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Articles 22801 - 22802 of 22802
Full-Text Articles in Entire DC Network
Activation Of Signal Transduction Pathways During Hepatic Oncogenesis, W Chung, M Kim, S De La Monte, L Longato, R Carlson, B L. Slagle, X Dong, J R. Wands
Activation Of Signal Transduction Pathways During Hepatic Oncogenesis, W Chung, M Kim, S De La Monte, L Longato, R Carlson, B L. Slagle, X Dong, J R. Wands
Faculty, Staff and Students Publications
BACKGROUND AND AIMS: Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS: Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) was achieved and transgenic mice were followed from birth to age 21 months. Liver and tumor tissue were assessed for histologic changes as well as activation of signal transduction pathways by qRT-PCR and multiplex ELISA protein assays. RESULTS: Overexpression of HBx and IRS1 stimulates liver cell proliferation in the double transgenic mice. Only the male mice …
Sensitivity Of Maize Yield Potential To Regional Climate In The Southwestern U.S., Seung Hee Kim, Boksoon Myoung, David Stack, Jinwon Kim, Menas Kafatos
Sensitivity Of Maize Yield Potential To Regional Climate In The Southwestern U.S., Seung Hee Kim, Boksoon Myoung, David Stack, Jinwon Kim, Menas Kafatos
Mathematics, Physics, and Computer Science Faculty Articles and Research
The sensitivity of maize yields to the regional climate in the Southwestern U.S. (SWUS) has been investigated by using the Agricultural Production Systems sIMulator (APSIM) model in conjunction with meteorological forcings [daily maximum and minimum temperature (Tmax and Tmin), precipitation, and radiation] from the North American Regional Reanalysis (NARR) dataset. Sensitivity experiments showed that potential crop production responded nonlinearly to variations in Tmax, Tmin, and downwelling solar radiation at the surface. Mean annual yield potential (Yp) was changed by -3.0 and 1.79 Mg ha-1 for the +1 and -1 standard deviations (σ) of Tmax variation for entire the SWUS. The …