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The Human Disease-Associated Ab Amyloid Core Sequence Forms Functional Amyloids In A Fungal Adhesin, Rachele D. Rameau, Desmond N. Jackson, Audrey Beaussary, Yves F. Dufrêne, Peter N. Lipke

Publications and Research

There is increasing evidence that many amyloids in living cells have physiological functions. On the surfaces of fungal cells, amyloid core sequences in adhesins can aggregate into 100- to 1,000-nm-wide patches to form high-avidity adhesion nanodomains on the cell surface. The nanodomains form through interactions that have amyloid-like properties: binding of amyloid dyes, perturbation by antiamyloid agents, and interaction with homologous sequences. To test whether these functional interactions are mediated by typical amyloid interactions, we substituted an amyloid core sequence, LVFFA, from human A protein for the native sequence IVIVA in the 1,419-residue Candida albicans adhesin Als5p. The chimeric protein …

Impact Of The 2010 Deepwater Horizon Oil Spill On Population Size And Genetic Structure Of Horse Flies In Louisiana Marshes, Claudia Husseneder, Jennifer R. Donaldson, Lane D. Foil

Faculty Publications

The greenhead horse fly, Tabanus nigrovittatus Macquart, is frequently found in coastal marshes of the Eastern United States. The greenhead horse fly larvae are top predators in the marsh and thus vulnerable to changes in the environment, and the adults potentially are attracted to polarized surfaces like oil. Therefore, horse fly populations could serve as bioindicators of marsh health and toxic effects of oil intrusion. In this study, we describe the impact of the April 2010 Deep Water Horizon oil spill in the Gulf of Mexico on tabanid population abundance and genetics as well as mating structure. Horse fly populations …

Changes In Depression And Stress After Release From A Tobacco-Free Prison In The United States, Jacob J. Van Der Berg, Mary B. Roberts, Beth C. Bock, Rosemarie A. Martin, L.A.R. Stein, Donna R. Parker, Arthur R. Mcgovern, Sarah Hart Shuford, Jennifer G. Clarke

Psychology Faculty Publications

Prior research has found high levels of depression and stress among persons who are incarcerated in the United States (U.S.). However, little is known about changes in depression and stress levels among inmates post-incarceration. The aim of this study was to examine changes in levels of depression and stress during and after incarceration in a tobacco-free facility. Questionnaires that included valid and reliable measures of depression and stress were completed by 208 male and female inmates approximately eight weeks before and three weeks after release from a northeastern U.S. prison. Although most inmates improved after prison, 30.8% had a worsening …

Targeted Curing Of All Lysogenic Bacteriophage From Streptococcus Pyogenes Using A Novel Counter-Selection Technique, Chad W. Euler, Barbara Juncosa, Patricia A. Ryan, Douglas R. Deutsch, W. Michael Mcshan, Vincent A. Fischetti

Publications and Research

Streptococcus pyogenes is a human commensal and a bacterial pathogen responsible for a wide variety of human diseases differing in symptoms, severity, and tissue tropism. The completed genome sequences of >37 strains of S. pyogenes, representing diverse disease- causing serotypes, have been published. The greatest genetic variation among these strains is attributed to numerous integrated prophage and prophage-like elements, encoding several virulence factors. A comparison of isogenic strains, differing in prophage content, would reveal the effects of these elements on streptococcal pathogenesis. However, curing strains of prophage is often difficult and sometimes unattainable. We have applied a novel counter-selection approach …

Common Sense Beliefs About The Central Self, Moral Character, And The Brain, D. Fernandez-Duque, Barry Schwartz

Psychology Faculty Works

To assess lay beliefs about self and brain, we probed people's opinions about the central self, in relation to morality, willful control, and brain relevance. In study 1, 172 participants compared the central self to the peripheral self. The central self, construed at this abstract level, was seen as more brain-based than the peripheral self, less changeable through willful control, and yet more indicative of moral character. In study 2, 210 participants described 18 specific personality traits on 6 dimensions: centrality to self, moral relevance, willful control, brain dependence, temporal stability, and desirability. Consistent with Study 1, centrality to the …

Highly Distinct Chromosomal Structures In Cowpea (Vigna Unguiculata), As Revealed By Molecular Cytogenetic Analysis, Aiko Iwata-Otsubo, Jer-Young Lin, Navdeep Gill, Scott Jackson

Biology Faculty Articles

Cowpea (Vigna unguiculata (L.) Walp) is an important legume, particularly in developing countries. However, little is known about its genome or chromosome structure. We used molecular cytogenetics to characterize the structure of pachytene chromosomes to advance our knowledge of chromosome and genome organization of cowpea. Our data showed that cowpea has highly distinct chromosomal structures that are cytologically visible as brightly DAPI-stained heterochromatic regions. Analysis of the repetitive fraction of the cowpea genome present at centromeric and pericentromeric regions confirmed that two retrotransposons are major components of pericentromeric regions and that a 455-bp tandem repeat is found at seven …

The Regulatory Life Of Threatened Species Lists, Irus Braverman

Contributions to Books

Published as Chapter 1 in Animals, Biopolitics, Law: Lively Legalities, Irus Braverman, ed.

“The Regulatory Life of Threatened Species Lists” explores a prominent technology for the legal regulation of nonhuman life: the threatened species list. I argue that threatened species lists are biopolitical technologies: they produce and reinforce underlying species ontologies by creating, calculating, and governing the boundaries between various nonhuman species. Such a differentiated treatment of the life and death of nonhuman species through their en-listing, down- and up-listing, multi-listing, and un-listing translates into the positive protection and active governance of such species. Listing threatened species thus becomes a …

Gbs-Snp-Crop: A Reference-Optional Pipeline For Snp Discovery And Plant Germplasm Characterization Using Variable Length, Paired-End Genotyping-By-Sequencing Data, Arthur Tavares De Oliveira Melo, Radhika Bartaula, Iago L. Hale

New Hampshire Agricultural Experiment Station Publications

Background: With its simple library preparation and robust approach to genome reduction, genotyping-by-sequencing (GBS) is a flexible and cost-effective strategy for SNP discovery and genotyping, provided an appropriate reference genome is available. For resource-limited curation, research, and breeding programs of underutilized plant genetic resources, however, even low-depth references may not be within reach, despite declining sequencing costs. Such programs would find value in an open-source bioinformatics pipeline that can maximize GBS data usage and perform high-density SNP genotyping in the absence of a reference.

Results: The GBS SNP-Calling Reference Optional Pipeline (GBS-SNP-CROP) developed and presented here adopts a clustering strategy …

Multiplatform Molecular Profiling Identifies Potentially Targetable Biomarkers In Malignant Phyllodes Tumors Of The Breast., Zoran Gatalica, Semir Vranic, Anatole Ghazalpour, Joanne Xiu, Idris Tolgay Ocal, John Mcgill, Ryan P Bender, Erin Discianno, Aaron Schlum, Souzan Sanati, Juan P. Palazzo, Sandeep Reddy, Barbara Pockaj

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Malignant phyllodes tumor is a rare breast malignancy with sarcomatous overgrowth and with limited effective treatment options for recurrent and metastatic cases. Recent clinical trials indicated a potential for anti-angiogenic, anti-EGFR and immunotherapeutic approaches for patients with sarcomas, which led us to investigate these and other targetable pathways in malignant phyllodes tumor of the breast. Thirty-six malignant phyllodes tumors (including 8 metastatic tumors with two cases having matched primary and metastatic tumors) were profiled using gene sequencing, gene copy number analysis, whole genome expression, and protein expression. Whole genome expression analysis demonstrated consistent over-expression of genes involved in angiogenesis including …

Volume 113, Number 13 – Tuesday, January 12, 2016, Saint Mary's College Of California

The Collegian

No abstract provided.

A Novel Loop-Mediated Isothermal Amplification Assay For Serogroup Identification Of Neisseria Meningitidis In Cerebrospinal Fluid, Dokyung Lee, Eun Jin Kim, Paul E. Kilgore, Hideyuki Takahashi, Jun Tomono, Shigehiko Miyamoto, Daisuke Omagari, Dong Wook Kim, Mitsuko Seki

Department of Pharmacy Practice

We have developed a novel Neisseria meningitidis serogroup-specific loop-mediated isothermal amplification (LAMP) assay for six of the most common meningococcal serogroups (A, B, C, W, X, and Y). The assay was evaluated using a set of 31 meningococcal LAMP assay positive cerebrospinal fluid (CSF) specimens from 1574 children with suspected meningitis identified in prospective surveillance between 1998 and 2002 in Vietnam, China, and Korea. Primer specificity was validated using 15 N. meningitidis strains (including serogroups A, B, C, E, W, X, Y, and Z) and 19 non-N. meningitidis species. The N. meningitidis serogroup LAMP detected down to ten copies …

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Epigenetic Repression Of Pdz-Lim Domain-Containing Protein 2 Promotes Ovarian Cancer Via Nos2-Derived Nitric Oxide Signaling., Linjie Zhao, Chuan Yu, Shengtao Zhou, Wayne Bond Lau, Bonnie Lau, Zhongyue Luo, Qiao Lin, Huiliang Yang, Yu Xuan, Tao Yi, Xia Zhao, Yuquan Wei

Department of Emergency Medicine Faculty Papers

Ovarian cancer constitutes one of the most lethal gynaecological malignancies worldwide and currently no satisfactory therapeutic approaches have been established. Therefore, elucidation of molecular mechanisms to develop targeted therapy of ovarian cancer is crucial. PDLIM2 is critical to promote ubiquitination of nuclear p65 and thus its role in inflammation has been highlighted recently. We demonstrate that PDLIM2 is decreased in both ovarian high-grade serous carcinoma and in various human ovarian cancer cell lines compared with normal ovary tissues and human ovarian surface epithelial cells (HOSE). Further functional analysis revealed that PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition …

Biological Lignocellulose Solubilization: Comparative Evaluation Of Biocatalysts And Enhancement Via Cotreatment, Julie M. D. Paye, Anna Guseva, Sarah K. Hammer, Erica Gjersing

Dartmouth Scholarship

Feedstock recalcitrance is the most important barrier impeding cost-effective production of cellulosic biofuels. Pioneer commercial cellulosic ethanol facilities employ thermochemical pretreatment and addition of fungal cellulase, reflecting the main research emphasis in the field. However, it has been suggested that it may be possible to process cellulosic biomass without thermochemical pretreatment using thermophilic, cellulolytic bacteria. To further explore this idea, we examine the ability of various biocatalysts to solubilize autoclaved but otherwise unpretreated cellulosic biomass under controlled but not industrial conditions.

Reconsidering State-Society Relations In South Asia: A Himalayan Case Study, Sanjog Rupakheti

HIMALAYA, the Journal of the Association for Nepal and Himalayan Studies

Since the mid-eighteenth century when armies serving the English East India Company (EIC) clashed with the Gorkhali power, British officers depicted Nepal as an example of classical Hindu despotism. Subsequent scholars of the region have not challenged these representations, taking such colonial descriptors as ‘facts.’ The portrayal of the centralized and ‘despotic’ state in South Asian pasts rests upon a certain understanding of the state’s relationship with society. It calls for imagining the Gorkhali regime as alien to the rest of society and supposing that ethnicity and caste are inflexible from one century to the next. The excessive attention given …

On The Distribution Of The Genus Rhopalurus Thorell, 1876 (Scorpiones: Buthidae) In The Southern Caribbean Islands, Rolando Teruel, Michiel A.C. Cozijn

Euscorpius

In the present note, we report on the occurrence of the genus Rhopalurus Thorell, 1898, in the southern Caribbean islands offshore Venezuela. The only published records are from Isla Margarita and Los Roques, but our study of new specimens (including an important collection assembled by the late Pieter Wagenaar Hummelinck) proved this genus to be widely distributed along several archipelagos such as Los Testigos, Los Frailes, and Los Hermanos, as well as the larger, separate islands of Margarita, Cubagua, La Tortuga, and Coche. These specimens are tentatively referred here to Rhopalurus laticauda Thorell, 1876, but their precise identity still warrants …

Tityus Carolineae Sp. N. From Suriname And Guyana (Scorpiones: Buthidae), František Kovařík, Rolando Teruel, Michiel A.C. Cozijn, Michael Seiter

Euscorpius

Tityus carolineae sp. n. from Suriname and Guyana is described and compared with other species of the "Tityus metuendus" complex, inside the "Tityus asthenes" group. Tityus carolineae sp. n. is the largest species of this complex, with total length of males 82–100 mm.

A New Species Of Androctonus Ehrenberg, 1828 From Northwestern Egypt (Scorpiones: Buthidae), Rolando Teruel, František Kovařík, Carlos Turiel

Euscorpius

Androctonus tenuissimus sp. n. from two coastal localities placed in northwestern Egypt is herein described, an addition that represents the fifth species of this genus confirmed to occur in this North African country. It is most closely related only to Androctonus bicolor Ehrenberg, 1828, which is widely distributed across northeast Africa and the Middle East and also occurs in Egypt. Both are the only species in the genus whose adults of both sexes show the following combination of three diagnostic characters: coloration uniformly blackish, pedipalp chelae con-spicuously narrower than patella in adults, and pedipalp fingers with basal lobe/notch combination entirely …

A New Species Of Vaejovis From The Mogollon Rim Of Northern Arizona (Scorpiones: Vaejovidae), Richard F. Ayrey

Euscorpius

A new scorpion species, Vaejovis trinityae sp. nov. is described. This small brown species is found along the Mogollon Rim above Strawberry, Arizona. This is the first description of a new species of the “vorhiesi” group scorpions whose DNA phylogenetic analysis was published (Bryson et al., 2013); based on DNA data, the new species is most related to V. lapidicola Stahnke and V. crumpi Ayrey et Soleglad. It represents one of the “twenty-seven geographically cohesive lineages inferred from the mtDNA tree”. A unique characteristic of this species is that it exhibits arboreal behavior, being frequently found on Ponderosa …

A Review Of Thaicharmus Kovařík, 1995, With Description Of Thaicharmus Indicus, František Kovařík

Euscorpius

Thaicharmus indicus sp. n. from India (Goa State) is described and compared with T. mahunkai Kovařík, 1995 from Thailand and T. lowei Kovařík, Soleglad et Fet, 2007 from India. The genus Thaicharmus Kovařík, 1995 is discussed and a key is provided. Photos of male T. mahunkai are published for the first time.

A New Species Of Euscorpius Thorell, 1876 From The Western Balkans (Scorpiones: Euscorpiidae), Gioele Tropea

Euscorpius

A new scorpion species, Euscorpius feti sp. n., is described from the western Balkans based on morphological evidence. It is characterized by long-limbed overall appearance, medium-large size, light brown to reddish color, and a high trichobothrial count (Pv = 11–12, et = 8, em = 4 and eb = 4).

A New Scorpion Genus, Gint Gen. N., From The Horn Of Africa (Scorpiones: Buthidae), František Kovařík, Graeme Lowe, Jana Plíšková, František Šťáhlavský

Euscorpius

A new scorpion genus is described, Gint gen. n., similar to genera Buthacus Birula, 1908 and Neobuthus Hirst, 1911 to which it is compared. Buthus calviceps Pocock, 1900 is transferred to the new genus, which includes only two species, Gint gaitako sp. n. from Ethiopia and Gint calviceps comb. n. from Somaliland and Somalia (Puntland). Information is provided on the localities and habitats of both species. In addition to morphological analysis we described also karyotype of male paratype of Gint gaitako sp. n., 2n=30.

A New Species Of The Genus Centruroides Marx, 1890 (Scorpiones: Buthidae) From Guatemala, Luis F. De Armas, Rony E. Trujillo

Euscorpius

A new species of the genus Centruroides Marx, 1890 is described from northeastern Guatemala on basis to an adult male. By its general pattern and slight sexual dimorphism, the new species looks like C. flavopictus (Pocock, 1898), a larger species from Veracruz, Mexico, with higher pectinal tooth count (males: 21 to 24 teeth) and stronger subaculear tubercle. It also resembles Centruroides chamulaensis Hoffmann, 1932, from Chiapas, Mexico, a smaller species with small to obsolete subaculear tubercle, stronger metasomal carinae, pedipalp chelae narrower than patella, and anterior margin of carapace almost straight (V-shaped in the new species).

Shape Of Burrows Built By Scorpio Maurus L., 1758 (Scorpiones: Scorpionidae) From Turkey, With Description Of Capture Methods, Mehmet Çolak, Ayşegül Karataş

Euscorpius

Shapes of burrows built by Scorpio maurus in southern and south-eastern Turkey were investigated. S. maurus were observed to build burrows with average 20 cm depth and 30 cm length. The burrows were concentrated in agricultural fields, farms, near gardens, and in areas with 5–10% slope. 116 specimens were captured, 77.5% from underground burrows, and 22.5% from their burrows under stones. A new method was tried in order to drive Scorpio maurus, an obligate digger type of scorpions, out of their burrows. Water was poured into a burrow, and the scorpion, which came out near the entrance of the …

Scorpions Of Iran (Arachnida, Scorpiones). Part Ix. Hormozgan Province, With A Description Of Odontobuthus Tavighiae Sp. N. (Buthidae), Shahrokh Navidpour, Michael E. Soleglad, Victor Fet, František Kovařík

Euscorpius

Twenty species of scorpions belonging to three families are reported from the Hormozgan Province of Iran. Of these, eight species and subspecies are recorded from the province for the first time: Buthacus macrocentrus (Ehrenberg, 1828), Compsobuthus persicus Navidpour et al., 2008, Iranobuthus krali Kovařík, 1997, Mesobuthus eupeus persicus (Pocock, 1899), Mesobuthus phillipsii (Pocock, 1889), Odontobuthus bidentatus Lourenço & Pézier, 2002, Odontobuthus doriae (Thorell, 1876), and Razianus zarudnyi (Birula, 1903). Odontobuthus tavighiae sp. n. is described and compared with all species of the genus Odontobuthus Vachon, 1950. Paraorthochirus goyffoni Lourenco et Vachon, 1995 is synonymized with Orthochirus farzanpayi (Vachon et Farzanpay, …

Local Parasite Lineage Sharing In Temperate Grassland Birds Provides Clues About Potential Origins Of Galapagos Avian Plasmodium, Iris I. Levin, Rachel E. Colborn, Daniel Kim, Noah G. Perlut, Rosalind B. Renfrew, Patricia G. Parker

Environmental Studies Faculty Publications

Oceanic archipelagos are vulnerable to natural introduction of parasites via migratory birds. Our aim was to characterize the geographic origins of two Plasmodium parasite lineages detected in the Galapagos Islands and in North American breeding bobolinks (Dolichonyx oryzivorus) that regularly stop in Galapagos during migration to their South American overwintering sites. We used samples from a grassland breeding bird assemblage in Nebraska, United States, and parasite DNA sequences from the Galapagos Islands, Ecuador, to compare to global data in a DNA sequence registry. Homologous DNA sequences from parasites detected in bobolinks and more sedentary birds (e.g., brown-headed cowbirds …

The Folklore Of Flowers, Lisa Karen Miller

DLPS Faculty Publications

This presentation was prepared for WKU's Society for Lifelong Learning. It relates history and folklore of a variety of flowers, including their use in folk medicine, as food, and other stories and beliefs.

Local Parasite Lineage Sharing In Temperate Grassland Birds Provides Clues About Potential Origins Of Galapagos Avian Plasmodium, Patricia Parker, Iris Levin, Rachel Colborn, Daniel Kim, Noah Perlut, Rosalind Renfrew

Biology Department Faculty Works

Oceanic archipelagos are vulnerable to natural introduction of parasites via migratory birds. Our aim was to characterize the geographic origins of two Plasmodium parasite lineages detected in the Galapagos Islands and in North American breeding bobolinks (Dolichonyx oryzivorus) that regularly stop in Galapagos during migration to their South American overwintering sites. We used samples from a grassland breeding bird assemblage in Nebraska, United States, and parasite DNA sequences from the Galapagos Islands, Ecuador, to compare to global data in a DNA sequence registry. Homologous DNA sequences from parasites detected in bobolinks and more sedentary birds (e.g., brown‐headed cowbirds Molothrus ater, …

Peanuts Mutants Violets And Pests Undergrad Researchers Get Funding, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.