Digital Commons Network^™

The Role Of The Unusual Threonine String In The Conversion Of Prion Protein, Romany Abskharon, Fei Wang, Kayla J. Vander Stel, Kumar Sinniah

University Faculty Publications and Creative Works

The conversion of normal prion protein (PrP) into pathogenic PrP conformers is central to prion disease, but the mechanism remains unclear. The α-helix 2 of PrP contains a string of four threonines, which is unusual due to the high propensity of threonine to form β-sheets. This structural feature was proposed as the basis for initiating PrP conversion, but experimental results have been conflicting. We studied the role of the threonine string on PrP conversion by analyzing mouse Prnpa and Prnpb polymorphism that contains a polymorphic residue at the beginning of the threonine string, and PrP mutants in which threonine 191 …

Vocabulary Development In The Science Classroom: Using Hypermedia Authoring To Support English Learners, Robert Pritchard, Susan O'Hara

TAPESTRY

This study investigated the impact of authoring hypermedia projects on the academic vocabulary development of middle school, ESL students. Vocabulary definitions, inprocess verbalizations, observations and semi-structured interviews were the primary means of collecting data and assessing vocabulary growth. The results of this study indicate that hypermedia authoring had a positive impact on students' understanding of grade level, science concepts as well as on student engagement in and attitudes toward vocabulary building activities. Thus, the procedures implemented in this study provide a potential model for teachers to follow as they attempt to facilitate their students' vocabulary and concept development.

How The West Was Played: The Influence Of Wild West Shows On American Identity And Perceptions Of Gender, 1870 To 1920, Justine Macauley

Historical Perspectives: Santa Clara University Undergraduate Journal of History, Series II

No abstract provided.

Higgins, Maryellen. Hollywood’S Africa After 1994. Athens: Ohio University Press, 2013, 288 Pp., Dawne Curry

Journal of Retracing Africa

No abstract provided.

Like Disney For Adults: Life In Freedom Village, Janice G. Schuster

Sociology Between the Gaps: Forgotten and Neglected Topics

With an increasingly aging population, American society needs to more effectively address living options for the aging population in the present and future. Older adults have unique needs due to their age, physical and mental condition, varying needs for medical and health care and assistance with their daily activities. Freedom Village is an example of a very successful continuing care retirement community (CCRC) in Holland, Michigan. Using a case study approach and structured questions to ask two residents of Freedom Village, her aunt and uncle, over a period of several months, the author learned that they have lived very happily …

The Wrongfully Judged: A Study Of Perceptions And Reality Regarding Indian Prostitution During The California Gold Rush, Michelle Khoury

Historical Perspectives: Santa Clara University Undergraduate Journal of History, Series II

No abstract provided.

Use Of Microplate Respirometry To Measure Respiration Of Individual Adult Coral Polyps Exposed To Deepwater Horizon Oil, Brittany A. Jensen

Open Access Theses

The Deepwater Horizon (DWH) blowout of 2010 exposed many coastal and marine ecosystems in the Gulf of Mexico (GoM) to the acute and chronic effects of crude oil. To date, no studies have investigated the toxicity of DWH oil on shallow reef-building corals despite the relative proximity of some reef sites to the DWH (Flower Garden Banks, TX) and the potential for downstream oil transport to other more distant sites (Pulley Ridge and Florida Keys, FL). In this study, we investigated the effect of acute DWH oil exposure on reef corals, both alone and in combination with elevated temperature, to …

Stress Physiology And Weapon Integrity Of Intertidal Mantis Shrimp Under Future Ocean Conditions, Maya Devries, Summer Webb, Jenny Tu, Esther Cory, Victoria Morgan, Robert Sah, Dimitri Deheyn, Jennifer Taylor

Faculty Publications, Biological Sciences

Calcified marine organisms typically experience increased oxidative stress and changes in mineralization in response to ocean acidification and warming conditions. These effects could hinder the potency of animal weapons, such as the mantis shrimp’s raptorial appendage. The mechanical properties of this calcified weapon enable extremely powerful punches to be delivered to prey and aggressors. We examined oxidative stress and exoskeleton structure, mineral content, and mechanical properties of the raptorial appendage and the carapace under long-term ocean acidification and warming conditions. The predatory appendage had significantly higher % Mg under ocean acidification conditions, while oxidative stress levels as well as the …

The Murray Ledger And Times, December 15, 2016, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Persuasive Power Of Video Game Narratives: Addressing Empathy And Attitudes Toward People With Mental Illness, Kristy M. Najarian

Master of Arts in Communication

Many college students find themselves struggling with mental health problems (ACHA, 2015). Individuals with mental illness not only battle with the disease, but with the stigma society has developed toward them, leading to a diminished quality of life. Education and contact are two antistigma approaches utilized in this study (Corrigan & Watson, 2002). This thesis aims to understand players’ involvement in the video game narrative (i.e., narrative engagement and transportation) and its relationship with empathy and attitudes toward people with mental illness. As a way to alleviate stigma, college students (N = 97) were surveyed after playing the video game …

The Role Of Liberian Community Organizations In The Integration Of Liberian Immigrants: A Case Study Of Immigrants In Philadelphia, Pennsylvania, Solomon M. Muin

Capstone Collection

Immigrants that settled in a dominant new culture face challenges during the process of acculturation. Though minority culture is always at the disadvantaged end of acculturation in most cases, most research done on acculturation in the West mostly focused on the impact of immigrants on their societies, or on ways of strengthening integration in the host countries. As this continues, the dominant culture role and importance of the majority culture is what influence most narratives and not much is seeing from the minority culture. Most research on acculturation in the United States, for example, placed more emphasis on the Hispanic …

Assessing The Vulnerability Of Fishery Villages Influenced By Climate Change And Anthropogenic Activity In The Coastal Zone Of The Tamsui River, Sheng-Yuan Teng, Ming-An Lee, Jhen Hsu, Tzu-Ping Lin, Yu-Chen Lin, Yi Chang

Journal of Marine Science and Technology–Taiwan

Coastal zones located in populated and rapidly developing areas face high risks of natural and anthropogenic disasters. In this study, a framework was developed to determine the indicators of vulnerability to natural and anthropogenic disasters in Chuwei and Tamsui, two northern Taiwanese fishing villages in the coastal zone of the Tamsui River. The analytical hierarchy process (AHP) was used to determine the vulnerability indices of the locations, with experts evaluating the weights assigned to a range of criteria, namely hydrological data (such as sea surface temperature and sea level), stakeholder perceptions, and fishery data. These two villages have a considerably …

Biogeography, Interspecific Introgression, And The Evolution Of Hemoglobin Genes In The High Andes: The Evolutionary History Of The South American Siskins (Spinus), Elizabeth Jane Beckman

Biology ETDs

Landscape features, interspecific introgression, and adaptation work in concert to shape the evolutionary history of a clade. Understanding the independent and cumulative consequences of these evolutionary processes on diversification is critical to revealing the origins of extant biodiversity. Studying these processes within rapid radiations, a significant contributor to global biodiversity, can provide powerful insight into the process of diversification. To assess how diversification is shaped by these evolutionary forces, I examined the biogeographic history, patterns of interspecific introgression and adaptation to high elevation in a recent, rapid radiation of finches, the South American siskins (Fringillidae: Spinus). I found that …

The Influence Of The Invasive Chinese Tallow (Triadica Sebifera) Leaf Litter On Aquatic Chemistry And Microbial Community Composition, Raymond D. Montez

Electronic Theses and Dissertations

Global climate change and anthropogenic activity have facilitated the movement and invasive potential of nonnative plants in native environments. These invasions can have negative effects on ecosystem diversity and function. The nonnative and invasive plant, Chinese Tallow (Triadica sebifera), has already invaded much of the south eastern US where it is outcompeting native tree species and changing ecosystem diversity in a variety of habitats. Leaf litter from the Chinese tallow has been shown cause changes in dissolved oxygen and pH in the aquatic environment. Turbidity is also affected when Chinese tallow litter is present in water. A series of …

The Church And Magna Carta, R. H. Helmholz

William & Mary Bill of Rights Journal

No abstract provided.

Interpretation And Re-Interpretation Of A Clause: Magna Carta And The Widow’S Quarantine, Janet Loengard

William & Mary Bill of Rights Journal

No abstract provided.

Forest Law Through The Looking Glass: Distortions Of The Forest Charter In The Outlaw Fiction Of Late Medieval England, Sarah Harlan-Haughey

William & Mary Bill of Rights Journal

No abstract provided.

Forest Eyre Justices In The Reign Of Henry Iii (1216–1272), Ryan Rowberry

William & Mary Bill of Rights Journal

No abstract provided.

Guided Medical Data Segmentation Using Structure-Aligned Planar Contours, Michelle Vaughan Holloway

McKelvey School of Engineering Graduate Student Theses & Dissertations

Segmentation of 3D/4D biological images is a critical step for a wide range of applications such as treatment planning, quantitative analysis, virtual simulations, and rendering visualizations. Automatic segmentation methods are becoming more reliable, but many experts still rely on manual intervention which makes segmentation a time and resource intensive bottleneck. Marking boundary contours in 3D images can be difficult when images are often noisy or the delineation of biological tissue is unclear. Non-parallel contours can be more accurate and reduce the amount of marking necessary, but require extra effort to ensure boundary consistency and maintain spatial orientation. This dissertation focuses …

On Control Systems Of The Brain: A Study Of Their Connections, Activations, And Interactions, Haoxin Sun

McKelvey School of Engineering Graduate Student Theses & Dissertations

Implementation of daily functions in humans crucially relies on both the bottom-up moment-to- moment processing of relevant input and output information as well as the top-down controls that instantiate and regulate goal-directed strategies. The current dissertation focuses on different systems of brain regions related to task control. We are interested in investigating, in detail, some of the basic activity patterns that different control systems carry during simple tasks, and how differences in activity patterns may shed new insight onto the distinctions among the systems' functional roles. In addition, carefully coordinated interactions between brain regions specialized for control-related activity and regions …

New Techniques And Optimizations Of Short Echo-Time 1h Mri With Applications In Murine Lung, Jinbang Guo

Arts & Sciences Graduate Student Theses and Dissertations

Although x-ray computed tomography (CT) is a gold standard for pulmonary imaging, it has high ionizing radiation, which puts patients at greater risk of cancer, particularly in a longitudinal study with cumulative doses. Magnetic resonance imaging (MRI) doesn't involve exposure to ionizing radiation and is especially useful for visualizing soft tissues and organs such as ligaments, cartilage, brain, and heart. Many efforts have been made to apply MRI to study lung function and structure of both humans and animals. However, lung is a unique organ and is very different from other solid organs like the heart and brain due to …

The Dynamic Brain In Action: Cortical Oscillations And Coordination Dynamics, Mahmood Hoseini

Arts & Sciences Graduate Student Theses and Dissertations

Cortical oscillations are electrical activities with rhythmic and/or repetitive nature generated spontaneously and in response to stimuli. Study of cortical oscillations has become an area of converging interests since the last two decades and has deepened our understanding of its physiological basis across different behavioral states. Experimental and modeling work has taught us that there is a wide diversity of cellular and circuit mechanisms underlying the generation of cortical rhythms. A wildly diverse set of functions has pertained to synchronous oscillations but their significance in cognition should be better appraised in the more general framework of correlation between spike times …

Structure, Dynamics, And Regulation Of Collective Cell Migration, Andrew J. Loza

Arts & Sciences Graduate Student Theses and Dissertations

Collective migration is the process by which cells organize individual motions to productively migrate as a group and plays a fundamental role in organism development, tissue regeneration, and cancer invasion. In development, coordinated migration facilitates the formation of complex organ structures and is required for proper dissemination of neural crest cells throughout an organism. After injury, this process allows breaches in epithelial layers to be repaired while maintaining tissue integrity, and in cancer, collective behavior enhances invasion of tumor cells into the surrounding tissue. Chapter 1 provides an introduction for the role of collective migration across an organism’s lifespan, the …

Genetic Mechanisms For The Maintenance Of Behavioral Mating Barriers In Drosophila, Kathleen M. Mortland

Arts & Sciences Graduate Student Theses and Dissertations

One of the most successful and diverse systems involved in the maintenance of behavioral barriers between closely related animal species is pheromonal communication. In the fruit fly, contact chemosensation input is especially important during sexual decision-making as it allows for the sensing of sex and species-specific non-volatile cuticular hydrocarbons (CHCs), which function as insect pheromones. However, how pheromonal systems support the maintenance of mating barriers is puzzling since any change in either pheromone ligands or their cognate receptors would carry a fitness cost, which should be eliminated by stabilizing selection. To resolve this evolutionary conundrum I hypothesized that pleiotropic genes …

A Study On The Role And Regulation Of The Na+-Leak Channel, Non-Selective (Nalcn) In Myometrial Function, Erin Lynn Reinl

Arts & Sciences Graduate Student Theses and Dissertations

Uterine contractions are tightly regulated throughout pregnancy, remaining relatively quiescent for the majority of pregnancy to promote fetal development, while becoming highly activated at term to effectively expel the fetus. Contractions are coordinated through electrical and mechanical coupling of myometrial smooth muscle cells (MSMCs). Ion channel activity, which alters the electrical activity of MSMCs, can directly affect the contraction profile. Thus there is great interest in the field of reproduction to understand which ion channels regulate uterine excitability, and particularly how they may enable the transition from uterine quiescence to uterine activation for labor. The focus thus far has been …

Discovery And Functional Implication Of Genetic Alterations Associated With Clonal Hematopoietic Expansion, Mingchao Xie

Arts & Sciences Graduate Student Theses and Dissertations

Cancers, including hematologic malignancies, arise as a result of the stepwise accumulation of mutations. Some early mutations that potentially initiate clonal expansion might exist in patients many years before they develop obvious disease symptoms. Therefore, identifying and characterizing these early mutations are critical to understanding the genetic basis of tumorigenesis. Here, we analyzed blood-derived DNA sequencing data from 2,728 individuals without apparent hematologic malignancies and identified 77 blood-specific mutations in 31 cancer-associated genes. Importantly, 83% of all mutations occurred in 19 genes that have been previously linked to hematological malignancies, such as DNMT3A, TET2, JAK2, and ASXL1. By investigating these …

Implicit Prosody And Cue-Based Retrieval: L1 And L2 Agreement And Comprehension During Reading, Elizabeth Pratt, Eva M. Fernández

Publications and Research

This project focuses on structural and prosodic effects during reading, examining their influence on agreement processing and comprehension in native English (L1) and Spanish–English bilingual (L2) speakers. We consolidate research from several distinct areas of inquiry—cognitive processing, reading fluency, and L1/L2 processing—in order to support the integration of prosody with a cue-based retrieval mechanism for subject-verb agreement. To explore this proposal, the experimental design manipulated text presentation to influence implicit prosody, using sentences designed to induce subject-verb agreement attraction errors. Materials included simple and complex relative clauses with head nouns and verbs that were either matched or mismatched for number. …

Selective Suppression Of The Α Isoform Of P38 Mapk Rescues Late-Stage Tau Pathology, Nicole Maphis, Shanya Jiang, Guixiang Xu, Olga N. Kokiko-Cochran, Saktimayee M. Roy, Linda J. Van Eldik, D. Martin Watterson, Bruce T. Lamb, Kiran Bhaskar

Sanders-Brown Center on Aging Faculty Publications

Background: Hyperphosphorylation and aggregation of tau protein are the pathological hallmarks of Alzheimer’s disease and related tauopathies. We previously demonstrated that the microglial activation induces tau hyperphosphorylation and cognitive impairment via activation of p38 mitogen-activated protein kinase (p38 MAPK) in the hTau mouse model of tauopathy that was deficient for microglial fractalkine receptor CX3CR1.

Method: We report an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK (MW181) and its effects on tau phosphorylation in vitro and in hTau mice.

Results: First, pretreatment of mouse primary cortical neurons with MW181 completely blocked inflammation-induced p38α MAPK activation and AT8 …

Global Citizenship Certificate Program, Alison C. Meighan

Capstone Collection

In today’s highly globalized and increasingly interconnected world, we face many pressing world problems including poverty, social inequalities, and climate change, to name a few. Reflecting this stark reality and acknowledging that these problems are indeed borderless, it has become vital to rethink education and provide the next generation of worldwide change-makers with the knowledge, skills, and attitudes necessary to solve these problems and make our world more equitable and sustainable. One avenue for achieving this shift in education and fostering these global problem-solving skills and attitudes, is global citizenship. United Nations Secretary General Ban Ki-moon corroborates this point, stating, …

One For Mirth, Two For Sorrow, Hananah Zaheer

Westview

No abstract provided.