alternatives. All-trans retinoic acid (ATRA) is an immunomodulatory molecule with host-dependent effects on macrophage function; however, its therapeutic use is hindered by instability and poor solubility. Solid lipid nanoparticles (SLNs) offer a controlled and biocompatible delivery platform capable of enhancing intracellular drug accumulation.

Materials and methods: ATRA-loaded SLNs were prepared and characterized for size, polydispersity index, zeta potential, and morphology. Their antileishmanial activity was evaluated …

Characterization Of Poly-Β-Hydroxybutyrate And Its Biosynthesis In Priestia Endophytica Ucm B-5715, Alina Kharchuk, Maksym Kharchuk, Maksym Kharkhota, Sergiy Rogalsky, Oksana Tarasyuk, Oleksandr Kisten, Anastasiia Hubina, Illya Kapats, Liliia Avdieieva

Turkish Journal of Biology

Background/aim: Polyhydroxyalkanoates (PHAs) are biodegradable biopolymers with promising applications in biotechnology and medicine; however, the diversity of their biosynthesis within the genus Priestia remains poorly characterized. Although Priestia species have been recognized as potential PHA producers, the detailed genomic architecture and physicochemical properties of the polymers synthesized by these bacteria, particularly in the type strain, remain poorly understood. This study aimed to characterize the poly-β-hydroxybutyrate (PHB) produced by Priestia endophytica UCM B-5715 and to investigate the PHB biosynthetic genes across related strains.

Materials and methods: PHB granules were visualized and measured using fluorescence microscopy, transmission electron microscopy, and scanning electron …

Nutrient Uptake Of Two Microalgae From Culture Medium Under Nickel Treatment, Di̇lara Erdaği, Büşranur Şeker, Celal Caner, Gi̇zem Çeti̇n, Hüseyi̇n Altundağ, Hati̇ce Tunca

Turkish Journal of Biology

Background/aim: Phycoremediation is essential for purifying wastewater of heavy metals to ensure a sustainable environment, as these components can be detrimental to organisms upon entering the food chain. Among heavy metals, nickel is vital at low concentrations due to its presence in the active sites of many metalloenzymes in algae. However, at high concentrations, it disrupts the functioning of many metabolic reactions. This study examines the effects of nickel treatment on the uptake of macro- and micronutrients in medium by algae via ion exchange pathways or in competition with other metals. The study aims to determine the effects of nickel …

Deep Seabed Mining And The Law Of The Sea: Strategic Competition, Institutional Failure, And The Third Age, Michael W. Lodge

International Law Studies

Edited and annotated speech by Michael Lodge, former Secretary-General of the International Seabed Authority (2017–2024), delivered at the U.S. Naval War College, Newport, Rhode Island, on March 11, 2026.

Beyond Predation: Invasive Green Crab (Carcinus Maenas) Alters Juvenile Pacific Oyster (Magallana Gigas) Function And Survival Across Environmental Gradients, Isabel Helena Mize

Dissertations and Theses

The establishment of the invasive green crab, Carcinus maenas, creates ecological and economic impacts in estuaries, particularly through predation on bivalves and alteration of species interactions. This thesis evaluates the direct predation, non-consumptive predator presence, and spatial management implications of C. maenas impacts on filtration rate of juvenile Pacific oysters, Magallana gigas, across laboratory, field, and GIS-based vulnerability mapping approaches. In laboratory conditions, clearance rates of M. gigas were measured over 72 hours across two temperatures (14°C and 18°C) and predator treatments including C. maenas, Pacific rock crab (Romaleon antennarium), both predators together, and a …

Contribution Of Phosphorylation To Hp1a Function, James Walts

ETDs from 2020-2029

Heterochromatin Protein 1 (HP1) family members are highly conserved, non-histone chromosomal proteins essential for heterochromatin formation and transcriptional regulation. In Drosophila melanogaster, HP1a functions both as a transcriptional repressor and activator, as well as other functions, and undergoes post-translational modifications, including phosphorylation. The functional consequences of HP1a phosphorylation remain largely unexplored. This thesis investigates the role of phosphorylation at serines 89/90/91 (S899091) of HP1a by generating two mutant alleles: a phospho-mimic (SE) and a phospho-block (SA). Both alleles produce stable mRNA transcripts; however, Western blot analysis revealed reduced protein accumulation relative to wildtype HP1a. Homozygous phospho-block animals are embryonic lethal …

Culturally Informed Approaches To Support Perinatal Mental Health: Perceptions And Experiences Of Perinatal Depression And Support Systems Among Postpartum African-Born Women In The United States, Joyce O. Imafidon

ETDs from 2020-2029

Perinatal mental health (PMH) of African-born women (ABW) is underrepresented in research and practice in the United States (US) despite known consequences of poor mental wellbeing on one’s overall health, relationships and productivity. Beyond their fundamental role in family support, ABW contribute significantly to the US workforce, education sector, and economy. This three-paper dissertation enhances understanding on PMH outcomes, perception and experiences of ABW in the US. Perinatal depression (PD), one of the most common mood disorders affecting 1 in 8 women, is highlighted. The overarching question is to what extent does the US health system address PMH of ABW …

Behind The Screen: Exploring How Undergraduate Students Experience Sense Of Belonging In Online Learning Environments In The United States, Grace Ellen Kiersznowski

ETDs from 2020-2029

Enrollment in online courses in higher education has been rising rapidly over the past couple of decades and has accelerated since the COVID-19 pandemic. This has made higher learning more accessible for students who would otherwise have difficulty earning a degree. Online education poses many barriers to students’ development of a sense of belonging, something research has been found to be of great importance to student success and well-being. Relatively little was known about students’ sense of belonging in online learning environments prior to the pandemic. Since the pandemic, online education has undergone major changes, changing the landscape in a …

Bone Marrow Adiposity, Obesity, And Tumor Burden In Newly Diagnosed Multiple Myeloma, Ananya Deshpande

ETDs from 2020-2029

Multiple Myeloma (MM) is the second most common hematologic malignancy in the United States. It is characterized by the accumulation of clonally expanded plasma cells in the bone marrow, which leads to end organ damage and myeloma-defining events requiring treatment. The only modifiable risk factor for MM is obesity. However, associations between obesity, bone marrow adipocytes, and tumor burden at MM diagnosis remain unclear. We evaluated associations of bone marrow adipocytes, body mass index (BMI), and clinical features of tumor burden among 168 patients with histologically confirmed newly diagnosed multiple myeloma (NDMM) enrolled in the Integrative Molecular and Genetic Epidemiology …

Challenges Of Lutetium-177 Metastable Concentration In Radiopharmaceutical Waste, Cameron Robert Liggitt

ETDs from 2020-2029

Lutetium-177 (Lu-177) is an upcoming radiopharmaceutical with commercial use recently approved for cancer treatment by the Federal Drug Administration (FDA). During production, a contaminate, Lutetium-177 metastable (Lu-177m), can also be produced. The concentration of Lu-177m will vary greatly depending on the production method. One of the largest problems posed by this metastable contaminant is disposal challenges due to its longer half-life and more energetic decay process. This research models the potential for the decay in storage method to be used for disposal of Lu-177 waste based on the concentration of Lu-177m. Utilizing varying ratios of metastable per therapeutic dose, this …

Shaping Fibroblast Fate To Drive Fibrotic Remodeling In Pulmonary Fibrosis: Decoding S100a4, Spring Li

ETDs from 2020-2029

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by persistent fibroblast activation, excessive extracellular matrix (ECM) deposition, and irreversible remodeling of lung architecture. A central feature of disease progression is the accumulation of fibroblasts that evade apoptosis and persist in a pathologically activated state. However, the molecular mechanisms that sustain this aberrant phenotype remain incompletely understood. The calcium-binding protein S100A4 has been implicated in fibrotic processes, but its role in orchestrating fibroblast fate and profibrotic behavior has not been fully defined, particularly with respect to its influence on fibroblast survival and activation in IPF. In the first …

The Medicalization Of Rapists In Psychiatry From 2000-2024, Lily Plowden

ETDs from 2020-2029

The process of human problems coming to be defined as medical conditions and thus under the purview of medical professionals is called medicalization. This study examines how psychiatrists medicalize perpetrators of sexual violence, looking particularly at debates around whether to include a new disorder, Paraphilic Coercive Disorder, in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Using a content analysis of n=102 articles, it finds that discussions of the pathology of sexual violence perpetration were prevalent among psychiatric journals from 2000-2024. Psychiatrists medicalize rapists through three pathways: advocating for a new medical disorder; attributing the cause of sexual …

Evaluating The Service Life Of A Respirator Cartridge When Exposed To Various Volatile Organic Compounds, Neha Murad Alwani

ETDs from 2020-2029

Inhalation is the most common exposure pathway. With the significant presence of respiratory exposure, respirator cartridges are widely used as personal protective equipment (PPE) to reduce exposure to gases, vapors, and volatile organic compounds (VOCs). This study evaluated the breakthrough time of respirator cartridges under various VOC environments commonly encountered in beauty salons and automotive repair shops. Breakthrough time is the duration a respirator cartridge can provide protection before contaminants can be inhaled and the respirator cartridge is no longer effective. The breakthrough time of three VOCs was examined: acetone, toluene, and m-xylene. Using a custom designed test chamber equipped …

Clinical Validation Of Tabpfn-2.5: Zero-Shot Performance, Data-Scarce Robustness, And Distilled Models For Real-Time Clinical Decision Support, Baraa Aljawawdeh

ETDs from 2020-2029

Accurate clinical risk prediction plays an important role in improving patient outcomes, particularly in perioperative settings where early intervention can influence care decisions. Although machine learning has shown promising results using electronic health record (EHR) data, its use in clinical practice is often limited by complex development processes, the need for hyperparameter tuning, and variability in performance across datasets. These challenges are especially relevant in data-scarce clinical settings. This thesis evaluates TabPFN-2.5, a transformer-based tabular foundation model designed to perform classification without dataset-specific training. The model was applied to two real-world perioperative prediction tasks: unplanned care escalation (UCE) following post-anesthesia …

Fibulin-4 Expressed In Metastatic Breast Cancer Is A Target Of Peptide-Based Imaging Probes And Experimental Therapeutics, Alexes C Daquinag, Sukhen C Ghosh, Solmaz Aghaamiri, Stephen M Farmer, Sheng Zhang, Servando Hernandez Vargas, Ashwin K Ramesh, Zhiqiang An, Ali Azhdarinia, Mikhail G Kolonin

The Brown Foundation: Institute of Molecular Medicine

There is a lack of approaches to detect and kill metastatic cells. As an agent for metastasis targeting, a cyclic peptide BLMP6 has been previously characterized. As a step toward translation, we designed AZDye555-labeled BLMP6 and demonstrated its homing to metastases of human MDA-MB-231 cells in mice. We show that 68Ga-radiolabeled BLMP6 can be used for the detection of MDA-MB-231 metastases. We designed a peptide-drug conjugate consisting of monomethyl auristatin E (MMAE) and BLMP6. We show that MMAE-BLMP6 kills MDA-MB-231 cells in cell culture and in vivo. In mouse models of lung metastases, treatment with MMAE-BLMP6 suppressed metastasis growth …

Epidemiology And Ultrasonographic Observations Of Urogenital Schistosomiasis Related Urinary Tract Morbidity In Itilima District, Simiyu Region, Tanzania, Coletha Yohana, Bruno A. Nyundo, Jared S. Bakuza, Peter F. Rambau, Safari M. Kinung’Hi

Tanzania Journal of Science

Chronic infection of urogenital schistosomiasis in humans is a major cause of urinary tract morbidity in endemic areas. However, information on the prevalence of schistosomiasisrelated urinary tract morbidity is lacking in most endemic countries including Tanzania. This study was conducted to determine the prevalence of schistosomiasis-related urinary tract morbidity in schoolchildren and adults in Itilima District. Urine samples from 682 residents were examined for Schistosoma haematobium infection using urine filtration technique. Urinary tract morbidity was examined by ultrasound. The prevalence of S. haematobium infection was 16.4% (112/682) and varied significantly between villages (range 3.2% to 29.5%, χ2 = 48.467, p < 0.001). There was no significant variation of S. haematobium infection between male and female (8.3 % vs 8.1%, χ2 = 0.679, p = 0.410). Majority (93.8%) had light infections (

Centrifugally Spun Silica Fibers For Lithium-Ion Battery Anodes: Structure And Cycling Stability, Alejandra Guerrero, Valeria Tirado, Jason Parsons, Mataz Alcoutlabi

Mechanical Engineering Faculty Publications

Introduction: Silicon dioxide (SiO2) fiber structures have attracted attention as alternative anode materials for lithium-ion batteries because of their ability to improve cycling stability compared to commercial silicon particles.

Materials and methods: SiO2 composite fibers were prepared by centrifugal spinning of polyvinylpyrrolidone (PVP)/SiO2 precursor solutions followed by calcination at 500–700 ◦C for different holding times to produce short-fiber composites and micro-belt SiO2 fiber structures. The morphology and crystal structure of the SiO2 short fibers and micro-belts were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), and X-ray Photoelectron Spectroscopy (XPS). Electrochemical performance was evaluated using CR2032 half-cells.

Results: The …

A Multimodal Artificial Intelligence Model To Guide Use Of Whole-Pelvic Radiation Therapy In Patients With Localized Prostate Cancer: Exploratory Analysis Of Rtog 9413, Mutlay Sayan, Huei-Chung Huang, Erin L. Stewart, Timothy N. Showalter, Adam P. Dicker, George Daniel Grass, Elizabeth M. Gore, Andrew Michael Mcdonald, J. Daniel Pennington, Mark A. Hallman, Igor J. Barani, I-Chow Hsu, Michael Rooney, Stephanie L. Pugh, Paul L. Nguyen, Phuoc T. Tran, Mack Roach Iii

Department of Radiation Oncology Faculty Papers

Background/Objectives: This study explored whether a multimodal artificial intelligence (MMAI) model integrating digitized histopathology and clinical features can identify prostate cancer patients who may benefit from neoadjuvant hormonal therapy (NHT) and whole-pelvic radiotherapy (WPRT). Methods: This secondary analysis of NRG/RTOG 9413 included NHT-treated patients with digitized biopsy slides and clinical data who were not part of the MMAI model optimization. A previously validated MMAI model estimated long-term risk, and Fine-Gray models evaluated interactions between MMAI-derived scores and the radiation field (WPRT vs. prostate-only RT [PORT]) for biochemical failure (BF), chosen over progression-free survival because of extended follow-up and distant metastasis …

Qeith: Quantifies Tumor Ecosystem Heterogeneity To Predict Cancer Progression And Treatment Benefit, Qiqi Liu, Jiangti Luo, Jiawei Wang, Bangqi Zhao, Xiaosheng Wang, Linjun You

Faculty, Staff and Student Publications

Intratumor heterogeneity (ITH) is a fundamental driver of therapeutic failure and disease progression. However, the complexity of the tumor ecosystem is a critical yet underexplored aspect, making its precise quantification essential for fully deciphering ITH and its clinical implications. To address this, we developed Quantifying Ecosystem Intratumor Heterogeneity (QeITH), a computational framework that applies Shannon entropy to quantify ecosystem heterogeneity by measuring the diversity and distributional entropy of cellular compositions and functional states across single-cell, bulk, and spatial transcriptomics. At the single-cell resolution, QeITH identifies elevated ITH as intrinsic markers of malignant transformation, yet enhanced sensitivity to therapy. Pan-cancer bulk …

Driving Innovation: Transatlantic Attitudes To The Bionics Bus As A Vehicle For Health Transformation And Stem Engagement, Christopher James, Sarang Shankar, Madeleine Dale, Bhathika Perera, Richard Laugharne, Matthew Allen, Maria Feijoo‐Renones, Rohit Shankar

Peninsula Medical School

Emerging mobile health and STEM engagement platforms are increasingly recognised as catalysts for improving public understanding of biomedical technologies and supporting digitally enabled models of healthcare delivery. The Bionics Bus (https://bionicsbus.org/) is a novel mobile laboratory designed to democratise access to robotics, artificial intelligence, prosthetics and digital diagnostics by delivering hands-on experiences directly to schools, communities and healthcare settings. This study provides the first transatlantic comparison of public attitudes toward the Bionics Bus within the United Kingdom and the United States of America (USA), two countries with contrasting healthcare systems and digital transformation priorities. Using a mixed-methods cross-sectional design, 78 …

‘Latest And Greatest Findings In Aboriginal Cancer Research In Wa ’, Andrew Redfern

Talking Heads Seminar Series

In this talk we will invite the audience to walk with us along the path we have taken over the last 20 years, exploring the reasons why Aboriginal people can experience poorer outcomes when they develop cancer. From there we discuss our search for solutions; cultural, biological and medical, looking at how both improving and personalising our approach to the individual person and the services we build for them may overcome the problems uncovered.

Starting with improved cancer prevention, the talk will move to screening issues and their possible remedies, then on to optimising cure in people with early cancer …

Illinois Masonic Medical Center School Of Nursing Bulletin, 1974-1976, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: This IMMC Nursing School bulletin provides information about the school including admission criteria, cost, student services, policies, opportunities, and curriculum.

Illinois Masonic Medical Center School Of Nursing Bulletin, 1969-1971, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: This IMMC Nursing School bulletin provides information about the school including admission criteria, cost, student services, policies, opportunities, and curriculum.

Medical Staff Journal, 1993, V3 N3, Fall, Advocate Health - Midwest

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Quarterly publication produced by and for medical staff at Lutheran General Hospital. This issue includes case studies, professional activities, and a directory of new staff members.

Medical Staff Journal, 1993, V3 N2, Summer, Advocate Health - Midwest

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Quarterly publication produced by and for medical staff at Lutheran General Hospital. This issue includes case studies, professional activities, and a directory of new staff members.

Medical Staff Journal, 1992, V2 N2, Summer, Advocate Health - Midwest

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Quarterly publication produced by and for medical staff at Lutheran General Hospital. This issue includes case studies, professional activities, and a directory of new staff members.

Medical Staff Journal, 1992, V2 N1, Winter, Advocate Health - Midwest

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Quarterly publication produced by and for medical staff at Lutheran General Hospital. This issue includes case studies, professional activities, abstracts, and a directory of new staff members.

Aurora Today : The Aurora Health Care Employee Newsletter, 2001 September, Advocate Health - Midwest

Historical Documents - Combined

Aurora Health Care, Milwaukee, WI: Aurora Today is published monthly for the employees of Aurora Health Care. This newsletter publishes news and updates from around the Aurora Health Care system.

Medical Staff Journal, 1991, V1 N2, Spring, Advocate Health - Midwest

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Quarterly publication produced by and for medical staff at Lutheran General Hospital. This issue includes case studies, professional activities, and a directory of new staff members.