Digital Commons Network^™

Analyzing And Modeling The Dysfunction Of Inhibitory Neurons In Alzheimer’S Disease, Carlos Perez, Jokubas Ziburkus, Ghamim Ullah

Physics Faculty Publications

Alzheimer’s disease (AD) is characterized by the abnormal proteolytic processing of amyloid precursor protein, resulting in increased production of a self-aggregating form of beta amyloid (Aβ). Several lines of work on AD patients and transgenic mice with high Aβ levels exhibit altered rhythmicity, aberrant neuronal network activity and hyperexcitability reflected in clusters of hyperactive neurons, and spontaneous epileptic activity. Recent studies highlight that abnormal accumulation of Aβ changes intrinsic properties of inhibitory neurons, which is one of the main reasons underlying the impaired network activity. However, specific cellular mechanisms leading to interneuronal dysfunction are not completely …

Department Of Audit, 2016 Annual Report, Tennessee. Comptroller Of The Treasury.

Annual Reports

No abstract provided.

Estuarine Habitat Use By The California Sea Otter (Enhydra Lutris Nereis), Jacqueline Kimberly Lindsey

Master's Theses

As the southern sea otter (Enhydra lutris nereis) range expands into northern and southern California, it will encounter estuaries that have been historically occupied by sea otters. Understanding how otters use re-colonized estuarine environments will inform how estuaries might be managed to encourage future sea otter range expansion. This project addressed the question: how do southern sea otters use space in the unique estuarine habitats of Elkhorn Slough? I compared the locations and behaviors of 25 individual sea otters of different status (male, female, and female with pup) among eelgrass, saltmud, saltmarsh, tidal creek, and main channel habitats in Elkhorn …

Variants In Wfs1 And Other Mendelian Deafness Genes Are Associated With Cisplatin-Associated Ototoxicity, Heather E. Wheeler, Eric R. Gamazon, Robert Frisina, Carlos Perez-Cervantes, Omar El Charif, Brandon Mapes, Sophie D. Fossa, Darren Feldman, Robert Hamilton, David J. Vaughn, Clair Beard, Chunkit Fung, Chiristian Kollmannsberger, Jeri Kim, Taisei Mushiroda, Michiaki Kubo, Shirin Ardeshir-Rouhani-Fard, Lawrence H. Einhorn, Nancy Cox, M. Eileen Dolan, Lois Travis

Bioinformatics Faculty Publications

Cisplatin is one of the most commonly used chemotherapy drugs worldwide and one of the most ototoxic. We sought to identify genetic variants that modulate cisplatin-associated ototoxicity (CAO). Experimental Design: We performed a genome-wide association study (GWAS) of CAO using quantitative audiometry (4-12 kHz) in 511 testicular cancer survivors of European genetic ancestry. We performed polygenic modeling and functional analyses using a variety of publicly available databases. We used an electronic health record cohort to replicate our top mechanistic finding. Results: One SNP, rs62283056, in the first intron of Mendelian deafness gene WFS1 (wolframin ER transmembrane glycoprotein) and an expression …

Uji Efektivitas Antihiperglikemia Kombinasi Jus Pare (Momordica Charantia L) Dan Jus Tomat (Solanum Lycopersicum L) Pada Tikus Wistar Jantan Dengan Metode Toleransi Glukosa, Wulandari Wulandari

Pharmaceutical Sciences and Research

Diabetes melitus (DM) is a metabolic disorder condition characterized by hyperglycemia. Bitter melon (Momordica charantia L) and tomato (Solanum lycopersicum L) is a plant that have actvity antihiperglicemic compounds that contain triterpenoid, flavonoid, alkaloid, and saponin. This study was aimed to determine the effect of the combination antihiperglicemic bitter melon juice and tomato juice on male Wistar rats induced sucrose. Animals used are male Wistar Rattus norvegicus healthy in divided into 6 groups . Blood glucose levels were measured at 30th, 60th, 90th and 120th minutes with enzymatic method using a glucometer. Data were analyzed statistically by KruskalWallis and Mann-Whitney …

Sex-Specific Diet And Rockfish Consumption In California Sea Lions (Zalophus Californianus): Insights From Molecular Scatology, Keith Michael Hernandez

Master's Theses

Molecular diet analysis has the potential to overcome the limitations of traditional methods. I used prey hard parts and molecular methods to examine sex-specific diet trends and rockfish consumption of California sea lions (Zalophus californianus, CSL). Fresh scat samples (n=219) were collected from Año Nuevo Island, CA (ANI), during the summers of 2013 and 2014. Prey taxa were identified from fish otoliths and cephalopod beaks recovered from cleaned scats. Sex of the CSL depositing the scat was assigned via multiplex PCR of a CSL microsatellite and a carnivore Y chromosome marker. Prey species also were identified using multiple loci in …

Variation In Organismic Rna And Dna Content: Analysis And Application To The Assessment Of Living Planktonic Biomass, Elizabeth Lam Gagneron

Master's Theses

Modern analysis of DNA and RNA nucleic acid sequences has yielded profound changes in our understanding of the genetic biodiversity of planktonic organisms within the microbial food web of aquatic ecosystems. However, the bulk environmental concentrations of DNA and RNA, and their relative ratios, also potentially provide important information on the biomass and metabolic activity of planktonic organisms. Currently, there is a need to quantify the relative living biomass levels of natural water contained in ships’ ballast tanks to regulate the spread of aquatic invasive species (AIS) resulting from ballast water discharge practices within the international shipping industry. Ultraviolet (UV) …

Aria 2016: Care Pathways Implementing Emerging Technologies For Predictive Medicine In Rhinitis And Asthma Across The Life Cycle, J Bousquet, P. W. Hellings, I. Agache, A. Bedbrook, C. Bachert, K. C. Bergmann, M. Bewick, C. Bindslev-Jensen, S. Bosnic-Anticevitch, C. Bucca, D. P. Caimmi, P. A.M. Camargos, G. W. Canonica, T. Casale, N. H. Chavannes, A. A. Cruz, Carlo G De, R. Dahl, P. Demoly, P. Devillier, J. Fonseca, W. J. Fokkens, N. A. Guldemond, T. Haahtela, M. Illario, J. Just, T. Keil, L. Klimek, P. Kuna, D. Larenas-Linnemann

School of Psychology

No abstract provided.

French Travellers And Adventurers’ Retrospect Of Idol Worship, Sanctity Of The Ganga And Divinity Of Cow, Sakul Kundra, Bhawna -

Asia-Pacific Social Science Review

The 17th and the 18th-century French travellers’ and adventurers’ perceptions about the Hindu socio-religious beliefs, practices, and myths have always been a relatively un-researched but fascinating area. This article, based on a study of their memoirs (both translated and un-translated), purports to analyze their perceptions of and observations on three specific aspects of the Hindu socio-religious world in North India during the Mughal period, namely, idol worship, reverence of cow, and Ganga. Objective of this article is to comprehend French travellers’ vision towards identity formation of idol worship, its sacredness, and the practices attached to promulgate its belief among Hindus …

Effecting Some Physical And Motor Abilities Using Auxiliary Tools And Achieving The Effectiveness Of Javelin Throwing, Ibtisam Haydar Bektaş

Modern Sport

This study aimed to identify the impact of exercises designed in some physical and motor abilities using utilities and completion of the effectiveness of the javelin throw, the researcher used the experimental method for suitability and the nature of the research, which included research sample (52) students from the first year for the academic year 2013/2014, divided evenly into two groups. (experimental and control group), as the experimental group used some utilities designed by the researcher (shaft tool weights, different sizes and animation tool roller medical and balls), while the control group based on the usual way of learning and …

Assembling Barbarity, Dirt, And Violence: A Provisional Note On Food And Social Analysis, Macario B. Lacbawan

Asia-Pacific Social Science Review

The key to understanding any social phenomenon is to follow how actors tread the social landscape and describe how they form groups, fuse meanings, and create associations with different frames. In this paper, I employ Bruno Latour’s reconceptualization of assemblage to trace how NGOs and other actors create assemblages by fusing or defusing dog-eating with discourses on dirt, epidemic, and human rights. More specifically, NGOs such as LinisGobyerno and Animal Kingdom Foundation (AKF) produce assemblages that align dog-eating with sanitation, violence, and epidemic. Conversely, supporters of the practice try to invert these claims by foregrounding dog-meat consumption as an entitlement …

A Response To The Libertarian Critics Of Open-Borders Libertarianism, Walter Block

Lincoln Memorial University Law Review Archive

Libertarians are split on the controversial issue of immigration (as is the rest of the population). The open borders libertarians claim that immigration is not a per se violation of the bedrock of libertarianism, the non-aggression principle (NAP); therefore, any violent interference with cross-border travel, such as limits to immigration, is incompatible with this philosophy. Their opponents within this community of scholars maintain the very opposite; that free untrammeled migration amounts to trespass. Their case, of late, has been strengthened by the debacle in Germany, Sweden and other European nations who have taken in migrants by the thousands, and have …

Antitumor Activity Of 2,9-Di-Sec-Butyl-1,10-Phenanthroline, Dongsheng Wang, Shifang Peng, Arm R. Amin, Mohammad Aminur Rahman, Sreenivas Nannapaneni, Yuan Liu, Dong M. Shin, Nabil F. Saba, Jack F. Eichler, Zhuo G. Chen

Pharmaceutical Science and Research

The anti-tumor effect of a chelating phen-based ligand 2,9-di-sec-butyl-1,10-phenanthroline (dsBPT) and its combination with cisplatin were examined in both lung and head and neck cancer cell lines and xenograft animal models in this study. The effects of this agent on cell cycle and apoptosis were investigated. Protein markers relevant to these mechanisms were also assessed. We found that the inhibitory effect of dsBPT on lung and head and neck cancer cell growth (IC50 ranged between 0.1–0.2 μM) was 10 times greater than that on normal epithelial cells. dsBPT alone induced autophagy, G1 cell cycle arrest, and apoptosis. Our in vivo …

Book Review: The Question Of The Animal And Religion: Theoretical Stakes, Practical Implications, A. G. Holdier

Between the Species

No abstract provided.

Natal Host Plants Can Alter Herbivore Competition, Huipeng Pan, Evan L. Preisser, Qi Su, Xiaoguo Jiao, Wen Xie, Shaoli Wang, Qingjun Wu, Youjun Zhang

Biological Sciences Faculty Publications

Interspecific competition between herbivores is widely recognized as an important determinant of community structure. Although researchers have identified a number of factors capable of altering competitive interactions, few studies have addressed the influence of neighboring plant species. If adaptation to/ epigenetic effects of an herbivore's natal host plant alter its performance on other host plants, then interspecific herbivore interactions may play out differently in heterogeneous and homogenous plant communities. We tested wether the natal host plant of a whitefly population affected interactions between the Middleeast Asia Minor 1 (MEAM1) and Mediterranean (MED) cryptic species of the whitefly Bemisia tabaci by …

Benefits Of Ethanol Based Noni Leaf (Morinda Citrifolia L.) Extract On Oral Mucosal Wound Healing By Examination Of Fibroblast Cells, Indah Pr Sabirin, Euis R. Yuslianti

Journal of Dentistry Indonesia

Wound healing is a biological response that occurs following a trauma or pathologic condition of the oral mucosa. Wounds require proper management so they may heal faster and without complication. The number of fibroblast cells seen in the oral mucosa is a strong indicator of wound healing. In the remodelling phase of wound healing, fibroblast cell proliferation decreases as collagen fibres are synthesized. Noni leaf (Morinda citrifolia L.), a part of the noni plant, is traditionally used to heal soft tissue wounds in Indonesia. The leaves have potential chemical compounds that may be useful in the wound repair process. Objective: …

Identification Of A Strain Of High Yieldacetic Acid Bacteria From Ferment And Its Acid-Producing Characteristics, Lu Mengyao, Liu Shuliang, Hu Kaidi, Zhang Aiqing

Food and Machinery

A strain of high yield acetic acid bacteria LMY-1 was isolated from 10 kinds of ferment samples by isolation and purification, the acid qualitative and quantitative screen for producing. The strain was identified as Acetobacter cibinongensis by analysis of morphology, physiological and biochemical indicators and identification of 16S rDNA. The growth and acid-producing characteristics of strain LMY-1 was studied by fruit and vegetable culture medium with apple, pear and cucumber. Results, the optimum acid temperature for strain LMY-1 was 30 ℃； In 4 mL/100 mL ethanol content, strain LMY-1 produced the highest acid amount (22.72 g/L), higher than strain CICC7015(Acetobacter …

Determination Of Acetaldehyde In Wine By Gas Chromatography-Mass Spectrometry, Wei Xiaoqun, Zheng Xuan, Guo Qingyuan, Ling Li, Zeng Guangfeng, Huang Jin, Cai Chun

Food and Machinery

A method for determination of acetaldehyde in wine by gas chromatography-mass spectrometry (GC-MS) was established, in which the influence factor on the detected results were studied, such as extraction agent, desorption pH, derivatization reagents. As a result, the limit of determination (LOD) of vanillin and ethyl-vanillin was 0.12 mg/kg. linearity range was 0.2～100.0 mg/kg(R²=0.999 4), The spiked recovery was between 89.3%～113.0%, and the RSD ranged from 1.28%～9.42%(n＝6). This method was applicable for determination of acetaldehyde in wine.

Research Progress On Physiological Activities And Its Mechanismof Beta-Cryptoxanthin, Sheng Ran, Sun Zhigao, Huang Qiaojuan, Hao Jingmei, Fang Ming, Yu Fengsheng

Food and Machinery

The beta-cryptoxanthin is composed of multiple prenyl units, belonging to the oxidation of carotenoid. It widely exists in persimmon, citrus and other plants, and also can be produced by microbial fermentation..Based on beta-cryptoxanthin, the mechanism of its absorption and physiological activities was reviewed, in order to provide reference for improving research and clinic application of beta-cryptoxanthin.

Evaluating Models Of Coulomb Stress Transfer: Is Variable Fault Geometry Important?, Zoe K. Mildon, Shinji Toda, Walker Jp Faure, Gerald P. Roberts

School of Geography, Earth and Environmental Sciences

No abstract provided.

Slis Connecting Volume 5, Issue 2, Stacy Creel, Teresa S. Welsh Ph.D., Mlis

SLIS Connecting

SLIS Connecting Volume 5, Issue 2 (Fall/Winter 2016)

Core Values: Intellectual Freedom And Privacy In Public Libraries, Stephanie A. Evans

SLIS Connecting

With the passing of the USA Patriot Act in 2001 following the events of 9/11, libraries on the national scale have had to staunchly defend issues of privacy and confidentially more-so than ever before. Evidence of this lies not only in statements within the ALA’s Resolution on the USA PATRIOT Act and Libraries but also in other core documents which guide policy development in public libraries (ALA 2005). Intellectual Freedom and privacy are two of the major issues addressed and protected by the American Library Association through the Office of Intellectual Freedom and the Library Bill of Rights (ALA 1996).

In The News: Dec. 27, 2016, Michael Duricy

Marian Library Blog Archive

Read recent items about Mary in both Catholic and secular news. Also see International Marian Research Institute news and updates.

12/27/2016 Obituary Records, Hawaii Obituaries

Obituaries

List of Obituaries for individuals who passed away on 12/27/2016. Scroll down to see the names and obituary description.

Novel Models Of Visual Topographic Map Alignment In The Superior Colliculus., Ruben A Tikidji-Hamburyan, Tarek A El-Ghazawi, Jason W. Triplett

Pediatrics Faculty Publications

The establishment of precise neuronal connectivity during development is critical for sensing the external environment and informing appropriate behavioral responses. In the visual system, many connections are organized topographically, which preserves the spatial order of the visual scene. The superior colliculus (SC) is a midbrain nucleus that integrates visual inputs from the retina and primary visual cortex (V1) to regulate goal-directed eye movements. In the SC, topographically organized inputs from the retina and V1 must be aligned to facilitate integration. Previously, we showed that retinal input instructs the alignment of V1 inputs in the SC in a manner dependent on …

Every Student Can Be An Einstein: Addressing Math Anxiety In Today’S Classrooms, Joseph M. Furner

Transformations

This article is geared toward mathematics educators in hopes that they can ultimately excite young people about mathematics, encourage students to be confident in their ability to solve problems, understand mathematical concepts, and see math as a human endeavor. The author believes that as students feel less anxious about and more confident in their abilities to do math that their performance will improve. As math test scores are often a concern for principals, teachers, and society at large, success and confidence with mathematics is critical in our high-tech globally competitive world. Math anxiety has become a growing concern in the …

Higher Ed Needs New Forms Of Marketing., Aldemaro Romero Jr.

Publications and Research

In this day and age of crises – financial, enrollment,

even scandal – among institutions of higher education,

image “management” has become a tool to help

some institutions stay afloat. Countless colleges and

universities have resorted to spending money on

glossy brochures, billboards and even on expensive

TV airtime.

The images they portray are usually one of happy

and attractive students having fun on campus, enjoying

athletic events and amenities that used to be more

likely to be found at country clubs than colleges. The

quality of education is almost an afterthought. The

name of the institution is being sold …

Using A Novel Partitivirus In Pseudogymnoascus Destructan, Vaskar Thapa, Gregory G. Turner, Susan Hafenstein, Barrie E. Overton, Karen J. Vanderwolf, Marilyn J. Roossinck

KIP Articles

No abstract provided.

Generation Of Germ-Free /Ciona Intestinalis For Studies Of Gut-Microbe Interactions, Brittany A Leigh, Assunta Liberti, Larry J Dishaw

Marine Science Faculty Publications

Microbes associate with animal hosts, often providing shelter in a nutrient-rich environment. The gut, however, can be a harsh environment with members of the microbiome settling in distinct niches resulting in more stable, adherent biofilms. These diverse communities can provide orders of magnitude more gene products than the host genome; selection and maintenance of a functionally relevant and useful microbiome is now recognized to be an essential component of homeostasis. Germ-free (GF) model systems allow dissection of host-microbe interactions in a simple and direct way where each member of the symbiosis can be studied in isolation. In addition, because immune …

Macroinvertebrate Community Composition, Food Web Structure, And Emergence Rate In Neotropical Cloud-Forest Streams In Mindo, Ecuador, Anna M. Harris

Masters Theses

Tropical cloud forest streams are one of the most threatened and understudied ecosystems in the world. Understanding how these ecosystems function is essential for effective conservation. In this study, macroinvertebrate community composition, functional feeding group analysis, ecosystem attributes, and physicochemical parameters were used to evaluate biophysical stream conditions of 3 low-order Neotropical cloud forest streams at Reserva Las Gralarias in Mindo, Ecuador. Additionally, food web structure was analyzed via stable isotope analysis and aquatic insect emergence rate was also examined. As stream size increased from 1st to 3rd order, the macroinvertebrate communities shifted from being collector-gatherer dominated (65.2 to 29.8%, …