Digital Commons Network^™

Inside The Juvenile Justice System, Megan Phalon

Master's Projects and Capstones

The United States of America is known for freedom and integrity and being a nation that stands for justice and equality for all. Within the United States there are systems in place to better the people and communities in order to provide safety and order. However, just as any nation, there is a struggle with violent behavior and tendencies among adults and adolescents. Within the last three decades, the United States has created a correctional system that specifically targets adolescents, and that acknowledges the differences between adult and juvenile development and deviant behavior. Within this literature review, academic databases were …

Teaching Place: Heritage, Home And Community, The Heart Of Education, Judy Kay Lorenzen

Department of English: Dissertations, Theses, and Student Research

This dissertation examines the implementation of a Place-conscious pedagogy as a means to teach heritage and sense of place. This pedagogy is framed upon the premise that trying to understand our heritage and place—ourselves—are crucial elements in our ability to live well as individuals who are connected school/community members, who help our schools/communities thrive, becoming Place-conscious citizens. I argue that in teaching in such a culturally diverse community, tensions rise as immigration has become a main focus. Our school/community has experienced many ethnic groups with vast social differences for which Place-conscious education offers practical solutions. These students have a great …

Design And Synthesis Of Next Generation Propargyl-Linked Antifolates, Eric Scocchera

Doctoral Dissertations

Antibiotic resistance is an ever-present problem that reduces the arsenal of antibiotics human’s possess to fight pathogenic infections. New generations of antibiotics are therefore always required. Recent history has seen few novel classes of antibiotics, instead structural modifications of previous classes are often the source of new antibiotics. Antifolates are a colloquial name given to various compound classes that are capable of inhibiting the bacterial production of folate or enzymes that require folate for proper cellular function. Dihydrofolate reductase (DHFR) is a crucial enzyme in this pathway, and is inhibited in bacteria only by trimethoprim (TMP). TMP is used clinically …

Assessing Epigenetic Features Of Gaba(A) Receptor Genes In Ipscs, Ipsc-Derived Neuroepithelial Cells, And Ipsc-Derived Neural Cell Cultures, Maegan Watson

Doctoral Dissertations

Alcohol use disorders (AUDs) affect approximately 13.9% of the population in the United States. Many groups have found a correlation between AUDs and a synonymous SNP in exon 5 of the GABRA2 gene (rs279858 T to C; C allele associated with AUDs). However, the biological effects of this and other SNPs in this region are unknown.

Our lab has been using iPSC technology for the past few years to study AUDs. The lab has shown, using qPCR of mRNA, that a cluster of GABA_A receptor subunit genes on chromosome 4p12 is expressed at minimal levels in neural cells derived …

The Psychological Impacts Of Engaging In Creative Work, Jeanine Kunshek

Electronic Theses & Dissertations

Although the literature investigating creativity is extensive, this research is designed to address deficits in knowledge regarding the first-hand accounts of individuals who engage in creative work and the motivations and gratifications they draw from those experiences. This study employs the use of in vivo analysis to articulate and explore the benefits and disadvantages of individuals who pursue careers in five creative industries identified by Taylor and Littleton (2012). Based on qualitative data gathered from focus groups and interviews, most frequent benefits include social connections, cognitive challenges, boosted esteem, communication, and personal and professional development. Disadvantages include time demands, lack …

Design, Synthesis, And Evaluation Of Aryl Hydantoins And Ureas As Antischistosomal Agents, Chunkai Wang

Theses & Dissertations

Schistosomiasis is a tropical parasitic disease caused by infections with flukes of the genus Schistosoma, affecting as many as 440 million individuals worldwide, with 779 million living at risk of infection. A new drug for schistosomiasis is urgently needed as praziquantel (PZQ) is currently the drug of last resort and the development of resistance cannot be ignored, particularly in view of its large-scale use in many endemic countries. Furthermore, PZQ is active against adult but not juvenile schistosomes; this may be an important factor in the frequently observed treatment ‘failures’ in areas endemic for schistosomiasis.

The introduction of PZQ in …

The Functions Of The Cid And Lrg Operons In S. Aureus Programmed Cell Death, Xinyan Zhang

Theses & Dissertations

Staphylococcus aureus cid/lrg operons regulate the formation of S.aureus biofilm formation and programmed cell death based on previous in vivo work done in Dr. Bayles's lab. cid operon, which encodes CidA/CidB/CidC proteins, has been shown to be an effector in leading to the lysis and death of the S.aureus; While lrg operon, encoding LrgA and LrgB proteins, is an inhibitor of the lysis and death. Recent studies suggest that CidA behaves like holin proteins from bacterial phage, by increasing the murein hydrolysis activity under aerobic culturing conditions. LrgA, together with LrgB, appears to inhibit this function. …

Global Gene Expression Profiling Of Healthy Human Brain And Its Application In Studying Neurological Disorders, Simarjeet K. Negi

Theses & Dissertations

The human brain is the most complex structure known to mankind and one of the greatest challenges in modern biology is to understand how it is built and organized. The power of the brain arises from its variety of cells and structures, and ultimately where and when different genes are switched on and off throughout the brain tissue. In other words, brain function depends on the precise regulation of gene expression in its sub-anatomical structures. But, our understanding of the complexity and dynamics of the transcriptome of the human brain is still incomplete. To fill in the need, we designed …

Tp53-Inducible Glycolysis And Apoptosis Regulator (Tigar) Metabolically Reprograms Carcinoma And Stromal Cells In Breast Cancer., Ying-Hui Ko, Marina Domingo-Vidal, Megan Roche, Zhao Lin, Diana Whitaker-Menezes, Erin Seifert, Claudia Capparelli, Madalina Tuluc, Ruth C. Birbe, Patrick Tassone, Joseph M. Curry, Àurea Navarro-Sabaté, Anna Manzano, Ramon Bartrons, Jaime Caro, Ubaldo E. Martinez-Outshoorn

Department of Medical Oncology Faculty Papers

A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces glycolysis and is highly expressed in carcinoma cells in the majority of human breast cancers. Hence we set out to determine the effects of TIGAR expression on breast carcinoma and fibroblast glycolytic phenotype and tumor growth. The overexpression of this bisphosphatase in carcinoma cells induces expression of enzymes and transporters involved in the catabolism of lactate and glutamine. Carcinoma cells overexpressing TIGAR have higher oxygen consumption rates …

Pancreatic Cancer Invasion Of The Lymphatic Vasculature And Contributions Of The Tumor Microenvironment: Roles For E-Selectin And Cxcr4, Maria M. Steele

Theses & Dissertations

As the fourth leading cause of cancer-related deaths, pancreatic cancer is one of the most lethal forms of cancers in the United States. Lymphatic vessel invasion and subsequent metastasis to the lymph nodes are early and significant events observed during pancreatic cancer progression and are used to determine patient prognosis and therapy selection. Although clinicians and researchers recognize the importance of lymph node involvement for patient prognosis and therapy selection, the biological mechanisms that govern lymphatic invasion and metastasis and the contributions of the pancreatic tumor microenvironment to these processes remain poorly understood. In this dissertation, we characterize the interactions …

Short Branch Attraction, The Fundamental Bipartition In Cellular Life, And Eukaryogenesis, Amanda A. Dick Phd

Doctoral Dissertations

Short Branch Attraction occurs when BLAST searches are used as surrogate for phylogenetic analysis. This results from branch length heterogeneity. The short branches, not the long, are attracting.

The root of cellular life is on the bacterial branch, meaning the Archaea and eukaryotic nucleocytoplasm form a clade. This split, the realm, is the first in the cellular tree of life. I name the clade containing the Archaea and eukaryotic nucleocytoplasm the Ibisii based on shared characteristics involved in information processing and translation. The Bacteria are members of the other realm, the Bacterii.

Eukaryogenesis is the study of how the Eukarya …

Achieving Access: Designing A Museum Accessibility Consulting Firm, Lauren J. Garnese

Master's Projects and Capstones

This capstone paper explores the need for an accessibility consulting firm to help museums and cultural institutions implement Americans with Disabilities Act policy adherence, universal design and accessible programming that increases the inclusion of people with disabilities in their organizations. The paper begins with a literature review that synthesizes the history of disability legislation and its relationship to museums, explores how museums can go beyond legal compliance and discusses the infrastructure suggested to implement accessibility efforts in an institution. The paper then proposes a project to create an accessibility consulting firm that assists museums in achieving their accessibility goals and …

Natural Burial: Being Green In Life, Now In Death Too, Brandon C. Shaik

Capstones

Nearly 80 million baby boomers are approaching the end of their lives. Being more environmentally conscious than previous generations, the environmentally minded individuals are increasingly choosing natural burial as the next progression of sustainability — reducing an individual impact even after death. A 2015 poll conducted by Harris Poll on behalf of the Funeral and Memorial Information Council found that 64 percent of adults over the age of 40 were interested in natural burial, up from 21 percent in 2010. Individuals who have chosen natural burial indicate the environmental benefit as a primary reason for their decision. There are currently …

Woof, Joseph D. Jaafari

Capstones

About 10 percent of Americans identify as polyamorous, defined as having multiple love affairs within a single relationship. Those relationships are as diverse as they are complicated with some ranging from having multiple people within a relationship to a couple having outside individual relationships.

Within the gay world, polyamory and open relationships has become a norm, and within the gay fetish scene it’s almost a requirement.

https://drive.google.com/open?id=0B_MnWyJVYJneYVAzXzcxU2U3bFE

But polyamory has its own set of complications legally. Because in America we have a system where only one person can receive benefits (be it through marriage or blood), there are complications if, …

Why We Still Need To Worry About Bees, Meaghan Lee Callaghan

Capstones

American honey bees, and other native bee species, are still in decline, though the specter of colony collapse disorder may be fading behind us. Colony decline, the loss of bees overwinter experienced across the country at a quarter to third lost per hive (sometimes more), is now expected. Losses can include those from colony collapse disorder. The author discusses the different causes for colony decline and speaks to bee health scientists and local beekeepers. Read more at: http://www.meaghanleecallaghan.com/capstone/index.html

Riding The Mind Lightning, William A. Fortuna

Capstones

Neuromodulation is the practice of applying external stimulation, either electric or magnetic, to the human in order to affect positive change. TDCS or transcranial direct current stimulation is a neuromodulatory technique using a 9-volt battery. Because of the simplicity of the device, and it's relatively low potential for harm, the technique is popular with both researchers and at-home enthusiasts. To find out whether this technique works the way some people say it does, I built my own.

Nyc Waterfronts, Pollution And Access, Guglielmo Mattioli

Capstones

This capstone is about the waterfronts of New York and their relation with access and pollution.

The city has come a long way since the 80s in terms of cleaning up open waters, rivers, and creeks. Many new promenades have been open and development spurred along the city shores. Yet too many miles of waterfront are still not accessible to the one most in need.

Jamaica Bay, Newtown Creek, and Flushing Bay are some of the most representative examples of where there is little access to the water and pollution levels are still too high. This capstone, organized in two …

Arresting Survival, Mariya Moseley

Capstones

The feature documentary ‘Arresting Survival’ examines the lives of previously incarcerated domestic violence survivors while exposing how the criminal justice system disproportionately affects women of color and women in low-income communities. While women are the fastest growing population within the prison system, the film aims to display the impact of the injustices of these women.

Hidden Jews Of The Balkans, Joshua A. Futtersak

Capstones

The history of the Jewish people is one filled with trials, triumphs, and often devastation. Many believe themselves to be educated in Jewish history, but we often have blind spots in our research and schooling. This project aims to look at just one region of Jewish history to tell the stories that are not usually told.

The Balkan region is incredibly diverse in its ethnicities and cultures. The history of the Jews in this region expresses that diversity. This project focuses on the unique stories of the Jewish communities in Bosnia, Serbia, and Greece. These stories of survival and perseverance …

Different Names For Bullying, Marco Poggio

Capstones

“There's all different forms of bullying,” says Steven Gray, a Lakota rancher and former law enforcement officer living in South Dakota. In this look into Gray’s life, we learn about two instances of bullying: the psychological and physical harassment that pushed his son, Tanner Thomas Gray, to commit suicide at age 12; And the controversial construction of an oil pipeline in an ancient tribal land that belongs to the Lakota people by rights of a treaty signed in 1851, which Gray sees as an institutional abuse infringing on the sovereignty of his people. Gray is involved in the movement that …

The Museum Wiki: A Model For Online Collections In Museums, Morgan Schlesinger

Master's Projects and Capstones

Museums increasingly use the Internet, digitization, and social tagging to publicize their collections in online databases. However, these online collections museums frequently lack contextual and interpretive information that objects require to be understood by the general public. Other sources, such as Wikipedia, consistently deliver more in-depth information on artworks than museums. The Museum Wiki proposes a solution for the Museum Studies field to address this information gap by emulating Wikipedia’s framework of interlinked articles for online museum collections. Additionally, this model raises the online visibility of these collections by editing relevant Wikipedia articles with information from articles written for …

Drink Me And Abort Your Baby: The Herbal Abortion Tea, Maya Lewis

Capstones

For most of history every abortion was a herbal abortion. Herbal abortion is exactly what it sounds like––a series of herbs that, if taken at the right time, in the right form and dosage, can induce a miscarriage. It's risky, under researched and rarely supported. But with women's clinic dwindling all over the country and a president elect who wants to repeal Roe v. Wade, herbal abortion might soon make a major come back–– for better or worse.

Link to capstone project: https://medium.com/@maya.lewis/drink-me-and-abort-your-baby-the-herbal-abortion-tea-46aadd15f659

The Future Of Music: Exploring Noise And Pop With Cienfuegos, Reed Dunlea

Capstones

Pop music today has become increasingly filled with sonic elements that are much more abrasive than traditionally acceptable. This piece explores how pop music got to this point, the underground subcultures that it draws influence from, and what's next.

Flight Of The Freshwater Fish, Michael H. Wilson

Capstones

Michael H. Wilson

Capstone Abstract

December 27, 2016

Flight of the Freshwater Fish

The Hudson River provides for millions of people as a path for commercial and private transportation, a source of food and energy, and perhaps most importantly for many living in the tri-state area as a destination for recreation and relaxation. The most overlooked feature of the river is how the wildlife shows clear signs of a changing climate and rapid environmental response to the impacts of global warming on the river.

Entire populations of fish species in the lower Hudson have been forced to leave the river …

Alternative Protein Sources In The Diet Modulate Microbiota And Functionality In The Distal Intestine Of Atlantic Salmon ( Salmo Salar ), Karina Gajardo, Alexander Jaramillo-Torres, Trond M. Kortner, Daniel L. Merrifield, John Tinsley, Anne Marie Bakke, Åshild Krogdahl

School of Biological and Marine Sciences

No abstract provided.

Staphylococcus Aureus Biofilms Interfere With Macrophage Antimicrobial Responses Through Differential Gene Regulation, Toxin Production, And Purine Metabolism, Tyler D. Scherr

Theses & Dissertations

Staphylococcus aureus (S. aureus) is an opportunistic pathogen that is a leading cause of both nosocomial and community-associated infections. Armed with a myriad of virulence factors and the propensity to form a biofilm on native tissues and implanted medical devices alike, S. aureus infections represent a very real public health threat, the treatment of which results in an excessive economic burden. S. aureus biofilm infections are notoriously recalcitrant to antibiotic therapy and adept at evading and neutralizing the host immune antimicrobial response. Previous studies from our laboratory have shown that S. aureus biofilms are able to cause persistent …

Improving Preadmission Testing Nurses' Knowledge Of Aortic Stenosis And Transcatheter Aortic Valve Replacement, Alberta Lynn Canale

Master's Projects and Capstones

Abstract

The purpose of this Clinical Nurse Leader (CNL) project was to reduce gaps in nursing knowledge through staff education. Guided by the CNL theme of educator and information manager, the goals were to increase PreAdmission Testing (PAT) nurses’ knowledge of severe/critical aortic stenosis (AS), transcatheter aortic valve replacement (TAVR) procedure and patient selection, and satisfaction with knowledge by 10%. Rapid growth of the TAVR program has contributed to a gap in nursing knowledge leading to inconsistent patient care and education. An educational program was developed and spread through a series of Plan-Do-Study-Act cycles. Pre- and post- implementation surveys were …

Model Behavior: Using Photogrammetry For Collections Storage Planning, Katherine Sundra

Master's Projects and Capstones

Proper and efficient collections storage is often a challenge for museums. As collections outgrow their facilities, institutions struggle to find additional space, often resorting to hasty moves of their objects into ill-fitting placements. A large-scale collections move is a slowgoing process, requiring manual measurement and countless trial-and-error sessions. An unnoticed support beam, a low entryway, or uneven flooring can derail even the most well-planned collections move, costing an organization unexpected additions in time and labor expenses. Advancements in emerging technologies, however, may soon eliminate this problem. This capstone explores the use of photogrammetry and 3D modeling to plan a collections …

The Immigrants In The Central Coast Of California Need Motivation To Attend Classes And Learn English As Their Second Language, Martin Rodriguez-Juarez

Master's Projects and Capstones

This field project shows that the immigrant community that works in the fields from the Central Coast of California need the motivation to attend adult school to learn English as their second language. A six-week courses is included.

Motivational Interviewing In General Dental Practice: A Review Of The Evidence, E. J. Kay, D. Vascott, A. Hocking, H. Nield

Peninsula Dental School

No abstract provided.